KEGG   PATHWAY: vlg04015
Entry
vlg04015                    Pathway                                
Name
Rap1 signaling pathway - Vulpes lagopus (Arctic fox)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
vlg04015  Rap1 signaling pathway
vlg04015

Other DBs
GO: 0007264
Organism
Vulpes lagopus (Arctic fox) [GN:vlg]
Gene
121490661  RAP1A; ras-related protein Rap-1A [KO:K04353]
121476667  ras-related protein Rap-1b-like [KO:K07836]
121491095  RAP1B; ras-related protein Rap-1b [KO:K07836]
121478704  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
121474513  RAPGEF5; rap guanine nucleotide exchange factor 5 [KO:K08019]
121474730  DOCK4; dedicator of cytokinesis protein 4 isoform X1 [KO:K17697]
121473250  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
121488229  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
121479649  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
121485632  CALML4; calmodulin-like protein 4 [KO:K02183]
121485676  CALM3; calmodulin-3 [KO:K02183]
121485677  calmodulin-1 [KO:K02183]
121478795  calmodulin-1 [KO:K02183]
121496486  calmodulin-like protein 3 [KO:K02183]
121497964  CALML5; calmodulin-like protein 5 [KO:K02183]
121490986  CALM2; calmodulin-2 [KO:K02183]
121493011  CALM1; calmodulin-1 [KO:K02183]
121500599  CALML6; calmodulin-like protein 6 [KO:K02183]
121493375  calmodulin-alpha-like [KO:K02183]
121489615  F2R; proteinase-activated receptor 1 [KO:K03914]
121495758  F2RL3; proteinase-activated receptor 4 [KO:K04236]
121479002  P2RY1; P2Y purinoceptor 1 [KO:K04270]
121495881  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
121495507  LPAR2; lysophosphatidic acid receptor 2 isoform X1 [KO:K04291]
121486420  LPAR3; lysophosphatidic acid receptor 3 isoform X1 [KO:K04294]
121483391  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
121479718  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
121475373  ADORA2A; adenosine receptor A2a isoform X1 [KO:K04266]
121499505  ADORA2B; adenosine receptor A2b isoform X1 [KO:K04267]
121477898  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
121477899  neuroendocrine secretory protein 55 [KO:K04632]
121490100  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
121492610  LOW QUALITY PROTEIN: adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
121477531  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
121491160  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
121493259  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
121501047  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
121479760  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
121497930  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
121498514  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
121486234  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
121479984  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
121471317  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
121484745  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
121476506  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
121477755  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
121478236  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
121472045  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
121491177  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
121501819  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
121492863  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
121496849  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
121493095  FGF2; fibroblast growth factor 2 isoform X1 [KO:K18497]
121488316  FGF10; fibroblast growth factor 10 [KO:K04358]
121489733  FGF20; fibroblast growth factor 20 [KO:K04358]
121483251  FGF16; fibroblast growth factor 16 isoform X1 [KO:K04358]
121484246  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
121485347  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
121486238  FGF18; fibroblast growth factor 18 [KO:K04358]
121471654  FGF3; fibroblast growth factor 3 [KO:K04358]
121479729  FGF6; fibroblast growth factor 6 isoform X1 [KO:K04358]
121496013  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
121497953  FGF9; fibroblast growth factor 9 [KO:K04358]
121498143  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
121493777  FGF5; fibroblast growth factor 5 [KO:K04358]
121501375  FGF4; fibroblast growth factor 4 [KO:K04358]
121471655  FGF19; fibroblast growth factor 19 [KO:K22603]
121484859  FGF21; fibroblast growth factor 21 [KO:K22429]
121480100  FGF23; fibroblast growth factor 23 [KO:K22428]
121490401  NGF; beta-nerve growth factor [KO:K02582]
121471415  INS; insulin [KO:K04526]
121481162  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
121487555  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
121491690  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
121481069  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
121499558  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
121487528  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
121481201  KITLG; kit ligand isoform X1 [KO:K05461]
121486776  VEGFA; vascular endothelial growth factor A [KO:K05448]
121471253  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
121493888  PGF; placenta growth factor isoform X1 [KO:K16859]
121489397  VEGFC; vascular endothelial growth factor C [KO:K05449]
121483299  VEGFD; vascular endothelial growth factor D [KO:K05449]
121471954  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
121498809  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
121489212  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
121478289  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
121489215  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
121485809  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
121494203  EFNA2; ephrin-A2 [KO:K05462]
121495905  EFNA1; ephrin-A1 [KO:K05462]
121471236  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
121489119  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
121484320  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
121489705  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
121488199  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
121473983  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
121494318  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
121490029  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
121472891  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
121486777  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
121487635  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
121473772  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
121496478  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
121494999  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
121473247  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
121474658  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
121494752  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
121497510  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
121473371  CRK; adapter molecule crk isoform X1 [KO:K04438]
121475542  CRKL; crk-like protein [KO:K04438]
121473724  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
121499705  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
121500345  CDH1; cadherin-1 [KO:K05689]
121500539  cadherin-1-like [KO:K05689]
121478755  CTNNB1; catenin beta-1 [KO:K02105]
121494692  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
121472367  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
121491402  MAGI3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X1 [KO:K06112]
121481097  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
121494942  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
121486346  LAT; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
121486496  FYB1; FYN-binding protein 1 isoform X1 [KO:K17698]
121488106  LCP2; lymphocyte cytosolic protein 2 [KO:K07361]
121474202  SKAP1; src kinase-associated phosphoprotein 1 [KO:K17699]
121477887  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
121473288  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
121487652  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
121480810  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
121484930  PRKD2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
121491585  PRKD3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
121493390  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
121500301  DRD2; D(2) dopamine receptor [KO:K04145]
121492006  CNR1; cannabinoid receptor 1 [KO:K04277]
121471255  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
121487463  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
121495419  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
121496666  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
121497453  rap1 GTPase-activating protein 1 isoform X1 [KO:K17700]
121493027  SIPA1L1; signal-induced proliferation-associated 1-like protein 1 isoform X1 [KO:K17701]
121471267  SIPA1; signal-induced proliferation-associated protein 1 [KO:K08013]
121487360  SIPA1L2; signal-induced proliferation-associated 1-like protein 2 isoform X1 [KO:K17702]
121483891  SIPA1L3; signal-induced proliferation-associated 1-like protein 3 [KO:K17703]
121478079  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
121479866  THBS1; thrombospondin-1 [KO:K16857]
121473707  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
121471412  RALA; ras-related protein Ral-A [KO:K07834]
121482021  RALB; ras-related protein Ral-B [KO:K07835]
121486443  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
121479474  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
121490389  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
121473005  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
121496473  amyloid beta A4 precursor protein-binding family B member 1-interacting protein [KO:K17704]
121482806  TLN2; talin-2 isoform X1 [KO:K06271]
121494417  TLN1; talin-1 isoform X1 [KO:K06271]
121472806  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
121473834  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
121482531  profilin-1-like [KO:K05759]
121478980  PFN2; profilin-2 isoform X1 [KO:K05759]
121487276  PFN3; profilin-3 [KO:K05759]
121490553  PFN4; profilin-4 [KO:K05759]
121500740  PFN1; profilin-1 [KO:K05759]
121485663  vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
121489082  ENAH; protein enabled homolog isoform X1 [KO:K05746]
121493383  EVL; ena/VASP-like protein isoform X1 [KO:K23487]
121473578  ACTG1; actin, cytoplasmic 2 [KO:K05692]
121483270  actin, cytoplasmic 1 [KO:K05692]
121477556  actin, cytoplasmic 2-like [KO:K05692]
121487542  ACTB; actin, cytoplasmic 1 [KO:K05692]
121497329  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
121494185  RHOA; transforming protein RhoA [KO:K04513]
121478063  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
121498124  FARP2; FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1 [KO:K06082]
121484133  cell division control protein 42 homolog [KO:K04393]
121496975  cell division control protein 42 homolog [KO:K04393]
121497282  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
121472914  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
121486695  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
121496301  VAV1; proto-oncogene vav [KO:K05730]
121479551  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
121496593  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
121481909  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
121478163  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
121500588  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
121499817  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
121477501  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
121485222  AFDN; afadin isoform X1 [KO:K05702]
121472107  CTNND1; catenin delta-1 isoform X1 [KO:K05690]
121475154  KRIT1; krev interaction trapped protein 1 [KO:K17705]
121488205  RGS14; regulator of G-protein signaling 14 [KO:K17706]
121501601  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
121487568  ITGAL; integrin alpha-L [KO:K05718]
121488350  ITGAM; integrin alpha-M [KO:K06461]
121479390  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
121497152  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
121489076  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
121494281  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
121484067  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
121495470  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
121475510  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121486545  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121499935  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
121473314  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
121482054  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
121485950  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
121491672  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
121491673  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
121477352  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121478805  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
121499678  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121481416  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
121496480  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121494738  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
121488903  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121482033  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121482375  LOW QUALITY PROTEIN: RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
121493415  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121481963  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
121472124  HRAS; GTPase HRas isoform X1 [KO:K02833]
121479900  KRAS; GTPase KRas isoform X1 [KO:K07827]
121491321  NRAS; GTPase NRas [KO:K07828]
121485834  RRAS; ras-related protein R-Ras [KO:K07829]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
vlg04010  MAPK signaling pathway
vlg04014  Ras signaling pathway
vlg04020  Calcium signaling pathway
vlg04151  PI3K-Akt signaling pathway
vlg04510  Focal adhesion
vlg04520  Adherens junction
vlg04660  T cell receptor signaling pathway
vlg04810  Regulation of actin cytoskeleton
KO pathway
ko04015   
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