KEGG   DRUG: Bupropion hydrochloride
Entry
D00817                      Drug                                   

Name
Bupropion hydrochloride (JAN/USP);
Wellbutrin (TN);
Zyban (TN)
Product
  Generic
BUPROPION (BluePoint Laboratories), BUPROPION (Cadila Healthcare Limited), BUPROPION (Coupler Enterprises), BUPROPION (Proficient Rx LP), BUPROPION (Zydus Pharmaceuticals (USA)), BUPROPION HCL ER (Direct_Rx), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (SR) (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (XL) (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (SR) (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (A-S Medication Solutions), BUPROPION HYDROCHLORIDE (Accord Healthcare), BUPROPION HYDROCHLORIDE (Actavis Pharma), BUPROPION HYDROCHLORIDE (Actavis Pharma), BUPROPION HYDROCHLORIDE (Actavis Pharma), BUPROPION HYDROCHLORIDE (Actavis Pharma), BUPROPION HYDROCHLORIDE (Alembic Pharmaceuticals Limited), BUPROPION HYDROCHLORIDE (Alvogen), BUPROPION HYDROCHLORIDE (American Health Packaging), BUPROPION HYDROCHLORIDE (American Health Packaging), BUPROPION HYDROCHLORIDE (American Health Packaging), BUPROPION HYDROCHLORIDE (American Health Packaging), BUPROPION HYDROCHLORIDE (Amneal Pharmaceuticals of New York LLC), BUPROPION HYDROCHLORIDE (Amneal Pharmaceuticals of New York LLC), BUPROPION HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUPROPION HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUPROPION HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUPROPION HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUPROPION HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUPROPION HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUPROPION HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUPROPION HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUPROPION HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), BUPROPION HYDROCHLORIDE (Apotex Corp), BUPROPION HYDROCHLORIDE (AvPAK), BUPROPION HYDROCHLORIDE (AvPAK), BUPROPION HYDROCHLORIDE (Biocon Pharma Inc.,), BUPROPION HYDROCHLORIDE (BluePoint Laboratories), BUPROPION HYDROCHLORIDE (BluePoint Laboratories), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (XL) (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (SR) (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (Bryant Ranch Prepack), BUPROPION HYDROCHLORIDE (CIPLA USA INC.,), BUPROPION HYDROCHLORIDE (CIPLA USA INC.,), BUPROPION HYDROCHLORIDE (Cadila Pharmaceuticals Limited), BUPROPION HYDROCHLORIDE (Cardinal Health), BUPROPION HYDROCHLORIDE (Cardinal Health), BUPROPION HYDROCHLORIDE (Cardinal Health), BUPROPION HYDROCHLORIDE (SR) (Cipla USA Inc.,), BUPROPION HYDROCHLORIDE (Clinical Solutions Wholesale), BUPROPION HYDROCHLORIDE (Clinical Solutions Wholesale), BUPROPION HYDROCHLORIDE (Contract Pharmacy Services-PA), BUPROPION HYDROCHLORIDE (DIRECT RX), BUPROPION HYDROCHLORIDE (DIRECT RX), BUPROPION HYDROCHLORIDE (SR) (Denton Pharma), BUPROPION HYDROCHLORIDE (Denton Pharma), BUPROPION HYDROCHLORIDE (Denton Pharma), BUPROPION (Denton Pharma), BUPROPION HYDROCHLORIDE (Denton Pharma), BUPROPION HYDROCHLORIDE (Denton Pharma), BUPROPION HYDROCHLORIDE (DirectRX), BUPROPION HYDROCHLORIDE (Direct_Rx), BUPROPION HYDROCHLORIDE (Direct_Rx), BUPROPION HYDROCHLORIDE (Direct_Rx), BUPROPION HYDROCHLORIDE (Dr Reddys Laboratories), BUPROPION HYDROCHLORIDE (SR) (Dr. Reddy's Laboratories), BUPROPION HYDROCHLORIDE (Dr. Reddy's Laboratories), BUPROPION HYDROCHLORIDE (Dr. Reddy's Laboratories), BUPROPION HYDROCHLORIDE (Eon Labs), BUPROPION HYDROCHLORIDE (Epic Pharma), BUPROPION HYDROCHLORIDE (Exelan Pharmaceuticals), BUPROPION HYDROCHLORIDE (Golden State Medical Supply), BUPROPION HYDROCHLORIDE (Golden State Medical Supply), BUPROPION HYDROCHLORIDE (Golden State Medical Supply), BUPROPION HYDROCHLORIDE (Golden State Medical Supply), BUPROPION HYDROCHLORIDE (Golden State Medical Supply), BUPROPION HYDROCHLORIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), BUPROPION HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), BUPROPION (Lake Erie Medical DBA Quality Care Products LLC), BUPROPION HYDROCHLORIDE (Lupin Pharmaceuticals), BUPROPION HYDROCHLORIDE (Major Pharmaceuticals), BUPROPION HYDROCHLORIDE (Major Pharmaceuticals), BUPROPION HYDROCHLORIDE (Major Pharmaceuticals), BUPROPION HYDROCHLORIDE EXTENDED RELEASE (Marlex Pharmaceuticals), BUPROPION HYDROCHLORIDE (McKesson Corporation dba SKY Packaging), BUPROPION HYDROCHLORIDE (Medsource Pharmaceuticals), BUPROPION HYDROCHLORIDE (SR) (Medsource Pharmaceuticals), BUPROPION HYDROCHLORIDE (Micro Labs Limited), BUPROPION HYDROCHLORIDE (Mylan Institutional), BUPROPION HYDROCHLORIDE (Mylan Pharmaceuticals), BUPROPION HYDROCHLORIDE (NCS HealthCare of KY), BUPROPION HYDROCHLORIDE (NCS HealthCare of KY), BUPROPION (NCS HealthCare of KY), BUPROPION HYDROCHLORIDE (NCS HealthCare of KY), BUPROPION HYDROCHLORIDE (NCS HealthCare of KY), BUPROPION HYDROCHLORIDE (NCS HealthCare of KY), BUPROPION (Northwind Pharmaceuticals), BUPROPION HYDROCHLORIDE (NuCare Pharmaceuticals), BUPROPION HYDROCHLORIDE (NuCare Pharmaceuticals), BUPROPION HYDROCHLORIDE (NuCare Pharmaceuticals), BUPROPION HYDROCHLORIDE (NuCare Pharmaceuticals), BUPROPION (NuCare Pharmaceuticals), BUPROPION HYDROCHLORIDE (NuCare Pharmaceuticals), BUPROPION HYDROCHLORIDE (PD-Rx Pharmaceuticals), BUPROPION HYDROCHLORIDE (PD-Rx Pharmaceuticals), BUPROPION HYDROCHLORIDE (PD-Rx Pharmaceuticals), BUPROPION HYDROCHLORIDE (PD-Rx Pharmaceuticals), BUPROPION HYDROCHLORIDE (PD-Rx Pharmaceuticals), BUPROPION HYDROCHLORIDE (PD-Rx Pharmaceuticals), BUPROPION HYDROCHLORIDE (PD-Rx Pharmaceuticals), BUPROPION HYDROCHLORIDE (PD-Rx Pharmaceuticals), BUPROPION HYDROCHLORIDE (PD-Rx Pharmaceuticals), BUPROPION HYDROCHLORIDE (PD-Rx Pharmaceuticals), BUPROPION HYDROCHLORIDE (Par Pharmaceutical), BUPROPION (Preferred Pharmaceuticals), BUPROPION HYDROCHLORIDE (Preferred Pharmaceuticals), BUPROPION HYDROCHLORIDE (XL) (Preferred Pharmaceuticals), BUPROPION HYDROCHLORIDE (Preferred Pharmaceuticals), BUPROPION HYDROCHLORIDE (Preferred Pharmaceuticals), BUPROPION HYDROCHLORIDE (Preferred Pharmaceuticals), BUPROPION HYDROCHLORIDE (Preferred Pharmaceuticals), BUPROPION HYDROCHLORIDE (Preferred Pharmaceuticals), BUPROPION HYDROCHLORIDE (Preferred Pharmaceuticals), BUPROPION HYDROCHLORIDE (Preferred Pharmaceuticals), BUPROPION HYDROCHLORIDE (Preferred Pharmaceuticals), BUPROPION HYDROCHLORIDE (Preferred Pharmaceuticals), BUPROPION HYDROCHLORIDE (Preferred Pharmaceuticals), BUPROPION (Preferred Pharmaceuticals), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (XL) (Proficient Rx LP), BUPROPION HYDROCHLORIDE (XL) (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Proficient Rx LP), BUPROPION HYDROCHLORIDE (Quality Care Products), BUPROPION HYDROCHLORIDE (Quality Care Products), BUPROPION HYDROCHLORIDE (Quality Care Products), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (XL) (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (SR) (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (REMEDYREPACK), BUPROPION HYDROCHLORIDE (Rising Pharmaceuticals), BUPROPION HYDROCHLORIDE (XL) (Sandoz), BUPROPION HYDROCHLORIDE (ScieGen Pharmaceuticals), BUPROPION HYDROCHLORIDE (ScieGen Pharmaceuticals), BUPROPION HYDROCHLORIDE (ScieGen Pharmaceuticals), BUPROPION HYDROCHLORIDE (Slate Run Pharmaceuticals), BUPROPION (Solco Healthcare US LLC), BUPROPION HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), BUPROPION HYDROCHLORIDE (Sun Pharmaceutical Industries), BUPROPION HYDROCHLORIDE (Sun Pharmaceutical Industries), BUPROPION HYDROCHLORIDE (TWi Pharmaceuticals), BUPROPION HYDROCHLORIDE (Unit Dose Services), BUPROPION (Unit Dose Services), BUPROPION HYDROCHLORIDE (Unit Dose Services), BUPROPION HYDROCHLORIDE (Unit Dose Services), BUPROPION HYDROCHLORIDE (Wockhardt USA LLC.), BUPROPION HYDROCHLORIDE (Wockhardt USA LLC.), BUPROPION HYDROCHLORIDE (Wockhardt USA LLC.), BUPROPION HYDROCHLORIDE (medsource pharmaceuticals), BUPROPION HYDROCHLORIDE (XL) (DIRECT RX), BUPROPION HYDROCHLORIDE (Graviti Pharmaceuticals Private Limited)
Formula
C13H18ClNO. HCl
Exact mass
275.0844
Mol weight
276.2021
Structure
Simcomp
Remark
ATC code: N06AX12
Chemical structure group: DG00957
Product (DG00957): D00817<US> D07938<US>
Product (mixture): D10751<US>
Efficacy
Antidepressant, Noradrenalin and dopamine reuptake inhibitor
  Disease
Major depressive disorder [DS:H01646]
Target
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
SLC6A3 (DAT1) [HSA:6531] [KO:K05036]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04728  Dopaminergic synapse
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX12 Bupropion
      D00817  Bupropion hydrochloride (JAN/USP) <US>
USP drug classification [BR:br08302]
 Anti-Addiction/Substance Abuse Treatment Agents
  Smoking Cessation Agents
   Bupropion
    D00817  Bupropion hydrochloride (JAN/USP)
 Antidepressants
  Antidepressants, Other
   Bupropion
    D00817  Bupropion hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D00817  Bupropion hydrochloride (JAN/USP) <US>
    SLC6A3 (DAT1)
     D00817  Bupropion hydrochloride (JAN/USP) <US>
Other DBs
CAS: 31677-93-7
PubChem: 7847882
ChEBI: 3220
ChEMBL: CHEMBL1698
DrugBank: DB01156
LigandBox: D00817
NIKKAJI: J280.800E
LinkDB
KCF data

ATOM        17
            1   C8y C    15.4700  -16.1700
            2   C5a C    16.7300  -15.4700
            3   C8x C    14.2800  -15.4700
            4   C8x C    15.4700  -17.5700
            5   C1c C    17.9200  -16.1700
            6   O5a O    16.7300  -14.0700
            7   C8y C    13.0900  -16.1700
            8   C8x C    14.2800  -18.2700
            9   N1b N    19.1100  -15.4700
            10  C1a C    17.9200  -17.5700
            11  C8x C    13.0900  -17.5700
            12  X   Cl   11.9000  -15.4700
            13  C1d C    20.3700  -16.1700
            14  C1a C    21.5600  -15.4700
            15  C1a C    20.3700  -17.5700
            16  C1a C    21.5600  -16.9400
            17  X   Cl   25.3400  -15.4700
BOND        16
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     4   8 2
            8     5   9 1
            9     5  10 1
            10    7  11 2
            11    7  12 1
            12    9  13 1
            13   13  14 1
            14   13  15 1
            15   13  16 1
            16    8  11 1

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