KEGG   PATHWAY: zca05163
Entry
zca05163                    Pathway                                
Name
Human cytomegalovirus infection - Zalophus californianus (California sea lion)
Description
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. HCMV is best known for causing significant morbidity and mortality in immunocompromised populations. As with other herpesviruses, HCMV gB and gH/gL envelope glycoproteins are essential for virus entry. HCMV gB could activate the PDGFRA, and induce activation of the oncogenic PI3-K/AKT pathway. Though it is unlikely that HCMV by itself can act as an oncogenic factor, HCMV may have an oncomodulatory role, to catalyze an oncogenic process that has already been initiated. US28, one of the four HCMV-encoded vGPCRs (US27, US28, UL33 and UL78), also has a specific role in the oncomodulatory properties. In addition, HCMV has developed numerous mechanisms for manipulating the host immune system. The virally encoded US2, US3, US6 and US11 gene products all interfere with major histocompatibility complex (MHC) class I antigen presentation. HCMV encodes several immediate early (IE) antiapoptotic proteins (IE1, IE2, vMIA and vICA). These proteins might avoid immune clearance of infected tumor cells by cytotoxic lymphocytes and NK cells.
Class
Human Diseases; Infectious disease: viral
Pathway map
zca05163  Human cytomegalovirus infection
zca05163

Organism
Zalophus californianus (California sea lion) [GN:zca]
Gene
113925340  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
113924761  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113917022  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113918898  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
113928897  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
113917179  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
113911688  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
113935537  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113932035  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113910017  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113934213  TSC1; hamartin isoform X1 [KO:K07206]
113933431  TSC2; tuberin isoform X1 [KO:K07207]
113911233  RHEB; GTP-binding protein Rheb [KO:K07208]
113929550  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
113924910  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
113933743  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
113912763  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
113914285  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
113908204  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
113923411  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
113924180  IKBKB; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
113930597  NF-kappa-B essential modulator isoform X1 [KO:K07210]
113930605  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118356554  NF-kappa-B essential modulator-like isoform X1 [KO:K07210]
113924266  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
113914948  RELA; transcription factor p65 [KO:K04735]
113911010  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
113939579  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
113937127  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
113908972  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
113914876  HRAS; GTPase HRas isoform X1 [KO:K02833]
113921792  KRAS; GTPase KRas isoform X1 [KO:K07827]
113931879  NRAS; GTPase NRas [KO:K07828]
113916244  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
113908979  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
113917006  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
113933258  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
113912320  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
113930372  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
113921297  SP1; transcription factor Sp1 [KO:K04684]
113919409  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
113939702  ITGB3; integrin beta-3 [KO:K06493]
113937725  SRC; proto-oncogene tyrosine-protein kinase Src isoform X2 [KO:K05704] [EC:2.7.10.2]
113932378  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
113919987  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
113922696  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
113908122  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
113930801  transforming protein RhoA-like [KO:K04513]
113916294  RHOA; transforming protein RhoA [KO:K04513]
113926618  CGAS; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
113929903  STING1; stimulator of interferon genes protein isoform X1 [KO:K12654]
113921986  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
113936398  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
113934655  interferon alpha-1-like [KO:K05414]
113934682  LOW QUALITY PROTEIN: interferon alpha-3-like [KO:K05414]
113934985  interferon alpha-14-like [KO:K05414]
113934667  LOW QUALITY PROTEIN: interferon alpha-1/2-like [KO:K05414]
113934678  LOW QUALITY PROTEIN: interferon alpha-1/2-like [KO:K05414]
113912225  LOW QUALITY PROTEIN: interferon alpha-1/2-like [KO:K05414]
113934419  IFNB1; interferon beta [KO:K05415]
113927740  TNF; tumor necrosis factor [KO:K03156]
113922015  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
113927116  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
113935781  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
113933278  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
113934602  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
113937839  IL1B; interleukin-1 beta [KO:K04519]
113938587  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
113910226  NFKBIA; NF-kappa-B inhibitor alpha isoform X1 [KO:K04734]
113907932  C-C motif chemokine 2 [KO:K14624]
113939093  CCL5; C-C motif chemokine 5 [KO:K12499]
113925270  CXCL8; interleukin-8 [KO:K10030]
113911910  IL6; interleukin-6 [KO:K05405]
113939549  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
113933707  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
113910568  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2-like [KO:K04537]
113930871  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2-like [KO:K04537]
113921349  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
113917860  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
113910139  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
113910148  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
113914021  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
113923917  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
113920778  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
113938552  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
113916388  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
113936668  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
113934076  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
113924224  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
118356752  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
113921542  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
113911303  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
113925046  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11-like [KO:K04546]
113908830  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11-like [KO:K04546]
113916979  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
113933485  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X1 [KO:K04547]
113911302  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
113939476  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
113934691  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
113917830  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
113937245  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
113915286  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
113909205  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
113937989  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
113918169  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
113921922  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
113927035  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
113922995  calmodulin-like [KO:K02183]
113923011  CALML3; LOW QUALITY PROTEIN: calmodulin-like protein 3 [KO:K02183]
113936086  CALM3; calmodulin-3 [KO:K02183]
113914077  calmodulin-1-like [KO:K02183]
113929195  calmodulin-1-like [KO:K02183]
113925822  calmodulin-1-like [KO:K02183]
113929739  calmodulin-A-like [KO:K02183]
113914445  CALML6; calmodulin-like protein 6 [KO:K02183]
113908798  CALM1; calmodulin-1 [KO:K02183]
113910547  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
113920384  neo-calmodulin-like [KO:K02183]
113937538  CALM2; calmodulin-2 [KO:K02183]
113922505  calmodulin-A-like [KO:K02183]
118356210  calmodulin-A-like [KO:K02183]
113924138  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
113924414  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
113919467  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
113934908  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
113937385  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
113926172  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
113938162  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
113935527  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
113910134  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
113933515  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
113930637  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
113917448  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
113911420  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
113935890  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
113911474  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
113929853  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
113937275  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
113908984  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
113917313  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
113922228  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
113935770  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
113934371  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
113932237  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
113931821  PRKACB; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
113916866  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
113908217  CCL3L3; C-C motif chemokine 3-like 1 [KO:K05408]
113939090  LOW QUALITY PROTEIN: C-C motif chemokine 3-like [KO:K05408]
113939711  regakine-1-like [KO:K05408]
113908218  C-C motif chemokine 4 [KO:K12964]
113936197  CX3CL1; fractalkine [KO:K05508]
113933210  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
113939205  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
113936356  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
113931956  ARHGEF11; rho guanine nucleotide exchange factor 11 isoform X1 [KO:K12331]
113915523  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
113909082  AKAP13; A-kinase anchor protein 13 isoform X1 [KO:K16529]
113912439  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
113937156  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
113917714  CTNNB1; catenin beta-1 [KO:K02105]
113916281  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
113910179  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
113934232  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
113929210  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
113936968  neuroendocrine secretory protein 55 [KO:K04632]
113936966  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
113918509  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
113914083  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
113911568  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
113932706  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
113908976  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
113939486  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
113927959  VEGFA; vascular endothelial growth factor A [KO:K05448]
113908216  MAP2K6; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
113923113  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
113926549  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
113921975  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
113927499  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
113919503  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
113919173  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
113921771  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
113933699  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
113934022  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
113914325  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
113917002  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
113911293  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
113911563  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
113926300  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
113919912  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
113919282  CXCR4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
113939477  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
113932280  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
113935801  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
113924963  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
113910123  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
113936040  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
113912750  CRKL; crk-like protein [KO:K04438]
113939500  CRK; adapter molecule crk isoform X1 [KO:K04438]
113912633  PXN; paxillin isoform X1 [KO:K05760]
113914150  IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
113918090  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
113920300  CXCR2; C-X-C chemokine receptor type 2 isoform X1 [KO:K05050]
113918188  CCR1; C-C chemokine receptor type 1 [KO:K04176]
113918189  C-C chemokine receptor type 3 [KO:K04178]
113918767  C-C chemokine receptor type 5 isoform X1 [KO:K04180]
113926807  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
113927043  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
113927262  tapasin [KO:K08058]
113908900  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
113911802  LOW QUALITY PROTEIN: protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
113918790  CALR; calreticulin [KO:K08057]
113930887  LOW QUALITY PROTEIN: calreticulin-like [KO:K08057]
113926316  HLA class I histocompatibility antigen, A alpha chain [KO:K06751]
113927768  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
113927989  translation initiation factor IF-2 [KO:K06751]
113926585  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
113915714  patr class I histocompatibility antigen, B-2 alpha chain-like [KO:K06751]
113915700  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
113915741  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
118357226  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
113910221  B2M; beta-2-microglobulin [KO:K08055]
113921844  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
113939587  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
113927327  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
113921783  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
113911106  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
113919651  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
113938493  E2F1; transcription factor E2F1 [KO:K17454]
113912376  E2F2; transcription factor E2F2 [KO:K09389]
113927180  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
113931754  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
113921804  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
113914747  FADD; FAS-associated death domain protein [KO:K02373]
113931151  LOW QUALITY PROTEIN: FAS-associated death domain protein-like [KO:K02373]
113919983  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
113922975  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
113935677  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
113927365  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
113911261  cytochrome c [KO:K08738]
113926974  cytochrome c-like [KO:K08738]
113909591  CASP9; LOW QUALITY PROTEIN: caspase-9 [KO:K04399] [EC:3.4.22.62]
113924509  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00584  Prostaglandin E2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
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Related
pathway
zca00590  Arachidonic acid metabolism
zca03050  Proteasome
zca04010  MAPK signaling pathway
zca04064  NF-kappa B signaling pathway
zca04110  Cell cycle
zca04150  mTOR signaling pathway
zca04151  PI3K-Akt signaling pathway
zca04210  Apoptosis
zca04612  Antigen processing and presentation
zca04623  Cytosolic DNA-sensing pathway
zca04630  JAK-STAT signaling pathway
zca04668  TNF signaling pathway
zca04810  Regulation of actin cytoskeleton
KO pathway
ko05163   
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