KEGG   PATHWAY: sfm04261
Entry
sfm04261                    Pathway                                
Name
Adrenergic signaling in cardiomyocytes - Scleropages formosus (Asian bonytongue)
Description
Cardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, and alpha-1C). In the human heart the beta-1-AR is the pre- dominate receptor. Acute sympathetic stimulation of cardiac beta-1-ARs induces positive inotropic and chronotropic effects, the most effective mechanism to acutely increase output of the heart, by coupling to Gs, formation of cAMP by adenylyl cyclase (AC), and PKA- dependent phosphorylation of various target proteins (e.g., ryanodine receptor [RyR]; phospholamban [PLB], troponin I [TnI], and the L-type Ca2+ channel [LTCC]). Chronic beta-1-AR stimulation is detrimental and induces cardiomyocyte hypertrophy and apoptosis. beta-2-AR coupled to Gs exerts a proapoptotic action as well as beta-1-AR, while beta-2-AR coupled to Gi exerts an antiapoptotic action.
Class
Organismal Systems; Circulatory system
Pathway map
sfm04261  Adrenergic signaling in cardiomyocytes
sfm04261

Other DBs
GO: 0001997
Organism
Scleropages formosus (Asian bonytongue) [GN:sfm]
Gene
114910243  adrb1; beta-1 adrenergic receptor [KO:K04141]
108934207  beta-2 adrenergic receptor-like [KO:K04142]
108936872  beta-2 adrenergic receptor [KO:K04142]
108930457  guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
108928411  gnas; guanine nucleotide-binding protein G(s) subunit alpha isoform X2 [KO:K04632]
108939197  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
108937596  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
108919207  adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
108940527  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
108930627  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
114911923  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
108929094  adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
108936601  adenylate cyclase type 5-like [KO:K08045] [EC:4.6.1.1]
108930060  adenylate cyclase type 5-like isoform X1 [KO:K08045] [EC:4.6.1.1]
108918490  adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
108939304  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
108932972  adenylate cyclase type 2-like isoform X2 [KO:K08047] [EC:4.6.1.1]
108918520  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
108937764  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
108928849  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
108930202  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
108937298  bves; blood vessel epicardial substance [KO:K21108]
108926859  popdc2; popeye domain-containing protein 2 isoform X1 [KO:K26206]
108937297  popdc3; popeye domain-containing protein 3 [KO:K26207]
108924047  kcnk2; potassium channel subfamily K member 2 [KO:K04913]
108923518  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
108935762  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
108935274  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
108919757  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
108922112  atp1a3; sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
108926579  sodium/potassium-transporting ATPase subunit alpha-3-like [KO:K01539] [EC:7.2.2.13]
108931711  sodium/potassium-transporting ATPase subunit alpha-1-like [KO:K01539] [EC:7.2.2.13]
108931712  sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
108937926  sodium/potassium-transporting ATPase subunit alpha-2-like isoform X1 [KO:K01539] [EC:7.2.2.13]
108938015  sodium/potassium-transporting ATPase subunit alpha-1 isoform X1 [KO:K01539] [EC:7.2.2.13]
108920345  sodium/potassium-transporting ATPase subunit beta-2-like [KO:K01540]
108923116  sodium/potassium-transporting ATPase subunit beta-2-like [KO:K01540]
108920558  atp1b1; sodium/potassium-transporting ATPase subunit beta-1 isoform X1 [KO:K01540]
108930990  atp1b4; protein ATP1B4 isoform X1 [KO:K01540]
108933198  sodium/potassium-transporting ATPase subunit beta-233-like [KO:K01540]
108932419  sodium/potassium-transporting ATPase subunit beta-3-like [KO:K01540]
108919129  sodium/hydrogen exchanger 1-like [KO:K05742]
108931410  potassium voltage-gated channel subfamily KQT member 1-like [KO:K04926]
108934709  potassium voltage-gated channel subfamily KQT member 1-like [KO:K04926]
108942397  potassium voltage-gated channel subfamily KQT member 1 [KO:K04926]
108931724  potassium voltage-gated channel subfamily E member 1-like [KO:K04894]
108918468  atp2b3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
108929803  atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X3 [KO:K05850] [EC:7.2.2.10]
108925547  LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
108939261  plasma membrane calcium-transporting ATPase 3-like isoform X1 [KO:K05850] [EC:7.2.2.10]
108931538  atp2b1; plasma membrane calcium-transporting ATPase 1 [KO:K05850] [EC:7.2.2.10]
108938219  atp2b4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
108919446  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
108925325  sodium/calcium exchanger 1-like [KO:K05849]
108920375  sodium/calcium exchanger 1-like [KO:K05849]
108927105  slc8a1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
108928725  sodium/calcium exchanger 2 [KO:K05849]
108933770  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
108927986  sodium channel protein type 4 subunit alpha-like [KO:K04838]
108931972  sodium channel protein type 4 subunit alpha-like [KO:K04838]
108919108  sodium channel subunit beta-1-like [KO:K04845]
108919194  sodium channel subunit beta-1-like isoform X1 [KO:K04845]
108933392  sodium channel subunit beta-1-like [KO:K04845]
108932185  scn4b; sodium channel subunit beta-4 [KO:K04848]
108934289  sodium channel subunit beta-4-like [KO:K04848]
108920904  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
108925619  cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
108933838  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
108918279  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
108934768  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
108931184  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
108933625  cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
108941755  voltage-dependent L-type calcium channel subunit beta-1-like isoform X1 [KO:K04862]
108919588  voltage-dependent L-type calcium channel subunit beta-1 isoform X5 [KO:K04862]
108937087  cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X2 [KO:K04863]
108939151  voltage-dependent L-type calcium channel subunit beta-3-like [KO:K04864]
108918540  cacnb3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
108936607  voltage-dependent L-type calcium channel subunit beta-4-like isoform X2 [KO:K04865]
108930040  cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
108921141  cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
108936376  voltage-dependent calcium channel subunit alpha-2/delta-1-like isoform X1 [KO:K04858]
108925615  cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
108933831  voltage-dependent calcium channel subunit alpha-2/delta-2-like isoform X1 [KO:K04859]
108925576  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
108933830  voltage-dependent calcium channel subunit alpha-2/delta-3-like isoform X1 [KO:K04860]
108920806  cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
108936736  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
108939957  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
108928828  voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
108930674  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
108926653  cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
108937227  voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868]
108936727  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
108939979  cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
108939967  cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
108924817  cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
108924780  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
108931764  voltage-dependent calcium channel gamma-7 subunit-like isoform X1 [KO:K04872]
108924502  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
108931757  voltage-dependent calcium channel gamma-4 subunit-like isoform X1 [KO:K04873]
108918106  calm2; calmodulin-2 [KO:K02183]
108920356  calmodulin [KO:K02183]
108919607  calm1; calmodulin-1 [KO:K02183]
108932425  calm3; calmodulin-3 [KO:K02183]
108931560  calmodulin [KO:K02183]
108933585  calml6; calmodulin-like protein 6 [KO:K02183]
108942225  calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
108924083  calmodulin [KO:K02183]
108934368  calmodulin [KO:K02183]
114911079  calmodulin-like [KO:K02183]
108923134  calcium/calmodulin-dependent protein kinase type II subunit alpha-like isoform X1 [KO:K04515] [EC:2.7.11.17]
108925892  calcium/calmodulin-dependent protein kinase type II delta chain-like isoform X1 [KO:K04515] [EC:2.7.11.17]
108920687  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
108934409  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
108932918  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
108942762  camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
108940337  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
108934887  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
108939633  ryr2; ryanodine receptor 2 isoform X1 [KO:K04962]
108929931  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
108934452  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
108938118  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like [KO:K04382] [EC:3.1.3.16]
108929745  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
108928737  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
108936239  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
108923631  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
108936847  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
108934333  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X2 [KO:K04354]
108918894  ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
108924200  ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
108919487  ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
108920451  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta-like [KO:K11583]
108927562  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha-like isoform X1 [KO:K11583]
108926497  ppp2r3b; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
108935207  ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
108929320  ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
108930818  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like isoform X1 [KO:K11584]
108918062  ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
108920373  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform-like [KO:K11584]
108919647  ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X2 [KO:K11584]
108925472  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
108941504  ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
108941963  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform-like isoform X1 [KO:K11584]
108921956  serine/threonine-protein phosphatase PP1-gamma catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
108929319  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like isoform X1 [KO:K06269] [EC:3.1.3.16]
108936091  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
108934323  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
108919391  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
108941815  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
108922004  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
108918360  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
108929811  troponin C, slow skeletal and cardiac muscles isoform X1 [KO:K05865]
108939382  tnnt2; LOW QUALITY PROTEIN: troponin T, cardiac muscle [KO:K12045]
108931399  troponin T, cardiac muscle-like [KO:K12045]
108931690  tropomyosin alpha-1 chain [KO:K10373]
108941122  tropomyosin alpha-1 chain-like isoform X1 [KO:K10373]
108925224  tropomyosin alpha-3 chain isoform X3 [KO:K10373]
108931756  tropomyosin alpha-3 chain-like isoform X1 [KO:K10373]
108929913  tropomyosin beta chain isoform X1 [KO:K10374]
108921714  tropomyosin alpha-1 chain-like isoform X1 [KO:K10375]
108930578  tropomyosin alpha-1 chain isoform X1 [KO:K10375]
108928298  actin, alpha cardiac [KO:K12314]
108932839  acta1; actin, alpha skeletal muscle [KO:K12314]
108941121  actin, alpha cardiac muscle 1-like [KO:K12314]
108924075  actin, alpha cardiac muscle 1 [KO:K12314]
108927716  myosin-7 [KO:K17751]
108930075  myosin-7-like [KO:K17751]
108934025  myosin-7-like [KO:K17751]
108934018  myosin-7-like [KO:K17751]
108930074  myosin-7-like [KO:K17751]
108933343  myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
108941718  myosin light chain 4-like isoform X1 [KO:K12750]
108924846  myosin light chain 4-like [KO:K12750]
108928534  pln; cardiac phospholamban [KO:K05852]
108934607  cardiac phospholamban-like [KO:K05852]
108921928  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
108925889  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like isoform X1 [KO:K05853] [EC:7.2.2.10]
108934934  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
108928097  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
108941794  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
108932829  agt; angiotensinogen [KO:K09821]
108934912  agtr1; type-1 angiotensin II receptor [KO:K04166]
108925417  type-2 angiotensin II receptor-like [KO:K04167]
108920029  type-2 angiotensin II receptor-like isoform X2 [KO:K04167]
108921894  alpha-1A adrenergic receptor-like [KO:K04135]
108923586  alpha-1A adrenergic receptor-like [KO:K04135]
108934154  alpha-1A adrenergic receptor-like [KO:K04136]
108936751  adra1b; alpha-1B adrenergic receptor [KO:K04136]
108926014  alpha-1D adrenergic receptor-like [KO:K04137]
108924383  alpha-1A adrenergic receptor-like [KO:K04137]
108921572  guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04634]
108938603  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
108922946  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
108919358  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2 [KO:K05858] [EC:3.1.4.11]
108925497  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
108929356  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
108929291  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
108937063  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
108940048  prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
108928367  protein phosphatase 1 regulatory subunit 1A-like [KO:K08050]
114909316  protein phosphatase 1 regulatory subunit 1A-like [KO:K08050]
108920146  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108933025  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108941664  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
108922615  rps6ka5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
108924108  ribosomal protein S6 kinase alpha-5-like [KO:K04445] [EC:2.7.11.1]
108918913  cyclic AMP-responsive element-binding protein 1-like [KO:K05870]
108922300  cyclic AMP-responsive element-binding protein 1 [KO:K05870]
108920372  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
108928057  cyclic AMP-dependent transcription factor ATF-2-like isoform X1 [KO:K04450]
108930667  atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
108920980  creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
108941868  creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
108938370  cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
108921408  cyclic AMP-responsive element-binding protein 3-like protein 3-B [KO:K09048]
108919787  cyclic AMP-responsive element-binding protein 3-like protein 3-B isoform X1 [KO:K09048]
108929030  creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
108940915  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
108927363  cyclic AMP-responsive element-binding protein 5-like isoform X1 [KO:K09047]
108933413  cyclic AMP-responsive element-binding protein 5-like isoform X2 [KO:K09047]
108935684  atf6b; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
108937680  cAMP-responsive element modulator isoform X1 [KO:K09052]
108927802  cAMP-responsive element modulator-like isoform X1 [KO:K09052]
108931633  apoptosis regulator Bcl-2-like [KO:K02161]
108937589  apoptosis regulator Bcl-2-like isoform X1 [KO:K02161]
108939388  rap guanine nucleotide exchange factor 3-like isoform X1 [KO:K08014]
108920713  rapgef4; rap guanine nucleotide exchange factor 4 [KO:K04351]
108920347  rap guanine nucleotide exchange factor 4-like isoform X1 [KO:K04351]
108931109  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
108931124  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
108938227  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
108928253  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
108939429  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
108920961  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
108923396  guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630]
108936982  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
108923276  guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
108918751  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
108925594  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform-like [KO:K21289] [EC:2.7.1.153]
108937162  phosphoinositide 3-kinase regulatory subunit 6-like isoform X3 [KO:K21290]
108940164  pik3r5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
108940182  phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
108921701  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108932833  akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108919646  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108927252  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
Compound
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00238  Potassium cation
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00788  L-Adrenaline
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C07056  Isoproterenol
Reference
PMID:19883653
  Authors
Grimm M, Brown JH
  Title
Beta-adrenergic receptor signaling in the heart: role of CaMKII.
  Journal
J Mol Cell Cardiol 48:322-30 (2010)
DOI:10.1016/j.yjmcc.2009.10.016
Reference
PMID:21212391
  Authors
Yang JH, Saucerman JJ
  Title
Computational models reduce complexity and accelerate insight into cardiac signaling networks.
  Journal
Circ Res 108:85-97 (2011)
DOI:10.1161/CIRCRESAHA.110.223602
Reference
PMID:16765984
  Authors
Schaub MC, Hefti MA, Zaugg M
  Title
Integration of calcium with the signaling network in cardiac myocytes.
  Journal
J Mol Cell Cardiol 41:183-214 (2006)
DOI:10.1016/j.yjmcc.2006.04.005
Reference
PMID:22022314
  Authors
Taggart P, Boyett MR, Logantha S, Lambiase PD
  Title
Anger, emotion, and arrhythmias: from brain to heart.
  Journal
Front Physiol 2:67 (2011)
DOI:10.3389/fphys.2011.00067
Reference
PMID:17988210
  Authors
Bers DM
  Title
Calcium cycling and signaling in cardiac myocytes.
  Journal
Annu Rev Physiol 70:23-49 (2008)
DOI:10.1146/annurev.physiol.70.113006.100455
Reference
PMID:20923637
  Authors
Soltis AR, Saucerman JJ
  Title
Synergy between CaMKII substrates and beta-adrenergic signaling in regulation of cardiac myocyte Ca(2+) handling.
  Journal
Biophys J 99:2038-47 (2010)
DOI:10.1016/j.bpj.2010.08.016
Reference
PMID:12439640
  Authors
Wallukat G
  Title
The beta-adrenergic receptors.
  Journal
Herz 27:683-90 (2002)
DOI:10.1007/s00059-002-2434-z
Reference
PMID:11604549
  Authors
Xiao RP
  Title
Beta-adrenergic signaling in the heart: dual coupling of the beta2-adrenergic receptor to G(s) and G(i) proteins.
  Journal
Sci STKE 2001:re15 (2001)
DOI:10.1126/stke.2001.104.re15
Reference
PMID:10571541
  Authors
Xiao RP, Cheng H, Zhou YY, Kuschel M, Lakatta EG
  Title
Recent advances in cardiac beta(2)-adrenergic signal transduction.
  Journal
Circ Res 85:1092-100 (1999)
DOI:10.1161/01.RES.85.11.1092
Reference
PMID:15979723
  Authors
Zheng M, Zhu W, Han Q, Xiao RP
  Title
Emerging concepts and therapeutic implications of beta-adrenergic receptor subtype signaling.
  Journal
Pharmacol Ther 108:257-68 (2005)
DOI:10.1016/j.pharmthera.2005.04.006
Reference
PMID:17826821
  Authors
Kuzumoto M, Takeuchi A, Nakai H, Oka C, Noma A, Matsuoka S
  Title
Simulation analysis of intracellular Na+ and Cl- homeostasis during beta 1-adrenergic stimulation of cardiac myocyte.
  Journal
Prog Biophys Mol Biol 96:171-86 (2008)
DOI:10.1016/j.pbiomolbio.2007.07.005
Reference
PMID:11805843
  Authors
Bers DM
  Title
Cardiac excitation-contraction coupling.
  Journal
Nature 415:198-205 (2002)
DOI:10.1038/415198a
Reference
PMID:20658186
  Authors
Ho D, Yan L, Iwatsubo K, Vatner DE, Vatner SF
  Title
Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5.
  Journal
Heart Fail Rev 15:495-512 (2010)
DOI:10.1007/s10741-010-9183-5
Reference
PMID:15142747
  Authors
Saucerman JJ, McCulloch AD
  Title
Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.
  Journal
Prog Biophys Mol Biol 85:261-78 (2004)
DOI:10.1016/j.pbiomolbio.2004.01.005
Reference
PMID:15765137
  Authors
Yano M, Ikeda Y, Matsuzaki M
  Title
Altered intracellular Ca2+ handling in heart failure.
  Journal
J Clin Invest 115:556-64 (2005)
DOI:10.1172/JCI24159
Reference
PMID:15232578
  Authors
Wehrens XH, Marks AR
  Title
Novel therapeutic approaches for heart failure by normalizing calcium cycling.
  Journal
Nat Rev Drug Discov 3:565-73 (2004)
DOI:10.1038/nrd1440
Reference
PMID:19874988
  Authors
Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J
  Title
The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.
  Journal
J Am Coll Cardiol 54:1747-62 (2009)
DOI:10.1016/j.jacc.2009.05.015
Reference
PMID:18407781
  Authors
Barry SP, Davidson SM, Townsend PA
  Title
Molecular regulation of cardiac hypertrophy.
  Journal
Int J Biochem Cell Biol 40:2023-39 (2008)
DOI:10.1016/j.biocel.2008.02.020
Related
pathway
sfm04020  Calcium signaling pathway
sfm04260  Cardiac muscle contraction
KO pathway
ko04261   
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