KEGG   PATHWAY: vpc05161
Entry
vpc05161                    Pathway                                
Name
Hepatitis B - Vicugna pacos (alpaca)
Description
Hepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and converted into a covalently closed circular molecule cccDNA. The cccDNA is the template for transcription of all viral RNAs including the pregenomic RNA (pgRNA), encoding for 7 viral proteins: large, middle, and small envelope proteins (LHBs, MHBs, and SHBs) that form the surface antigen (HBsAg), the core antigen (HBcAg), the e antigen (HBeAg), the HBV polymerase, and the regulatory protein X (HBx). The pgRNA interacts with the viral polymerase protein to initiate the encapsidation into the core particles. Through endoplasmic reticulum, the core particles finish assembling with the envelope proteins and are released. HBV infection leads to a wide spectrum of liver diseases raging from chronic hepatitis, cirrhosis to hepatocellular carcinoma. The mechanism of liver injury is still not clear. However, HBV proteins target host proteins, involved in a variety of functions, thus regulating transcription, cellular signaling cascades, proliferation, differentiation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
vpc05161  Hepatitis B
vpc05161

Organism
Vicugna pacos (alpaca) [GN:vpc]
Gene
102545237  HSPG2; LOW QUALITY PROTEIN: basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
102537394  SLC10A1; sodium/bile acid cotransporter [KO:K14341]
102539136  TGFB1; transforming growth factor beta-1 proprotein precursor [KO:K13375]
102543548  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
102534848  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
102526363  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
102529547  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
102531396  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
102538980  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
102528221  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102543430  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102539859  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102541072  MYC; myc proto-oncogene protein [KO:K04377]
102546004  EGR2; E3 SUMO-protein ligase EGR2 isoform X1 [KO:K12496]
102541867  EGR3; early growth response protein 3 isoform X1 [KO:K12497]
102531948  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
102535153  CREBBP; LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
102536116  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102525836  DDB1; DNA damage-binding protein 1 [KO:K10610]
102532209  DDB2; DNA damage-binding protein 2 isoform X7 [KO:K10140]
102530799  MAP3K1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
102543164  YWHAQ; 14-3-3 protein theta [KO:K16197]
102535937  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
102535483  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
102541172  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
102540289  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102524821  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102543068  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102532395  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102536302  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102536225  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102526860  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102546009  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102542031  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102534431  CHUK; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
102528824  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
102541871  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102524630  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
102532161  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102540197  RELA; transcription factor p65 isoform X1 [KO:K04735]
102528343  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
102538080  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
102538813  BAD; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
102535267  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
102542071  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
102540480  CASP10; LOW QUALITY PROTEIN: caspase-10 [KO:K04400] [EC:3.4.22.63]
102537080  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
102543566  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
102538116  APAF1; apoptotic protease-activating factor 1 isoform X3 [KO:K02084]
102534683  cytochrome c, testis-specific [KO:K08738]
102535382  cytochrome c [KO:K08738]
116282869  caspase-9-like [KO:K04399] [EC:3.4.22.62]
102541258  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
102543682  BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
102530959  TP53; cellular tumor antigen p53 [KO:K04451]
102534727  CCNA2; cyclin-A2 [KO:K06627]
102540650  CCNA1; cyclin-A1 isoform X2 [KO:K06627]
102539563  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
102537154  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
102527596  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
102545797  RB1; LOW QUALITY PROTEIN: retinoblastoma-associated protein [KO:K06618]
102527293  E2F1; transcription factor E2F1 [KO:K17454]
102525226  E2F2; transcription factor E2F2 [KO:K09389]
102539538  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
102536972  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
102541926  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
102526158  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
102542323  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102543250  NFATC1; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
102541219  nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
102529936  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
102544740  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
102541924  TNF; tumor necrosis factor [KO:K03156]
102544505  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
102544515  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
102537935  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
102528960  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
102541847  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
102544679  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X5 [KO:K11220]
102545696  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
102544953  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
102537862  signal transducer and activator of transcription 5A [KO:K11223]
102538126  signal transducer and activator of transcription 5B [KO:K11224]
102543450  STAT6; signal transducer and activator of transcription 6 isoform X3 [KO:K11225]
102527881  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
102535738  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
102526522  SRC; proto-oncogene tyrosine-protein kinase Src isoform X2 [KO:K05704] [EC:2.7.10.2]
102532895  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102541429  SOS2; son of sevenless homolog 2 [KO:K03099]
102543818  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102525363  HRAS; GTPase HRas isoform X1 [KO:K02833]
102529990  KRAS; GTPase KRas isoform X2 [KO:K07827]
102534785  NRAS; GTPase NRas [KO:K07828]
102541687  JUN; LOW QUALITY PROTEIN: transcription factor AP-1 [KO:K04448]
102532183  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
102542128  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
102531048  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
102544965  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
102534415  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
102538690  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
102534951  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
102541872  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
102531881  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102540303  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X5 [KO:K09047]
102530505  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
102533127  CXCL8; interleukin-8 [KO:K10030]
102526038  PCNA; proliferating cell nuclear antigen [KO:K04802]
102529339  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
102528789  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
102543308  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102530118  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102534668  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102536713  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102528720  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102533186  FOS; proto-oncogene c-Fos [KO:K04379]
102525227  TLR2; toll-like receptor 2 [KO:K10159]
102538305  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
102540249  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
102529688  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
102544486  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
102529835  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
102540938  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
102530894  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
102534039  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
102534059  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
102529729  IL6; interleukin-6 [KO:K05405]
102530139  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
102545165  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
102525219  MAPK12; mitogen-activated protein kinase 12 isoform X7 [KO:K04441] [EC:2.7.11.24]
102531650  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
102540698  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
102541290  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
102525041  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
102529482  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
102525148  TLR3; toll-like receptor 3 [KO:K05401]
102531050  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
102535469  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
102543498  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
102539671  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
102529156  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
102539212  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
102530199  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
102535183  DDX3X; ATP-dependent RNA helicase DDX3X isoform X3 [KO:K11594] [EC:5.6.2.7]
102536109  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
102527909  IRF7; interferon regulatory factor 7 [KO:K09447]
116280218  interferon alpha-1-like [KO:K05414]
102540000  interferon alpha-6-like [KO:K05414]
102539757  interferon alpha-1-like [KO:K05414]
102544554  interferon alpha-1-like [KO:K05414]
102540243  IFNB1; interferon beta [KO:K05415]
102530410  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
Compound
C00076  Calcium cation
Reference
PMID:30059722
  Authors
Caballero A, Tabernero D, Buti M, Rodriguez-Frias F
  Title
Hepatitis B virus: The challenge of an ancient virus with multiple faces and a remarkable replication strategy.
  Journal
Antiviral Res 158:34-44 (2018)
DOI:10.1016/j.antiviral.2018.07.019
Reference
PMID:22869468
  Authors
Walsh R, Locarnini S
  Title
Hepatitis B precore protein: pathogenic potential and therapeutic promise.
  Journal
Yonsei Med J 53:875-85 (2012)
DOI:10.3349/ymj.2012.53.5.875
Reference
PMID:26239691
  Authors
Liang TJ, Block TM, McMahon BJ, Ghany MG, Urban S, Guo JT, Locarnini S, Zoulim F, Chang KM, Lok AS
  Title
Present and future therapies of hepatitis B: From discovery to cure.
  Journal
Hepatology 62:1893-908 (2015)
DOI:10.1002/hep.28025
Reference
PMID:26776362
  Authors
Morikawa K, Suda G, Sakamoto N
  Title
Viral life cycle of hepatitis B virus: Host factors and druggable targets.
  Journal
Hepatol Res 46:871-7 (2016)
DOI:10.1111/hepr.12650
Reference
PMID:19201080
  Authors
Feitelson MA, Reis HM, Tufan NL, Sun B, Pan J, Lian Z
  Title
Putative roles of hepatitis B x antigen in the pathogenesis of chronic liver disease.
  Journal
Cancer Lett 286:69-79 (2009)
DOI:10.1016/j.canlet.2008.12.010
Reference
PMID:19263472
  Authors
Murata M, Matsuzaki K, Yoshida K, Sekimoto G, Tahashi Y, Mori S, Uemura Y, Sakaida N, Fujisawa J, Seki T, Kobayashi K, Yokote K, Koike K, Okazaki K
  Title
Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)-beta signaling from tumor suppression to oncogenesis in early chronic hepatitis B.
  Journal
Hepatology 49:1203-17 (2009)
DOI:10.1002/hep.22765
Reference
PMID:15173177
  Authors
Yoo YG, Lee MO
  Title
Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor.
  Journal
J Biol Chem 279:36242-9 (2004)
DOI:10.1074/jbc.M401290200
Reference
PMID:16459163
  Authors
Zhang X, Zhang H, Ye L
  Title
Effects of hepatitis B virus X protein on the development of liver cancer.
  Journal
J Lab Clin Med 147:58-66 (2006)
DOI:10.1016/j.lab.2005.10.003
Reference
PMID:19854353
  Authors
Benhenda S, Cougot D, Buendia MA, Neuveut C
  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
  Journal
Adv Cancer Res 103:75-109 (2009)
DOI:10.1016/S0065-230X(09)03004-8
Reference
PMID:21994562
  Authors
Benhenda S, Cougot D, Neuveut C, Buendia MA
  Title
Liver cell transformation in chronic HBV infection.
  Journal
Viruses 1:630-46 (2009)
DOI:10.3390/v1030630
Reference
PMID:11099494
  Authors
Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA, Woodgett JR, Penninger J, Richardson CD
  Title
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
  Journal
J Biol Chem 276:8328-40 (2001)
DOI:10.1074/jbc.M006026200
Reference
PMID:16891440
  Authors
Park NH, Song IH, Chung YH
  Title
Chronic hepatitis B in hepatocarcinogenesis.
  Journal
Postgrad Med J 82:507-15 (2006)
DOI:10.1136/pgmj.2006.047431
Reference
PMID:28820498
  Authors
Lin S, Zhang YJ
  Title
Interference of Apoptosis by Hepatitis B Virus.
  Journal
Viruses 9:E230 (2017)
DOI:10.3390/v9080230
Reference
PMID:16173017
  Authors
Zhang X, Dong N, Yin L, Cai N, Ma H, You J, Zhang H, Wang H, He R, Ye L
  Title
Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues.
  Journal
J Med Virol 77:374-81 (2005)
DOI:10.1002/jmv.20466
Reference
PMID:18481805
  Authors
Kim HJ, Kim SY, Kim J, Lee H, Choi M, Kim JK, Ahn JK
  Title
Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria.
  Journal
IUBMB Life 60:473-80 (2008)
DOI:10.1002/iub.68
Reference
PMID:21647825
  Authors
Ng SA, Lee C
  Title
Hepatitis B virus X gene and hepatocarcinogenesis.
  Journal
J Gastroenterol 46:974-90 (2011)
DOI:10.1007/s00535-011-0415-9
Reference
PMID:9195957
  Authors
Cong YS, Yao YL, Yang WM, Kuzhandaivelu N, Seto E
  Title
The hepatitis B virus X-associated protein, XAP3, is a protein kinase C-binding protein.
  Journal
J Biol Chem 272:16482-9 (1997)
DOI:10.1074/jbc.272.26.16482
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:9738022
  Authors
Lee YH, Yun Y
  Title
HBx protein of hepatitis B virus activates Jak1-STAT signaling.
  Journal
J Biol Chem 273:25510-5 (1998)
DOI:10.1074/jbc.273.39.25510
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Reference
PMID:17059849
  Authors
Chami M, Oules B, Paterlini-Brechot P
  Title
Cytobiological consequences of calcium-signaling alterations induced by human viral proteins.
  Journal
Biochim Biophys Acta 1763:1344-62 (2006)
DOI:10.1016/j.bbamcr.2006.09.025
Reference
PMID:11743185
  Authors
Ganem D
  Title
Virology. The X files--one step closer to closure.
  Journal
Science 294:2299-300 (2001)
DOI:10.1126/science.1067850
Reference
PMID:15132991
  Authors
Chung TW, Lee YC, Kim CH
  Title
Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential.
  Journal
FASEB J 18:1123-5 (2004)
DOI:10.1096/fj.03-1429fje
Reference
PMID:18605975
  Authors
Gurtsevitch VE
  Title
Human oncogenic viruses: hepatitis B and hepatitis C viruses and their role in hepatocarcinogenesis.
  Journal
Biochemistry (Mosc) 73:504-13 (2008)
DOI:10.1134/S0006297908050039
Reference
PMID:21994545
  Authors
Schadler S, Hildt E
  Title
HBV life cycle: entry and morphogenesis.
  Journal
Viruses 1:185-209 (2009)
DOI:10.3390/v1020185
Reference
PMID:28862649
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
PMID:28704708
  Authors
Nosratabadi R, Alavian SM, Zare-Bidaki M, Shahrokhi VM, Arababadi MK
  Title
Innate immunity related pathogen recognition receptors and chronic hepatitis B infection.
  Journal
Mol Immunol 90:64-73 (2017)
DOI:10.1016/j.molimm.2017.07.002
Reference
PMID:24530748
  Authors
Bagheri V, Askari A, Arababadi MK, Kennedy D
  Title
Can Toll-Like Receptor (TLR) 2 be considered as a new target for immunotherapy against hepatitis B infection?
  Journal
Hum Immunol 75:549-54 (2014)
DOI:10.1016/j.humimm.2014.02.018
Reference
PMID:25550115
  Authors
Zhang E, Lu M
  Title
Toll-like receptor (TLR)-mediated innate immune responses in the control of hepatitis B virus (HBV) infection.
  Journal
Med Microbiol Immunol 204:11-20 (2015)
DOI:10.1007/s00430-014-0370-1
Reference
PMID:20375222
  Authors
Yu S, Chen J, Wu M, Chen H, Kato N, Yuan Z
  Title
Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3.
  Journal
J Gen Virol 91:2080-90 (2010)
DOI:10.1099/vir.0.020552-0
Reference
PMID:23363957
  Authors
Revill P, Yuan Z
  Title
New insights into how HBV manipulates the innate immune response to establish acute and persistent infection.
  Journal
Antivir Ther 18:1-15 (2013)
DOI:10.3851/IMP2542
Reference
PMID:28893934
  Authors
Hopcraft SE, Damania B
  Title
Tumour viruses and innate immunity.
  Journal
Philos Trans R Soc Lond B Biol Sci 372:20160267 (2017)
DOI:10.1098/rstb.2016.0267
Reference
PMID:22504921
  Authors
Dandri M, Locarnini S
  Title
New insight in the pathobiology of hepatitis B virus infection.
  Journal
Gut 61 Suppl 1:i6-17 (2012)
DOI:10.1136/gutjnl-2012-302056
Related
pathway
vpc04010  MAPK signaling pathway
vpc04064  NF-kappa B signaling pathway
vpc04110  Cell cycle
vpc04115  p53 signaling pathway
vpc04151  PI3K-Akt signaling pathway
vpc04210  Apoptosis
vpc04620  Toll-like receptor signaling pathway
vpc04622  RIG-I-like receptor signaling pathway
vpc04630  JAK-STAT signaling pathway
KO pathway
ko05161   
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