KEGG   PATHWAY: rro05165
Entry
rro05165                    Pathway                                
Name
Human papillomavirus infection - Rhinopithecus roxellana (golden snub-nosed monkey)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
rro05165  Human papillomavirus infection
rro05165

Organism
Rhinopithecus roxellana (golden snub-nosed monkey) [GN:rro]
Gene
104679729  WNT1; proto-oncogene Wnt-1 [KO:K03209]
104682628  WNT2; protein Wnt-2 [KO:K00182]
104658925  WNT2B; protein Wnt-2b [KO:K00182]
104672034  WNT3A; protein Wnt-3a [KO:K00312]
104682399  WNT3; proto-oncogene Wnt-3 [KO:K00312]
104663222  WNT4; protein Wnt-4 [KO:K00408]
104662531  WNT5B; protein Wnt-5b [KO:K00444]
104676516  WNT5A; protein Wnt-5a [KO:K00444]
104660036  WNT6; protein Wnt-6 [KO:K00445]
104676099  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
104679020  WNT7A; protein Wnt-7a [KO:K00572]
104656476  WNT8B; protein Wnt-8b [KO:K00714]
104681717  WNT8A; protein Wnt-8a isoform X1 [KO:K00714]
104672033  WNT9A; protein Wnt-9a isoform X2 [KO:K01064]
104682400  WNT9B; protein Wnt-9b [KO:K01064]
104660037  WNT10A; protein Wnt-10a [KO:K01357]
104679730  WNT10B; protein Wnt-10b [KO:K01357]
104665095  WNT11; protein Wnt-11 isoform X3 [KO:K01384]
104677318  WNT16; LOW QUALITY PROTEIN: protein Wnt-16 [KO:K01558]
104680806  FZD7; frizzled-7 [KO:K02432]
104655247  FZD1; frizzled-1 [KO:K02432]
104654721  FZD2; frizzled-2 [KO:K02235]
104668245  FZD3; frizzled-3 [KO:K02329]
104656419  FZD4; frizzled-4 isoform X2 [KO:K02354]
104680216  FZD5; frizzled-5 [KO:K02375]
104682682  FZD8; frizzled-8 [KO:K02375]
104655138  FZD6; frizzled-6 isoform X1 [KO:K02376]
104655547  FZD10; frizzled-10 [KO:K02842]
104681229  FZD9; frizzled-9 [KO:K02842]
104679742  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
104673334  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
104664635  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
104680990  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
104676962  AXIN1; axin-1 isoform X1 [KO:K02157]
104675432  AXIN2; LOW QUALITY PROTEIN: axin-2 [KO:K04385]
104669245  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
104671452  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
104670934  CTNNB1; catenin beta-1 [KO:K02105]
104677933  CSNK1A1L; casein kinase I [KO:K08957] [EC:2.7.11.1]
104680771  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
104668701  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
104659811  TCF7; transcription factor 7 isoform X9 [KO:K02620]
104659731  TCF7L1; transcription factor 7-like 1 isoform X2 [KO:K04490]
104664436  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
104656439  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
104673812  TLR3; toll-like receptor 3 isoform X2 [KO:K05401]
104665406  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
104654431  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
104661734  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
104680828  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
104667206  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
104670295  IFNB1; interferon beta [KO:K05415]
104673260  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
104672289  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
104667158  TADA3; transcriptional adapter 3 [KO:K11315]
104661662  TP53; cellular tumor antigen p53 [KO:K04451]
104660500  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
104675158  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
104661201  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
104661406  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
104662378  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
104655625  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
104671216  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
104653559  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
104663221  CDC42; cell division control protein 42 homolog [KO:K04393]
104671698  SCRIB; protein scribble homolog isoform X7 [KO:K16175]
104676365  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
104662560  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
104678790  DLG3; disks large homolog 3 isoform X6 [KO:K21098]
104665882  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
104681307  LLGL2; lethal(2) giant larvae protein homolog 2 isoform X7 [KO:K06094]
104665367  CRB3; protein crumbs homolog 3 [KO:K06090]
104668052  PATJ; inaD-like protein isoform X2 [KO:K06092]
104665049  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
104680130  VWF; LOW QUALITY PROTEIN: von Willebrand factor [KO:K03900]
104659681  THBS1; thrombospondin-1 [KO:K16857]
104659600  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
104680172  THBS4; thrombospondin-4 [KO:K04659]
104681915  THBS2; thrombospondin-2 [KO:K04659]
104680632  COMP; cartilage oligomeric matrix protein [KO:K04659]
104669238  FN1; fibronectin isoform X1 [KO:K05717]
104680270  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
104682783  COL1A2; collagen alpha-2(I) chain [KO:K06236]
104654840  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
104679242  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
104658850  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
104671965  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
104671966  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
104679243  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
104665145  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
104658033  COL6A3; collagen alpha-3(VI) chain isoform X4 [KO:K06238]
104656442  collagen alpha-4(VI) chain-like isoform X1 [KO:K06238]
104667602  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
104675733  collagen alpha-6(VI) chain [KO:K06238]
104667603  COL6A1; collagen alpha-1(VI) chain isoform X1 [KO:K06238]
104667404  COL6A5; LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
104663835  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
104668793  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
104654892  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
104670221  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
104655298  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
104678039  laminin subunit alpha-3 isoform X2 [KO:K06240]
104663822  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
104659760  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
104677415  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
104667469  LAMB2; laminin subunit beta-2 [KO:K06243]
104664167  LAMB3; laminin subunit beta-3 [KO:K06244]
104672365  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
104666795  LAMC1; laminin subunit gamma-1 [KO:K05635]
104666798  LAMC2; laminin subunit gamma-2 [KO:K06246]
104660568  LAMC3; laminin subunit gamma-3 [KO:K06247]
104680276  CHAD; chondroadherin [KO:K06248]
104673554  RELN; reelin [KO:K06249] [EC:3.4.21.-]
104664613  SPP1; osteopontin [KO:K06250]
104669368  VTN; vitronectin [KO:K06251]
104679259  TNC; tenascin isoform X1 [KO:K06252]
104674099  tenascin-X isoform X1 [KO:K06252]
104665530  TNN; tenascin-N isoform X1 [KO:K06252]
104665533  TNR; tenascin-R isoform X1 [KO:K06252]
104665913  IBSP; bone sialoprotein 2 [KO:K06253]
104680210  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
104672477  ITGA2; integrin alpha-2 [KO:K06481]
104654717  ITGA2B; integrin alpha-IIb [KO:K06476]
104680261  ITGA3; integrin alpha-3 [KO:K06482]
104666588  ITGA4; integrin alpha-4 [KO:K06483]
104670562  ITGA5; integrin alpha-5 [KO:K06484]
104673514  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
104673715  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
104664159  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
104672775  ITGA9; integrin alpha-9 [KO:K06585]
104671046  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
104662593  ITGA11; integrin alpha-11 [KO:K06587]
104667754  ITGAV; integrin alpha-V isoform X2 [KO:K06487]
104663301  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
104662513  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
104681299  ITGB4; integrin beta-4 isoform X4 [KO:K06525]
104655400  ITGB5; integrin beta-5 [KO:K06588]
104674711  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
104670606  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
104658643  ITGB8; integrin beta-8 [KO:K06591]
104679749  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
104666247  PXN; paxillin isoform X1 [KO:K05760]
104661913  TNF; tumor necrosis factor isoform X1 [KO:K03156]
104680127  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
104655653  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
104669600  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
104675147  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
104677132  FADD; FAS-associated death domain protein [KO:K02373]
104671864  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
104666783  caspase-3-like [KO:K02187] [EC:3.4.22.56]
104673791  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
104681336  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
104659809  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
104668221  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
104672685  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
104677337  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
104659744  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X5 [KO:K04354]
104678160  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
104673955  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
104667559  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
104679853  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
104663356  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
104663566  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
115895932  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta-like [KO:K11583]
104662840  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
104673923  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
104669493  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
104667330  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
104654440  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
104669743  TSC1; hamartin isoform X2 [KO:K07206]
104681538  TSC2; tuberin isoform X1 [KO:K07207]
104678707  RHEB; GTP-binding protein Rheb [KO:K07208]
104654362  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
104679650  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
104662932  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
104664740  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
104658958  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
104673141  BAD; bcl2-associated agonist of cell death [KO:K02158]
104670408  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
104663050  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104665061  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104670605  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104662124  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104675620  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104680672  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
104673041  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104676121  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104654186  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
115893905  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104671116  FOXO1; forkhead box protein O1 isoform X2 [KO:K07201]
104668343  CDKN1B; cyclin-dependent kinase inhibitor 1B isoform X1 [KO:K06624]
104682880  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
104677168  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
104658979  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
104667309  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
104682344  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
104682750  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
104660331  CCNE2; G1/S-specific cyclin-E2 isoform X2 [KO:K06626]
104656155  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
104673700  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
104662760  RB1; retinoblastoma-associated protein [KO:K06618]
104655806  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
104658250  RBL2; retinoblastoma-like protein 2 [KO:K16332]
104662043  26S proteasome regulatory subunit 4 [KO:K03062]
104670546  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
104682317  26S proteasome regulatory subunit 4 [KO:K03062]
104658905  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 4 [KO:K03062]
104660298  E2F1; transcription factor E2F1 [KO:K17454]
104661791  CCNA2; cyclin-A2 [KO:K06627]
104677942  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
104660482  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
104682194  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
104667362  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
104656469  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
104666046  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
104667046  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
104662315  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
104664815  RELA; transcription factor p65 [KO:K04735]
104658667  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
104679986  NFX1; transcriptional repressor NF-X1 isoform X3 [KO:K12236]
104654770  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
104677352  histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
104657112  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
104680111  CHD4; chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
104659840  IRF1; interferon regulatory factor 1 [KO:K09444]
104674401  TBP; TATA-box-binding protein [KO:K03120]
104669139  TBPL2; TATA box-binding protein-like protein 2 [KO:K03120]
104678239  TBPL1; TATA box-binding protein-like protein 1 [KO:K03120]
104670209  patr class I histocompatibility antigen, B-2 alpha chain isoform X1 [KO:K06751]
104668193  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-42 alpha chain-like [KO:K06751]
104674706  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
104661905  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
115897009  HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751]
104676771  mamu class I histocompatibility antigen, alpha chain F [KO:K06751]
104678084  HLA class I histocompatibility antigen, B-38 alpha chain-like [KO:K06751]
104668434  HLA class I histocompatibility antigen, A-30 alpha chain isoform X1 [KO:K06751]
104677089  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like isoform X1 [KO:K06751]
104673193  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-14 alpha chain [KO:K06751]
104676774  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
104666183  popy class I histocompatibility antigen, alpha chain E isoform X1 [KO:K06751]
104678248  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-67 alpha chain [KO:K06751]
104661180  BCAP31; B-cell receptor-associated protein 31 [KO:K14009]
104660614  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
104661334  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform isoform X1 [KO:K02147]
104672558  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
104675197  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
104655141  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
104665038  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
104663179  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
104676301  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
104674437  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
104661911  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
104667885  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
104658268  ATP6V1G3; V-type proton ATPase subunit G 3 isoform X2 [KO:K02152]
104681661  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
104656614  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
104680265  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
104664717  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform X2 [KO:K02154]
104666329  ATP6V0A2; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
104671774  ATP6V0D2; V-type proton ATPase subunit d 2 isoform X1 [KO:K02146]
104655633  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
104670135  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
104675263  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
104667384  V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
104681554  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
104669044  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
104667038  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
104682421  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
104675886  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
104681311  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
104663024  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
104682751  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
104654600  HRAS; GTPase HRas isoform X1 [KO:K02833]
104670041  KRAS; GTPase KRas isoform X1 [KO:K07827]
104669078  NRAS; GTPase NRas [KO:K07828]
104673299  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
104662575  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104665487  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104676897  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104681150  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
104664377  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
104676931  PTGER4; prostaglandin E2 receptor EP4 subtype isoform X1 [KO:K04261]
104663797  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
104663799  neuroendocrine secretory protein 55 [KO:K04632]
104662061  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma isoform X1 [KO:K04345] [EC:2.7.11.11]
104677489  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
104661051  LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
104666540  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
104680220  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
104672444  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
104663511  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
104665486  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
104668385  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
104656623  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
104681895  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
104679837  UBR4; E3 ubiquitin-protein ligase UBR4 isoform X5 [KO:K10691] [EC:2.3.2.27]
104680173  TUBG1; tubulin gamma-1 chain [KO:K10389]
104680166  TUBG2; tubulin gamma-2 chain [KO:K10389]
104663550  PKM; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
104670273  interferon alpha-1/13 [KO:K05414]
104670275  IFNA8; interferon alpha-8 [KO:K05414]
104670276  interferon alpha-1/13-like [KO:K05414]
104670278  IFNA6; interferon alpha-6 [KO:K05414]
104670280  interferon alpha-14 [KO:K05414]
104670290  interferon alpha-4 [KO:K05414]
104670292  interferon alpha-10-like [KO:K05414]
104680728  interferon alpha-10 [KO:K05414]
115893964  interferon alpha-4 [KO:K05414]
115893973  interferon alpha-10-like [KO:K05414]
104658750  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
104658748  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
104668074  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
104670479  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
104675282  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
104673676  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
104662694  IRF9; interferon regulatory factor 9 [KO:K04693]
115897716  interferon regulatory factor 9 [KO:K04693]
104669977  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
104666268  OASL; 2'-5'-oligoadenylate synthase-like protein [KO:K14608]
104655127  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
104655128  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
104673206  ISG15; LOW QUALITY PROTEIN: ubiquitin-like protein ISG15 [KO:K12159]
104655766  JAG1; protein jagged-1 [KO:K06052]
104669778  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
104660335  NOTCH2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
104661025  NOTCH3; neurogenic locus notch homolog protein 3 isoform X2 [KO:K20995]
104673909  NOTCH4; neurogenic locus notch homolog protein 4 isoform X1 [KO:K20996]
104656202  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
104664990  beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
104682508  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe [KO:K05948] [EC:2.4.1.222]
104654981  RFNG; beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
104654335  MAML3; mastermind-like protein 3 [KO:K06061]
104676227  MAML1; LOW QUALITY PROTEIN: mastermind-like protein 1 [KO:K06061]
104671804  MAML2; mastermind-like protein 2 isoform X1 [KO:K06061]
104678850  RBPJL; recombining binding protein suppressor of hairless-like protein isoform X1 [KO:K06053]
104666019  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
104669884  HES1; transcription factor HES-1 [KO:K06054]
104661705  HES7; transcription factor HES-7 [KO:K09087]
104658048  HES6; transcription cofactor HES-6 isoform X1 [KO:K09087]
104657574  HES2; transcription factor HES-2 [KO:K09087]
104657577  HES3; transcription factor HES-3 [KO:K09088]
104679037  HES4; transcription factor HES-4 isoform X1 [KO:K09089]
104677090  HES5; transcription factor HES-5 [KO:K06055]
104660010  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
104674230  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1 [KO:K09091]
104654874  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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Reference
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Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
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Reference
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Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
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Reference
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NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
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Mol Cell Biol 28:4819-28 (2008)
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Reference
PMID:23536685
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  Title
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Related
pathway
rro04064  NF-kappa B signaling pathway
rro04110  Cell cycle
rro04115  p53 signaling pathway
rro04150  mTOR signaling pathway
rro04151  PI3K-Akt signaling pathway
rro04210  Apoptosis
rro04310  Wnt signaling pathway
rro04330  Notch signaling pathway
rro04510  Focal adhesion
rro04520  Adherens junction
rro04530  Tight junction
rro04612  Antigen processing and presentation
rro04620  Toll-like receptor signaling pathway
rro04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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