KEGG   PATHWAY: sdu04540
Entry
sdu04540                    Pathway                                
Name
Gap junction - Seriola dumerili (greater amberjack)
Description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
sdu04540  Gap junction
sdu04540

Other DBs
GO: 0005921
Organism
Seriola dumerili (greater amberjack) [GN:sdu]
Gene
111237647  gap junction alpha-1 protein-like [KO:K07372]
111216383  gap junction delta-2 protein-like [KO:K07373]
111232864  gap junction delta-2 protein-like [KO:K07373]
111225886  gjd2; gap junction delta-2 protein [KO:K07373]
111234395  gap junction delta-2 protein-like isoform X1 [KO:K07373]
111237500  lysophosphatidic acid receptor 1 [KO:K04289]
111224502  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
111218964  guanine nucleotide-binding protein G(k) subunit alpha-like [KO:K04630]
111222064  guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630]
111222840  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
111228491  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
111216525  platelet-derived growth factor subunit A-like [KO:K04359]
111227111  pdgfa; platelet-derived growth factor subunit A [KO:K04359]
111216519  uncharacterized protein LOC111216519 [KO:K17386]
111224145  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
111232625  pdgfc; platelet-derived growth factor C [KO:K05450]
111232468  egf; pro-epidermal growth factor [KO:K04357]
111226338  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
111226471  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
111239485  platelet-derived growth factor receptor beta-like [KO:K05089] [EC:2.7.10.1]
111237405  melanoma receptor tyrosine-protein kinase-like isoform X1 [KO:K04361] [EC:2.7.10.1]
111231258  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
111238087  grb2; growth factor receptor-bound protein 2 [KO:K04364]
111225570  sos2; son of sevenless homolog 2 [KO:K03099]
111237578  sos1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
111228382  hras; GTPase HRas [KO:K02833]
111228455  kras; GTPase KRas isoform X1 [KO:K07827]
111230220  GTPase HRas-like [KO:K07827]
111217320  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111228471  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111232170  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111229041  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
111236845  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111230214  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
111233537  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
111235128  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
111222725  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
111238645  map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
111220321  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
111218848  tubulin alpha chain [KO:K07374]
111218849  tubulin alpha chain-like [KO:K07374]
111218500  tubulin alpha chain-like [KO:K07374]
111221326  tubulin alpha chain-like [KO:K07374]
111234751  tubulin alpha-1A chain-like [KO:K07374]
111234760  tubulin alpha-1A chain-like [KO:K07374]
111234759  tubulin alpha chain-like [KO:K07374]
111233470  tubulin alpha-1C chain-like [KO:K07374]
111234898  tubulin alpha-1B chain [KO:K07374]
111230197  tubulin alpha-1C chain-like isoform X1 [KO:K07374]
111230200  tubulin alpha-1C chain-like [KO:K07374]
111234930  tubulin alpha-8 chain-like isoform X1 [KO:K07374]
111234965  tubulin alpha chain [KO:K07374]
111234966  tubulin alpha-1B chain-like [KO:K07374]
111225571  tubulin beta-4B chain [KO:K07375]
111220880  tubulin beta chain-like [KO:K07375]
111223933  tubulin beta chain-like [KO:K07375]
111228817  tubulin beta-1 chain [KO:K07375]
111229229  tubulin beta-4B chain-like [KO:K07375]
111231260  tubulin beta chain-like isoform X1 [KO:K07375]
111237390  tubulin beta-5 chain [KO:K07375]
111227125  tubulin beta-4B chain-like [KO:K07375]
111230072  tubulin beta chain isoform X1 [KO:K07375]
111237100  casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
111217804  casein kinase I-like [KO:K08959] [EC:2.7.11.1]
111239201  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
111229539  tight junction protein ZO-1-like isoform X1 [KO:K05701]
111238329  tight junction protein ZO-1-like isoform X1 [KO:K05701]
111219546  adrb1; beta-1 adrenergic receptor [KO:K04141]
111217213  drd1; D(1A) dopamine receptor [KO:K04144]
111226681  D(1) dopamine receptor-like [KO:K04144]
111231393  D(1) dopamine receptor-like [KO:K04144]
111218983  gnas; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
111223941  guanine nucleotide-binding protein G(s) subunit alpha isoforms short-like isoform X1 [KO:K04632]
111235768  D(2) dopamine receptor A-like [KO:K04145]
111228043  drd2; D(2) dopamine receptor [KO:K04145]
111227562  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
111231027  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
111227902  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
111238586  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
111233172  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
111227842  LOW QUALITY PROTEIN: adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
111236629  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
111218374  adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
111219014  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
111217291  adenylate cyclase type 6-like isoform X1 [KO:K08046] [EC:4.6.1.1]
111217971  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
111236701  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
111235549  LOW QUALITY PROTEIN: adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
111233908  adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
111227004  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
111229246  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
111220870  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
111229212  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
111227008  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
111218433  htr2b; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
111233466  5-hydroxytryptamine receptor 2C-like [KO:K04157]
111237980  htr2a; 5-hydroxytryptamine receptor 2A [KO:K04157]
111225349  metabotropic glutamate receptor 1-like [KO:K04603]
111240111  grm1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
111217123  metabotropic glutamate receptor 5-like [KO:K04604]
111224046  grm5; metabotropic glutamate receptor 5 [KO:K04604]
111232198  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04635]
111239870  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
111239871  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04634]
111230911  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
111226150  guanine nucleotide-binding protein G(q) subunit alpha-like isoform X1 [KO:K04634]
111227394  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
111225989  plcb2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
111240392  plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
111240424  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
111231312  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
111221456  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
111221798  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
111228375  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
111235419  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
111227115  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
111236289  prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111216674  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
111230195  prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
111230118  protein kinase C gamma type-like [KO:K19663] [EC:2.7.11.13]
111224115  gucy1a2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
111231447  gucy1a3; guanylate cyclase soluble subunit alpha-3 [KO:K12318] [EC:4.6.1.2]
111231448  gucy1b3; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
111228038  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
111232397  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
111235208  cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
111216303  cGMP-dependent protein kinase 2-like [KO:K19477] [EC:2.7.11.12]
111228005  prkg2; cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00681  1-Acyl-sn-glycerol 3-phosphate
C00780  Serotonin
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
Reference
PMID:14506308
  Authors
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
  Title
Plasma membrane channels formed by connexins: their regulation and functions.
  Journal
Physiol Rev 83:1359-400 (2003)
DOI:10.1152/physrev.00007.2003
Reference
PMID:15033580
  Authors
Warn-Cramer BJ, Lau AF.
  Title
Regulation of gap junctions by tyrosine protein kinases.
  Journal
Biochim Biophys Acta 1662:81-95 (2004)
DOI:10.1016/j.bbamem.2003.10.018
Reference
PMID:9535909
  Authors
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
  Title
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
  Journal
J Biol Chem 273:9188-96 (1998)
DOI:10.1074/jbc.273.15.9188
Reference
PMID:10751659
  Authors
Roerig B, Feller MB.
  Title
Neurotransmitters and gap junctions in developing neural circuits.
  Journal
Brain Res Brain Res Rev 32:86-114 (2000)
DOI:10.1016/S0165-0173(99)00069-7
Reference
PMID:10873290
  Authors
Hatton GI.
  Title
Synaptic modulation of neuronal coupling.
  Journal
Cell Biol Int 22:765-80 (1998)
DOI:10.1006/cbir.1998.0386
Reference
PMID:12566218
  Authors
Cruciani V, Mikalsen SO.
  Title
Connexins, gap junctional intercellular communication and kinases.
  Journal
Biol Cell 94:433-43 (2002)
DOI:10.1016/S0248-4900(02)00014-X
Reference
PMID:15094344
  Authors
Giepmans BN.
  Title
Gap junctions and connexin-interacting proteins.
  Journal
Cardiovasc Res 62:233-45 (2004)
DOI:10.1016/j.cardiores.2003.12.009
Reference
PMID:15955302
  Authors
Laird DW.
  Title
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
  Journal
Biochim Biophys Acta 1711:172-82 (2005)
DOI:10.1016/j.bbamem.2004.09.009
Reference
PMID:15033579
  Authors
Peracchia C.
  Title
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
  Journal
Biochim Biophys Acta 1662:61-80 (2004)
DOI:10.1016/j.bbamem.2003.10.020
Reference
PMID:15033578
  Authors
Bukauskas FF, Verselis VK.
  Title
Gap junction channel gating.
  Journal
Biochim Biophys Acta 1662:42-60 (2004)
DOI:10.1016/j.bbamem.2004.01.008
Related
pathway
sdu04010  MAPK signaling pathway
sdu04020  Calcium signaling pathway
sdu04060  Cytokine-cytokine receptor interaction
sdu04070  Phosphatidylinositol signaling system
sdu04080  Neuroactive ligand-receptor interaction
KO pathway
ko04540   
LinkDB

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