KEGG   PATHWAY: sara05161
Entry
sara05161                   Pathway                                
Name
Hepatitis B - Sorex araneus (European shrew)
Description
Hepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and converted into a covalently closed circular molecule cccDNA. The cccDNA is the template for transcription of all viral RNAs including the pregenomic RNA (pgRNA), encoding for 7 viral proteins: large, middle, and small envelope proteins (LHBs, MHBs, and SHBs) that form the surface antigen (HBsAg), the core antigen (HBcAg), the e antigen (HBeAg), the HBV polymerase, and the regulatory protein X (HBx). The pgRNA interacts with the viral polymerase protein to initiate the encapsidation into the core particles. Through endoplasmic reticulum, the core particles finish assembling with the envelope proteins and are released. HBV infection leads to a wide spectrum of liver diseases raging from chronic hepatitis, cirrhosis to hepatocellular carcinoma. The mechanism of liver injury is still not clear. However, HBV proteins target host proteins, involved in a variety of functions, thus regulating transcription, cellular signaling cascades, proliferation, differentiation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
sara05161  Hepatitis B
sara05161

Organism
Sorex araneus (European shrew) [GN:sara]
Gene
101548643  HSPG2; LOW QUALITY PROTEIN: basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
101550516  SLC10A1; LOW QUALITY PROTEIN: sodium/bile acid cotransporter [KO:K14341]
101551346  TGFB1; transforming growth factor beta-1 [KO:K13375]
101549205  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
101546290  TGFB3; transforming growth factor beta-3 [KO:K13377]
101537676  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
101553495  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
101544572  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
101543917  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
101538553  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101556557  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101556063  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101541387  MYC; myc proto-oncogene protein [KO:K04377]
101538660  EGR2; E3 SUMO-protein ligase EGR2 isoform X2 [KO:K12496]
101553165  EGR3; early growth response protein 3 isoform X2 [KO:K12497]
101542504  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
101558222  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
101537422  DDB1; DNA damage-binding protein 1 [KO:K10610]
101555848  DDB2; DNA damage-binding protein 2 [KO:K10140]
101554394  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
101541000  YWHAQ; 14-3-3 protein theta [KO:K16197]
101553880  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
101550847  YWHAZ; 14-3-3 protein zeta/delta isoform X1 [KO:K16197]
101542924  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
101542917  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101556597  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101548304  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101547106  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101541868  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101540938  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101543096  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101559009  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101543371  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101538389  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101540472  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101536840  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101556810  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101549580  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
101543163  RELA; transcription factor p65 [KO:K04735]
101545527  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
101545820  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101549930  BAD; bcl2-associated agonist of cell death [KO:K02158]
101537769  FADD; FAS-associated death domain protein [KO:K02373]
101543078  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
101546492  BID; BH3-interacting domain death agonist [KO:K04726]
101540951  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
101537432  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
101558408  cytochrome c, somatic [KO:K08738]
101538879  cytochrome c-like [KO:K08738]
101549686  cytochrome c, somatic [KO:K08738]
101543860  cytochrome c 2 [KO:K08738]
101537803  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
101539340  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105942814  caspase-12-like [KO:K04741] [EC:3.4.22.-]
101543114  BIRC5; LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 5 [KO:K08731]
101558045  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
101553498  CCNA1; cyclin-A1 [KO:K06627]
101556698  CCNA2; cyclin-A2 [KO:K06627]
101544122  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
101542272  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
101550200  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
101548470  RB1; retinoblastoma-associated protein [KO:K06618]
101555654  E2F1; transcription factor E2F1 [KO:K17454]
101544935  E2F2; transcription factor E2F2 [KO:K09389]
101538345  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
101551961  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101547658  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
101539279  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
101554287  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
101555053  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
101549236  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
101538630  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
101558664  TNF; tumor necrosis factor [KO:K03156]
101556525  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101550196  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
101553455  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
101550098  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
101552896  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
101554357  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101550386  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
101554621  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
101552631  signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
101552185  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
101554096  STAT6; signal transducer and activator of transcription 6 [KO:K11225]
101539505  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
101544808  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
101559065  SRC; proto-oncogene tyrosine-protein kinase Src isoform X2 [KO:K05704] [EC:2.7.10.2]
101544020  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101550972  SOS1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
101555769  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101546777  HRAS; GTPase HRas [KO:K02833]
101557531  KRAS; GTPase KRas isoform X1 [KO:K07827]
101559343  NRAS; GTPase NRas [KO:K07828]
101552483  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
101539734  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101552417  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
101554214  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
101538215  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
101543170  CREB3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101542980  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101553377  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
101539159  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101554016  CREB5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
101551180  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
101559441  CXCL8; interleukin-8 [KO:K10030]
101540562  PCNA; proliferating cell nuclear antigen [KO:K04802]
101555255  proliferating cell nuclear antigen-like [KO:K04802]
101554406  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
101550676  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
101545329  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101550720  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101555057  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101559341  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101541587  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
101545848  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
101545059  FOS; proto-oncogene c-Fos isoform X1 [KO:K04379]
101555656  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
101542483  TLR2; toll-like receptor 2 [KO:K10159]
101552741  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
101548691  TLR4; toll-like receptor 4 [KO:K10160]
101547526  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
101539504  IRAK1; LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
101543216  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101547502  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
101539336  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
101546102  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101540363  IL6; interleukin-6 [KO:K05405]
101555912  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
101542881  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
101536977  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101537598  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101554044  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101545321  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101554595  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101539539  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
101552190  TLR3; toll-like receptor 3 [KO:K05401]
101557102  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
101557300  DDX58; LOW QUALITY PROTEIN: probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
101559134  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
101542406  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
101538970  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101552901  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
101542553  TBK1; serine/threonine-protein kinase TBK1 isoform X2 [KO:K05410] [EC:2.7.11.10]
101539350  DDX3X; ATP-dependent RNA helicase DDX3X isoform X1 [KO:K11594] [EC:5.6.2.7]
101542890  IRF3; interferon regulatory factor 3 [KO:K05411]
101545292  IRF7; interferon regulatory factor 7 [KO:K09447]
101549593  LOW QUALITY PROTEIN: interferon alpha-14 [KO:K05414]
101548268  IFNB1; interferon beta [KO:K05415]
101558656  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
Compound
C00076  Calcium cation
Reference
PMID:30059722
  Authors
Caballero A, Tabernero D, Buti M, Rodriguez-Frias F
  Title
Hepatitis B virus: The challenge of an ancient virus with multiple faces and a remarkable replication strategy.
  Journal
Antiviral Res 158:34-44 (2018)
DOI:10.1016/j.antiviral.2018.07.019
Reference
PMID:22869468
  Authors
Walsh R, Locarnini S
  Title
Hepatitis B precore protein: pathogenic potential and therapeutic promise.
  Journal
Yonsei Med J 53:875-85 (2012)
DOI:10.3349/ymj.2012.53.5.875
Reference
PMID:26239691
  Authors
Liang TJ, Block TM, McMahon BJ, Ghany MG, Urban S, Guo JT, Locarnini S, Zoulim F, Chang KM, Lok AS
  Title
Present and future therapies of hepatitis B: From discovery to cure.
  Journal
Hepatology 62:1893-908 (2015)
DOI:10.1002/hep.28025
Reference
PMID:26776362
  Authors
Morikawa K, Suda G, Sakamoto N
  Title
Viral life cycle of hepatitis B virus: Host factors and druggable targets.
  Journal
Hepatol Res 46:871-7 (2016)
DOI:10.1111/hepr.12650
Reference
PMID:19201080
  Authors
Feitelson MA, Reis HM, Tufan NL, Sun B, Pan J, Lian Z
  Title
Putative roles of hepatitis B x antigen in the pathogenesis of chronic liver disease.
  Journal
Cancer Lett 286:69-79 (2009)
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Reference
PMID:19263472
  Authors
Murata M, Matsuzaki K, Yoshida K, Sekimoto G, Tahashi Y, Mori S, Uemura Y, Sakaida N, Fujisawa J, Seki T, Kobayashi K, Yokote K, Koike K, Okazaki K
  Title
Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)-beta signaling from tumor suppression to oncogenesis in early chronic hepatitis B.
  Journal
Hepatology 49:1203-17 (2009)
DOI:10.1002/hep.22765
Reference
PMID:15173177
  Authors
Yoo YG, Lee MO
  Title
Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor.
  Journal
J Biol Chem 279:36242-9 (2004)
DOI:10.1074/jbc.M401290200
Reference
PMID:16459163
  Authors
Zhang X, Zhang H, Ye L
  Title
Effects of hepatitis B virus X protein on the development of liver cancer.
  Journal
J Lab Clin Med 147:58-66 (2006)
DOI:10.1016/j.lab.2005.10.003
Reference
PMID:19854353
  Authors
Benhenda S, Cougot D, Buendia MA, Neuveut C
  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
  Journal
Adv Cancer Res 103:75-109 (2009)
DOI:10.1016/S0065-230X(09)03004-8
Reference
PMID:21994562
  Authors
Benhenda S, Cougot D, Neuveut C, Buendia MA
  Title
Liver cell transformation in chronic HBV infection.
  Journal
Viruses 1:630-46 (2009)
DOI:10.3390/v1030630
Reference
PMID:11099494
  Authors
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  Title
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
  Journal
J Biol Chem 276:8328-40 (2001)
DOI:10.1074/jbc.M006026200
Reference
PMID:16891440
  Authors
Park NH, Song IH, Chung YH
  Title
Chronic hepatitis B in hepatocarcinogenesis.
  Journal
Postgrad Med J 82:507-15 (2006)
DOI:10.1136/pgmj.2006.047431
Reference
PMID:28820498
  Authors
Lin S, Zhang YJ
  Title
Interference of Apoptosis by Hepatitis B Virus.
  Journal
Viruses 9:E230 (2017)
DOI:10.3390/v9080230
Reference
PMID:16173017
  Authors
Zhang X, Dong N, Yin L, Cai N, Ma H, You J, Zhang H, Wang H, He R, Ye L
  Title
Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues.
  Journal
J Med Virol 77:374-81 (2005)
DOI:10.1002/jmv.20466
Reference
PMID:18481805
  Authors
Kim HJ, Kim SY, Kim J, Lee H, Choi M, Kim JK, Ahn JK
  Title
Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria.
  Journal
IUBMB Life 60:473-80 (2008)
DOI:10.1002/iub.68
Reference
PMID:21647825
  Authors
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  Title
Hepatitis B virus X gene and hepatocarcinogenesis.
  Journal
J Gastroenterol 46:974-90 (2011)
DOI:10.1007/s00535-011-0415-9
Reference
PMID:9195957
  Authors
Cong YS, Yao YL, Yang WM, Kuzhandaivelu N, Seto E
  Title
The hepatitis B virus X-associated protein, XAP3, is a protein kinase C-binding protein.
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J Biol Chem 272:16482-9 (1997)
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Reference
PMID:12686421
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  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:9738022
  Authors
Lee YH, Yun Y
  Title
HBx protein of hepatitis B virus activates Jak1-STAT signaling.
  Journal
J Biol Chem 273:25510-5 (1998)
DOI:10.1074/jbc.273.39.25510
Reference
PMID:18251977
  Authors
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  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
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Reference
PMID:17059849
  Authors
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  Title
Cytobiological consequences of calcium-signaling alterations induced by human viral proteins.
  Journal
Biochim Biophys Acta 1763:1344-62 (2006)
DOI:10.1016/j.bbamcr.2006.09.025
Reference
PMID:11743185
  Authors
Ganem D
  Title
Virology. The X files--one step closer to closure.
  Journal
Science 294:2299-300 (2001)
DOI:10.1126/science.1067850
Reference
PMID:15132991
  Authors
Chung TW, Lee YC, Kim CH
  Title
Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential.
  Journal
FASEB J 18:1123-5 (2004)
DOI:10.1096/fj.03-1429fje
Reference
PMID:18605975
  Authors
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  Title
Human oncogenic viruses: hepatitis B and hepatitis C viruses and their role in hepatocarcinogenesis.
  Journal
Biochemistry (Mosc) 73:504-13 (2008)
DOI:10.1134/S0006297908050039
Reference
PMID:21994545
  Authors
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  Title
HBV life cycle: entry and morphogenesis.
  Journal
Viruses 1:185-209 (2009)
DOI:10.3390/v1020185
Reference
PMID:28862649
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
PMID:28704708
  Authors
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  Title
Innate immunity related pathogen recognition receptors and chronic hepatitis B infection.
  Journal
Mol Immunol 90:64-73 (2017)
DOI:10.1016/j.molimm.2017.07.002
Reference
PMID:24530748
  Authors
Bagheri V, Askari A, Arababadi MK, Kennedy D
  Title
Can Toll-Like Receptor (TLR) 2 be considered as a new target for immunotherapy against hepatitis B infection?
  Journal
Hum Immunol 75:549-54 (2014)
DOI:10.1016/j.humimm.2014.02.018
Reference
PMID:25550115
  Authors
Zhang E, Lu M
  Title
Toll-like receptor (TLR)-mediated innate immune responses in the control of hepatitis B virus (HBV) infection.
  Journal
Med Microbiol Immunol 204:11-20 (2015)
DOI:10.1007/s00430-014-0370-1
Reference
PMID:20375222
  Authors
Yu S, Chen J, Wu M, Chen H, Kato N, Yuan Z
  Title
Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3.
  Journal
J Gen Virol 91:2080-90 (2010)
DOI:10.1099/vir.0.020552-0
Reference
PMID:23363957
  Authors
Revill P, Yuan Z
  Title
New insights into how HBV manipulates the innate immune response to establish acute and persistent infection.
  Journal
Antivir Ther 18:1-15 (2013)
DOI:10.3851/IMP2542
Reference
PMID:28893934
  Authors
Hopcraft SE, Damania B
  Title
Tumour viruses and innate immunity.
  Journal
Philos Trans R Soc Lond B Biol Sci 372:20160267 (2017)
DOI:10.1098/rstb.2016.0267
Reference
PMID:22504921
  Authors
Dandri M, Locarnini S
  Title
New insight in the pathobiology of hepatitis B virus infection.
  Journal
Gut 61 Suppl 1:i6-17 (2012)
DOI:10.1136/gutjnl-2012-302056
Related
pathway
sara04010  MAPK signaling pathway
sara04064  NF-kappa B signaling pathway
sara04110  Cell cycle
sara04115  p53 signaling pathway
sara04151  PI3K-Akt signaling pathway
sara04210  Apoptosis
sara04620  Toll-like receptor signaling pathway
sara04622  RIG-I-like receptor signaling pathway
sara04630  JAK-STAT signaling pathway
KO pathway
ko05161   
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