KEGG ORTHOLOGY: K05071

ORTHOLOGY: K05071

Entry

K05071                      KO

Symbol

IL4R, CD124

Name

interleukin 4 receptor

Pathway

map04060

Cytokine-cytokine receptor interaction

map04151

PI3K-Akt signaling pathway

map04630

JAK-STAT signaling pathway

map04640

Hematopoietic cell lineage

map04658

Th1 and Th2 cell differentiation

map04659

Th17 cell differentiation

map05200

Pathways in cancer

map05321

Inflammatory bowel disease

Disease

H00079

Asthma

H01563

HIV infection

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05071  IL4R, CD124; interleukin 4 receptor
   04151 PI3K-Akt signaling pathway
    K05071  IL4R, CD124; interleukin 4 receptor
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05071  IL4R, CD124; interleukin 4 receptor
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K05071  IL4R, CD124; interleukin 4 receptor
   04658 Th1 and Th2 cell differentiation
    K05071  IL4R, CD124; interleukin 4 receptor
   04659 Th17 cell differentiation
    K05071  IL4R, CD124; interleukin 4 receptor
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05071  IL4R, CD124; interleukin 4 receptor
  09163 Immune disease
   05321 Inflammatory bowel disease
    K05071  IL4R, CD124; interleukin 4 receptor
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors
    K05071  IL4R, CD124; interleukin 4 receptor
   04090 CD molecules
    K05071  IL4R, CD124; interleukin 4 receptor
Cytokine receptors [BR:ko04050]
Interleukin receptor families
  IL2 receptor family
   K05071  IL4R, CD124; interleukin 4 receptor
CD molecules [BR:ko04090]
Proteins
  K05071  CD124, IL4R; interleukin 4 receptor

Other DBs

GO:

0004913

Genes

HSA:	3566(IL4R)

PTR:	454005(IL4R)

PPS:	100969808(IL4R)

GGO:	101124934(IL4R)

PON:	100449812(IL4R)

PPYG:

129015082(IL4R)

NLE:	100606206(IL4R)

HMH:	116471167(IL4R)

SSYN:

129457483(IL4R)

MCC:	705404(IL4R)

MCF:	102133649(IL4R)

MTHB:

126944434

MNI:	105463220(IL4R)

CSAB:

103230069(IL4R)

CATY:

105598447(IL4R)

PANU:

101022672(IL4R)

TGE:	112614423(IL4R)

MLEU:

105541484(IL4R)

RRO:	104665638(IL4R)

RBB:	108538856(IL4R)

TFN:	117087558(IL4R)

PTEH:

111526911(IL4R)

CANG:

105505602(IL4R)

CJC:	100412639(IL4R)

SBQ:	101044733(IL4R)

CIMI:

108308561(IL4R)

ANAN:

105725533(IL4R)

CSYR:

103269365(IL4R)

MMUR:

105879693(IL4R)

LCAT:

123632505(IL4R)

PCOQ:

105810941(IL4R)

OGA:	100949360(IL4R)

MMU:	16190(Il4ra)

MCAL:

110299093(Il4r)

MPAH:

110322992(Il4r)

RNO:	25084(Il4r)

MCOC:

116102932(Il4r)

ANU:	117721253(Il4r)

ASYL:

127696784(Il4r)

MUN:	110564641(Il4r)

CGE:	100762840(Il4r)

MAUA:

101844429(Il4r)

PROB:

127228311(Il4r)

PLEU:

114692223(Il4r)

MORG:

121457943(Il4r)

MFOT:

126502313

AAMP:

119814441(Il4r)

NGI:	103741011(Il4r)

HGL:	101704138(Il4r)

CPOC:

100721566(Il4r)

CCAN:

109698033(Il4r)

DORD:

105981826(Il4r)

DSP:	122096205(Il4r)

PLOP:

125341213(Il4r)

NCAR:

124970111

MMMA:

107146879(Il4r)

ITI:	101959615(Il4r)

OCU:

100337721

OPI:	101530616(IL4R)

TUP:	102469844(IL4R)

GVR:	103585606(IL4R)

CFA:	489957(IL4R)

CLUD:

112640010(IL4R)

VVP:	112929179(IL4R)

VLG:	121487679(IL4R)

NPO:	129519937(IL4R)

AML:	100476095(IL4R)

UMR:	103657902(IL4R)

UAH:	113267608(IL4R)

UAR:	123778065(IL4R)

ELK:

111162191

LLV:

125090748

MPUF:

101671915(IL4R)

MNP:	132026795(IL4R)

MLK:	131819330(IL4R)

NVS:	122895383(IL4R)

ORO:	101373228(IL4R)

EJU:	114214562(IL4R)

ZCA:	113932298(IL4R)

MLX:	117999673(IL4R)

NSU:	110589743 123323761

LWW:	102741941(IL4R)

FCA:	101096277(IL4R)

PYU:	121022503(IL4R)

PCOO:

112856560(IL4R)

PBG:	122471527(IL4R)

PVIV:

125154127(IL4R)

LRUF:

124517909

LGF:	123588725(IL4R)

AJU:

106966182

PTG:	102949893(IL4R)

PPAD:

109256524(IL4R)

PUC:

125927986

PLEZ:

122209405(IL4R)

HHV:	120249049(IL4R)

BTA:	404154(IL4R)

BOM:	102273764(IL4R)

BIU:	109578521(IL4R)

BBUB:

102394204(IL4R)

BBIS:

104986596(IL4R)

CHX:	102176382(IL4R)

OAS:	101109063(IL4R)

BTAX:

128063317(IL4R)

CSUM:

138075296(IL4R)

ODA:	120876403(IL4R)

CCAD:

122432797(IL4R)

MREE:

136160625(IL4R)

OVR:	110146861(IL4R)

MBEZ:

129545473(IL4R)

SSC:	397614(IL4R)

CFR:	102504937(IL4R)

CBAI:

105073657(IL4R)

CDK:	105098257(IL4R)

VPC:	102529915(IL4R)

BACU:

103017383(IL4R)

BMUS:

118881909(IL4R)

LVE:	103085500(IL4R)

OOR:	101281237(IL4R)

LALB:

132504734(IL4R)

GMF:	115861126(IL4R)

DDP:	132438095(IL4R)

DLE:	111182213(IL4R)

PCAD:

102979109(IL4R)

PSIU:

116740907(IL4R)

PPHC:

136134904(IL4R)

NASI:

112399331(IL4R)

ECB:	791252(IL4R)

EPZ:	103556347(IL4R)

EAI:	106829083(IL4R)

MYB:

102243995

MYD:	102752440(IL4R)

MMYO:

118652869 118656213

MLF:	102423070 102436222(IL4R)

MDT:	132232694 132232825

MYUM:

139009252 139009366

PKL:	118731638(IL4R) 118731640

EFUS:

114226821 114228405

MNA:	107539670 107544754

DRO:	112304724 112304842(IL4R)

SHON:

119001758(IL4R)

AJM:

119055092

PDIC:

114512581 114512758(IL4R)

PHAS:

123825528 123825621

MMF:	118641533 118641654

PPAM:

129077993 129078096(IL4R)

HAI:	109385965(IL4R)

RFQ:	117019653(IL4R)

PALE:

102882815(IL4R)

PGIG:

120620155

PVP:	105303367(IL4R)

RAY:	107506151(IL4R)

MJV:	108405149(IL4R)

TOD:	119241806(IL4R)

SARA:

101557640(IL4R)

SFUM:

130046015(IL4R)

SETR:

126029520(IL4R)

LAV:	100654822(IL4R)

TMU:

101351007

ETF:	101647853(IL4R)

DNM:	101433800(IL4R)

MDO:	103092514(IL4R)

GAS:	123230876(IL4R)

SHR:	100922104(IL4R)

AFZ:

127555713

PCW:	110221658(IL4R)

TVP:	118831067(IL4R)

PBRV:

138143010(IL4R)

OAA:	103164911(IL4R)

TACU:

119942660(IL4R)

GGA:	416585(IL4R)

PCOC:

116237644(IL4R)

MGP:	100541265(IL4R)

CJO:	107320714(IL4R)

TPAI:

128078971(IL4R)

LMUT:

125700790(IL4R)

NMEL:

110405596(IL4R)

APLA:

101796552(IL4R)

ACYG:

106046042(IL4R)

CATA:

118256371(IL4R)

AFUL:

116495214(IL4R)

TGU:	100220266(IL4R)

LSR:	110477758(IL4R)

SCAN:

103817792(IL4R)

PMOA:

120513203(IL4R)

OTC:	121334371(IL4R)

PRUF:

121365870(IL4R)

ATRC:

139598388(IL4R)

GFR:	102032458(IL4R)

FAB:	101812385(IL4R)

OMA:	130259085(IL4R)

PHI:	102114232(IL4R)

PMAJ:

107211179(IL4R)

CCAE:

111936216(IL4R)

CCW:	104684903(IL4R)

CBRC:

103615643(IL4R)

ACOE:

138118599(IL4R)

ETL:	114061435(IL4R)

ZAB:	102060769(IL4R)

ZLE:	135454390(IL4R)

SVG:	106859294(IL4R)

MMEA:

130576470(IL4R)

HRT:	120759771(IL4R)

SATI:

136368049(IL4R)

CCIC:

134050462(IL4R)

FPG:	101913747(IL4R)

FCH:	102059925(IL4R)

CCRI:

104169551(IL4R)

SHAB:

115606227(IL4R)

ACUN:

113485935(IL4R)

TALA:

104357582(IL4R)

ACHC:

115335706(IL4R)

HALD:

104312245(IL4R)

HLE:	104833672(IL4R)

AGEN:

126033980

HHAR:

128134781(IL4R)

GCL:

127022205

CSTI:

104555249(IL4R)

LDI:	104345870(IL4R)

MNB:	103773919(IL4R)

DPUB:

104299384(IL4R)

PPUS:

135180991(IL4R)

AVIT:

104269030

BRHI:

104501126(IL4R)

EGZ:	104131347(IL4R)

NNI:	104015288(IL4R)

PCRI:

104026312(IL4R)

PCAO:

104045250(IL4R)

PADL:

103913920(IL4R)

AFOR:

103904948(IL4R)

FGA:	104083358(IL4R)

GSTE:

104256893(IL4R)

CBOY:

140659155(IL4R)

CLV:	102092650(IL4R)

CNIC:

135994484(IL4R)

MUI:

104542256

EHS:

104513840

CMAC:

104487479(IL4R)

CUCA:

104065050(IL4R)

TEO:	104382801(IL4R)

BREG:

104634546(IL4R)

OHA:	104336158(IL4R)

ACAR:

104527892(IL4R)

CPEA:

104393117(IL4R)

CVF:	104295523(IL4R)

RTD:	128914370(IL4R)

CRID:

134519897(IL4R)

LMIC:

141747196(IL4R)

AAM:	106486134(IL4R)

AROW:

112975584(IL4R)

NPD:	112959972(IL4R)

DNE:	112991421(IL4R)

SCAM:

104139027(IL4R)

ASN:

102384900

AMJ:	102563749(IL4R)

CPOO:

109314783(IL4R)

GGN:	109294441(IL4R)

PSS:	102459395(IL4R)

CMY:	102929479(IL4R)

CCAY:

125643571(IL4R)

DCC:	119862472(IL4R)

CPIC:

101942260(IL4R)

TST:	117883843(IL4R)

CABI:

116830029(IL4R)

MRV:	120373339(IL4R)

ACS:	103281083(il4r)

PVT:

110085007

SUND:

121937531(IL4R)

PBI:	103065038(IL4R)

TSR:	106546610(IL4R)

VKO:	123034817(IL4R)

PMUA:

114584165(IL4R)

STOW:

125431399(IL4R)

XLA:	108701563 108703132

XTR:	101732450(il4r) 105948365

DTC:	141058966(IL4R)

DRE:	563674(il4r.2)

SRX:

107745579

SANH:

107674679 107703316

SGH:	107564686 107564689 107568934

CCAR:

109051533 109051538 109054693 109056524

CAUA:

113049822 113071524 113071526

CGIB:

127952417

PTET:

122341808

LROH:

127162800 127162801

OMC:	131536802 131536804

PPRM:

120489955

RKG:	130071024 130071037

MAMB:

125270093 125270099 125270120

CIDE:

CERY:

MASI:

TROS:

TDW:

MANU:

PDAB:

IPU:	108257347(il4r.2) 108280483

IFU:	128600595 128624072

PHYP:

113535949(il4r) 113546473

SMEO:

124376065 124376066(il4r.2) 124403472

TFD:	113649521 113650130 125138438 125140128 125140129

TVC:	132844080 132863913(il4r.1)

NGRA:

132900805

AMEX:

111195543

CMAO:

118805754

EEE:	113575903(il4r)

NCC:

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

134863069(il4r.1)

ELY:	117266966 117270543

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:	120833032 120833038

PPUG:

119228436

AFB:	129105025 129105526

CLUM:

PSWI:

CANA:

CVE:

MSAM:

SCHU:

CUD:	121505290 121505481 121505482 121509929

SPUL:

LMIX:

ALAT:

ASTR:

MZE:	101486062 101486355

ONL:	100705710 102081220

OAU:	116313256 116313258

OLA:	101171817 111947159

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

GMU:

NWH:

AOCE:

EJA:

BFRE:

CSEM:

POV:

SSEN:

SSOE:

HHIP:

PPLT:

SMAU:

LCF:

SDU:

XGL:

BPEC:

SJO:

SSCO:

SASA:

100195064(il4ra) 106601108

STRU:

115171176 115171180

OTW:	112226040 112246014

OMY:	100136646(il21r) 100653445(il4r2) 110538260 118936372

OGO:	123999645 124015141

ONE:	115104187 115110328 115110330

OKI:	109892250 109893380

OKE:

118365308

OMM:	135554097 135555660 135555661

OCLA:

139364732 139421222 139421223

SALP:

111979922

SNH:	120034230 120036493 120036576

SFON:

129830324 129830357 129833072 129833074

CCLU:

121550662 121550740

ELS:	105013235 114840419

SFM:

108932964

PKI:	111846440(il4r)

AANG:

AROT:

LOC:

PSPA:

ARUT:

Reference

PMID:2307934

Authors

Idzerda RL, March CJ, Mosley B, Lyman SD, Vanden Bos T, Gimpel SD, Din WS, Grabstein KH, Widmer MB, Park LS, et al.

Title

Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily.

Journal

J Exp Med 171:861-73 (1990)
DOI:10.1084/jem.171.3.861

Sequence

[hsa:3566]

Reference

PMID:8124718

Authors

Keegan AD, Nelms K, White M, Wang LM, Pierce JH, Paul WE

Title

An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth.

Journal

Cell 76:811-20 (1994)
DOI:10.1016/0092-8674(94)90356-5

LinkDB

DBGET integrated database retrieval system