KEGG   PATHWAY: shon04015
Entry
shon04015                   Pathway                                
Name
Rap1 signaling pathway - Sturnira hondurensis
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
shon04015  Rap1 signaling pathway
shon04015

Other DBs
GO: 0007264
Organism
Sturnira hondurensis [GN:shon]
Gene
118982036  RAP1A; ras-related protein Rap-1A [KO:K04353]
118989371  RAP1B; ras-related protein Rap-1b [KO:K07836]
118997527  MRAS; ras-related protein M-Ras [KO:K07831]
118983645  DOCK4; dedicator of cytokinesis protein 4 [KO:K17697]
118980121  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
119002924  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
118978468  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
118990028  calmodulin-1 [KO:K02183]
118998106  CALML6; calmodulin-like protein 6 [KO:K02183]
118999921  calmodulin-alpha-like [KO:K02183]
118976572  CALM1; calmodulin-1 [KO:K02183]
118992351  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
119000796  calmodulin-A-like [KO:K02183]
119000797  CALML3; calmodulin-like protein 3 [KO:K02183]
119001010  calmodulin-2/4 [KO:K02183]
119001255  CALM2; calmodulin-2 [KO:K02183]
118995942  CALM3; calmodulin-3 [KO:K02183]
118977327  F2R; proteinase-activated receptor 1 [KO:K03914]
118975206  F2RL3; proteinase-activated receptor 4 [KO:K04236]
118986103  P2RY1; P2Y purinoceptor 1 [KO:K04270]
118979710  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
118975067  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
118997361  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
118996752  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
119002175  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
119001852  ADORA2A; adenosine receptor A2a [KO:K04266]
119002796  ADORA2B; adenosine receptor A2b isoform X1 [KO:K04267]
118996538  guanine nucleotide-binding protein G(s) subunit alpha-like isoform X1 [KO:K04632]
118996540  neuroendocrine secretory protein 55-like [KO:K04632]
118983483  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
118998674  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
119001392  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
118980863  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
118990736  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
118976509  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
119001137  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
118988683  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
118975805  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
118997444  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
118985700  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
118976055  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
118990867  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
118990869  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
118991671  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
118993594  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
119001280  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
118991686  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
118977074  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
118998653  FGF1; fibroblast growth factor 1 [KO:K18496]
118995576  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
118980540  FGF9; fibroblast growth factor 9 [KO:K04358]
118996740  FGF16; fibroblast growth factor 16 [KO:K04358]
118981674  FGF10; fibroblast growth factor 10 [KO:K04358]
118990454  FGF5; fibroblast growth factor 5 [KO:K04358]
118998373  FGF4; fibroblast growth factor 4 [KO:K04358]
118998410  FGF3; fibroblast growth factor 3 [KO:K04358]
118975163  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
118999542  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
119000021  FGF6; fibroblast growth factor 6 [KO:K04358]
118984625  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
118992607  FGF7; fibroblast growth factor 7 [KO:K04358]
118992994  FGF20; fibroblast growth factor 20 [KO:K04358]
118994948  FGF18; fibroblast growth factor 18 [KO:K04358]
118998372  FGF19; fibroblast growth factor 19 [KO:K22603]
118999897  FGF23; fibroblast growth factor 23 [KO:K22428]
118982016  NGF; beta-nerve growth factor [KO:K02582]
118988340  INS; insulin [KO:K04526]
119002367  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
118995064  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
119002339  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
119000403  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
118995347  PDGFC; platelet-derived growth factor C [KO:K05450]
118981911  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
118999914  KITLG; kit ligand isoform X1 [KO:K05461]
118993927  VEGFA; vascular endothelial growth factor A [KO:K05448]
118991667  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
118976883  PGF; placenta growth factor isoform X1 [KO:K16859]
118993053  VEGFC; vascular endothelial growth factor C [KO:K05449]
118987248  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
119000987  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
118988598  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
118999042  ANGPT2; angiopoietin-2 [KO:K05466]
118985591  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
118990168  EFNA1; ephrin-A1 [KO:K05462]
118990172  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
118990174  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
118984407  EFNA2; ephrin-A2 isoform X1 [KO:K05462]
118977270  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
118983507  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
118993177  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
118996291  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
118987768  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
118999740  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
118978151  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
118987715  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
118992013  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
118978642  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
118986157  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
118986159  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
118978582  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
118986919  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
118995808  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
118995107  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
118978574  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
118996978  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
118986305  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
119001789  CRKL; crk-like protein [KO:K04438]
119003414  CRK; adapter molecule crk isoform X1 [KO:K04438]
118980055  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
118999214  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
118983812  CDH1; cadherin-1 [KO:K05689]
118976240  CTNNB1; catenin beta-1 [KO:K02105]
118983421  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
118981893  MAGI3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X1 [KO:K06112]
118995360  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
118990113  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
118995118  uncharacterized protein LOC118995118 [KO:K10784]
118998794  FYB1; FYN-binding protein 1 isoform X1 [KO:K17698]
118994938  LCP2; lymphocyte cytosolic protein 2 isoform X1 [KO:K07361]
118978209  SKAP1; src kinase-associated phosphoprotein 1 [KO:K17699]
118985484  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
119003729  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
119004000  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
118986634  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
118980803  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
119001258  PRKD3; serine/threonine-protein kinase D3 isoform X1 [KO:K06070] [EC:2.7.11.13]
118995975  PRKD2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
119000546  DRD2; D(2) dopamine receptor [KO:K04145]
118982356  CNR1; cannabinoid receptor 1 [KO:K04277]
118989455  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
118990034  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
119000994  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
118983964  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
118977732  rap1 GTPase-activating protein 1 isoform X1 [KO:K17700]
118976854  SIPA1L1; signal-induced proliferation-associated 1-like protein 1 isoform X1 [KO:K17701]
118991734  SIPA1; signal-induced proliferation-associated protein 1 [KO:K08013]
118996705  SIPA1L2; signal-induced proliferation-associated 1-like protein 2 isoform X1 [KO:K17702]
118976323  SIPA1L3; signal-induced proliferation-associated 1-like protein 3 isoform X1 [KO:K17703]
118985333  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
118993608  THBS1; thrombospondin-1 [KO:K16857]
118980105  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
119001847  ras-related protein Ral-A-like [KO:K07834]
118994012  RALA; ras-related protein Ral-A [KO:K07834]
118989536  RALB; ras-related protein Ral-B [KO:K07835]
118995001  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
119002327  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
119002854  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
118980578  amyloid beta A4 precursor protein-binding family B member 1-interacting protein [KO:K17704]
118992280  TLN2; talin-2 [KO:K06271]
118979887  TLN1; talin-1 isoform X1 [KO:K06271]
119001963  ITGA2B; integrin alpha-IIb [KO:K06476]
119003549  ITGB3; integrin beta-3 [KO:K06493]
118997925  PFN2; profilin-2 isoform X1 [KO:K05759]
118999750  PFN3; profilin-3 [KO:K05759]
119001070  PFN1; profilin-1 [KO:K05759]
119001435  PFN4; profilin-4 [KO:K05759]
118995549  vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
119003140  ENAH; protein enabled homolog isoform X1 [KO:K05746]
118976941  EVL; ena/VASP-like protein isoform X1 [KO:K23487]
118995015  ACTB; actin, cytoplasmic 1 [KO:K05692]
119002891  ACTG1; actin, cytoplasmic 2 [KO:K05692]
118998505  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
118989480  RHOA; transforming protein RhoA [KO:K04513]
118985454  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
119003097  FARP2; FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1 [KO:K06082]
118977719  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
118990068  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
118984571  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
118980066  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
118983246  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
118982724  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
118996496  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
118983855  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
118979953  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
118998179  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
118987413  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
118998349  AFDN; afadin isoform X1 [KO:K05702]
118982777  CTNND1; catenin delta-1 isoform X1 [KO:K05690]
119000955  KRIT1; krev interaction trapped protein 1 [KO:K17705]
118999748  RGS14; regulator of G-protein signaling 14 isoform X1 [KO:K17706]
119001649  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
118997404  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
118978279  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
119000253  ITGB2; integrin beta-2 [KO:K06464]
118991564  integrin beta-1 [KO:K05719]
118989073  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
118990300  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
118992336  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
118984505  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
119000423  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119001903  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119002731  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
119003578  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
118988883  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
118988898  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
118998971  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
118998973  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
118997522  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118986375  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118995662  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118982454  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
118975178  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
118998595  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118988441  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119003271  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118988089  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118987999  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
118982230  HRAS; GTPase HRas isoform X1 [KO:K02833]
118978497  KRAS; GTPase KRas isoform X1 [KO:K07827]
118981977  NRAS; GTPase NRas [KO:K07828]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
shon04010  MAPK signaling pathway
shon04014  Ras signaling pathway
shon04020  Calcium signaling pathway
shon04151  PI3K-Akt signaling pathway
shon04510  Focal adhesion
shon04520  Adherens junction
shon04660  T cell receptor signaling pathway
shon04810  Regulation of actin cytoskeleton
KO pathway
ko04015   
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