KEGG   ORTHOLOGY: K21672
Entry
K21672                      KO                                     

Name
ord
Definition
2,4-diaminopentanoate dehydrogenase [EC:1.4.1.12 1.4.1.26]
Pathway
ko00310  Lysine degradation
ko00330  Arginine and proline metabolism
ko00472  D-Arginine and D-ornithine metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K21672  ord; 2,4-diaminopentanoate dehydrogenase
   00330 Arginine and proline metabolism
    K21672  ord; 2,4-diaminopentanoate dehydrogenase
  09106 Metabolism of other amino acids
   00472 D-Arginine and D-ornithine metabolism
    K21672  ord; 2,4-diaminopentanoate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.4  Acting on the CH-NH2 group of donors
   1.4.1  With NAD+ or NADP+ as acceptor
    1.4.1.12  2,4-diaminopentanoate dehydrogenase
     K21672  ord; 2,4-diaminopentanoate dehydrogenase
    1.4.1.26  2,4-diaminopentanoate dehydrogenase (NAD+)
     K21672  ord; 2,4-diaminopentanoate dehydrogenase
Other DBs
RN: R02825 R04200 R04201 R04687 R04688
GO: 0047530
Genes
CEH: CEW89_15600
EAV: EH197_05050
VCP: H9L18_06400
VHY: G7082_14535
CSQ: CSCA_0127
CACE: CACET_c17480(dapB2)
CEU: A7L45_16560
CFM: BJL90_14515
CARG: RSJ17_08675
CDRK: B9W14_17905
AMT: Amet_2367
AOE: Clos_1699
GFE: Gferi_26730
CALE: FDN13_03020
CRS: FQB35_06685
CAZO: G3A45_03845
FPLA: A4U99_15095
CDF: CD630_04420(ord)
PDC: CDIF630_00570(ord)
CDC: CD196_0399
CDL: CDR20291_0385
PDF: CD630DERM_04420(ord)
CST: CLOST_1294(ord)
DAI: Desaci_1873
VGU: HYG85_19050
VPY: HZI73_17680
ACAE: HYG86_08075
AMIJ: EQM06_12600
AMIC: Ami3637_07690
ABUT: Ami103574_00595
EUU: ADJ67_00765
TTE: TTE1234
TEX: Teth514_1477
THX: Thet_1426
TPD: Teth39_1040
TBO: Thebr_1067
TWI: Thewi_1184
TOC: Toce_1489
NTH: Nther_1166
HOR: Hore_21120
AFT: BBF96_13560
KME: H0A61_00511(ord)
SPOA: EQM13_10965
KPAR: JL105_07140
SEDZ: JYG23_00910
PFT: JBW_01651
MBJ: KQ51_00248
TBM: BK010_05560
TBZ: BK011_05600
MPHU: MPHO_01310
ARS: ADJ73_08360
PAC: PPA2276
PAK: HMPREF0675_5353
PAV: TIA2EST22_11160
PAX: TIA2EST36_11135
PAZ: TIA2EST2_11080
PAW: PAZ_c23740(dapB2)
PAD: TIIST44_04200
PCN: TIB1ST10_11600
PACC: PAC1_11610
PACH: PAGK_2185
PACN: TIA1EST1_11230
CACN: RN83_00010
PRL: BCB70_06960
CGRN: 4412665_00379
PAUS: NCTC13651_02412
PPC: HMPREF9154_0892
ARUB: J5A65_10535
ABAT: CFX1CAM_0745
TPI: TREPR_1364
SLR: L21SP2_1023
FHW: RN87_08680
FPD: CTM68_09160
FCI: I6I83_05765
SBR: SY1_03600
TME: Tmel_0905
TAF: THA_1160
THP: BG95_05265
THER: Y592_05345
FNO: Fnod_1646
FPE: Ferpe_1990
FIA: NA23_09975
OCY: OSSY52_03900(ord)
PMO: Pmob_1166
MPZ: Marpi_1533
MARN: LN42_08170
DTN: DTL3_0759
KOL: Kole_0356
KPF: IX53_10190
MPG: Theba_1251
MINF: MESINF_2284
ASAC: ATHSA_0997
AG: CAQ42978(ord)
 » show all
Reference
PMID:4684685
  Authors
Somack R, Costilow RN
  Title
2,4-diaminopentanoic acid C 4 dehydrogenase. Purification and properties of the protein.
  Journal
J Biol Chem 248:385-8 (1973)
  Sequence
Reference
  Authors
Fonknechten N, Perret A, Perchat N, Tricot S, Lechaplais C, Vallenet D, Vergne C, Zaparucha A, Le Paslier D, Weissenbach J, Salanoubat M
  Title
A conserved gene cluster rules anaerobic oxidative degradation of L-ornithine.
  Journal
J Bacteriol 191:3162-7 (2009)
DOI:10.1128/JB.01777-08
  Sequence
LinkDB

KEGG   ENZYME: 1.4.1.26
Entry
EC 1.4.1.26                 Enzyme                                 

Name
2,4-diaminopentanoate dehydrogenase (NAD+);
DAPDH (ambiguous)
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(2R,4S)-2,4-diaminopentanoate:NADP+ oxidoreductase (deaminating)
Reaction(IUBMB)
(2R,4S)-2,4-diaminopentanoate + H2O + NAD+ = (2R)-2-amino-4-oxopentanoate + NH3 + NADH + H+ [RN:R04200]
Reaction(KEGG)
R04200
Substrate
(2R,4S)-2,4-diaminopentanoate [CPD:C03943];
H2O [CPD:C00001];
NAD+ [CPD:C00003]
Product
(2R)-2-amino-4-oxopentanoate [CPD:C03341];
NH3 [CPD:C00014];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from an unknown bacterium in an environmental sample, has some activity with (2R,4R)-2,4-diaminopentanoate. It has very low activity with NADP+ (cf. EC 1.4.1.12, 2,4-diaminopentanoate dehydrogenase).
History
EC 1.4.1.26 created 2017
Pathway
ec00472  D-Arginine and D-ornithine metabolism
ec01100  Metabolic pathways
Orthology
K21672  2,4-diaminopentanoate dehydrogenase
Genes
CEH: CEW89_15600
EAV: EH197_05050
VCP: H9L18_06400
VHY: G7082_14535
CSQ: CSCA_0127
CACE: CACET_c17480(dapB2)
CEU: A7L45_16560
CFM: BJL90_14515
CARG: RSJ17_08675
CDRK: B9W14_17905
AMT: Amet_2367
AOE: Clos_1699
GFE: Gferi_26730
CALE: FDN13_03020
CRS: FQB35_06685
CAZO: G3A45_03845
FPLA: A4U99_15095
CDF: CD630_04420(ord)
PDC: CDIF630_00570(ord)
CDC: CD196_0399
CDL: CDR20291_0385
PDF: CD630DERM_04420(ord)
CST: CLOST_1294(ord)
DAI: Desaci_1873
VGU: HYG85_19050
VPY: HZI73_17680
ACAE: HYG86_08075
AMIJ: EQM06_12600
AMIC: Ami3637_07690
ABUT: Ami103574_00595
EUU: ADJ67_00765
TTE: TTE1234
TEX: Teth514_1477
THX: Thet_1426
TPD: Teth39_1040
TBO: Thebr_1067
TWI: Thewi_1184
TOC: Toce_1489
NTH: Nther_1166
HOR: Hore_21120
AFT: BBF96_13560
KME: H0A61_00511(ord)
SPOA: EQM13_10965
KPAR: JL105_07140
SEDZ: JYG23_00910
PFT: JBW_01651
MBJ: KQ51_00248
TBM: BK010_05560
TBZ: BK011_05600
MPHU: MPHO_01310
ARS: ADJ73_08360
PAC: PPA2276
PAK: HMPREF0675_5353
PAV: TIA2EST22_11160
PAX: TIA2EST36_11135
PAZ: TIA2EST2_11080
PAW: PAZ_c23740(dapB2)
PAD: TIIST44_04200
PCN: TIB1ST10_11600
PACC: PAC1_11610
PACH: PAGK_2185
PACN: TIA1EST1_11230
CACN: RN83_00010
PRL: BCB70_06960
CGRN: 4412665_00379
PAUS: NCTC13651_02412
PPC: HMPREF9154_0892
ARUB: J5A65_10535
ABAT: CFX1CAM_0745
TPI: TREPR_1364
SLR: L21SP2_1023
FHW: RN87_08680
FPD: CTM68_09160
FCI: I6I83_05765
SBR: SY1_03600
TME: Tmel_0905
TAF: THA_1160
THP: BG95_05265
THER: Y592_05345
FNO: Fnod_1646
FPE: Ferpe_1990
FIA: NA23_09975
OCY: OSSY52_03900(ord)
PMO: Pmob_1166
MPZ: Marpi_1533
MARN: LN42_08170
DTN: DTL3_0759
KOL: Kole_0356
KPF: IX53_10190
MPG: Theba_1251
MINF: MESINF_2284
ASAC: ATHSA_0997
 » show all
Reference
1  [PMID:19251850]
  Authors
Fonknechten N, Perret A, Perchat N, Tricot S, Lechaplais C, Vallenet D, Vergne C, Zaparucha A, Le Paslier D, Weissenbach J, Salanoubat M
  Title
A conserved gene cluster rules anaerobic oxidative degradation of L-ornithine.
  Journal
J Bacteriol 191:3162-7 (2009)
DOI:10.1128/JB.01777-08
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.4.1.26
IUBMB Enzyme Nomenclature: 1.4.1.26
ExPASy - ENZYME nomenclature database: 1.4.1.26
BRENDA, the Enzyme Database: 1.4.1.26
LinkDB

KEGG   REACTION: R04200
Entry
R04200                      Reaction                               

Name
D-threo-2,4-diaminopentanoate:NAD+ oxidoreductase (deaminating)
Definition
(2R,4S)-2,4-Diaminopentanoate + H2O + NAD+ <=> 2-Amino-4-oxopentanoic acid + Ammonia + NADH + H+
Equation
Comment
R04201 (NADP)
Reaction class
RC00001  C00003_C00004
RC00249  C03341_C03943
Enzyme
1.4.1.12        1.4.1.26
Pathway
rn00472  D-Arginine and D-ornithine metabolism
rn01100  Metabolic pathways
Orthology
K21672  2,4-diaminopentanoate dehydrogenase [EC:1.4.1.12 1.4.1.26]
Other DBs
RHEA: 24199
LinkDB

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