KEGG ORTHOLOGY: K00460

ORTHOLOGY: K00460

Entry

K00460                      KO

Symbol

ALOX15

Name

arachidonate 15-lipoxygenase [EC:1.13.11.33]

Pathway

map00590

Arachidonic acid metabolism

map00591

Linoleic acid metabolism

map01100

Metabolic pathways

map04148

Efferocytosis

map04216

Ferroptosis

map04217

Necroptosis

map04726

Serotonergic synapse

Reaction

R01593

arachidonate:oxygen 15-oxidoreductase

R03626

linoleate:oxygen 13-oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K00460  ALOX15; arachidonate 15-lipoxygenase
   00591 Linoleic acid metabolism
    K00460  ALOX15; arachidonate 15-lipoxygenase
09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    K00460  ALOX15; arachidonate 15-lipoxygenase
  09143 Cell growth and death
   04216 Ferroptosis
    K00460  ALOX15; arachidonate 15-lipoxygenase
   04217 Necroptosis
    K00460  ALOX15; arachidonate 15-lipoxygenase
09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K00460  ALOX15; arachidonate 15-lipoxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.33  arachidonate 15-lipoxygenase
     K00460  ALOX15; arachidonate 15-lipoxygenase

Other DBs

GO:

0050473

Genes

HSA:	246(ALOX15)

PTR:	748294(ALOX15)

PPS:	100990568(ALOX15)

GGO:	101130490(ALOX15)

PON:	100174413(ALOX15)

PPYG:

129018111(ALOX15)

NLE:	100598410(ALOX15)

HMH:	116459226(ALOX15)

SSYN:

129470266(ALOX15) 134731306

MCC:	100425071 709212(ALOX15)

MCF:	102124513(ALOX15)

MTHB:

126939685

MNI:	105472240(ALOX15)

CSAB:

103242192(ALOX15)

CATY:

105583615(ALOX15)

PANU:

101014249(ALOX15) 101016522

TGE:	112609437(ALOX15) 112610174

MLEU:

105539984(ALOX15)

RRO:	104677212(ALOX15)

RBB:	108520722(ALOX15)

TFN:	117067883(ALOX15)

CANG:

105523522(ALOX15) 105523680

CJC:	100388086(ALOX15)

SBQ:	101031385(ALOX15)

CIMI:

108306442

ANAN:

105714417(ALOX15)

CSYR:

103253284(ALOX15)

MMUR:

105879207(ALOX15) 105879210

LCAT:

123621261(ALOX15)

PCOQ:

105822846(ALOX15)

OGA:	100953458(ALOX15)

MMU:	11687(Alox15)

MCAL:

110305643

MPAH:

110332116

RNO:	81639(Alox15)

ANU:	117710957(Alox15)

ASYL:

127694664

MUN:	110542750(Alox15)

PLEU:

114693249

MORG:

121456877(Alox15)

MFOT:

126514012

AAMP:

119812940(Alox15)

NGI:	103752179(Alox15)

CCAN:

109697448(Alox15)

DORD:

105983203 105983296 105983343

DSP:	122100398 122100448 122108619

DMER:

138813171 138813172 138813280

PLOP:

125365834 125365978

NCAR:

124980592

MMMA:

107159314(Alox15)

ITI:	101973674(Alox15)

OCU:	100009114(ALOX15)

OPI:	101518498(ALOX15)

TUP:	102478167(ALOX15) 102488255

GVR:

103588408

CFA:	489458(ALOX15)

CLUD:

112647513(ALOX15)

VVP:	112924802(ALOX15)

VLG:

121500376

NPO:	129497273(ALOX15) 129497891

AML:	100479002(ALOX15)

UMR:	103660453(ALOX15)

UAH:	113271093(ALOX15)

UAR:	123792173(ALOX15)

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:	101380189(ALOX15)

EJU:

114225435

ZCA:

113908304

MLX:

117999977

NSU:	110584449 110584496

LWW:	102732006 102750374

LGF:

123604211

PUC:

125926176

HHV:

120227740

BTA:	282139(ALOX15)

BOM:	102285661(ALOX15)

BIU:

109574003

BBUB:

102397311(ALOX15)

BBIS:

104993943

CHX:

102179132

OAS:	101116587(ALOX15)

BTAX:

CSUM:

ODA:

CCAD:

MREE:

136148954(ALOX15)

OVR:

110150179

MBEZ:

129542456

SSC:	396971(ALOX15)

CFR:	102522465 116669221

CBAI:

105066404(ALOX15)

CDK:

105106001

VPC:	102544743(ALOX15)

BACU:

103006231(ALOX15)

BMUS:

118887047(ALOX15)

LVE:	103073785(ALOX15)

OOR:	101281563(ALOX15)

LALB:

132511482(ALOX15)

GMF:	115856204(ALOX15)

DDP:	132414259(ALOX15)

DLE:	111185975(ALOX15)

PCAD:

102986457(ALOX15)

PSIU:

116745707(ALOX15)

PPHC:

136137980(ALOX15)

NASI:

112394032(ALOX15)

ECB:	100072900(ALOX15)

EAI:	106844159(ALOX15)

MYB:

102240358

MYD:	102765226 102769401

MMYO:

118672418(ALOX15)

MLF:	102421516 102421821 102427209 102427827 102433865 106694362

MDT:	132218115(ALOX15)

MYUM:

138993692 138994085 138994127 138994149 138994311 138994406

PKL:	118726749 118726750 118726751

EFUS:

103299846(ALOX15) 129147367

MNA:	107528023(ALOX15)

DRO:	112308861(ALOX15)

SHON:

119001049(ALOX15)

AJM:	119043192(ALOX15)

PDIC:

114515339(ALOX15)

PHAS:

123809317(ALOX15)

MMF:	118634572(ALOX15)

PPAM:

129072206(ALOX15)

HAI:	109394595(ALOX15)

RFQ:	117013821(ALOX15)

PALE:

102896986(ALOX15)

PGIG:

120607865(ALOX15)

PVP:	105291746(ALOX15)

RAY:	107509499(ALOX15)

MJV:	108386766(ALOX15)

TOD:

119232067

SARA:

101547759(ALOX15)

SFUM:

130024404

SETR:

126011015

LAV:	100660599 104845446

TMU:

101359454

ETF:	101649462 101654335

DNM:

101445760

MDO:	100015976(ALOX15)

GAS:

PCW:

TVP:

PBRV:

MLAO:

Reference

PMID:12432923

Authors

Kuhn H, Walther M, Kuban RJ

Title

Mammalian arachidonate 15-lipoxygenases structure, function, and biological implications.

Journal

Prostaglandins Other Lipid Mediat 68-69:263-90 (2002)
DOI:10.1016/S0090-6980(02)00035-7

Reference

PMID:3202857

Authors

Sigal E, Craik CS, Highland E, Grunberger D, Costello LL, Dixon RA, Nadel JA

Title

Molecular cloning and primary structure of human 15-lipoxygenase.

Journal

Biochem Biophys Res Commun 157:457-64 (1988)
DOI:10.1016/S0006-291X(88)80271-7

Sequence

[hsa:246]

LinkDB

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