KEGG   ORTHOLOGY: K22699
Entry
K22699                      KO                                     
Symbol
thi4
Name
sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59]
Pathway
map00730  Thiamine metabolism
map01100  Metabolic pathways
map01240  Biosynthesis of cofactors
Module
M00896  Thiamine biosynthesis, archaea, AIR (+ NAD+) => TMP/TPP
Reaction
R12026  NAD+:glycine ADP-D-ribosyltransferase (sulfide-adding)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00730 Thiamine metabolism
    K22699  thi4; sulfide-dependent adenosine diphosphate thiazole synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.2  Pentosyltransferases
    2.4.2.59  sulfide-dependent adenosine diphosphate thiazole synthase
     K22699  thi4; sulfide-dependent adenosine diphosphate thiazole synthase
Other DBs
COG: COG1635
Genes
BBAR: RHAL1_03078
CAUL: KCG34_24290
MALU: KU6B_16750
HMR: Hipma_0421
DAV: DESACE_08810
DMA: DMR_31420
DCB: C3Y92_06440
DGG: DGI_1133
DMS: E8L03_06730
DAF: Desaf_0994
DOL: Dole_2426
DAL: Dalk_2394
DLI: dnl_00920(thiG)
DMM: dnm_073520(thiG)
DBR: Deba_1981
DMP: FAK_22910
CTHI: THC_0653
TACI: TDSAC_0747
PDI: BDI_1609
MBAS: ALGA_3764
PAA: Paes_1007
TTK: TST_0727(thi1)
NDE: NIDE1062
NJA: NSJP_2079
NIF: W02_33410
CSQ: CSCA_1812
DAU: Daud_0859
MBX: BCGT_0584
MPHL: MPHLCCUG_05062(ksdD_3)
TAI: Taci_1358
TLI: Tlie_1851
TMA: TM0787
TMW: THMA_0806
TMQ: THMB_0806
TMX: THMC_0806
TPT: Tpet_0142
TNP: Tnap_0143
TRQ: TRQ2_0140
TNA: CTN_1791
TLE: Tlet_1750
TME: Tmel_1590
TAF: THA_1798
THER: Y592_08765
FNO: Fnod_1422
MJA: MJ_0601
MESG: MLAUSG7_1377(thi)
MESA: MLASG1_0803(thi)
MMP: MMP1352
MMAD: MMJJ_14870
MAE: Maeo_0798
MVO: Mvol_0738
MTH: MTH_1620
MWO: MWSIV6_0166(Thi4)
MTEE: MTTB_13720
METC: MTCT_1479
METE: tca_01569
MEB: Abm4_1461
MFV: Mfer_0175
MKA: MK0430
AFU: AF_0702
FPL: Ferp_0628
GAC: GACE_0145
GAH: GAH_01007
PFU: PF1530
PFI: PFC_06880
PHO: PH1357(PH1357)
PAB: PAB0536(thi1)
PYS: Py04_1231
TKO: TK0434
TGA: TGAM_1270
THE: GQS_02015
THM: CL1_0036
TLT: OCC_06556
THS: TES1_1982
TNU: BD01_0513
TEU: TEU_09505
TCQ: TIRI35C_0994(thi)
PPAC: PAP_08770
MBAR: MSBR2_2375
MBAK: MSBR3_2431
MAC: MA_2851
MMA: MM_0222
MMAC: MSMAC_2441
METM: MSMTP_1119
MTHR: MSTHT_0054
MTHE: MSTHC_0676
MHOR: MSHOH_1299
MBU: Mbur_2109
MMH: Mmah_0298
MTP: Mthe_1121
MCJ: MCON_3229
MHI: Mhar_2378
MHU: Mhun_1935
MLA: Mlab_0277
MBG: BN140_1460(thi1)
MEMA: MMAB1_1869
MPI: Mpet_0116
MAQE: RJ40_07140
MEZ: Mtc_1604(thi4-1) Mtc_2398(thi4-2)
HAL: VNG_2604G(thi1)
HSL: OE_4651F(thi4)
HHB: Hhub_1122(thi4)
SALI: L593_09560
HARA: AArcS_1966(thi4)
HMA: rrnAC1782(thi1)
HHI: HAH_2313(thi1)
NPH: NP_5174A(thi4)
NMO: Nmlp_3882(thi4)
HUT: Huta_2718
HTI: HTIA_2465
HASV: SVXHr_1858(thi4)
HABN: HBNXHr_1846(thi4)
HMU: Hmuk_0002
HALL: LC1Hm_2563(thi4)
HDS: HSR122_2321(thi4)
HWA: HQ_1276A(thi4)
HWC: Hqrw_1306(thi4)
HVO: HVO_0665(thi4)
HLN: SVXHx_0624(thi4)
HME: HFX_0634
HLA: Hlac_2980
HDF: AArcSl_1355(thi4)
HTU: Htur_1462
NMG: Nmag_2419(thi4)
NAT: NJ7G_3680
MELU: MTLP_07010
ABI: Aboo_0963
ACJ: ACAM_1344
IHO: Igni_0560
IIS: EYM_05510
IPC: IPA_05695
DKA: DKAM_0713
IAG: Igag_0295
HBU: Hbut_0253
PABI: PABY_00710
STO: STK_03610
SSO: SSO0436
SOL: Ssol_1411
SSOA: SULA_1456
SSOL: SULB_1457
SSOF: SULC_1455
SCAS: SACC_05940
SID: M164_1717
SII: LD85_1927
SIH: SiH_1645
SIR: SiRe_1566
SIC: SiL_1558
SAI: Saci_0854(thi)
MSE: Msed_2221
MEMJ: MJ1HA_2541
MCN: Mcup_0086
AHO: Ahos_0692
ACIH: HS5_20660
CSTY: KN1_20130
STEP: IC006_1529
SAHS: HS7_05390
PAI: PAE0175
PIS: Pisl_1998
PCL: Pcal_1555
PAS: Pars_1498
PYR: P186_0936
POG: Pogu_0708
TNE: Tneu_1052
CMA: Cmaq_1420
TUZ: TUZN_0079
VDI: Vdis_2373
VMO: VMUT_0723
KCR: Kcr_0795
NMR: Nmar_0678
NCT: NMSP_1025
NEV: NTE_02257
NFN: NFRAN_0414(thi)
NCV: NCAV_0396(thi)
NDV: NDEV_0758
NBV: T478_0555
CCAI: NAS2_0821
BARB: AOA66_0043
 » show all
Reference
  Authors
Eser BE, Zhang X, Chanani PK, Begley TP, Ealick SE
  Title
From Suicide Enzyme to Catalyst: The Iron-Dependent Sulfide Transfer in Methanococcus jannaschii Thiamin Thiazole Biosynthesis.
  Journal
J Am Chem Soc 138:3639-42 (2016)
DOI:10.1021/jacs.6b00445
  Sequence
[mja:MJ_0601]
Reference
  Authors
Hwang S, Cordova B, Chavarria N, Elbanna D, McHugh S, Rojas J, Pfeiffer F, Maupin-Furlow JA
  Title
Conserved active site cysteine residue of archaeal THI4 homolog is essential for thiamine biosynthesis in Haloferax volcanii.
  Journal
BMC Microbiol 14:260 (2014)
DOI:10.1186/s12866-014-0260-0
  Sequence
[hvo:HVO_0665]
LinkDB

KEGG   ENZYME: 2.4.2.59
Entry
EC 2.4.2.59                 Enzyme                                 
Name
sulfide-dependent adenosine diphosphate thiazole synthase;
Thi4 (ambiguous)
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
Sysname
NAD+:glycine ADP-D-ribosyltransferase (sulfide-adding)
Reaction(IUBMB)
NAD+ + glycine + sulfide = nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 3 H2O [RN:R12026]
Reaction(KEGG)
R12026
Substrate
NAD+ [CPD:C00003];
glycine [CPD:C00037];
sulfide [CPD:C00283]
Product
nicotinamide [CPD:C00153];
ADP-5-ethyl-4-methylthiazole-2-carboxylate [CPD:C20784];
H2O [CPD:C00001]
Comment
This iron dependent enzyme, found in most archaea, is involved in the biosynthesis of thiamine phosphate. The homologous enzyme from plants and fungi (EC 2.4.2.60, cysteine-dependent adenosine diphosphate thiazole synthase) uses an intrinsic cysteine as sulfur donor and, unlike the archaeal enzyme, is a single turn-over enzyme.
History
EC 2.4.2.59 created 2018
Pathway
ec00730  Thiamine metabolism
ec01100  Metabolic pathways
Orthology
K22699  sulfide-dependent adenosine diphosphate thiazole synthase
Genes
BBARRHAL1_03078
CAULKCG34_24290
MALUKU6B_16750
HMRHipma_0421
DAVDESACE_08810
DMADMR_31420
DCBC3Y92_06440
DGGDGI_1133
DMSE8L03_06730
DAFDesaf_0994
DSXGD604_13095
DSDGD606_19515
DLMDPPLL_35930
DOLDole_2426
DALDalk_2394
DOVDSCO28_45120
DLIdnl_00920(thiG)
DMMdnm_073520(thiG)
DAODesac_0998
DAXFDQ92_03460
DBRDeba_1981
DMPFAK_22910
TIDThein_1804
TOPTOPB45_0915
TCMHL41_01820
THETF1847_03705
CTHITHC_0653
TAVG4V39_01630
TMAIFVE67_08730
DAWHS1_000304
MZLGKS04_01765
TNRThena_0778
TACITDSAC_0747
HBSIPV69_04150
LBVJYG24_04210
VAIBU251_06310 BU251_06360
BCELBcellWH2_01838
BISDXK01_001245
PSOECE91St14_02970
PDIBDI_1609
PARCCI960_06610
PMERINE87_00229
PGOLK6V26_06880
PJOLK449_05640
PFAINXY11_05335
PMZHMPREF0659_A5800
PITPIN17_A0608
PNIJ5A59_03980
PHERprwr041_11060
PSCJJ4856_09105
PBIVQP022_05995
RBCBN938_1539
TTZFHG85_07515
MBASALGA_3764
PAAPaes_1007
PROCPtc2401_01068
PRSB9H02_06355
PROSCHL67_06345
TAMTheam_0077
DTEDester_1473
TTKTST_0727(thi1)
NDENIDE1062
NMVNITMOv2_0947
NIONITINOP_1921
NJANSJP_2079
NKFNkreftii_003088
NIFW02_33410
NTIDNFV4_01351
NALLPP769_00420
NNEOPQG83_11585
DHRLGS26_09060
CLJCLJU_c30580
CSQCSCA_1812
CDRKB9W14_10240
CFERD4Z93_11890
CLOSDMR38_15480
DKUDesku_1659
TJRTherJR_1442
DAUDaud_0859
ADGAdeg_0421 Adeg_1609
GEKkuro4_04070
MBXBCGT_0584
MPHLMPHLCCUG_05062(ksdD_3)
SLKSLUN_34370
TAITaci_1358
TLITlie_1851
AMOAnamo_0225
TMATM0787
TMMTmari_0788
TMITHEMA_00715
TMWTHMA_0806
TMQTHMB_0806
TMXTHMC_0806
TPTTpet_0142
TNPTnap_0143
TRQTRQ2_0140
TNACTN_1791
THQT2812B_00715
THZCELL2_00740
THRTRQ7_00715
TLETlet_1750
TTATheth_1374
TMETmel_1590
TAFTHA_1798
THPBG95_08660
THERY592_08765
FNOFnod_1422
FPEFerpe_0640
FIANA23_03490
FRRIB67_05365
FNGJM64_03430
FGWQO060_03070
FTHLU0O82_08735
FSHQ2T83_00155
MJAMJ_0601
MFEMefer_1385
MVUMetvu_1585
MFSMFS40622_1580
MIFMetin_1281
MJHJH146_0825
MESGMLAUSG7_1377(thi)
MESAMLASG1_0803(thi)
MIGMetig_0735 Metig_1112
MMPMMP1352
MMQMmarC5_0226
MMXMmarC6_1321
MMZMmarC7_0597
MMAKMMKA1_15750
MMAOMMOS7_14560
MMADMMJJ_14870
MAEMaeo_0798
MVNMevan_0663
MVOMvol_0738
MOKMetok_0500
METFCFE53_00030
MTHMTH_1620
MMGMTBMA_c02060
MWOMWSIV6_0166(Thi4)
MTEEMTTB_13720
METCMTCT_1479
METEtca_01569
METZMETMT2_1460
METKFVF72_03520
MTHMFZP57_00720
METJFZP68_05735
MEBAbm4_1461
MELMetbo_0536 Metbo_1265
MEWMSWAN_0974 MSWAN_1853
METHMBMB1_1137 MBMB1_1486
MFCBRM9_0713 BRM9_1347
MFIDSM1535_0665 DSM1535_2031
MCUBMCBB_1020 MCBB_1725
MSUBBK009_06380
METNBK008_01970
METTCIT01_06780
METOCIT02_02510 CIT02_10600
MEMEHYG87_01485 HYG87_07505
MFEGGCM10025860_28950
MEERNKF70_04100 NKF70_14305
MRIDFGU46_07480
MFVMfer_0175
MKAMK0430
AFUAF_0702
AFGAFULGI_00007840
APOArcpr_1423
AVEArcve_1405
ASTAsulf_00980
FPLFerp_0628
GACGACE_0145
GAHGAH_01007
PFUPF1530
PFIPFC_06880
PHOPH1357(PH1357)
PABPAB0536(thi1)
PYNPNA2_1583 PNA2_1941
PYAPYCH_06240 PYCH_08650
PYSPy04_1231
PYCTQ32_10505
TKOTK0434
TGATGAM_1270
THEGQS_02015
THMCL1_0036
TLTOCC_06556
THSTES1_1982
TNUBD01_0513
TEUTEU_09505
TGYX802_10050
THVADU37_CDS17350 ADU37_CDS22280
TCHCHITON_1554
TPEPA0127_02260
TPIEA7C91_09070
TCEA3L02_01985
TTDA3L14_05500
TPRFA3L09_06395
TPAFA3L08_06895
THYA3L12_03095
TICFH039_06460
TCQTIRI35C_0994(thi)
THEMFPV09_02920
PPACPAP_08770
MBAMbar_A2100
MBYMSBRM_2409
MBWMSBRW_2643
MBARMSBR2_2375
MBAKMSBR3_2431
MACMA_2851
MMAMM_0222
MMAZMmTuc01_0227
MMJMSMAS_1078
MMACMSMAC_2441
MVCMSVAZ_1117
MEKMSKOL_1072
MLSMSLAZ_1169
METMMSMTP_1119
MEFMSWH1_1762
MEQMSWHS_1554
MSJMSSAC_2840
MSZMSSIH_2497
MSWMSSIT_2540
MTHRMSTHT_0054
MTHEMSTHC_0676
MHORMSHOH_1299
MFZAOB57_002245
MHABRSJ42_03320
METWAAY43_07280
MBUMbur_2109
MMETMCMEM_0306 MCMEM_0840
MELOJ7W08_02430 J7W08_11625
MMHMmah_0298
MHAZBHR79_02030
MPOTBKM01_06375
MEVMetev_0188
MZHMzhil_1372
MZIHWN40_08730
MMAVRE476_01435
MSEBRE474_11125
MTPMthe_1121
MCJMCON_3229
MHIMhar_2378
MHUMhun_1935
MRTJKHC33_14740
MLAMlab_0277
MEMMemar_2251
MBGBN140_1460(thi1)
MEMAMMAB1_1869
MCHKMchiMG62_25690
MSUMOH143_05540
MRCR6Y96_03785
MPIMpet_0116
MENDL6E24_07545
MEFWF1737_10475
MAQERJ40_07140
MFKE2N92_07295
MOUOU421_07750
MESBL1S32_11135
MANQL1994_01520
MFOMetfor_0238
MEZMtc_1604(thi4-1) Mtc_2398(thi4-2)
MJKN2V74_02430 N2V74_03430
HALVNG_2604G(thi1)
HSLOE_4651F(thi4)
HANRLJ422_10530
HHBHhub_1122(thi4)
HAGSJT689_11965
HABOJRZ79_10305
HNOLT974_00705
HLULT972_12875
HANXABSL23_05440
HSUHLASF_0331
HSFHLASA_0330
SALRFQU85_03530
HALREFA46_011875
HJEHacjB3_12970
HDOMUK72_07875
HALXM0R89_10525
HAXZM0R88_11005
HAYCNGM10_05370
HAXYNGM07_01030
SALIL593_09560
SAIMK0C01_03160
HARAAArcS_1966(thi4)
HMArrnAC1782(thi1)
HSINKDQ40_01865
HHIHAH_2313(thi1)
HHNHISP_11780
HABSG26_04110
HTABVU17_11255
HALJG9465_07010
NPHNP_5174A(thi4)
NMONmlp_3882(thi4)
NHOHWV23_12010
NSALHWV07_14560
HUTHuta_2718
HTIHTIA_2465
HALAHrd1104_02040
HASVSVXHr_1858(thi4)
HABNHBNXHr_1846(thi4)
HMUHmuk_0002
HALZE5139_03335
HALLLC1Hm_2563(thi4)
HAZPGBQ70_03335
HALIBV210_05585
HSNDV733_09670
HDSHSR122_2321(thi4)
HRRHZS55_08655
HPELHZS54_09780
HLTI7X12_05325
HARCHARCEL1_09615
HAADMW046_08650
HWAHQ_1276A(thi4)
HWCHqrw_1306(thi4)
HVOHVO_0665(thi4)
HALEG3A49_03390
HLNSVXHx_0624(thi4)
HMEHFX_0634
HGIABY42_03175
HLSKU306_07905
HBOHbor_25460
HAQDU484_06390
HAJDU500_06660
HAERDU502_04335
HRAEI982_09275
HLMDV707_12630
HLAHlac_2980
HALBEKH57_08560
HEZZEO776_03960
HALQHrr1229_002890
HSSJ7656_12905
HSAIHPS36_03250
HAZZKI388_01415
SRUBC2R22_02145
HAEhalTADL_1093
HALNB4589_006725
HALGHUG10_03970
HALUHUG12_12960
HMPK6T50_02080
HREK6T36_01900
HRMK6T25_14540
HACBHbl1158_08970
HDFAArcSl_1355(thi4)
HAHHalar_3704
HTUHtur_1462
HSALJMJ58_01385
HAKZJ0X25_14155
NMGNmag_2419(thi4)
HXAHalxa_2863
NATNJ7G_3680
NPENatpe_2830
NVRFEJ81_13195
NPLFGF80_13125
NAYHYG81_16885
HALYHYG82_19015
HJTDVR14_04265
HLOJ0X27_03870
NGENatgr_0926
HLCCHINAEXTREME16945
HRUHalru_1150
SAWLNGM29_17530
HALVNGM15_08750
NOUNatoc_0532
HLRHALLA_10200
NAJB1756_03455
NAGAArcMg_1121
NANAArc1_2501
NARAQQ977_09420
NBGDV706_12525
NASGCU68_13250
HDABB347_01930
MELUMTLP_07010
MEAMMU439_01690
MEAEQEN48_00685
ABIAboo_0963
ACFAciM339_1016
APEAPE_2149.1
ACJACAM_1344
SMRSmar_0052 Smar_0180
SHCShell_0764
IHOIgni_0560
IISEYM_05510
IPCIPA_05695
DKADKAM_0713
DFDDesfe_0795
IAGIgag_0295
THGTCELL_1023
HBUHbut_0253
PFMPyrfu_0366
PDLPyrde_0220 Pyrde_0347
PABIPABY_00710
STOSTK_03610
SOHD1869_01525
SJVSJAV_13520
SSOSSO0436
SOLSsol_1411
SSOASULA_1456
SSOLSULB_1457
SSOFSULC_1455
SSHIJ5U23_03002
SCASSACC_05940
SISLS215_1798
SIAM1425_1670
SIMM1627_1786
SIDM164_1717
SIYYG5714_1786
SINYN1551_1140
SIILD85_1927
SIHSiH_1645
SIRSiRe_1566
SICSiL_1558
SULABFU36_03640
SULEGFS03_09395
SAISaci_0854(thi)
SACNSacN8_04145
SACRSacRon12I_04135
SACSSUSAZ_03885
SULOGFS33_01210
SULLEWF20_02995
MSEMsed_2221
MEMJMJ1HA_2541
MCNMcup_0086
MHKDFR87_07430
MPRUDFR88_07115
MTENGWK48_04735
MJNMjAS7_0513
AHOAhos_0692
AMANB6F84_06895
ABRIDFR85_08045
ASULDFR86_05955
AAMBD1866_11245
ACIHHS5_20660
SACDHS1genome_2409
SAZOD1868_02625
CSTYKN1_20130
STEPIC006_1529
SMETRQ359_000407
SAHSHS7_05390
PAIPAE0175
PISPisl_1998
PCLPcal_1555
PASPars_1498
PYRP186_0936
POGPogu_0708
TNETneu_1052
PYWPYWP30_02101
CMACmaq_1420
TUZTUZN_0079
VDIVdis_2373
VMOVMUT_0723
VSOVsou_21150
FFOFFONT_0392
KCRKcr_0795
NMRNmar_0678
NIRNSED_03435
NKRNKOR_03495
NIDNPIRD3C_1584
NINNADRNF5_1474
NIWNisw_01510
NCLC5F47_05695
NOXC5F49_05585
NUEC5F50_04895
NIPNsoK4_05025
NZTNZOSNM25_001293
NCTNMSP_1025
NICDSQ20_03585
NGANgar_c21660
NVNNVIE_008130
NEVNTE_02257
TAANMY3_02935
NFNNFRAN_0414(thi)
NCVNCAV_0396(thi)
NDVNDEV_0758
CSYCENSYa_0361
NBVT478_0555
TAHSU86_002805
NIUDSQ19_03795
CCAINAS2_0821
BARBAOA66_0043
FLTSv326_1000
 » show all
Reference
1  [PMID:26919468]
  Authors
Zhang X, Eser BE, Chanani PK, Begley TP, Ealick SE
  Title
Structural Basis for Iron-Mediated Sulfur Transfer in Archael and Yeast Thiazole  Synthases.
  Journal
Biochemistry 55:1826-38 (2016)
DOI:10.1021/acs.biochem.6b00030
  Sequence
[mja:MJ_0601] [mig:Metig_0735]
Reference
2  [PMID:26928142]
  Authors
Eser BE, Zhang X, Chanani PK, Begley TP, Ealick SE
  Title
From Suicide Enzyme to Catalyst: The Iron-Dependent Sulfide Transfer in Methanococcus jannaschii Thiamin Thiazole Biosynthesis.
  Journal
J Am Chem Soc 138:3639-42 (2016)
DOI:10.1021/jacs.6b00445
  Sequence
[mja:MJ_0601]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.59
IUBMB Enzyme Nomenclature: 2.4.2.59
ExPASy - ENZYME nomenclature database: 2.4.2.59
BRENDA, the Enzyme Database: 2.4.2.59
LinkDB

KEGG   REACTION: R12026
Entry
R12026                      Reaction                               
Name
NAD+:glycine ADP-D-ribosyltransferase (sulfide-adding)
Definition
NAD+ + Glycine + Hydrogen sulfide <=> Nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 3 H2O
Equation
Reaction class
RC00033  C00003_C00153
RC03253  C00003_C20784
RC03254  C00037_C20784
Enzyme
Pathway
rn00730  Thiamine metabolism
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Module
M00896  Thiamine biosynthesis, archaea, AIR (+ NAD+) => TMP/TPP
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.4  Glycosyltransferases
   2.4.2  Pentosyltransferases
    2.4.2.59
     R12026  NAD+ + Glycine + Hydrogen sulfide <=> Nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 3 H2O
Orthology
K22699  sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59]
Other DBs
RHEA: 55707
LinkDB

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