KEGG   DRUG: Oxybutynin chloride
Entry
D00722                      Drug                                   

Name
Oxybutynin chloride (USP);
Oxybutynin hydrochloride (JAN);
Ditropan (TN);
Gelnique (TN)
Product
  Generic
OXYBUTYNIN (Bryant Ranch Prepack), OXYBUTYNIN (Cadila Healthcare Limited), OXYBUTYNIN (NCS HealthCare of KY), OXYBUTYNIN (NCS HealthCare of KY), OXYBUTYNIN (REMEDYREPACK), OXYBUTYNIN (Zydus Pharmaceuticals (USA)), OXYBUTYNIN CHLORIDE (A-S Medication Solutions), OXYBUTYNIN CHLORIDE (A-S Medication Solutions), OXYBUTYNIN CHLORIDE (A-S Medication Solutions), OXYBUTYNIN CHLORIDE (A-S Medication Solutions), OXYBUTYNIN CHLORIDE (A-S Medication Solutions), OXYBUTYNIN CHLORIDE (A-S Medication Solutions), OXYBUTYNIN CHLORIDE (ATLANTIC BIOLOGICALS CORP.), OXYBUTYNIN CHLORIDE (Accord Healthcare), OXYBUTYNIN CHLORIDE (Ajanta Pharma Limited), OXYBUTYNIN CHLORIDE (American Health Packaging), OXYBUTYNIN CHLORIDE (American Health Packaging), OXYBUTYNIN CHLORIDE (Amneal Pharmaceuticals LLC), OXYBUTYNIN CHLORIDE (Aphena Pharma Solutions - Tennessee), OXYBUTYNIN CHLORIDE (Aphena Pharma Solutions - Tennessee), OXYBUTYNIN CHLORIDE (Aphena Pharma Solutions - Tennessee), OXYBUTYNIN CHLORIDE (Aphena Pharma Solutions - Tennessee), OXYBUTYNIN CHLORIDE (Aphena Pharma Solutions - Tennessee), OXYBUTYNIN CHLORIDE (Aphena Pharma Solutions - Tennessee), OXYBUTYNIN CHLORIDE (Aphena Pharma Solutions - Tennessee), OXYBUTYNIN CHLORIDE (Aphena Pharma Solutions - Tennessee), OXYBUTYNIN CHLORIDE (Atlantic Biologicals Corps), OXYBUTYNIN CHLORIDE (AvKARE), OXYBUTYNIN CHLORIDE (AvPAK), OXYBUTYNIN CHLORIDE (Bionpharma), OXYBUTYNIN CHLORIDE (Bryant Ranch Prepack), OXYBUTYNIN CHLORIDE (Bryant Ranch Prepack), OXYBUTYNIN CHLORIDE (Bryant Ranch Prepack), OXYBUTYNIN CHLORIDE (Bryant Ranch Prepack), OXYBUTYNIN CHLORIDE (Bryant Ranch Prepack), OXYBUTYNIN CHLORIDE (Bryant Ranch Prepack), OXYBUTYNIN CHLORIDE (Bryant Ranch Prepack), OXYBUTYNIN CHLORIDE (Cardinal Health), OXYBUTYNIN CHLORIDE (Cardinal Health), OXYBUTYNIN CHLORIDE (DIRECT RX), OXYBUTYNIN CHLORIDE (DOH CENTRAL PHARMACY), OXYBUTYNIN CHLORIDE (Eywa Pharma), OXYBUTYNIN CHLORIDE (Golden State Medical Supply), OXYBUTYNIN CHLORIDE (Heritage Pharma Labs), OXYBUTYNIN CHLORIDE (KVK-Tech), OXYBUTYNIN CHLORIDE (Lannett Company), OXYBUTYNIN CHLORIDE (Lannett Company), OXYBUTYNIN CHLORIDE (Leading Pharma), OXYBUTYNIN CHLORIDE (Major Pharmaceuticals), OXYBUTYNIN CHLORIDE (Major Pharmaceuticals), OXYBUTYNIN CHLORIDE (Marlex Pharmaceuticals), OXYBUTYNIN CHLORIDE (Marlex Pharmaceuticals), OXYBUTYNIN CHLORIDE (McKesson Corporation dba SKY Packaging), OXYBUTYNIN CHLORIDE (Morton Grove Pharmaceuticals), OXYBUTYNIN CHLORIDE (NCS HealthCare of KY), OXYBUTYNIN CHLORIDE (Novitium Pharma LLC), OXYBUTYNIN CHLORIDE (NuCare Pharmaceuticals), OXYBUTYNIN CHLORIDE (NuCare Pharmaceuticals), OXYBUTYNIN CHLORIDE (PD-Rx Pharmaceuticals), OXYBUTYNIN CHLORIDE (PD-Rx Pharmaceuticals), OXYBUTYNIN CHLORIDE (PD-Rx Pharmaceuticals), OXYBUTYNIN CHLORIDE (PD-Rx Pharmaceuticals), OXYBUTYNIN CHLORIDE (Par Pharmaceutical), OXYBUTYNIN CHLORIDE (Preferred Pharmaceuticals), OXYBUTYNIN CHLORIDE (Preferred Pharmaceuticals), OXYBUTYNIN CHLORIDE (Proficient Rx LP), OXYBUTYNIN CHLORIDE (REMEDYREPACK), OXYBUTYNIN CHLORIDE (REMEDYREPACK), OXYBUTYNIN CHLORIDE (REMEDYREPACK), OXYBUTYNIN CHLORIDE (REMEDYREPACK), OXYBUTYNIN CHLORIDE (RedPharm Drug), OXYBUTYNIN CHLORIDE (Rising Pharmaceuticals), OXYBUTYNIN CHLORIDE (Rising Pharmaceuticals), OXYBUTYNIN CHLORIDE (Teva Pharmaceuticals USA), OXYBUTYNIN CHLORIDE (TruPharma LLC), OXYBUTYNIN CHLORIDE (Tulex Pharmaceuticals), OXYBUTYNIN CHLORIDE (Upsher-Smith Laboratories)
Formula
C22H31NO3. HCl
Exact mass
393.2071
Mol weight
393.9474
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
 DG02925  CYP3A5 substrate
Remark
Therapeutic category: 2590
ATC code: G04BD04
Chemical structure group: DG00478
Product (DG00478): D00465<US> D00722<JP/US>
Efficacy
Antipollakisuria, Overactive bladder agent, Muscarinic acetylcholine receptor antagonist
Target
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04B UROLOGICALS
    G04BD Urinary antispasmodics
     G04BD04 Oxybutynin
      D00722  Oxybutynin chloride (USP) <JP/US>
USP drug classification [BR:br08302]
 Genitourinary Agents
  Antispasmodics, Urinary
   Oxybutynin
    D00722  Oxybutynin chloride (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  25  Urogenital and anal organ agents
   259  Miscellaneous
    2590  Miscellaneous
     D00722  Oxybutynin chloride (USP); Oxybutynin hydrochloride (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM
     D00722  Oxybutynin chloride (USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00722
Other DBs
CAS: 1508-65-2
PubChem: 7847787
ChEBI: 7857
ChEMBL: CHEMBL1133
DrugBank: DB01062
LigandBox: D00722
NIKKAJI: J244.850E
LinkDB
KCF data

ATOM        27
            1   X   Cl   40.2271  -21.8179
            2   C3b C    28.3117  -21.2592
            3   C1b C    29.5266  -21.9607
            4   O7a O    30.7417  -21.2592
            5   C7a C    31.9567  -21.9607
            6   C1d C    33.1717  -21.2592
            7   C8y C    34.3868  -21.9607
            8   C8x C    35.6018  -21.2592
            9   C8x C    36.8167  -21.9607
            10  C8x C    34.3868  -23.3637
            11  C8x C    35.6018  -24.0652
            12  C8x C    36.8167  -23.3637
            13  C1y C    33.1717  -19.8562
            14  C1x C    34.3718  -19.1632
            15  C1x C    34.3717  -17.7602
            16  C1x C    33.1567  -17.0588
            17  C1x C    31.9565  -17.7518
            18  C1x C    31.9566  -19.1548
            19  O1a O    34.3868  -20.5577
            20  O6a O    31.9567  -23.3637
            21  C3b C    27.0967  -20.5577
            22  C1b C    25.8816  -19.8562
            23  N1c N    24.6479  -20.5687
            24  C1b C    23.4400  -19.8715
            25  C1b C    24.6482  -21.9606
            26  C1a C    22.2552  -20.5558
            27  C1a C    23.4450  -22.6556
BOND        27
            1     2   3 1
            2     3   4 1
            3     4   5 1
            4     5   6 1
            5     6   7 1
            6     7   8 1
            7     8   9 2
            8     7  10 2
            9    10  11 1
            10   11  12 2
            11    9  12 1
            12    6  13 1
            13   13  14 1
            14   14  15 1
            15   15  16 1
            16   16  17 1
            17   17  18 1
            18   13  18 1
            19    6  19 1
            20    5  20 2
            21    2  21 3
            22   21  22 1
            23   22  23 1
            24   23  24 1
            25   23  25 1
            26   24  26 1
            27   25  27 1

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