KEGG   ORTHOLOGY: K21672
Entry
K21672                      KO                                     
Symbol
ord
Name
2,4-diaminopentanoate dehydrogenase [EC:1.4.1.12 1.4.1.26]
Pathway
map00310  Lysine degradation
map00330  Arginine and proline metabolism
map00470  D-Amino acid metabolism
map01100  Metabolic pathways
Reaction
R02825  
R04200  D-threo-2,4-diaminopentanoate:NAD+ oxidoreductase (deaminating)
R04201  D-threo-2,4-diaminopentanoate:NADP+ oxidoreductase(deaminating)
R04687  2,5-diaminohexanoate:NAD+ oxidoreductase (deaminating)
R04688  2,5-diaminohexanoate:NADP+ oxidoreductase (deaminating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K21672  ord; 2,4-diaminopentanoate dehydrogenase
   00330 Arginine and proline metabolism
    K21672  ord; 2,4-diaminopentanoate dehydrogenase
  09106 Metabolism of other amino acids
   00470 D-Amino acid metabolism
    K21672  ord; 2,4-diaminopentanoate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.4  Acting on the CH-NH2 group of donors
   1.4.1  With NAD+ or NADP+ as acceptor
    1.4.1.12  2,4-diaminopentanoate dehydrogenase
     K21672  ord; 2,4-diaminopentanoate dehydrogenase
    1.4.1.26  2,4-diaminopentanoate dehydrogenase (NAD+)
     K21672  ord; 2,4-diaminopentanoate dehydrogenase
Other DBs
GO: 0047530
Genes
MECH: Q9L42_012450(ord)
MLAU: ACEPPP_07645(ord)
CEH: CEW89_15600
PBAE: P8S53_16565
TPI: TREPR_1364
SLR: L21SP2_1023
MSIL: METEAL_10850(ord)
EAV: EH197_05050
VCP: H9L18_06400
VHY: G7082_14535
FCT: NRE15_11415(ord)
CSQ: CSCA_0127
CACE: CACET_c17480(dapB2)
CEU: A7L45_16560
CFM: BJL90_14515
CARG: RSJ17_08675
CDRK: B9W14_17905
CTAG: LL095_13645 LL095_13650
CLOO: RCG18_00055(ord)
CALE: FDN13_03020
CALD: PWK10_08625
CRS: FQB35_06685
CPRF: K7H06_09005
CRAS: KVH43_11400
OCW: OW730_12710(ord)
PROQ: P6M73_15860(ord)
FPLA: A4U99_15095
PETR: QKW49_11305(ord)
DAI: Desaci_1873
AACX: DEACI_0846
ACAE: HYG86_08075
PROM: QO263_13855(ord)
VGU: HYG85_19050
VPY: HZI73_17680
AMIJ: EQM06_12600
AMIC: Ami3637_07690
ABUT: Ami103574_00595
ETM: CE91St48_39740(ord)
EMJ: V1225_02265(ord)
AHAD: FRZ06_16205
EUU: ADJ67_00765
AMT: Amet_2367
AOE: Clos_1699
GFE: Gferi_26730
CSPO: QNI18_08925(ord)
CDF: CD630_04420(ord)
PDC: CDIF630_00570(ord)
CDC: CD196_0399
CDL: CDR20291_0385
PDF: CD630DERM_04420(ord)
RHOM: FRIFI_0794
TEM: JW646_03950
TGC: L0P85_04325(ord)
TMY: TEMA_40290(ord)
TPET: TPHSE_10690(ord)
TEB: T8CH_0873(ord)
THYR: P4S50_12705(ord)
CST: CLOST_1294(ord)
TTE: TTE1234
TEX: Teth514_1477
THX: Thet_1426
TPD: Teth39_1040
TBO: Thebr_1067
TWI: Thewi_1184
THEZ: OEI98_001235(ord)
TOC: Toce_1489
NTH: Nther_1166
NCD: ACONDI_00602(ord)
HOR: Hore_21120
AFT: BBF96_13560
KME: H0A61_00511(ord)
HPRF: HLPR_14390(ord)
SPOA: EQM13_10965
KPAR: JL105_07140
CAZO: G3A45_03845
TIZ: RBU61_10280(ord)
SEDZ: JYG23_00910
SEDM: RBQ61_08925(ord)
PFT: JBW_01651
SSID: SPSIL_044650(ord)
SACV: SPACI_032180(ord)
FCZ: IMF26_05985
MANR: MPAN_008560(ord)
XCL: G4Z02_05170
TBK: HF295_00050
MBJ: KQ51_00248
TBM: BK010_05560
TBZ: BK011_05600
MYW: BVC93_16515
ARS: ADJ73_08360
PAC: PPA2276
PAK: HMPREF0675_5353
PAV: TIA2EST22_11160
PAX: TIA2EST36_11135
PAZ: TIA2EST2_11080
PAW: PAZ_c23740(dapB2)
PAD: TIIST44_04200
PCN: TIB1ST10_11600
PACC: PAC1_11610
PACH: PAGK_2185
PACN: TIA1EST1_11230
CACN: RN83_00010
PRL: BCB70_06960
CGRN: 4412665_00379
CEQU: O6R08_10890(ord)
PAUS: NCTC13651_02412
PPC: HMPREF9154_0892
ARUB: J5A65_10535
PROP: QQ658_14535(ord)
ABAT: CFX1CAM_0745
SBR: SY1_03600
TME: Tmel_0905
TAF: THA_1160
THP: BG95_05265
THER: Y592_05345
TFE: JYK00_04200
FNO: Fnod_1646
FPE: Ferpe_1990
FIA: NA23_09975(ord)
FRR: IB67_00430
FNG: JM64_07205
FGW: QO060_00435(ord)
FTHL: U0O82_03735(ord)
OCY: OSSY52_03900(ord)
PMO: Pmob_1166
MPZ: Marpi_1533
MARN: LN42_08170
MAEO: JRV97_04095
DTN: DTL3_0759
OCS: OF820_08020(ord)
KOL: Kole_0356
KPF: IX53_10190
MPG: Theba_1251
MINF: MESINF_2284
ASAC: ATHSA_0997
FHW: RN87_08680
FPD: CTM68_09160
FCI: I6I83_05765
AG: CAQ42978(ord)
 » show all
Reference
PMID:4684685
  Authors
Somack R, Costilow RN
  Title
2,4-diaminopentanoic acid C 4 dehydrogenase. Purification and properties of the protein.
  Journal
J Biol Chem 248:385-8 (1973)
  Sequence
[cst:CLOST_1294]
Reference
PMID:19251850
  Authors
Fonknechten N, Perret A, Perchat N, Tricot S, Lechaplais C, Vallenet D, Vergne C, Zaparucha A, Le Paslier D, Weissenbach J, Salanoubat M
  Title
A conserved gene cluster rules anaerobic oxidative degradation of L-ornithine.
  Journal
J Bacteriol 191:3162-7 (2009)
DOI:10.1128/JB.01777-08
  Sequence
[ag:CAQ42978]
LinkDB

KEGG   ENZYME: 1.4.1.26
Entry
EC 1.4.1.26                 Enzyme                                 
Name
2,4-diaminopentanoate dehydrogenase (NAD+);
DAPDH (ambiguous)
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(2R,4S)-2,4-diaminopentanoate:NADP+ oxidoreductase (deaminating)
Reaction(IUBMB)
(2R,4S)-2,4-diaminopentanoate + H2O + NAD+ = (2R)-2-amino-4-oxopentanoate + NH3 + NADH + H+ [RN:R04200]
Reaction(KEGG)
R04200
Substrate
(2R,4S)-2,4-diaminopentanoate [CPD:C03943];
H2O [CPD:C00001];
NAD+ [CPD:C00003]
Product
(2R)-2-amino-4-oxopentanoate [CPD:C03341];
NH3 [CPD:C00014];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from an unknown bacterium in an environmental sample, has some activity with (2R,4R)-2,4-diaminopentanoate. It has very low activity with NADP+ (cf. EC 1.4.1.12, 2,4-diaminopentanoate dehydrogenase).
History
EC 1.4.1.26 created 2017
Pathway
ec00470  D-Amino acid metabolism
ec01100  Metabolic pathways
Orthology
K21672  2,4-diaminopentanoate dehydrogenase
Genes
MECH: Q9L42_012450(ord)
MLAU: ACEPPP_07645(ord)
CEH: CEW89_15600
PBAE: P8S53_16565
TPI: TREPR_1364
SLR: L21SP2_1023
MSIL: METEAL_10850(ord)
EAV: EH197_05050
VCP: H9L18_06400
VHY: G7082_14535
FCT: NRE15_11415(ord)
CSQ: CSCA_0127
CACE: CACET_c17480(dapB2)
CEU: A7L45_16560
CFM: BJL90_14515
CARG: RSJ17_08675
CDRK: B9W14_17905
CTAG: LL095_13645 LL095_13650
CLOO: RCG18_00055(ord)
CALE: FDN13_03020
CALD: PWK10_08625
CRS: FQB35_06685
CPRF: K7H06_09005
CRAS: KVH43_11400
OCW: OW730_12710(ord)
PROQ: P6M73_15860(ord)
FPLA: A4U99_15095
PETR: QKW49_11305(ord)
DAI: Desaci_1873
AACX: DEACI_0846
ACAE: HYG86_08075
PROM: QO263_13855(ord)
VGU: HYG85_19050
VPY: HZI73_17680
AMIJ: EQM06_12600
AMIC: Ami3637_07690
ABUT: Ami103574_00595
ETM: CE91St48_39740(ord)
EMJ: V1225_02265(ord)
AHAD: FRZ06_16205
EUU: ADJ67_00765
AMT: Amet_2367
AOE: Clos_1699
GFE: Gferi_26730
CSPO: QNI18_08925(ord)
CDF: CD630_04420(ord)
PDC: CDIF630_00570(ord)
CDC: CD196_0399
CDL: CDR20291_0385
PDF: CD630DERM_04420(ord)
RHOM: FRIFI_0794
TEM: JW646_03950
TGC: L0P85_04325(ord)
TMY: TEMA_40290(ord)
TPET: TPHSE_10690(ord)
TEB: T8CH_0873(ord)
THYR: P4S50_12705(ord)
CST: CLOST_1294(ord)
TTE: TTE1234
TEX: Teth514_1477
THX: Thet_1426
TPD: Teth39_1040
TBO: Thebr_1067
TWI: Thewi_1184
THEZ: OEI98_001235(ord)
TOC: Toce_1489
NTH: Nther_1166
NCD: ACONDI_00602(ord)
HOR: Hore_21120
AFT: BBF96_13560
KME: H0A61_00511(ord)
HPRF: HLPR_14390(ord)
SPOA: EQM13_10965
KPAR: JL105_07140
CAZO: G3A45_03845
TIZ: RBU61_10280(ord)
SEDZ: JYG23_00910
SEDM: RBQ61_08925(ord)
PFT: JBW_01651
SSID: SPSIL_044650(ord)
SACV: SPACI_032180(ord)
FCZ: IMF26_05985
MANR: MPAN_008560(ord)
XCL: G4Z02_05170
TBK: HF295_00050
MBJ: KQ51_00248
TBM: BK010_05560
TBZ: BK011_05600
MYW: BVC93_16515
ARS: ADJ73_08360
PAC: PPA2276
PAK: HMPREF0675_5353
PAV: TIA2EST22_11160
PAX: TIA2EST36_11135
PAZ: TIA2EST2_11080
PAW: PAZ_c23740(dapB2)
PAD: TIIST44_04200
PCN: TIB1ST10_11600
PACC: PAC1_11610
PACH: PAGK_2185
PACN: TIA1EST1_11230
CACN: RN83_00010
PRL: BCB70_06960
CGRN: 4412665_00379
CEQU: O6R08_10890(ord)
PAUS: NCTC13651_02412
PPC: HMPREF9154_0892
ARUB: J5A65_10535
PROP: QQ658_14535(ord)
ABAT: CFX1CAM_0745
SBR: SY1_03600
TME: Tmel_0905
TAF: THA_1160
THP: BG95_05265
THER: Y592_05345
TFE: JYK00_04200
FNO: Fnod_1646
FPE: Ferpe_1990
FIA: NA23_09975(ord)
FRR: IB67_00430
FNG: JM64_07205
FGW: QO060_00435(ord)
FTHL: U0O82_03735(ord)
OCY: OSSY52_03900(ord)
PMO: Pmob_1166
MPZ: Marpi_1533
MARN: LN42_08170
MAEO: JRV97_04095
DTN: DTL3_0759
OCS: OF820_08020(ord)
KOL: Kole_0356
KPF: IX53_10190
MPG: Theba_1251
MINF: MESINF_2284
ASAC: ATHSA_0997
FHW: RN87_08680
FPD: CTM68_09160
FCI: I6I83_05765
 » show all
Reference
1  [PMID:19251850]
  Authors
Fonknechten N, Perret A, Perchat N, Tricot S, Lechaplais C, Vallenet D, Vergne C, Zaparucha A, Le Paslier D, Weissenbach J, Salanoubat M
  Title
A conserved gene cluster rules anaerobic oxidative degradation of L-ornithine.
  Journal
J Bacteriol 191:3162-7 (2009)
DOI:10.1128/JB.01777-08
  Sequence
[ag:CAQ42978]
Other DBs
ExplorEnz - The Enzyme Database: 1.4.1.26
IUBMB Enzyme Nomenclature: 1.4.1.26
ExPASy - ENZYME nomenclature database: 1.4.1.26
BRENDA, the Enzyme Database: 1.4.1.26
LinkDB

KEGG   REACTION: R04200
Entry
R04200                      Reaction                               
Name
D-threo-2,4-diaminopentanoate:NAD+ oxidoreductase (deaminating)
Definition
(2R,4S)-2,4-Diaminopentanoate + H2O + NAD+ <=> 2-Amino-4-oxopentanoic acid + Ammonia + NADH + H+
Equation
C03943 + C00001 + C00003 <=> C03341 + C00014 + C00004 + C00080
Comment
R04201 (NADP)
Reaction class
RC00001  C00003_C00004
RC00249  C03341_C03943
Enzyme
1.4.1.12        1.4.1.26
Pathway
rn00470  D-Amino acid metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.4  Acting on the CH-NH2 group of donors
   1.4.1  With NAD+ or NADP+ as acceptor
    1.4.1.12
     R04200  (2R,4S)-2,4-Diaminopentanoate + H2O + NAD+ <=> 2-Amino-4-oxopentanoic acid + Ammonia + NADH + H+
    1.4.1.26
     R04200  (2R,4S)-2,4-Diaminopentanoate + H2O + NAD+ <=> 2-Amino-4-oxopentanoic acid + Ammonia + NADH + H+
Orthology
K21672  2,4-diaminopentanoate dehydrogenase [EC:1.4.1.12 1.4.1.26]
Other DBs
RHEA: 24199
LinkDB

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