KEGG   PATHWAY: ssen04261
Entry
ssen04261                   Pathway                                
Name
Adrenergic signaling in cardiomyocytes - Solea senegalensis (Senegalese sole)
Description
Cardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, and alpha-1C). In the human heart the beta-1-AR is the pre- dominate receptor. Acute sympathetic stimulation of cardiac beta-1-ARs induces positive inotropic and chronotropic effects, the most effective mechanism to acutely increase output of the heart, by coupling to Gs, formation of cAMP by adenylyl cyclase (AC), and PKA- dependent phosphorylation of various target proteins (e.g., ryanodine receptor [RyR]; phospholamban [PLB], troponin I [TnI], and the L-type Ca2+ channel [LTCC]). Chronic beta-1-AR stimulation is detrimental and induces cardiomyocyte hypertrophy and apoptosis. beta-2-AR coupled to Gs exerts a proapoptotic action as well as beta-1-AR, while beta-2-AR coupled to Gi exerts an antiapoptotic action.
Class
Organismal Systems; Circulatory system
Pathway map
ssen04261  Adrenergic signaling in cardiomyocytes
ssen04261

Other DBs
GO: 0001997
Organism
Solea senegalensis (Senegalese sole) [GN:ssen]
Gene
122759026  adrb1; beta-1 adrenergic receptor [KO:K04141]
122777991  adrb2a; adrenoceptor beta 2, surface a [KO:K04142]
122779785  beta-2 adrenergic receptor-like isoform X1 [KO:K04142]
122777431  gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
122767567  guanine nucleotide-binding protein G(s) subunit alpha-like isoform X1 [KO:K04632]
122780642  adcy1a; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
122771664  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
122786587  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
122774912  adcy2a; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
122774154  adcy3a; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
122765338  adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
122777042  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
122777458  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
122772187  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
122762475  adcy8; LOW QUALITY PROTEIN: adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
122783786  si:dkey-206f10.1; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
122771216  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
122784928  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
122774214  bves; blood vessel epicardial substance [KO:K21108]
122784979  popdc2; popeye domain-containing 2 isoform X1 [KO:K26206]
122774164  popdc3; popeye domain-containing protein 3 [KO:K26207]
122764932  potassium channel subfamily K member 2-like [KO:K04913]
122772029  potassium channel subfamily K member 2-like [KO:K04913]
122780814  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
122771368  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
122772674  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
122785644  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
122769140  atp1a2a; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
122775031  atp1a3b; sodium/potassium-transporting ATPase subunit alpha-3b isoform X1 [KO:K01539] [EC:7.2.2.13]
122758131  atp1a1a.1; sodium/potassium-transporting ATPase subunit alpha-1a.1 [KO:K01539] [EC:7.2.2.13]
122758605  atp1a1a.4; sodium/potassium-transporting ATPase subunit alpha-1a.4 [KO:K01539] [EC:7.2.2.13]
122786298  atp1a3a; sodium/potassium-transporting ATPase subunit alpha-3a [KO:K01539] [EC:7.2.2.13]
122781319  atp1b1a; sodium/potassium-transporting ATPase subunit beta-1a [KO:K01540]
122765117  sodium/potassium-transporting ATPase subunit beta-233-like [KO:K01540]
122777216  atp1b3a; sodium/potassium-transporting ATPase subunit beta-3a [KO:K01540]
122766067  atp1b2a; sodium/potassium-transporting ATPase subunit beta-2a [KO:K01540]
122777999  atp1b4; protein ATP1B4 isoform X1 [KO:K01540]
122773381  sodium/potassium-transporting ATPase subunit beta-3-like [KO:K01540]
122779546  atp1b2b; sodium/potassium-transporting ATPase subunit beta-2b isoform X1 [KO:K01540]
122786706  Na(+)/H(+) exchanger beta-like [KO:K05742]
122774397  slc9a1a; sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
122776032  kcnq1.2; potassium voltage-gated channel subfamily KQT member 1 isoform X1 [KO:K04926]
122771998  kcnq1.1; potassium voltage-gated channel subfamily KQT member 1.1 [KO:K04926]
122773538  potassium voltage-gated channel subfamily KQT member 1-like [KO:K04926]
122762035  potassium voltage-gated channel subfamily E member 1-like [KO:K04894]
122768721  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
122775848  plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
122776930  atp2b3b; plasma membrane calcium-transporting ATPase 3b isoform X1 [KO:K05850] [EC:7.2.2.10]
122766804  atp2b1a; plasma membrane calcium-transporting ATPase 1a isoform X1 [KO:K05850] [EC:7.2.2.10]
122768252  atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
122781596  sodium/calcium exchanger 1-like [KO:K05849]
122762822  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
122782294  sodium/calcium exchanger 1-like [KO:K05849]
122782622  slc8a3; sodium/calcium exchanger 3 [KO:K05849]
122773169  slc8a2b; sodium/calcium exchanger 2b [KO:K05849]
122767277  sodium/calcium exchanger 3-like isoform X1 [KO:K05849]
122780107  slc8a2a; sodium/calcium exchanger 2a [KO:K05849]
122780239  slc8a4a; solute carrier family 8 member 4a [KO:K05849]
122768823  sodium channel protein type 4 subunit alpha-like isoform X1 [KO:K04838]
122776581  sodium channel protein type 4 subunit alpha B-like [KO:K04838]
122786244  scn1bb; sodium channel, voltage-gated, type I, beta b [KO:K04845]
122773734  sodium channel subunit beta-4-like [KO:K04848]
122779730  sodium channel subunit beta-4-like [KO:K04848]
122767001  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
122777142  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
122767592  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
122776983  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit isoform X1 [KO:K04853]
122777519  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
122760459  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
122768110  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like isoform X1 [KO:K04857]
122785155  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
122761051  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
122777048  cacnb3a; voltage-dependent L-type calcium channel subunit beta-3a isoform X1 [KO:K04864]
122777787  cacnb3b; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04864]
122765064  voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04865]
122765078  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865]
122775663  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
122766290  cacna2d1a; voltage-dependent calcium channel subunit alpha-2/delta-1a isoform X1 [KO:K04858]
122768754  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859]
122760953  voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859]
122777272  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
122767676  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
122776078  voltage-dependent calcium channel subunit alpha-2/delta-4-like isoform X1 [KO:K04861]
122767003  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
122770625  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
122785598  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
122770947  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
122785685  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
122770615  cacng3a; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
122785620  cacng3b; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
122770624  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
122784816  cacng4b; calcium channel, voltage-dependent, gamma subunit 4b [KO:K04869]
122771239  voltage-dependent calcium channel gamma-5 subunit-like [KO:K04870]
122785518  cacng5b; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
122774625  cacng6b; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
122786664  voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871]
122762683  voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871]
122786661  cacng7a; calcium channel, voltage-dependent, gamma subunit 7a [KO:K04872]
122775153  cacng7b; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
122774627  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
122786653  voltage-dependent calcium channel gamma-4 subunit-like isoform X1 [KO:K04873]
122760288  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
122768619  calglandulin-like [KO:K02183]
122775840  calmodulin-like protein 4 [KO:K02183]
122782973  calmodulin-1 [KO:K02183]
122772211  calml4a; calmodulin-like protein 4a [KO:K02183]
122783960  calmodulin-1 [KO:K02183]
122778620  calmodulin-like [KO:K02183]
122773594  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
122769541  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
122781651  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
122770769  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
122783734  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
122766468  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
122759364  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
122780179  calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
122782213  ryanodine receptor 2-like [KO:K04962]
122759400  ryr2a; ryanodine receptor 2 isoform X1 [KO:K04962]
122769700  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
122778823  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
122779991  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
122773647  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
122768994  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
122787121  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform-like [KO:K04354]
122781785  ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
122770784  ppp2r2ca; protein phosphatase 2, regulatory subunit B, gamma a [KO:K04354]
122778392  ppp2r2ba; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
122778482  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
122782788  ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
122783394  ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
122759145  ppp2r3b; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
122781603  ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
122782681  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
122782967  ppp2r5eb; protein phosphatase 2, regulatory subunit B', epsilon isoform X1 [KO:K11584]
122783636  ppp2r5cb; protein phosphatase 2, regulatory subunit B', gamma b isoform X1 [KO:K11584]
122783760  ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
122766411  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
122760207  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
122769805  serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
122783022  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
122765921  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
122766757  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
122759222  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
122776664  tnnc1a; troponin C type 1a (slow) [KO:K05865]
122776713  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
122768691  troponin T, cardiac muscle isoforms-like isoform X1 [KO:K12045]
122775601  tnnt2d; troponin T2d, cardiac [KO:K12045]
122776675  tnnt2a; troponin T type 2a (cardiac) isoform X1 [KO:K12045]
122765955  tnnt2e; troponin T2e, cardiac isoform X1 [KO:K12045]
122766146  tnnt2c; troponin T2c, cardiac [KO:K12045]
122775586  tpm1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
122772201  tpma; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
122758292  tropomyosin beta chain isoform X1 [KO:K10374]
122786432  tpm3; tropomyosin alpha-3 chain [KO:K09290]
122775046  tropomyosin alpha-4 chain-like isoform X1 [KO:K09290]
122780379  tpm4a; tropomyosin 4a isoform X1 [KO:K10375]
122761590  tropomyosin alpha-1 chain-like isoform X1 [KO:K10375]
122782779  actin, alpha cardiac muscle [KO:K12314]
122782840  actin, alpha cardiac muscle 1 [KO:K12314]
122772298  acta1b; actin alpha 1, skeletal muscle b [KO:K12314]
122784046  actc1a; actin, alpha cardiac muscle 1a [KO:K12314]
122760309  myh6; myosin-6 [KO:K17751]
122762587  myosin-7-like [KO:K17751]
122762684  myosin-7-like [KO:K17751]
122762790  myosin-7-like [KO:K17751]
122766297  myosin-7 [KO:K17751]
122766300  myosin-7-like [KO:K17751]
122769809  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
122767930  myl2a; myosin regulatory light chain 2a [KO:K10351]
122762329  myl13; myosin, light chain 13 [KO:K12749]
122787122  myosin light chain 4-like [KO:K12750]
122785164  pln; cardiac phospholamban [KO:K05852]
122769318  atp2a2a; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
122770873  si:dkey-28b4.8; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
122758238  atp2a2b; sarcoplasmic/endoplasmic reticulum calcium ATPase 2b [KO:K05853] [EC:7.2.2.10]
122785090  atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
122779537  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
122759220  atp2a1l; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like isoform X1 [KO:K05853] [EC:7.2.2.10]
122781633  agt; angiotensinogen isoform X1 [KO:K09821]
122773663  agtr1b; type-1 angiotensin II receptor [KO:K04166]
122778119  agtr2; type-2 angiotensin II receptor [KO:K04167]
122769083  adra1aa; adrenoceptor alpha 1Aa [KO:K04135]
122758435  alpha-1A adrenergic receptor-like [KO:K04135]
122778936  alpha-1A adrenergic receptor-like [KO:K04136]
122770638  adra1d; alpha-1D adrenergic receptor [KO:K04137]
122769267  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
122757985  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
122781695  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
122765502  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
122765902  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
122783981  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
122784068  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
122771238  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
122785514  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
122768616  protein phosphatase 1 regulatory subunit 1A-like [KO:K08050]
122769688  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122784921  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
122783024  rps6ka5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
122765076  cyclic AMP-responsive element-binding protein 1-like [KO:K05870]
122765108  cyclic AMP-responsive element-binding protein 1-like [KO:K05870]
122765116  cyclic AMP-responsive element-binding protein 1-like [KO:K05870]
122778824  cyclic AMP-responsive element-binding protein 1-like [KO:K05870]
122759712  atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
122771101  atf4a; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
122785474  atf4b; activating transcription factor 4b [KO:K04374]
122780407  creb3l3a; cyclic AMP-responsive element-binding protein 3-like protein 3-A isoform X1 [KO:K09048]
122775285  creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
122770036  creb3l3l; cAMP responsive element binding protein 3-like 3 like isoform X1 [KO:K09048]
122765246  cyclic AMP-responsive element-binding protein 3-like protein 3-B isoform X1 [KO:K09048]
122767136  creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
122785449  creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
122774857  creb5b; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
122786585  cyclic AMP-responsive element-binding protein 5-like [KO:K09047]
122764895  atf6b; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
122776895  cAMP-responsive element modulator-like isoform X1 [KO:K09052]
122771650  cAMP-responsive element modulator-like isoform X1 [KO:K09052]
122765183  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
122777200  rapgef3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
122765254  rapgef4a; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
122771580  rap guanine nucleotide exchange factor 4-like isoform X1 [KO:K04351]
122775763  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
122777114  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
122777639  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
122777856  zgc:171775; STKc_p38 domain-containing protein isoform X1 [KO:K04441] [EC:2.7.11.24]
122766959  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
122766961  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
122767630  mapk14b; mitogen-activated protein kinase 14B [KO:K04441] [EC:2.7.11.24]
122775825  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
122777566  gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
122766655  gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
122767760  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
122768120  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
122777271  si:rp71-17i16.5; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
122767177  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
122775043  phosphoinositide 3-kinase regulatory subunit 5-like [KO:K21290]
122775044  pik3r6b; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
122771530  pik3r5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
122771574  phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
122781615  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122762191  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122773275  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122779817  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
Compound
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00238  Potassium cation
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00788  L-Adrenaline
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C07056  Isoproterenol
Reference
PMID:19883653
  Authors
Grimm M, Brown JH
  Title
Beta-adrenergic receptor signaling in the heart: role of CaMKII.
  Journal
J Mol Cell Cardiol 48:322-30 (2010)
DOI:10.1016/j.yjmcc.2009.10.016
Reference
PMID:21212391
  Authors
Yang JH, Saucerman JJ
  Title
Computational models reduce complexity and accelerate insight into cardiac signaling networks.
  Journal
Circ Res 108:85-97 (2011)
DOI:10.1161/CIRCRESAHA.110.223602
Reference
PMID:16765984
  Authors
Schaub MC, Hefti MA, Zaugg M
  Title
Integration of calcium with the signaling network in cardiac myocytes.
  Journal
J Mol Cell Cardiol 41:183-214 (2006)
DOI:10.1016/j.yjmcc.2006.04.005
Reference
PMID:22022314
  Authors
Taggart P, Boyett MR, Logantha S, Lambiase PD
  Title
Anger, emotion, and arrhythmias: from brain to heart.
  Journal
Front Physiol 2:67 (2011)
DOI:10.3389/fphys.2011.00067
Reference
PMID:17988210
  Authors
Bers DM
  Title
Calcium cycling and signaling in cardiac myocytes.
  Journal
Annu Rev Physiol 70:23-49 (2008)
DOI:10.1146/annurev.physiol.70.113006.100455
Reference
PMID:20923637
  Authors
Soltis AR, Saucerman JJ
  Title
Synergy between CaMKII substrates and beta-adrenergic signaling in regulation of cardiac myocyte Ca(2+) handling.
  Journal
Biophys J 99:2038-47 (2010)
DOI:10.1016/j.bpj.2010.08.016
Reference
PMID:12439640
  Authors
Wallukat G
  Title
The beta-adrenergic receptors.
  Journal
Herz 27:683-90 (2002)
DOI:10.1007/s00059-002-2434-z
Reference
PMID:11604549
  Authors
Xiao RP
  Title
Beta-adrenergic signaling in the heart: dual coupling of the beta2-adrenergic receptor to G(s) and G(i) proteins.
  Journal
Sci STKE 2001:re15 (2001)
DOI:10.1126/stke.2001.104.re15
Reference
PMID:10571541
  Authors
Xiao RP, Cheng H, Zhou YY, Kuschel M, Lakatta EG
  Title
Recent advances in cardiac beta(2)-adrenergic signal transduction.
  Journal
Circ Res 85:1092-100 (1999)
DOI:10.1161/01.RES.85.11.1092
Reference
PMID:15979723
  Authors
Zheng M, Zhu W, Han Q, Xiao RP
  Title
Emerging concepts and therapeutic implications of beta-adrenergic receptor subtype signaling.
  Journal
Pharmacol Ther 108:257-68 (2005)
DOI:10.1016/j.pharmthera.2005.04.006
Reference
PMID:17826821
  Authors
Kuzumoto M, Takeuchi A, Nakai H, Oka C, Noma A, Matsuoka S
  Title
Simulation analysis of intracellular Na+ and Cl- homeostasis during beta 1-adrenergic stimulation of cardiac myocyte.
  Journal
Prog Biophys Mol Biol 96:171-86 (2008)
DOI:10.1016/j.pbiomolbio.2007.07.005
Reference
PMID:11805843
  Authors
Bers DM
  Title
Cardiac excitation-contraction coupling.
  Journal
Nature 415:198-205 (2002)
DOI:10.1038/415198a
Reference
PMID:20658186
  Authors
Ho D, Yan L, Iwatsubo K, Vatner DE, Vatner SF
  Title
Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5.
  Journal
Heart Fail Rev 15:495-512 (2010)
DOI:10.1007/s10741-010-9183-5
Reference
PMID:15142747
  Authors
Saucerman JJ, McCulloch AD
  Title
Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.
  Journal
Prog Biophys Mol Biol 85:261-78 (2004)
DOI:10.1016/j.pbiomolbio.2004.01.005
Reference
PMID:15765137
  Authors
Yano M, Ikeda Y, Matsuzaki M
  Title
Altered intracellular Ca2+ handling in heart failure.
  Journal
J Clin Invest 115:556-64 (2005)
DOI:10.1172/JCI24159
Reference
PMID:15232578
  Authors
Wehrens XH, Marks AR
  Title
Novel therapeutic approaches for heart failure by normalizing calcium cycling.
  Journal
Nat Rev Drug Discov 3:565-73 (2004)
DOI:10.1038/nrd1440
Reference
PMID:19874988
  Authors
Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J
  Title
The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.
  Journal
J Am Coll Cardiol 54:1747-62 (2009)
DOI:10.1016/j.jacc.2009.05.015
Reference
PMID:18407781
  Authors
Barry SP, Davidson SM, Townsend PA
  Title
Molecular regulation of cardiac hypertrophy.
  Journal
Int J Biochem Cell Biol 40:2023-39 (2008)
DOI:10.1016/j.biocel.2008.02.020
Related
pathway
ssen04020  Calcium signaling pathway
ssen04260  Cardiac muscle contraction
KO pathway
ko04261   
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