KEGG   ORTHOLOGY: K00109
Entry
K00109                      KO                                     
Symbol
L2HGDH
Name
2-hydroxyglutarate dehydrogenase [EC:1.1.99.2]
Pathway
map00650  Butanoate metabolism
map01100  Metabolic pathways
Reaction
R03534  2-hydroxyglutarate:(acceptor) 2-oxidoreductase
Disease
H01280  L-2-hydroxyglutaric aciduria
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00650 Butanoate metabolism
    K00109  L2HGDH; 2-hydroxyglutarate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.99  With unknown physiological acceptors
    1.1.99.2  L-2-hydroxyglutarate dehydrogenase
     K00109  L2HGDH; 2-hydroxyglutarate dehydrogenase
Other DBs
GO: 0047545
Genes
HSA: 79944(L2HGDH)
PTR: 452898(L2HGDH)
PPS: 100978899(L2HGDH)
GGO: 101139276(L2HGDH)
PON: 100172827(L2HGDH)
PPYG: 129012196(L2HGDH)
NLE: 100600833(L2HGDH)
HMH: 116484471(L2HGDH)
SSYN: 129487918(L2HGDH)
MCC: 705721(L2HGDH)
MCF: 102137911(L2HGDH)
MTHB: 126958511
MNI: 105481842(L2HGDH)
CSAB: 103228958(L2HGDH)
CATY: 105586729(L2HGDH)
PANU: 101004693(L2HGDH)
TGE: 112629080(L2HGDH)
MLEU: 105553624(L2HGDH)
RRO: 104682749(L2HGDH)
RBB: 108513673(L2HGDH)
TFN: 117069668(L2HGDH)
PTEH: 111549460(L2HGDH)
CANG: 105522388(L2HGDH)
CJC: 100410851(L2HGDH)
SBQ: 101047482(L2HGDH)
CIMI: 108287980(L2HGDH)
ANAN: 105719928(L2HGDH)
CSYR: 103276426(L2HGDH)
MMUR: 105867642(L2HGDH)
LCAT: 123649418(L2HGDH)
PCOQ: 105825869(L2HGDH)
OGA: 100958822(L2HGDH)
MMU: 217666(L2hgdh)
MCAL: 110307199(L2hgdh)
MPAH: 110324754(L2hgdh)
RNO: 314196(L2hgdh)
MCOC: 116081051(L2hgdh)
ANU: 117715708 117717300(L2hgdh)
ASYL: 127687274(L2hgdh)
MUN: 110556911(L2hgdh)
CGE: 100768751(L2hgdh)
MAUA: 101840183(L2hgdh)
PROB: 127230647(L2hgdh)
PLEU: 114684211(L2hgdh) 114699469
MORG: 121452313(L2hgdh)
MFOT: 126508441
AAMP: 119819643(L2hgdh)
NGI: 103731511(L2hgdh)
HGL: 101702109(L2hgdh)
CPOC: 100726948(L2hgdh)
DORD: 105982574(L2hgdh)
DSP: 122106558(L2hgdh)
DMER: 138830897(L2hgdh)
PLOP: 125363424(L2hgdh)
NCAR: 124978155
MMMA: 107146722(L2hgdh)
ITI: 101973905(L2hgdh)
OCU: 100350193
OPI: 101525748(L2HGDH)
TUP: 102480205(L2HGDH)
GVR: 103589433(L2HGDH)
CFA: 480316(L2HGDH)
CLUD: 112658015(L2HGDH)
VVP: 112921448(L2HGDH)
VLG: 121492464(L2HGDH)
NPO: 129496004(L2HGDH)
UMR: 103665372(L2HGDH)
UAH: 113266207(L2HGDH)
UAR: 123793268(L2HGDH)
ELK: 111140398
LLV: 125104045
MPUF: 101677511(L2HGDH)
MNP: 131999928(L2HGDH)
MLK: 131836539(L2HGDH)
NVS: 122894126(L2HGDH)
ORO: 101385619(L2HGDH)
EJU: 114205644(L2HGDH)
ZCA: 113909058(L2HGDH)
MLX: 118002663(L2HGDH)
NSU: 110590608(L2HGDH)
LWW: 102741764(L2HGDH)
FCA: 101094353(L2HGDH)
PYU: 121031739(L2HGDH)
PCOO: 112856267(L2HGDH)
PBG: 122469067(L2HGDH)
PVIV: 125167500(L2HGDH)
LRUF: 124512208
LGF: 123583806(L2HGDH)
AJU: 106981946
PTG: 102951061(L2HGDH)
PPAD: 109268501(L2HGDH)
PUC: 125909521
PLEZ: 122222578(L2HGDH)
HHV: 120220283(L2HGDH)
BTA: 514230(L2HGDH)
BOM: 102277294(L2HGDH)
BIU: 109565017(L2HGDH)
BBUB: 102414364(L2HGDH)
BBIS: 104990253(L2HGDH)
CHX: 102190421(L2HGDH)
OAS: 101121015(L2HGDH)
BTAX: 128054314(L2HGDH)
CSUM: 138073367(L2HGDH)
ODA: 120853130(L2HGDH)
CCAD: 122443466(L2HGDH)
MREE: 136172467(L2HGDH)
OVR: 110141953(L2HGDH)
MBEZ: 129562679(L2HGDH)
SSC: 100152180(L2HGDH)
CFR: 102520166(L2HGDH)
CBAI: 105078435(L2HGDH)
CDK: 105091405(L2HGDH)
VPC: 102541170(L2HGDH)
BACU: 103020579(L2HGDH)
BMUS: 118888586(L2HGDH)
LVE: 103075209(L2HGDH)
OOR: 101284995(L2HGDH)
LALB: 132516360(L2HGDH)
GMF: 115852267(L2HGDH)
DLE: 111173173(L2HGDH)
PCAD: 102974237(L2HGDH)
PSIU: 116746671(L2HGDH)
PPHC: 136118740(L2HGDH)
NASI: 112414411(L2HGDH)
ECB: 100066314(L2HGDH)
EPZ: 103559182(L2HGDH)
EAI: 106839519(L2HGDH)
MYB: 102238888(L2HGDH)
MYD: 102773864(L2HGDH)
MMYO: 118654881(L2HGDH)
MLF: 102436915(L2HGDH)
MDT: 132235017(L2HGDH)
MYUM: 139013741(L2HGDH)
PKL: 118718572(L2HGDH)
EFUS: 103283759(L2HGDH)
MNA: 107525853(L2HGDH)
DRO: 112310993(L2HGDH)
SHON: 118992376(L2HGDH)
AJM: 119057067(L2HGDH)
PDIC: 114492353(L2HGDH)
PHAS: 123808855(L2HGDH)
MMF: 118641009(L2HGDH)
PPAM: 129064132(L2HGDH) 129064133
HAI: 109375228(L2HGDH)
RFQ: 117022919(L2HGDH)
PALE: 102889350(L2HGDH)
PGIG: 120604449(L2HGDH)
PVP: 105309524(L2HGDH)
RAY: 107511438(L2HGDH)
MJV: 108401304(L2HGDH)
TOD: 119239072(L2HGDH)
SARA: 101542023 101552954(L2HGDH)
SFUM: 130041981(L2HGDH)
SETR: 125999216(L2HGDH)
LAV: 100657343(L2HGDH)
TMU: 101347817
ETF: 101643037(L2HGDH)
DNM: 101426209(L2HGDH)
MDO: 100018728(L2HGDH)
GAS: 123249242(L2HGDH)
SHR: 100933496(L2HGDH)
AFZ: 127539314
PCW: 110221753(L2HGDH)
TVP: 118851202(L2HGDH)
PBRV: 138166716(L2HGDH)
OAA: 100084662(L2HGDH)
TACU: 119937103(L2HGDH)
GGA: 423573(L2HGDH)
PCOC: 116234586(L2HGDH)
MGP: 100540849(L2HGDH)
CJO: 107315524(L2HGDH)
TPAI: 128087213(L2HGDH)
LMUT: 125695092(L2HGDH)
NMEL: 110401965(L2HGDH)
APLA: 101804444(L2HGDH)
ACYG: 106049309(L2HGDH)
CATA: 118250281(L2HGDH)
AFUL: 116489445(L2HGDH)
TGU: 100220092(L2HGDH)
LSR: 110473477(L2HGDH)
SCAN: 103826825(L2HGDH)
PMOA: 120497062(L2HGDH)
OTC: 121338797(L2HGDH)
PRUF: 121348713(L2HGDH)
ATRC: 139589601(L2HGDH)
GFR: 102033150(L2HGDH)
FAB: 101808533(L2HGDH)
OMA: 130253533(L2HGDH)
PHI: 102103991(L2HGDH)
PMAJ: 107206240(L2HGDH)
CCAE: 111929517(L2HGDH)
CCW: 104695923(L2HGDH)
CBRC: 103618908(L2HGDH)
ACOE: 138112018(L2HGDH)
ETL: 114070306(L2HGDH)
ZAB: 102065921(L2HGDH)
ZLE: 135449197(L2HGDH)
ACHL: 103799488(L2HGDH)
SVG: 106858941(L2HGDH)
MMEA: 130583787(L2HGDH)
HRT: 120748295(L2HGDH)
SATI: 136362715(L2HGDH)
CCIC: 134045814(L2HGDH)
FPG: 101912902(L2HGDH)
FCH: 102056594(L2HGDH)
CCRI: 104159884(L2HGDH)
NNT: 104399180(L2HGDH)
SHAB: 115607514(L2HGDH)
ACUN: 113480383(L2HGDH)
TALA: 104359874(L2HGDH)
ACHC: 115351825(L2HGDH)
HALD: 104310389
HLE: 104839518(L2HGDH)
AGEN: 126050731
HHAR: 128140150(L2HGDH)
GCL: 127017062
CSTI: 104559841
LDI: 104339918(L2HGDH)
MNB: 103773297(L2HGDH)
DPUB: 104299372(L2HGDH)
PPUS: 135175134(L2HGDH)
AVIT: 104277359(L2HGDH)
BRHI: 104489907(L2HGDH)
EGZ: 104135009(L2HGDH)
NNI: 104019490(L2HGDH)
PCRI: 104031113(L2HGDH)
PCAO: 104044237(L2HGDH)
PADL: 103914919(L2HGDH)
AFOR: 103907688(L2HGDH)
FGA: 104069391(L2HGDH)
GSTE: 104260279(L2HGDH)
CBOY: 140653348(L2HGDH)
CLV: 102089678(L2HGDH)
CNIC: 135988864(L2HGDH)
MUI: 104542690(L2HGDH)
PGUU: 104457605(L2HGDH)
PLET: 104623124(L2HGDH)
CMAC: 104473965(L2HGDH)
CUCA: 104057454(L2HGDH)
TEO: 104384101(L2HGDH)
BREG: 104641613(L2HGDH)
OHA: 104327784(L2HGDH)
ACAR: 104523364(L2HGDH)
CPEA: 104394705(L2HGDH)
CVF: 104294338(L2HGDH)
RTD: 128908939(L2HGDH)
CRID: 134515146(L2HGDH)
AAM: 106497441(L2HGDH)
AROW: 112961190(L2HGDH)
NPD: 112957761(L2HGDH)
TGT: 104568128(L2HGDH)
DNE: 112994129(L2HGDH)
SCAM: 104145514(L2HGDH)
ASN: 102387436(L2HGDH)
AMJ: 106737189(L2HGDH)
CPOO: 109320894(L2HGDH)
GGN: 109299276(L2HGDH)
PSS: 102458506(L2HGDH)
CMY: 102946571(L2HGDH)
CCAY: 125637665(L2HGDH)
DCC: 119857346(L2HGDH)
CPIC: 101935892(L2HGDH)
TST: 117876656(L2HGDH)
CABI: 116822134(L2HGDH)
MRV: 120404320(L2HGDH)
ACS: 100563174(l2hgdh)
ASAO: 132760726(L2HGDH)
PVT: 110089153(L2HGDH)
SUND: 121933538(L2HGDH)
PBI: 103059564(L2HGDH)
PMUR: 107296219(L2HGDH) 107300310
CTIG: 120301818(L2HGDH)
TSR: 106545963(L2HGDH)
PGUT: 117675047(L2HGDH)
PCAE: 139308212(L2HGDH)
APRI: 131188107(L2HGDH)
PTEX: 113435147(L2HGDH)
NSS: 113414131(L2HGDH)
VKO: 123026580(L2HGDH)
PRAF: 128411998(L2HGDH)
ZVI: 118075482(L2HGDH) 118077556
HCG: 128326813(L2HGDH)
GJA: 107122496(L2HGDH) 107122626
STOW: 125427105(L2HGDH)
EMC: 129324315(L2HGDH)
XLA: 108698751(l2hgdh.L)
XTR: 100145085(l2hgdh)
NPR: 108795062(L2HGDH)
RTEM: 120920990(L2HGDH)
ACAT: 141116385(L2HGDH)
BBUF: 120982398(L2HGDH)
BGAR: 122922049(L2HGDH)
DTC: 141091933(L2HGDH)
PWL: 138260309(L2HGDH)
MUO: 115478101(L2HGDH)
GSH: 117363450(L2HGDH)
DRE: 566872(l2hgdh)
SGH: 107553179 107602969(l2hgdh)
CCAR: 109057101(l2hgdh)
CAUA: 113056798(l2hgdh)
CGIB: 127969907
PTET: 122357086(l2hgdh)
LROH: 127175085(l2hgdh)
GRF: 141326183(l2hgdh)
OMC: 131551918(l2hgdh)
PPRM: 120467767(l2hgdh)
RKG: 130088247(l2hgdh)
MAMB: 125277305(l2hgdh)
CIDE: 127525063
CERY: 137020171(l2hgdh)
TROS: 130559216(l2hgdh)
TDW: 130431826(l2hgdh)
MANU: 129416180(l2hgdh)
PDAB: 135786769(l2hgdh)
IPU: 108263080
PHYP: 113541918(l2hgdh)
SMEO: 124394589(l2hgdh)
TFD: 113656881(l2hgdh)
TVC: 132846827(l2hgdh)
CGAR: 128528538(l2hgdh)
NGRA: 132888999(l2hgdh) 132889006
TRN: 134314297(l2hgdh)
AMEX: 103038136(l2hgdh)
CMAO: 118811060(l2hgdh)
EEE: 113577730(l2hgdh)
CHAR: 105890985(l2hgdh)
SPIL: 134067725(l2hgdh)
TRU: 101061325(l2hgdh)
TFS: 130539897(l2hgdh)
LCO: 104935982(l2hgdh)
TBEN: 117481406(l2hgdh)
PGEO: 117467288(l2hgdh)
GACU: 117533918(l2hgdh)
EMAC: 134881354(l2hgdh)
ELY: 117267127(l2hgdh)
EFO: 125901078(l2hgdh)
PLEP: 121953833(l2hgdh)
SLUC: 116057421(l2hgdh)
ECRA: 117935420(l2hgdh)
ESP: 116669718(l2hgdh)
PFLV: 114546504(l2hgdh)
GAT: 120832742(l2hgdh)
PPUG: 119227550(l2hgdh)
AFB: 129103174(l2hgdh)
CLUM: 117725288(l2hgdh)
PSWI: 130200972(l2hgdh)
CANA: 137787752(l2hgdh)
CVE: 137880270(l2hgdh)
MSAM: 119910239(l2hgdh)
SCHU: 122862136(l2hgdh)
CUD: 121526427(l2hgdh)
SPUL: 138591501(l2hgdh)
LMIX: 132967225(l2hgdh)
ALAT: 119004557(l2hgdh)
ASTR: 137610542(l2hgdh)
MZE: 101471313(l2hgdh)
ONL: 100693423(l2hgdh)
OAU: 116318049(l2hgdh)
OLA: 101160274(l2hgdh)
OML: 112148407(l2hgdh)
CSAI: 133462330(l2hgdh)
XMA: 102234259(l2hgdh)
XCO: 114134501(l2hgdh)
XHE: 116709345(l2hgdh)
PRET: 103458314(l2hgdh)
PFOR: 103144733(l2hgdh)
PLAI: 106946982(l2hgdh)
PMEI: 106922077(l2hgdh)
GAF: 122845944(l2hgdh)
PPRL: 129365084(l2hgdh)
CVG: 107097184(l2hgdh)
CTUL: 119783545(l2hgdh)
GMU: 124855285(l2hgdh)
NFU: 107391749(l2hgdh)
KMR: 108237533(l2hgdh)
ALIM: 106528408(l2hgdh)
NWH: 119427080(l2hgdh)
AOCE: 111579386(l2hgdh)
EJA: 138204965(l2hgdh)
BFRE: 138632267(l2hgdh)
MCEP: 125023188(l2hgdh)
CSEM: 103380943(l2hgdh)
POV: 109636312(l2hgdh)
SSEN: 122782868(l2hgdh)
SSOE: 131445257(l2hgdh)
HHIP: 117756671(l2hgdh)
HSP: 118117000(l2hgdh)
PPLT: 128450608(l2hgdh)
SMAU: 118286510(l2hgdh)
LCF: 108886702
SDU: 111225601(l2hgdh)
SLAL: 111665849(l2hgdh)
XGL: 120795133(l2hgdh)
HCQ: 109517328(l2hgdh)
SSCV: 125981028(l2hgdh)
SBIA: 133513614(l2hgdh)
PEE: 133413148(l2hgdh)
PTAO: 133487317(l2hgdh)
BPEC: 110174617(l2hgdh)
ENY: 140371048(l2hgdh)
MALB: 109973393(l2hgdh)
BSPL: 114848667(l2hgdh)
SJO: 128375054(l2hgdh)
SSCO: 134000679(l2hgdh)
GMH: 115544275(l2hgdh)
SASA: 106602521(l2hgdh)
STRU: 115172980(l2hgdh)
OTW: 112262152(l2hgdh)
OMY: 110498274(l2hgdh)
OGO: 124001327(l2hgdh)
ONE: 115123468(l2hgdh)
OKI: 109894633(l2hgdh)
OKE: 118377887 127913489(l2hgdh)
OMM: 135508535(l2hgdh)
OCLA: 139374393
SALP: 112074717(l2hgdh)
SNH: 120060119(l2hgdh)
CCLU: 121539096(l2hgdh)
ELS: 105025540(l2hgdh)
OEP: 134026418(l2hgdh)
SFM: 108919404(l2hgdh)
PKI: 111840026(l2hgdh)
AANG: 118233134(l2hgdh)
AROT: 135247432(l2hgdh)
CCOG: 133124973(l2hgdh)
LOC: 102696708(l2hgdh)
PSPA: 121329827(l2hgdh)
PSEX: 120519145(l2hgdh)
LCM: 102364974(L2HGDH)
CMK: 103175273(l2hgdh)
RTP: 109921716
CPLA: 122553583(l2hgdh)
HOC: 132817922(l2hgdh)
LERI: 129700523(l2hgdh)
HAKA: 140724951(l2hgdh)
PMRN: 116948346(L2HGDH)
LRJ: 133352578(L2HGDH)
BFO: 118425660
BBEL: 109472341
CIN: 100184325
SCLV: 120332968
SPU: 578357
LPIC: 129265497
AJJ: 139971754
APLC: 110989722
ARUN: 117296907
AAMU: 139947396
AFIL: 140153508
AJC: 117100812
SKO: 100376601
PFLL: 139149719
DME: Dmel_CG10639(L2HGDH)
DER: 6549344
DSE: 6614613
DSI: Dsimw501_GD21794(Dsim_GD21794)
DAN: 6497466
DSR: 110176882
DPO: 4816926
DPE: 6589400
DMN: 108162904
DWI: 6644340
DGR: 6561783
DAZ: 108611749
DNV: 115562394
DHE: 111595763
DVI: 6627935(L2HGDH)
CCAT: 101459974
BOD: 106617655
BDR: 105223105
AOQ: 129246976
ALUD: 128863023
TDA: 119689096
SCAC: 106094778
LCQ: 111679528
LSQ: 119612048
CVJ: 135951550(L2HGDH)
GFS: 119640624
ECOE: 129951749
CLON: 129615339
HIS: 119652210
AGA: 1278087
ACOZ: 120957117
AARA: 120902388
AMER: 121596911
ASTE: 118514128
AMAP: 126564705
AFUN: 125763484
AMOU: 128303617
AMRS: 128714282
AALI: 118460518
ACOS: 131266251
AAG: 110676307
ASUA: 134215741
CPII: 120413413
CBRI: 134832117
CNS: 116337955
LLL: 129794110
PPAP: 129804288
AME: 410999
ACER: 108002286
ALAB: 122719765
ADR: 102678583
AFLR: 100872278
BIM: 100749758
BBIF: 117208266
BVK: 117232015
BVAN: 117158104
BHUN: 126867800
BTER: 100651400
BAFF: 126914466
BPYO: 122566980
BPAS: 132909957
FVI: 122528499
CCAL: 108633134
OBB: 114872679
OLG: 117607665
MGEN: 117220837
NMEA: 116432498
CGIG: 122395366
SOC: 105200020
AEC: 105144701
ACEP: 105625974
ACOC: 108693851
MZT: 108723359(L2HGDH)
PBAR: 105427409
VEM: 105568115
COBS: 139106731(L2hgdh)
TLN: 139820955(L2hgdh)
HST: 105186316
DQU: 106748629
CFO: 105249825
FEX: 115242424
PMEC: 138942320(L2hgdh)
LHU: 105671500(L2HGDH)
PGC: 109855448
OBO: 105277467
PCF: 106784231
PFUC: 122517756
VPS: 122633701
VCRB: 124422340
VVE: 124946461
NVI: 100115746
CSOL: 105363875
LHT: 122506484
LBD: 127286338
MDL: 103571533
CGLO: 123275144
CTYP: 141529473(L2hgdh)
FAS: 105269212
DAM: 107041651
AGIF: 122848200
CINS: 118064287
VCAN: 122407601
CCIN: 107273133
DSM: 124406601
NPT: 124215300(L2HGDH)
NFB: 124178983
NLO: 107222141
NVG: 124301429
AROA: 105691471
ESIM: 136413118(L2HGDH)
EFOR: 136344248(L2HGDH)
CSET: 123310241
HAXR: 123685052
NVL: 108562516
APLN: 108738437
OTU: 111425060
BMOR: 101745774
BMAN: 114248641
MSEX: 115449335
BANY: 112045086
MJU: 123869424
NIQ: 126771129
VCD: 124531768
MCIX: 123655576
PMAC: 106714825
PPOT: 106101977
PXU: 106126058
BPHI: 137932610(L2HGDH)
PRAP: 110994004
PBX: 123708934
PNAP: 125050861
ZCE: 119834401
CCRC: 123693805
LSIN: 126965368
AAGE: 121739593
HAW: 110370685
HZE: 124629663
TNL: 113497247
SLIU: 111348308
OFU: 114364277
ONU: 135072585
ATRA: 106132425
GMW: 113512291
PXY: 105383252
PGW: 126368038
LGLY: 125230697
CSTB: 134745442
CFUM: 141431835(L2HGDH)
CCRN: 123295266
API: 100161579
DNX: 107173172
AGS: 114122022
RMD: 113554561
ACOO: 126846164
DVT: 126905795
BTAB: 109034234
HHAL: 106684302(L2HGDH)
HVI: 124356826
MQU: 128988135
FOC: 113215791
TPAL: 117653905
ZNE: 110839593
CSEC: 111861901
PAME: 138714798(L2HGDH)
SGRE: 126278100
BROR: 134542066
IEL: 124157401
HAMR: 139686308(L2HGDH)
FCD: 110842667
DPZ: 124311794
AFRA: 136042255
PVM: 138864010(L2HGDH)
PJA: 122258374
PCHN: 125043203
PMOO: 119585002
HAME: 121876086
PCLA: 123765477(L2HGDH)
PTRU: 123515988
ESN: 127004105
MNZ: 135220518
MRJ: 136830704(L2HGDH)
PORN: 139755327(L2HGDH)
HAZT: 108668244
EAF: 111709696
LSM: 121130696(L2HGDH)
TCF: 131885736
DSV: 119457594
RSAN: 119374770
RMP: 119167076
VDE: 111248653
VJA: 111265096
GOE: 100900974
TUT: 107368266
DPTE: 113798662
DFR: 124495119
CVS: 136988106(L2HGDH)
PTEP: 107445392
ABRU: 129980938
UDV: 129232607
SDM: 118195860
PMEO: 129589251
CEL: CELE_Y45G12B.3(lhgd-1)
CBR: CBG_06643
BMY: BM_BM6576(Bm6576)
TSP: Tsp_09673
PVUL: 126822682
PCAN: 112562380
LSAX: 138952754
BGT: 106056896
GAE: 121371255
HRF: 124119887
HRJ: 124289690
HASI: 137294483
HCRA: 139442259
CRG: 105338880
CANU: 128175894
OED: 125651145
MYI: 110461468
PMAX: 117323620
AIRR: 138318252
MCAF: 127738570
MMER: 123528892
RPHI: 132757918
DPOL: 127872866
MAEA: 128209238
OBI: 106870546
OSN: 115217198
LJP: 135468291
LAK: 106169805
SHX: MS3_00008045(L2HGDH)
LLON: 135484386
NVE: 5506318
EPA: 110250348
ATEN: 116302724
ADF: 107331220
AMIL: 114956637
MFOO: 137980322
PDAM: 113676926
SPIS: 111341504
DGT: 114520068
XEN: 124442749
HMG: 101241363
HSY: 130658035
RES: 135689814
AQU: 100634553
ATH: AT3G56840
ALY: 9314181
CRB: 17885421
BRP: 103841581
BOE: 106312181
RSZ: 108856716
CPAP: 110817154
CIT: 102609019
PVY: 116129226
MINC: 123197735
TCC: 18598621
GRA: 105786167
GAB: 108460382
HSYR: 120198577
DZI: 111312149
EGR: 104443589
RARG: 115731988
GMX: 100798359
GSJ: 114412325
PVU: 137837112
VRA: 106772172
VAR: 108345625
VUN: 114181963
VUM: 124832420
CCAJ: 109793634
APRC: 113867533
MTR: 11420087
TPRA: 123884796
CAM: 101512589
PSAT: 127124935
VVO: 131594491
LJA: 130717981
ADU: 107472023
LANG: 109336445
FVE: 101311454
AANS: 126788609
RCN: 112193613
PPER: 18771102
PMUM: 103339099
PAVI: 110772356
PDUL: 117635016
MDM: 103454693
MSYL: 126599758
PCOX: 137713039
MNT: 21410561
CSAV: 115724900
CSV: 101204963
CMO: 103495875
BHJ: 120073869
MCHA: 111021786
RCU: 8280365
MEAN: 126682146
JCU: 105637120
HBR: 110641410
POP: 7495656
PEU: 105136871
PALZ: 118052957
PNZ: 133688422
JRE: 109007945
CILL: 122277245
CAVE: 132191873
AGLU: 133872518
QSU: 112025402
QLO: 115951395
TWL: 119986884
VVI: 100255157
VRI: 117919654
SLY: 101243839
SPEN: 107031969
SSTN: 125865662
SDUL: 129876398
CANN: 107844695
LBB: 132607463
NSY: 104235362
NTO: 104092698
NAU: 109238833
INI: 109162108
ITR: 116025010
SIND: 105159876
OEU: 111370392
EGT: 105949407
SSPL: 121795825
SMIL: 131001958
SHIS: 125196864
APAN: 127256560
PEBU: 140832238
HAN: 110920848
ECAD: 122578997
LSV: 111880182
CCAV: 112517920
DCR: 108224905
CSIN: 114290177
RVL: 131312459
AEW: 130772885
DLT: 127790668
SOE: 110799881
ATRI: 130825989
MOF: 131144064
NNU: 104593510
MING: 122065489
TSS: 122642969
OSA: 4327565
OBR: 102718692
OGL: 127776315
BDI: 106866221
ATS: 109731554
TUA: 125544092
LPER: 127340143
LRD: 124666855
SBI: 8055270
ZMA: 100276389
SITA: 106804356
SVS: 117855082
PHAI: 112893238
PAUA: 133922849
TANG: 140776670
PDA: 103705022
EGU: 105032055
MUS: 135626901
DCT: 110091894
PEQ: 110024641
AOF: 109831714
MSIN: 131251042
ACAK: 137955458
NCOL: 116260468
ATR: 18426140
CJF: 131049227
PPP: 112289277
ERC: Ecym_3372
TDL: TDEL_0G02630(TDEL0G02630)
PIC: PICST_41267(GPH2)
LBG: 92205694(LODBEIA_P04980)
CAL: CAALFM_C106720CA(CaO19.6238)
CTEN: 18246792(PSN45_002560)
ASAU: 88174328(PUMCH_003264)
YLI: 2910634(YALI2_D00085g)
NCR: NCU08048
NTE: NEUTE1DRAFT121335(NEUTE1DRAFT_121335)
SMP: 10805121(SMAC4_03784)
RTHE: 98126184(VTJ83DRAFT_4990)
MGR: MGG_14905
PGRI: PgNI_11485
TATV: 25783895(TrAtP1_001726)
TASP: 36607383(TrAFT101_000842)
MBRN: 26237628(L2HGDH)
CMT: CCM_05328
CDET: 87944966(CDEST_08463)
MBE: MBM_06595
CPW: 9696844(D8B26_000490)
PTE: PTT_02289
PTRR: 6343254(PtrM4_120150)
ADAC: 96086286(ACET3X_005964)
CNE: CNA06700
CNB: CNBA6520
CDEU: CNBG_1237
CDEC: 89988515(IAS62_001741)
CTEG: 91987899(I308_101041)
CBAS: 91981075(I312_101027)
CDEP: 91089132(L203_104923)
KMG: 30166975(I203_100588)
KNE: 92181697(IAR55_004439)
KDJ: 28971497(I303_107794)
KBI: 30205923(I302_102829)
KPIN: 30176297(I206_106540)
KSH: 87959824(IL334_007694)
KER: 91105228(V865_006427)
TASA: A1Q1_07526
CCAC: CcaHIS019_0107690(CcaverHIS019_0107690)
ABP: AGABI1DRAFT127941(AGABI1DRAFT_127941)
ABV: AGABI2DRAFT202848(AGABI2DRAFT_202848)
SCM: SCHCO_02273132(SCHCODRAFT_02273132)
MGL: MGL_4098
MRT: MRET_3729
 » show all
Reference
  Authors
Rzem R, Van Schaftingen E, Veiga-da-Cunha M
  Title
The gene mutated in l-2-hydroxyglutaric aciduria encodes l-2-hydroxyglutarate dehydrogenase.
  Journal
Biochimie 88:113-6 (2006)
DOI:10.1016/j.biochi.2005.06.005
  Sequence
[hsa:79944]
Reference
  Authors
Hudig M, Maier A, Scherrers I, Seidel L, Jansen EE, Mettler-Altmann T, Engqvist MK, Maurino VG
  Title
Plants Possess a Cyclic Mitochondrial Metabolic Pathway similar to the Mammalian Metabolic Repair Mechanism Involving Malate Dehydrogenase and l-2-Hydroxyglutarate Dehydrogenase.
  Journal
Plant Cell Physiol 56:1820-30 (2015)
DOI:10.1093/pcp/pcv108
  Sequence
[ath:AT3G56840]
LinkDB

KEGG   ENZYME: 1.1.99.2
Entry
EC 1.1.99.2                 Enzyme                                 
Name
L-2-hydroxyglutarate dehydrogenase;
alpha-ketoglutarate reductase;
alpha-hydroxyglutarate dehydrogenase;
L-alpha-hydroxyglutarate dehydrogenase;
hydroxyglutaric dehydrogenase;
alpha-hydroxyglutarate oxidoreductase;
L-alpha-hydroxyglutarate:NAD+ 2-oxidoreductase;
alpha-hydroxyglutarate dehydrogenase (NAD+ specific);
(S)-2-hydroxyglutarate:(acceptor) 2-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors
Sysname
(S)-2-hydroxyglutarate:acceptor 2-oxidoreductase
Reaction(IUBMB)
(S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor [RN:R00298]
Reaction(KEGG)
R00298 > R03534
Substrate
(S)-2-hydroxyglutarate [CPD:C03196];
acceptor [CPD:C00028]
Product
2-oxoglutarate [CPD:C00026];
reduced acceptor [CPD:C00030]
History
EC 1.1.99.2 created 1961, modified 2013
Pathway
ec00650  Butanoate metabolism
ec01100  Metabolic pathways
Orthology
K00109  2-hydroxyglutarate dehydrogenase
Genes
HSA79944(L2HGDH)
PTR452898(L2HGDH)
PPS100978899(L2HGDH)
GGO101139276(L2HGDH)
PON100172827(L2HGDH)
PPYG129012196(L2HGDH)
NLE100600833(L2HGDH)
HMH116484471(L2HGDH)
SSYN129487918(L2HGDH)
MCC705721(L2HGDH)
MCF102137911(L2HGDH)
MTHB126958511
MNI105481842(L2HGDH)
CSAB103228958(L2HGDH)
CATY105586729(L2HGDH)
PANU101004693(L2HGDH)
TGE112629080(L2HGDH)
MLEU105553624(L2HGDH)
RRO104682749(L2HGDH)
RBB108513673(L2HGDH)
TFN117069668(L2HGDH)
PTEH111549460(L2HGDH)
CANG105522388(L2HGDH)
CJC100410851(L2HGDH)
SBQ101047482(L2HGDH)
CIMI108287980(L2HGDH)
ANAN105719928(L2HGDH)
CSYR103276426(L2HGDH)
MMUR105867642(L2HGDH)
LCAT123649418(L2HGDH)
PCOQ105825869(L2HGDH)
OGA100958822(L2HGDH)
MMU217666(L2hgdh)
MCAL110307199(L2hgdh)
MPAH110324754(L2hgdh)
RNO314196(L2hgdh)
MCOC116081051(L2hgdh)
ANU117715708 117717300(L2hgdh)
ASYL127687274(L2hgdh)
MUN110556911(L2hgdh)
CGE100768751(L2hgdh)
MAUA101840183(L2hgdh)
PROB127230647(L2hgdh)
PLEU114684211(L2hgdh) 114699469
MORG121452313(L2hgdh)
MFOT126508441
AAMP119819643(L2hgdh)
NGI103731511(L2hgdh)
HGL101702109(L2hgdh)
CPOC100726948(L2hgdh)
CCAN109686540 109687204
DORD105982574(L2hgdh)
DSP122106558(L2hgdh)
DMER138830897(L2hgdh)
PLOP125363424(L2hgdh)
NCAR124978155
MMMA107146722(L2hgdh)
ITI101973905(L2hgdh)
OCU100350193
OPI101525748(L2HGDH)
TUP102480205(L2HGDH)
GVR103589433(L2HGDH)
CFA480316(L2HGDH)
CLUD112658015(L2HGDH)
VVP112921448(L2HGDH)
VLG121492464(L2HGDH)
NPO129496004(L2HGDH)
UMR103665372(L2HGDH)
UAH113266207(L2HGDH)
UAR123793268(L2HGDH)
ELK111140398
LLV125104045
MPUF101677511(L2HGDH)
MNP131999928(L2HGDH)
MLK131836539(L2HGDH)
NVS122894126(L2HGDH)
ORO101385619(L2HGDH)
EJU114205644(L2HGDH)
ZCA113909058(L2HGDH)
MLX118002663(L2HGDH)
NSU110590608(L2HGDH)
LWW102741764(L2HGDH)
FCA101094353(L2HGDH)
PYU121031739(L2HGDH)
PCOO112856267(L2HGDH)
PBG122469067(L2HGDH)
PVIV125167500(L2HGDH)
LRUF124512208
LGF123583806(L2HGDH)
AJU106981946
PTG102951061(L2HGDH)
PPAD109268501(L2HGDH)
PUC125909521
PLEZ122222578(L2HGDH)
HHV120220283(L2HGDH)
BTA514230(L2HGDH)
BOM102277294(L2HGDH)
BIU109565017(L2HGDH)
BBUB102414364(L2HGDH)
BBIS104990253(L2HGDH)
CHX102190421(L2HGDH)
OAS101121015(L2HGDH)
BTAX128054314(L2HGDH)
CSUM138073367(L2HGDH)
ODA120853130(L2HGDH)
CCAD122443466(L2HGDH)
MREE136172467(L2HGDH)
OVR110141953(L2HGDH)
MBEZ129562679(L2HGDH)
SSC100152180(L2HGDH)
CFR102520166(L2HGDH)
CBAI105078435(L2HGDH)
CDK105091405(L2HGDH)
VPC102541170(L2HGDH)
BACU103020579(L2HGDH)
BMUS118888586(L2HGDH)
LVE103075209(L2HGDH)
OOR101284995(L2HGDH)
LALB132516360(L2HGDH)
GMF115852267(L2HGDH)
DLE111173173(L2HGDH)
PCAD102974237(L2HGDH)
PSIU116746671(L2HGDH)
PPHC136118740(L2HGDH)
NASI112414411(L2HGDH)
ECB100066314(L2HGDH)
EPZ103559182(L2HGDH)
EAI106839519(L2HGDH)
MYB102238888(L2HGDH)
MYD102773864(L2HGDH)
MMYO118654881(L2HGDH)
MLF102436915(L2HGDH)
MDT132235017(L2HGDH)
MYUM139013741(L2HGDH)
PKL118718572(L2HGDH)
EFUS103283759(L2HGDH)
MNA107525853(L2HGDH)
DRO112310993(L2HGDH)
SHON118992376(L2HGDH)
AJM119057067(L2HGDH)
PDIC114492353(L2HGDH)
PHAS123808855(L2HGDH)
MMF118641009(L2HGDH)
PPAM129064132(L2HGDH) 129064133
HAI109375228(L2HGDH)
RFQ117022919(L2HGDH)
PALE102889350(L2HGDH)
PGIG120604449(L2HGDH)
PVP105309524(L2HGDH)
RAY107511438(L2HGDH)
MJV108401304(L2HGDH)
TOD119239072(L2HGDH)
SARA101542023 101552954(L2HGDH)
SFUM130041981(L2HGDH)
SETR125999216(L2HGDH)
LAV100657343(L2HGDH)
TMU101347817
ETF101643037(L2HGDH)
DNM101426209(L2HGDH)
MDO100018728(L2HGDH)
GAS123249242(L2HGDH)
SHR100933496(L2HGDH)
AFZ127539314
PCW110221753(L2HGDH)
TVP118851202(L2HGDH)
PBRV138166716(L2HGDH)
OAA100084662(L2HGDH)
TACU119937103(L2HGDH)
GGA423573(L2HGDH)
PCOC116234586(L2HGDH)
MGP100540849(L2HGDH)
CJO107315524(L2HGDH)
TPAI128087213(L2HGDH)
LMUT125695092(L2HGDH)
NMEL110401965(L2HGDH)
APLA101804444(L2HGDH)
ACYG106049309(L2HGDH)
CATA118250281(L2HGDH)
AFUL116489445(L2HGDH)
TGU100220092(L2HGDH)
LSR110473477(L2HGDH)
SCAN103826825(L2HGDH)
PMOA120497062(L2HGDH)
OTC121338797(L2HGDH)
PRUF121348713(L2HGDH)
ATRC139589601(L2HGDH)
GFR102033150(L2HGDH)
FAB101808533(L2HGDH)
OMA130253533(L2HGDH)
PHI102103991(L2HGDH)
PMAJ107206240(L2HGDH)
CCAE111929517(L2HGDH)
CCW104695923(L2HGDH)
CBRC103618908(L2HGDH)
ACOE138112018(L2HGDH)
ETL114070306(L2HGDH)
ZAB102065921(L2HGDH)
ZLE135449197(L2HGDH)
ACHL103799488(L2HGDH)
SVG106858941(L2HGDH)
MMEA130583787(L2HGDH)
HRT120748295(L2HGDH)
SATI136362715(L2HGDH)
CCIC134045814(L2HGDH)
FPG101912902(L2HGDH)
FCH102056594(L2HGDH)
CCRI104159884(L2HGDH)
NNT104399180(L2HGDH)
SHAB115607514(L2HGDH)
ACUN113480383(L2HGDH)
TALA104359874(L2HGDH)
ACHC115351825(L2HGDH)
HALD104310389
HLE104839518(L2HGDH)
AGEN126050731
HHAR128140150(L2HGDH)
GCL127017062
CSTI104559841
LDI104339918(L2HGDH)
MNB103773297(L2HGDH)
DPUB104299372(L2HGDH)
PPUS135175134(L2HGDH)
AVIT104277359(L2HGDH)
BRHI104489907(L2HGDH)
EGZ104135009(L2HGDH)
NNI104019490(L2HGDH)
PCRI104031113(L2HGDH)
PCAO104044237(L2HGDH)
PADL103914919(L2HGDH)
AFOR103907688(L2HGDH)
FGA104069391(L2HGDH)
GSTE104260279(L2HGDH)
CBOY140653348(L2HGDH)
CLV102089678(L2HGDH)
CNIC135988864(L2HGDH)
MUI104542690(L2HGDH)
PGUU104457605(L2HGDH)
PLET104623124(L2HGDH)
CMAC104473965(L2HGDH)
CUCA104057454(L2HGDH)
TEO104384101(L2HGDH)
BREG104641613(L2HGDH)
OHA104327784(L2HGDH)
ACAR104523364(L2HGDH)
CPEA104394705(L2HGDH)
CVF104294338(L2HGDH)
RTD128908939(L2HGDH)
CRID134515146(L2HGDH)
AAM106497441(L2HGDH)
AROW112961190(L2HGDH)
NPD112957761(L2HGDH)
TGT104568128(L2HGDH)
DNE112994129(L2HGDH)
SCAM104145514(L2HGDH)
ASN102387436(L2HGDH)
AMJ106737189(L2HGDH)
CPOO109320894(L2HGDH)
GGN109299276(L2HGDH)
PSS102458506(L2HGDH)
CMY102946571(L2HGDH)
CCAY125637665(L2HGDH)
DCC119857346(L2HGDH)
CPIC101935892(L2HGDH)
TST117876656(L2HGDH)
CABI116822134(L2HGDH)
MRV120404320(L2HGDH)
ACS100563174(l2hgdh)
ASAO132760726(L2HGDH)
PVT110089153(L2HGDH)
SUND121933538(L2HGDH)
PBI103059564(L2HGDH)
PMUR107296219(L2HGDH) 107300310
CTIG120301818(L2HGDH)
TSR106545963(L2HGDH)
PGUT117675047(L2HGDH)
PCAE139308212(L2HGDH)
APRI131188107(L2HGDH)
PTEX113435147(L2HGDH)
NSS113414131(L2HGDH)
VKO123026580(L2HGDH)
PRAF128411998(L2HGDH)
ZVI118075482(L2HGDH) 118077556
HCG128326813(L2HGDH)
GJA107122496(L2HGDH) 107122626
STOW125427105(L2HGDH)
EMC129324315(L2HGDH)
XLA108698751(l2hgdh.L)
XTR100145085(l2hgdh)
NPR108795062(L2HGDH)
RTEM120920990(L2HGDH)
ACAT141116385(L2HGDH)
BBUF120982398(L2HGDH)
BGAR122922049(L2HGDH)
DTC141091933(L2HGDH)
PWL138260309(L2HGDH)
MUO115478101(L2HGDH)
GSH117363450(L2HGDH)
DRE566872(l2hgdh)
SRX107705441 107736610
SANH107654945 107682613
SGH107553179 107602969(l2hgdh)
CCAR109057101(l2hgdh)
CAUA113056798(l2hgdh)
CGIB127969907
PTET122357086(l2hgdh)
LROH127175085(l2hgdh)
GRF141326183(l2hgdh)
OMC131551918(l2hgdh)
PPRM120467767(l2hgdh)
RKG130088247(l2hgdh)
MAMB125277305(l2hgdh)
CIDE127525063
CERY137020171(l2hgdh)
MASI127411655 127413895
TROS130559216(l2hgdh)
TDW130431826(l2hgdh)
MANU129416180(l2hgdh)
PDAB135786769(l2hgdh)
IPU108263080
PHYP113541918(l2hgdh)
SMEO124394589(l2hgdh)
TFD113656881(l2hgdh)
TVC132846827(l2hgdh)
CGAR128528538(l2hgdh)
NGRA132888999(l2hgdh) 132889006
TRN134314297(l2hgdh)
AMEX103038136(l2hgdh)
CMAO118811060(l2hgdh)
EEE113577730(l2hgdh)
CHAR105890985(l2hgdh)
SPIL134067725(l2hgdh)
TRU101061325(l2hgdh)
TFS130539897(l2hgdh)
TNGGSTEN00035790G001
LCO104935982(l2hgdh)
TBEN117481406(l2hgdh)
PGEO117467288(l2hgdh)
GACU117533918(l2hgdh)
EMAC134881354(l2hgdh)
ELY117267127(l2hgdh)
EFO125901078(l2hgdh)
PLEP121953833(l2hgdh)
SLUC116057421(l2hgdh)
ECRA117935420(l2hgdh)
ESP116669718(l2hgdh)
PFLV114546504(l2hgdh)
GAT120832742(l2hgdh)
PPUG119227550(l2hgdh)
AFB129103174(l2hgdh)
CLUM117725288(l2hgdh)
PSWI130200972(l2hgdh)
CANA137787752(l2hgdh)
CVE137880270(l2hgdh)
MSAM119910239(l2hgdh)
SCHU122862136(l2hgdh)
CUD121526427(l2hgdh)
SPUL138591501(l2hgdh)
LMIX132967225(l2hgdh)
ALAT119004557(l2hgdh)
ASTR137610542(l2hgdh)
MZE101471313(l2hgdh)
ONL100693423(l2hgdh)
OAU116318049(l2hgdh)
OLA101160274(l2hgdh)
OML112148407(l2hgdh)
CSAI133462330(l2hgdh)
XMA102234259(l2hgdh)
XCO114134501(l2hgdh)
XHE116709345(l2hgdh)
PRET103458314(l2hgdh)
PFOR103144733(l2hgdh)
PLAI106946982(l2hgdh)
PMEI106922077(l2hgdh)
GAF122845944(l2hgdh)
PPRL129365084(l2hgdh)
CVG107097184(l2hgdh)
CTUL119783545(l2hgdh)
GMU124855285(l2hgdh)
NFU107391749(l2hgdh)
KMR108237533(l2hgdh)
ALIM106528408(l2hgdh)
NWH119427080(l2hgdh)
AOCE111579386(l2hgdh)
EJA138204965(l2hgdh)
BFRE138632267(l2hgdh)
MCEP125023188(l2hgdh)
CSEM103380943(l2hgdh)
POV109636312(l2hgdh)
SSEN122782868(l2hgdh)
SSOE131445257(l2hgdh)
HHIP117756671(l2hgdh)
HSP118117000(l2hgdh)
PPLT128450608(l2hgdh)
SMAU118286510(l2hgdh)
LCF108886702
SDU111225601(l2hgdh)
SLAL111665849(l2hgdh)
XGL120795133(l2hgdh)
HCQ109517328(l2hgdh)
SSCV125981028(l2hgdh)
SBIA133513614(l2hgdh)
PEE133413148(l2hgdh)
PTAO133487317(l2hgdh)
BPEC110174617(l2hgdh)
ENY140371048(l2hgdh)
MALB109973393(l2hgdh)
BSPL114848667(l2hgdh)
SJO128375054(l2hgdh)
SSCO134000679(l2hgdh)
GMH115544275(l2hgdh)
SASA106602521(l2hgdh)
STRU115172980(l2hgdh)
OTW112262152(l2hgdh)
OMY110498274(l2hgdh)
OGO124001327(l2hgdh)
ONE115123468(l2hgdh)
OKI109894633(l2hgdh)
OKE118377887 127913489(l2hgdh)
OMM135508535(l2hgdh)
OCLA139374393
SALP112074717(l2hgdh)
SNH120060119(l2hgdh)
CCLU121539096(l2hgdh)
ELS105025540(l2hgdh)
OEP134026418(l2hgdh)
SFM108919404(l2hgdh)
PKI111840026(l2hgdh)
AANG118233134(l2hgdh)
AROT135247432(l2hgdh)
CCOG133124973(l2hgdh)
LOC102696708(l2hgdh)
PSPA121329827(l2hgdh)
ARUT117415534 117973928
PSEX120519145(l2hgdh)
LCM102364974(L2HGDH)
CMK103175273(l2hgdh)
RTP109921716
CPLA122553583(l2hgdh)
HOC132817922(l2hgdh)
LERI129700523(l2hgdh)
HAKA140724951(l2hgdh)
PMRN116948346(L2HGDH)
LRJ133352578(L2HGDH)
BFO118425660
BBEL109472341
CIN100184325
SCLV120332968
SPU578357
LPIC129265497
AJJ139971754
APLC110989722
ARUN117296907
AAMU139947396
AFIL140153508
AJC117100812
SKO100376601
PFLL139149719
DMEDmel_CG10639(L2HGDH)
DER6549344
DSE6614613
DSIDsimw501_GD21794(Dsim_GD21794)
DYADyak_GE12689
DAN6497466
DSR110176882
DPO4816926
DPE6589400
DMN108162904
DWI6644340
DGR6561783
DMODmoj_GI17168
DAZ108611749
DNV115562394
DHE111595763
DVI6627935(L2HGDH)
CCAT101459974
BOD106617655
BDR105223105
RZE108353889 108370867
AOQ129246976
ALUD128863023
TDA119689096
MDE101896371 131800906
SCAC106094778
LCQ111679528
LSQ119612048
CVJ135951550(L2HGDH)
GFS119640624
ECOE129951749
CLON129615339
HIS119652210
AGA1278087
ACOZ120957117
AARA120902388
AMER121596911
ASTE118514128
AMAP126564705
AFUN125763484
AMOU128303617
AMRS128714282
AALI118460518
ACOS131266251
AAG110676307
AALB109408591 109423851 115254254 115270189
ASUA134215741
CPII120413413
CBRI134832117
CNS116337955
BCOO119066216 119079580 119079581
LLL129794110
PPAP129804288
AME410999
ACER108002286
ALAB122719765
ADR102678583
AFLR100872278
BIM100749758
BBIF117208266
BVK117232015
BVAN117158104
BHUN126867800
BTER100651400
BAFF126914466
BPYO122566980
BPAS132909957
FVI122528499
CCAL108633134
OBB114872679
OLG117607665
MGEN117220837
NMEA116432498
CGIG122395366
SOC105200020
MPHA105833196 118644030
AEC105144701
ACEP105625974
ACOC108693851
MZT108723359(L2HGDH)
PBAR105427409
VEM105568115
COBS139106731(L2hgdh)
TLN139820955(L2hgdh)
HST105186316
DQU106748629
CFO105249825
FEX115242424
PMEC138942320(L2hgdh)
LHU105671500(L2HGDH)
PGC109855448
OBO105277467
PCF106784231
PFUC122517756
VPS122633701
VCRB124422340
VVE124946461
NVI100115746
CSOL105363875
TPRE106651314 106657515
LHT122506484
LBD127286338
MDL103571533
CGLO123275144
CTYP141529473(L2hgdh)
FAS105269212
DAM107041651
AGIF122848200
CINS118064287
VCAN122407601
CCIN107273133
DSM124406601
NPT124215300(L2HGDH)
NFB124178983
NLO107222141
NVG124301429
AROA105691471
TCA663434 663451
TMOL138132510 138132511
DPA109532975 109532977
ESIM136413118(L2HGDH)
EFOR136344248(L2HGDH)
SOY115874125 115880394
AGRG126738333 126738389
ATD109597930 109597948
CSET123310241
HAXR123685052
AGB108912861 108912863
LDC111511179 111518166
DVV114335849 126881134
NVL108562516
APLN108738437
PPYR116169477 116175866
OTU111425060
BMOR101745774
BMAN114248641
MSEX115449335
DPLKGM_205781
BANY112045086
MJU123869424
NIQ126771129
VCD124531768
MCIX123655576
PMAC106714825
PPOT106101977
PXU106126058
BPHI137932610(L2HGDH)
PRAP110994004
PBX123708934
PNAP125050861
ZCE119834401
CCRC123693805
LSIN126965368
AAGE121739593
HAW110370685
HZE124629663
TNL113497247
SLIU111348308
OFU114364277
ONU135072585
ATRA106132425
GMW113512291
PXY105383252
PGW126368038
LGLY125230697
CSTB134745442
CFUM141431835(L2HGDH)
CFEL113385908 113385909
CCRN123295266
API100161579
DNX107173172
AGS114122022
RMD113554561
ACOO126846164
DVT126905795
BTAB109034234
DCI103512203 103524011
HHAL106684302(L2HGDH)
NLU111048250 111061381
HVI124356826
MQU128988135
PHUPhum_PHUM349820
FOC113215791
TPAL117653905
ZNE110839593
CSEC111861901
PAME138714798(L2HGDH)
SGRE126278100
BROR134542066
IEL124157401
HAMR139686308(L2HGDH)
FCD110842667
DPXDAPPUDRAFT_305386
DPZ124311794
AFRA136042255
PVM138864010(L2HGDH)
PJA122258374
PCHN125043203
PMOO119585002
HAME121876086
PCLA123765477(L2HGDH)
PTRU123515988
ESN127004105
MNZ135220518
MRJ136830704(L2HGDH)
PORN139755327(L2HGDH)
HAZT108668244
EAF111709696
LSM121130696(L2HGDH)
TCF131885736
PPOI119101963 119107026 119109796
DSV119457594
RSAN119374770
RMP119167076
VDE111248653
VJA111265096
GOE100900974
TUT107368266
DPTE113798662
DFR124495119
CSCU111642015 111642314
CVS136988106(L2HGDH)
PTEP107445392
ABRU129980938
UDV129232607
SDM118195860
LPOL106474935 106475151
PMEO129589251
CELCELE_Y45G12B.3(lhgd-1)
CBRCBG_06643
CRQGCK72_019082
NAINECAME_13279
BMYBM_BM6576(Bm6576)
LOALOAG_00810
TSPTsp_09673
HROHELRODRAFT_179569
LGILOTGIDRAFT_215736
PVUL126822682
PCAN112562380
LSAX138952754
BGT106056896
GAE121371255
HRF124119887
HRJ124289690
HASI137294483
HCRA139442259
CRG105338880
CANU128175894
CVN111129515 111129864
OED125651145
MYI110461468
PMAX117323620
AIRR138318252
MCAF127738570
MMER123528892
RPHI132757918
DPOL127872866
MAEA128209238
OBI106870546
OSN115217198
LJP135468291
LAK106169805
SMMSmp_050080
SHXMS3_00008045(L2HGDH)
OVIT265_00030 T265_10884
LLON135484386
NVE5506318
EPA110250348
ATEN116302724
ADF107331220
AMIL114956637
MCAZ138025667 138027929
MFOO137980322
PDAM113676926
SPIS111341504
DGT114520068
XEN124442749
HMG101241363
HSY130658035
RES135689814
TADTRIADDRAFT_51164
AQU100634553
ATHAT3G56840
ALY9314181
CRB17885421
CSAT104712343 104781577 104791973
EUSEUTSA_v10005964mg
BRP103841581
BNA106368050 125578197
BOE106312181
RSZ108856716
THJ104803249 104803303
CPAP110817154
CIT102609019
CICCICLE_v10011846mg
PVY116129226
MINC123197735
TCC18598621
GRA105786167
GHI107922088 107939016
GAB108460382
HSYR120198577
DZI111312149
EGR104443589
RARG115731988
GMX100798359
GSJ114412325
PVU137837112
VRA106772172
VAR108345625
VUN114181963
VUM124832420
CCAJ109793634
APRC113867533
MTR11420087
TPRA123884796
CAM101512589
PSAT127124935
VVO131594491
LJA130717981
ADU107472023
AIP107610063 107624200
AHF112716797 112766327 112783200
LANG109336445
PCIN129284397 129295640
QSAO6P43_006273
FVE101311454
AANS126788609
RCN112193613
PPER18771102
PMUM103339099
PAVI110772356
PDUL117635016
MDM103454693
MSYL126599758
PCOX137713039
MNT21410561
CSAV115724900
CSV101204963
CMO103495875
BHJ120073869
MCHA111021786
RCU8280365
MEAN126682146
JCU105637120
HBR110641410
MESC110619054 110624185
POP7495656
PEU105136871
PALZ118052957
PNZ133688422
JRE109007945
CILL122277245
CAVE132191873
AGLU133872518
QSU112025402
QLO115951395
TWL119986884
VVI100255157
VRI117919654
SLY101243839
SPEN107031969
SOT102580963 102595556
SSTN125865662
SDUL129876398
CANN107844695
LBB132607463
NTA107788841 107819020
NSY104235362
NTO104092698
NAU109238833
INI109162108
ITR116025010
SIND105159876
OEU111370392
EGT105949407
SSPL121795825
SMIL131001958
SHIS125196864
APAN127256560
PEBU140832238
HAN110920848
ECAD122578997
LSV111880182
CCAV112517920
DCR108224905
CSIN114290177
RVL131312459
AEW130772885
DLT127790668
BVG104889663 104889666
SOE110799881
CQI110711721 110714898
ATRI130825989
MOF131144064
NNU104593510
MING122065489
TSS122642969
PSOM113313279 113322729
OSA4327565
DOSAOs01g0809900
OBR102718692
OGL127776315
BDI106866221
ATS109731554
TDC119269333 119277332
TAES123062359 123071129 123079492
TUA125544092
LPER127340143
LRD124666855
SBI8055270
ZMA100276389
MFLO136450648 136455156
SITA106804356
SVS117855082
PVIR120673284 120708411
PHAI112893238
PAUA133922849
TANG140776670
PDA103705022
EGU105032055
MUS135626901
ZOF122031676 122035066
DCT110091894
PEQ110024641
AOF109831714
MSIN131251042
ACAK137955458
NCOL116260468
ATR18426140
CJF131049227
SMOSELMODRAFT_271760 SELMODRAFT_88360 SELMODRAFT_92593
PPP112289277
ERCEcym_3372
KLAKLLA0_E14763g
KMXKLMA_60011
LTHKLTH0F09526g
ZROZYRO0A07084g
TGBHG536_0A02610
TDLTDEL_0G02630(TDEL0G02630)
ZMKHG535_0D01560
SLUDSCDLUD_002702
DHADEHA2G21252g
PICPICST_41267(GPH2)
PGUPGUG_02491
SPAASPAPADRAFT_62681
LELPVL30_000585
LBG92205694(LODBEIA_P04980)
CALCAALFM_C106720CA(CaO19.6238)
CTPCTRG_04212
COTCORT_0A06390
CDUCD36_06290
CTEN18246792(PSN45_002560)
CLUCLUG_01842
CLUSA9F13_21g00242
CAURCJI96_0005365
ASAU88174328(PUMCH_003264)
PPAPAS_chr2-2_0452
BNNFOA43_002736
BBRXBRETT_002742
OPAHPODL_01730
YLI2910634(YALI2_D00085g)
SLBAWJ20_5189
NCRNCU08048
NTENEUTE1DRAFT121335(NEUTE1DRAFT_121335)
SMP10805121(SMAC4_03784)
PANPODANSg7269
PBELQC761_602640
PPSDQC762_602640
PPSPQC763_602640
PPSAQC764_602640
TTTTHITE_132641
MTMMYCTH_2298784
CTHRCTHT_0033760
RTHE98126184(VTJ83DRAFT_4990)
MGRMGG_14905
PPEIPpBr36_04679
PGRIPgNI_11485
TMNUCRPA7_6836
FGRFGSG_05122
FPUFPSE_06518
FPOAFPOAC1_008577
FVNFVRRES_09170
FVRFVEG_06111
FOXFOXG_08557
NHENECHADRAFT_32312
FFCNCS54_00247200
FKRNCS57_00242700
FMUJ7337_004665
TATV25783895(TrAtP1_001726)
TASP36607383(TrAFT101_000842)
MBRN26237628(L2HGDH)
PCHMVFPPC_09117
CMTCCM_05328
AMUSLMH87_006236
PTKZJDV02_007704
CFJCFIO01_00456
CLUPCLUP02_17322
CHIGCH63R_07748
CDET87944966(CDEST_08463)
SSLSS1G_09974
BFUBCIN_07g04400
MBEMBM_06595
PSCOLY89DRAFT_787317
GLZGLAREA_01990
AFMAFUA_1G04090
ACTACLA_030540
NFINFIA_020640
AORAO090003000940
ANGAn01g02920
AFVAFLA_000734
ALUCAKAW2_20460S
ACHEACHE_11581S
PCSN7525_010833
PDPPDIP_20670
TMFEYB26_008214
TRGTRUGW13939_00541
CIMCIMG_04999
CPW9696844(D8B26_000490)
AJEHCAG_06023
PNOSNOG_05922
PTEPTT_02289
PTRR6343254(PtrM4_120150)
BZECOCCADRAFT_91816
BSCCOCSADRAFT_38383
BORCOCMIDRAFT_101015
AALTCC77DRAFT_1031976
ADAC96086286(ACET3X_005964)
ARABEKO05_0000857
ZTRMYCGRDRAFT_111010
PFJMYCFIDRAFT_29489
FFUCLAFUR5_02954
CBETCB0940_03203
CNECNA06700
CNBCNBA6520
CNGCNAG_00692
CGICGB_A7510W
CDEUCNBG_1237
CDEC89988515(IAS62_001741)
CTEG91987899(I308_101041)
CBAS91981075(I312_101027)
CDEP91089132(L203_104923)
KMG30166975(I203_100588)
KNE92181697(IAR55_004439)
KDJ28971497(I303_107794)
KBI30205923(I302_102829)
KPIN30176297(I206_106540)
KSH87959824(IL334_007694)
KER91105228(V865_006427)
TMSTREMEDRAFT_34801
TASAA1Q1_07526
CCACCcaHIS019_0107690(CcaverHIS019_0107690)
TVSTRAVEDRAFT_115285
DSQDICSQDRAFT_60737
PCOPHACADRAFT_249787
SHSSTEHIDRAFT_158155
HIRHETIRDRAFT_408521
PSQPUNSTDRAFT_100030
ADLAURDEDRAFT_133588
FMEFOMMEDRAFT_135532
GTRGLOTRDRAFT_136462
RSXRhiXN_00724
LBCLACBIDRAFT_158383
CCICC1G_01295
ABPAGABI1DRAFT127941(AGABI1DRAFT_127941)
ABVAGABI2DRAFT202848(AGABI2DRAFT_202848)
MRRMoror_1445
MOREE1B28_004087
SCMSCHCO_02273132(SCHCODRAFT_02273132)
CPUTCONPUDRAFT_123520
SLASERLADRAFT_446497
WSEWALSEDRAFT_60608
UMAUMAG_05061
PFPPFL1_04759
SGRAEX895_002605
MGLMGL_4098
MRTMRET_3729
MSYMMSY001_3219
PGRPGTG_16481
PTRCPtA15_4A379
PSTRPst134EA_011229
MLRMELLADRAFT_104896
RIEOCT59_021789
MBRMONBRDRAFT_14006
SREPTSG_00278
CCURIAR63_02185
 » show all
Reference
1  [PMID:16746551]
  Authors
Weil-Malherbe H
  Title
The oxidation of l(-)alpha-hydroxyglutaric acid in animal tissues.
  Journal
Biochem J 31:2080-94 (1937)
DOI:10.1042/bj0312080
Other DBs
ExplorEnz - The Enzyme Database: 1.1.99.2
IUBMB Enzyme Nomenclature: 1.1.99.2
ExPASy - ENZYME nomenclature database: 1.1.99.2
BRENDA, the Enzyme Database: 1.1.99.2
CAS: 9028-80-2
LinkDB

KEGG   REACTION: R03534
Entry
R03534                      Reaction                               
Name
2-hydroxyglutarate:(acceptor) 2-oxidoreductase
Definition
2-Hydroxyglutarate + FAD <=> 2-Oxoglutarate + FADH2
Equation
Reaction class
RC00031  C00026_C02630
RC00126  C00016_C01352
Enzyme
Pathway
rn00650  Butanoate metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.99  With unknown physiological acceptors
    1.1.99.2
     R03534  2-Hydroxyglutarate + FAD <=> 2-Oxoglutarate + FADH2
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.1.99.2
   R00298  Acceptor <=> Reduced acceptor
    R03534  FAD <=> FADH2
Orthology
K00109  2-hydroxyglutarate dehydrogenase [EC:1.1.99.2]
Other DBs
RHEA: 25264
LinkDB

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