KEGG   DRUG: Norepinephrine hydrochloride
Entry
D09794                      Drug                                   

Name
Norepinephrine hydrochloride (JAN);
(+/-)-Noradrenaline hydrochloride
Formula
C8H11NO3. HCl
Exact mass
205.0506
Mol weight
205.6388
Structure
Simcomp
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01699  Catecholamine cardiotonic
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01448  alpha1-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
  DG01455  beta-Adrenergic receptor agonist
   DG01451  beta1-Adrenergic receptor agonist
   DG01452  beta2-Adrenergic receptor agonist
   DG01453  beta3-Adrenergic receptor agonist
 DG01951  Catecholamine adrenergic receptor agonist
Remark
ATC code: C01CA03
Chemical structure group: DG00212
Product (DG00212): D00076<JP> D05206<US>
Efficacy
Antihypotensive, Vasoconstrictor, Adrenergic receptor agonist
Comment
Catecholamine derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
ADRB [HSA:153 154 155] [KO:K04141 K04142 K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA03 Norepinephrine
      D09794  Norepinephrine hydrochloride (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D09794  Norepinephrine hydrochloride (JAN)
    ADRA2
     D09794  Norepinephrine hydrochloride (JAN)
    ADRB
     D09794  Norepinephrine hydrochloride (JAN)
Other DBs
CAS: 55-27-6
PubChem: 124490534
ChEMBL: CHEMBL1734806
LigandBox: D09794
LinkDB
KCF data

ATOM        13
            1   C8y C    31.0800  -22.1900
            2   C8x C    31.0800  -23.5900
            3   C8x C    29.8200  -21.4900
            4   C1c C    32.2700  -21.4900
            5   C8x C    29.8200  -24.2900
            6   C8y C    28.6300  -22.1900
            7   C1b C    33.4600  -22.1900
            8   O1a O    32.2700  -20.0900
            9   C8y C    28.6300  -23.5900
            10  N1a N    34.6500  -21.4900
            11  O1a O    27.4400  -24.2900
            12  O1a O    27.4400  -21.4900
            13  X   Cl   33.8800  -24.2900
BOND        12
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     4   8 1
            8     5   9 2
            9     7  10 1
            10    9  11 1
            11    6   9 1
            12    6  12 1

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