KEGG   PATHWAY: tru04310
Entry
tru04310                    Pathway                                
Name
Wnt signaling pathway - Takifugu rubripes (torafugu)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
Pathway map
tru04310  Wnt signaling pathway
tru04310

Other DBs
GO: 0016055
Organism
Takifugu rubripes (torafugu) [GN:tru]
Gene
101075803  porcn; protein-serine O-palmitoleoyltransferase porcupine [KO:K00181] [EC:2.3.1.250]
101068343  protein-serine O-palmitoleoyltransferase porcupine-like isoform X1 [KO:K00181] [EC:2.3.1.250]
115249167  protein-serine O-palmitoleoyltransferase porcupine-like isoform X1 [KO:K00181] [EC:2.3.1.250]
101061628  wnt1; proto-oncogene Wnt-1 [KO:K03209]
101071718  protein Wnt-2b-A [KO:K00182]
101071463  protein Wnt-2b-A [KO:K00182]
100137508  wnt2; protein Wnt-2 precursor [KO:K00182]
115246836  protein Wnt-2b-A-like [KO:K00182]
101069649  proto-oncogene Wnt-3 [KO:K00312]
101062356  wnt3a; protein Wnt-3a isoform X2 [KO:K00312]
101068089  wnt4; protein Wnt-4 isoform X1 [KO:K00408]
101067916  protein Wnt-4-like [KO:K00408]
101075293  wnt5a; protein Wnt-5a [KO:K00444]
101067574  protein Wnt-5b isoform X2 [KO:K00444]
101062888  wnt6; protein Wnt-6 [KO:K00445]
101078823  protein Wnt-7a [KO:K00572]
101071438  protein Wnt-7b isoform X2 [KO:K00572]
101073059  protein Wnt-8b [KO:K00714]
445897  wnt8; Wnt8.1 protein precursor [KO:K00714]
101068819  wnt9b; protein Wnt-9b [KO:K01064]
101062131  wnt9a; protein Wnt-9a isoform X1 [KO:K01064]
101061404  wnt10b; protein Wnt-10b isoform X1 [KO:K01357]
101062670  wnt10a; protein Wnt-10a [KO:K01357]
101078737  wnt11; LOW QUALITY PROTEIN: protein Wnt-11 [KO:K01384]
101072879  wnt16; protein Wnt-16 [KO:K01558]
445915  charon; DAN related protein precursor [KO:K01645]
101063641  palmitoleoyl-protein carboxylesterase notum1a [KO:K19882] [EC:3.1.1.98]
101062420  palmitoleoyl-protein carboxylesterase notum1a-like [KO:K19882] [EC:3.1.1.98]
101062197  palmitoleoyl-protein carboxylesterase notum1a-like isoform X2 [KO:K19882] [EC:3.1.1.98]
101061589  carboxylesterase notum2-like [KO:K19882] [EC:3.1.1.98]
101070335  sost; sclerostin [KO:K16834]
105416356  dickkopf-related protein 1-like [KO:K02165]
101075057  dickkopf-related protein 2-like isoform X1 [KO:K02165]
101063814  dkk2; dickkopf-related protein 2 [KO:K02165]
101068424  serpinf1; pigment epithelium-derived factor isoform X2 [KO:K19614]
101073317  sfrp1; secreted frizzled-related protein 1 [KO:K02166]
101076977  sfrp2; secreted frizzled-related protein 2 [KO:K02176]
101070726  frzb; secreted frizzled-related protein 3 isoform X2 [KO:K25481]
101078006  sfrp5; secreted frizzled-related protein 5 [KO:K02222]
101064242  R-spondin-1 [KO:K19471]
101069601  rspo2; R-spondin-2 [KO:K23097]
101067239  rspo3; R-spondin-3 isoform X1 [KO:K23098]
101066721  lgr4; leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1 [KO:K04309]
101073258  lgr5; leucine-rich repeat-containing G-protein coupled receptor 5 [KO:K04308]
101078678  lgr6; leucine-rich repeat-containing G-protein coupled receptor 6 [KO:K08399]
101078480  E3 ubiquitin-protein ligase RNF43-like [KO:K15694] [EC:2.3.2.27]
115252683  rnf43; E3 ubiquitin-protein ligase RNF43 [KO:K15694] [EC:2.3.2.27]
101065550  znrf3; E3 ubiquitin-protein ligase ZNRF3 isoform X1 [KO:K16273] [EC:2.3.2.27]
101078517  frizzled-7-A-like [KO:K02432]
101071806  frizzled-7-A-like [KO:K02432]
105416636  uncharacterized protein LOC105416636 [KO:K02432]
101070660  fzd2; frizzled-2 [KO:K02235]
101070067  frizzled-3-like isoform X1 [KO:K02329]
101074650  fzd3; frizzled-3 [KO:K02329]
101063657  fzd4; frizzled-4 [KO:K02354]
101069583  frizzled-5-like [KO:K02375]
101078921  fzd8; frizzled-8 [KO:K02375]
101064504  frizzled-8-like [KO:K02375]
101077702  fzd6; frizzled-6 [KO:K02376]
101075928  fzd10; frizzled-10 [KO:K02842]
101064960  LOW QUALITY PROTEIN: frizzled-9 [KO:K02842]
101073326  lrp6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
101069468  low-density lipoprotein receptor-related protein 5-like isoform X1 [KO:K03068]
101069477  bambi; BMP and activin membrane-bound inhibitor homolog isoform X1 [KO:K10162]
101069087  protein APCDD1-like [KO:K25812]
101074977  apcdd1; protein APCDD1 [KO:K25812]
101068125  casein kinase I [KO:K08960] [EC:2.7.11.1]
101067908  casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
101067087  protein Daple-like [KO:K25811]
101074176  dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X2 [KO:K02353]
101061269  dvl2; segment polarity protein dishevelled homolog DVL-2 isoform X3 [KO:K02353]
101061354  segment polarity protein dishevelled homolog DVL-3-like isoform X1 [KO:K02353]
101065936  dvl3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
101073270  frat2; GSK-3-binding protein FRAT2 [KO:K03096]
101063201  casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
101067113  casein kinase II subunit alpha'-like isoform X2 [KO:K03097] [EC:2.7.11.1]
101066395  csnk2a2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
101078433  casein kinase II subunit alpha-like isoform X1 [KO:K03097] [EC:2.7.11.1]
101062616  casein kinase II subunit beta [KO:K03115]
101074217  casein kinase II subunit beta [KO:K03115]
115251803  casein kinase II subunit beta [KO:K03115]
101077854  nkd2; protein naked cuticle homolog 2 isoform X1 [KO:K03213]
101066502  nkd1; protein naked cuticle homolog 1 [KO:K03213]
101073395  cxxc4; CXXC-type zinc finger protein 4 [KO:K03344]
105419947  DNA N6-methyl adenine demethylase-like isoform X1 [KO:K03344]
101061172  sentrin-specific protease 2-like isoform X1 [KO:K03345] [EC:3.4.22.68]
101067898  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101077931  ctnnb1; catenin beta-1 [KO:K02105]
101069214  catenin beta-1-like isoform X1 [KO:K02105]
101075840  axin-1-like isoform X1 [KO:K02157]
101065196  axin1; axin-1 [KO:K02157]
101071501  LOW QUALITY PROTEIN: axin-2-like [KO:K04385]
105419692  axin2; axin-2 [KO:K04385]
101079661  apc; adenomatous polyposis coli protein isoform X1 [KO:K02085]
101062949  adenomatous polyposis coli protein 2-like isoform X1 [KO:K02085]
101063741  csnk1a1; casein kinase I isoform X3 [KO:K08957] [EC:2.7.11.1]
101076516  tcf7; transcription factor 7 isoform X5 [KO:K02620]
101074632  transcription factor 7-like 1-B [KO:K04490]
115250984  transcription factor 7-like 1-B [KO:K04490]
115250985  transcription factor 7-like 1-A [KO:K04490]
101063163  transcription factor 7-like 1-B isoform X1 [KO:K04490]
115250775  transcription factor 7-like 1-C isoform X1 [KO:K04491]
101067664  tcf7l2; transcription factor 7-like 2 isoform X4 [KO:K04491]
101064872  lef1; lymphoid enhancer-binding factor 1 isoform X7 [KO:K04492]
115251054  lymphoid enhancer-binding factor 1-like isoform X1 [KO:K04492]
101065405  lzts2; leucine zipper putative tumor suppressor 2 [KO:K26471]
101075662  leucine zipper putative tumor suppressor 2 homolog [KO:K26471]
101071029  ctnnbip1; beta-catenin-interacting protein 1 [KO:K04493]
101068737  cby1; protein chibby homolog 1 [KO:K23402]
101062061  chd8; chromodomain-helicase-DNA-binding protein 8 isoform X1 [KO:K04494] [EC:5.6.2.-]
101061405  sirt1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
101080200  sox17; transcription factor SOX-17 [KO:K04495]
101074618  ctbp2; C-terminal-binding protein 2 isoform X1 [KO:K04496] [EC:1.1.1.428]
101063195  LOW QUALITY PROTEIN: C-terminal-binding protein 2 [KO:K04496] [EC:1.1.1.428]
101066137  C-terminal-binding protein 1-like isoform X1 [KO:K04496] [EC:1.1.1.428]
101063672  ctbp1; C-terminal-binding protein 1 isoform X3 [KO:K04496] [EC:1.1.1.428]
101065815  transducin-like enhancer protein 3-B isoform X1 [KO:K04497]
101079623  transducin-like enhancer protein 1 isoform X1 [KO:K04497]
101064354  transducin-like enhancer protein 4 isoform X1 [KO:K04497]
653007  tle3; transducin-like enhancer protein 3 [KO:K04497]
101078578  transducin-like enhancer protein 4 isoform X3 [KO:K04497]
101064580  transducin-like enhancer protein 1 isoform X1 [KO:K04497]
101072653  ctnnd2; catenin delta-2 isoform X1 [KO:K23491]
101077861  catenin delta-2 isoform X2 [KO:K23491]
101078373  crebbp; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
101070643  ep300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
446056  histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
101073984  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
115248448  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
101062423  ruvbl1; ruvB-like 1 [KO:K04499] [EC:5.6.2.4]
101068466  mothers against decapentaplegic homolog 4-like [KO:K04501]
101068039  mothers against decapentaplegic homolog 4-like [KO:K04501]
101072080  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
101074868  mothers against decapentaplegic homolog 3 [KO:K23605]
101063524  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101063351  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
445934  nlk; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
653028  myc; myc proto-oncogene protein [KO:K04377]
101072742  myc proto-oncogene protein-like [KO:K04377]
101079255  myc proto-oncogene protein-like isoform X1 [KO:K04377]
101077059  transcription factor AP-1 [KO:K04448]
101064806  jun; transcription factor AP-1 [KO:K04448]
101061278  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
101080220  G1/S-specific cyclin-D2 [KO:K10151]
101073562  G1/S-specific cyclin-D2-like [KO:K10151]
101066871  G1/S-specific cyclin-D3-like [KO:K10151]
115249879  G1/S-specific cyclin-D3-like [KO:K10151]
101063905  ccnd3; G1/S-specific cyclin-D3 isoform X2 [KO:K10152]
101061423  ccn4; WNT1-inducible-signaling pathway protein 1 [KO:K22471]
100049070  ppard; peroxisome proliferator-activated receptor delta [KO:K04504]
101077303  presenilin-1 [KO:K04505] [EC:3.4.23.-]
101069822  cAMP-dependent protein kinase catalytic subunit alpha isoform X3 [KO:K04345] [EC:2.7.11.11]
101067856  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101066292  cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
101062935  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101079595  cellular tumor antigen p53 [KO:K04451]
101074163  E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
101077365  cacybp; calcyclin-binding protein [KO:K04507]
101068627  skp1; S-phase kinase-associated protein 1 [KO:K03094]
101062383  F-box-like/WD repeat-containing protein TBL1X [KO:K04508]
101066969  F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508]
101072205  tbl1xr1; F-box-like/WD repeat-containing protein TBL1XR1 isoform X1 [KO:K04508]
101067263  fbxw11; F-box/WD repeat-containing protein 11 isoform X2 [KO:K03362]
101068951  cul1; LOW QUALITY PROTEIN: cullin-1 [KO:K03347]
101079814  RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
115248454  E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
115249889  E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
115249890  RING-box protein 1-like [KO:K03868] [EC:2.3.2.32]
101074418  glypican-6 [KO:K08110]
101078954  ror1; inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X1 [KO:K05122] [EC:2.7.10.1]
101064846  ror2; tyrosine-protein kinase transmembrane receptor ROR2 isoform X1 [KO:K05123] [EC:2.7.10.1]
101075560  ryk; tyrosine-protein kinase RYK [KO:K05128] [EC:2.7.10.1]
101070874  vang-like protein 1 [KO:K04510]
101070202  vangl1; vang-like protein 1 isoform X2 [KO:K04510]
101068730  vang-like protein 2 isoform X1 [KO:K04510]
101071775  vangl2; vang-like protein 2 [KO:K04510]
101078070  prickle3; prickle planar cell polarity protein 3 isoform X1 [KO:K04511]
101073220  prickle-like protein 1 [KO:K04511]
101071385  prickle-like protein 1 isoform X1 [KO:K04511]
101065313  prickle2; prickle-like protein 2 isoform X2 [KO:K04511]
101073257  prickle-like protein 2 [KO:K04511]
101070892  invs; inversin isoform X1 [KO:K19626]
101067817  disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512]
101069770  daam1; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512]
115248829  LOW QUALITY PROTEIN: disheveled-associated activator of morphogenesis 1-like [KO:K04512]
101064166  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
101070117  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
101076147  transforming protein RhoA [KO:K04513]
101068674  rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
101067715  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
101063410  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101067160  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
101071607  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101064595  ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
101073575  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101070190  mitogen-activated protein kinase 8 isoform X3 [KO:K04440] [EC:2.7.11.24]
101067839  mapk10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
101078548  mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
101065367  plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
101078708  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
101069591  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
101076025  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
101073102  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
115250847  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like [KO:K05858] [EC:3.1.4.11]
101068297  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X5 [KO:K04515] [EC:2.7.11.17]
101064236  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2 [KO:K04515] [EC:2.7.11.17]
101073370  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X7 [KO:K04515] [EC:2.7.11.17]
101062260  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101071995  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
101061448  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
101074783  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
101070452  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101073844  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
101072650  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X3 [KO:K04348] [EC:3.1.3.16]
101073266  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
101071292  calcineurin subunit B type 1-like [KO:K06268]
101074110  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
101064815  prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101071034  LOW QUALITY PROTEIN: protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101079815  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101065234  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101079823  protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
101079060  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
101065260  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
101068521  nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 [KO:K17332]
101068861  nuclear factor of activated T-cells, cytoplasmic 2-like isoform X1 [KO:K17332]
101063887  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
101073105  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
Compound
C00076  Calcium cation
Reference
PMID:14635791
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
DOI:10.1023/A:1025944723047
Reference
PMID:14745971
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
DOI:10.1002/bdrc.10026
Reference
PMID:12446114
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
DOI:10.1016/S0962-8924(02)02388-7
Reference
PMID:14530294
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
DOI:10.1242/dev.00821
Reference
PMID:15102436
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
DOI:10.1016/j.tibs.2003.12.004
Reference
PMID:12967557
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
DOI:10.1016/S1534-5807(03)00266-1
Reference
PMID:11433294
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
DOI:10.1038/35083016
Reference
PMID:23256519
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
DOI:10.3109/08977194.2012.752737
Reference
PMID:19482104
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
DOI:10.1053/j.gastro.2009.05.011
Reference
PMID:18838381
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
DOI:10.1074/jbc.M804039200
Reference
PMID:23151663
  Authors
Niehrs C
  Title
The complex world of WNT receptor signalling.
  Journal
Nat Rev Mol Cell Biol 13:767-79 (2012)
DOI:10.1038/nrm3470
Reference
PMID:28522145
  Authors
Abou Ziki MD, Mani A
  Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
  Journal
Atherosclerosis 262:171-178 (2017)
DOI:10.1016/j.atherosclerosis.2017.05.001
Reference
PMID:25808920
  Authors
He Y, Ki H, Kim H, Kim K
  Title
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
  Journal
Cell Biol Int 39:954-61 (2015)
DOI:10.1002/cbin.10465
Reference
PMID:32888647
  Authors
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
  Title
The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
  Journal
Biochem Biophys Res Commun 532:406-413 (2020)
DOI:10.1016/j.bbrc.2020.08.066
Reference
PMID:28242765
  Authors
Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
  Title
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
  Journal
J Biol Chem 292:6312-6324 (2017)
DOI:10.1074/jbc.M116.758078
Related
pathway
tru04010  MAPK signaling pathway
tru04110  Cell cycle
tru04115  p53 signaling pathway
tru04120  Ubiquitin mediated proteolysis
tru04350  TGF-beta signaling pathway
tru04510  Focal adhesion
tru04520  Adherens junction
KO pathway
ko04310   
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