KEGG   DRUG: ベラパミル塩酸塩
エントリ  
D00619                      Drug                                   

一般名   
ベラパミル塩酸塩 (JP17);
Verapamil hydrochloride (JP17/USP)
商品名   
  後発品
米国の商品 
  後発品
VERAPAMIL HCI (HF Acquisition Co LLC), VERAPAMIL HCL (Direct_Rx), VERAPAMIL HYDROCHLORIDE (A-S Medication Solutions), VERAPAMIL HYDROCHLORIDE (A-S Medication Solutions), VERAPAMIL HYDROCHLORIDE (A-S Medication Solutions), VERAPAMIL HYDROCHLORIDE (A-S Medication Solutions), VERAPAMIL HYDROCHLORIDE (A-S Medication Solutions), VERAPAMIL HYDROCHLORIDE (A-S Medication Solutions), VERAPAMIL HYDROCHLORIDE (Actavis Pharma), VERAPAMIL HYDROCHLORIDE (American Health Packaging), VERAPAMIL HYDROCHLORIDE (Amneal Pharmaceuticals LLC), VERAPAMIL HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), VERAPAMIL HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), VERAPAMIL HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), VERAPAMIL HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), VERAPAMIL HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), VERAPAMIL HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), VERAPAMIL HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), VERAPAMIL HYDROCHLORIDE (Armas Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Armas Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (AuroMedics Pharma LLC), VERAPAMIL HYDROCHLORIDE (AvKARE), VERAPAMIL HYDROCHLORIDE (Baxter Healthcare Corporation), VERAPAMIL HYDROCHLORIDE (Bryant Ranch Prepack), VERAPAMIL HYDROCHLORIDE (Bryant Ranch Prepack), VERAPAMIL HYDROCHLORIDE (Bryant Ranch Prepack), VERAPAMIL HYDROCHLORIDE (Bryant Ranch Prepack), VERAPAMIL HYDROCHLORIDE (Bryant Ranch Prepack), VERAPAMIL HYDROCHLORIDE (Bryant Ranch Prepack), VERAPAMIL HYDROCHLORIDE (Bryant Ranch Prepack), VERAPAMIL HYDROCHLORIDE (Bryant Ranch Prepack), VERAPAMIL HYDROCHLORIDE (Cadila Healthcare Limited), VERAPAMIL HYDROCHLORIDE (Cadila Pharmaceuticals Limited), VERAPAMIL HYDROCHLORIDE (Caplin Steriles Limited), VERAPAMIL HYDROCHLORIDE (DIRECT RX), VERAPAMIL HYDROCHLORIDE (Denton Pharma), VERAPAMIL HYDROCHLORIDE (Denton Pharma), VERAPAMIL HYDROCHLORIDE (Denton Pharma), VERAPAMIL HYDROCHLORIDE (Denton Pharma), VERAPAMIL HYDROCHLORIDE (Denton Pharma), VERAPAMIL HYDROCHLORIDE (Denton Pharma), VERAPAMIL HYDROCHLORIDE (General Injectables & Vaccines), VERAPAMIL HYDROCHLORIDE (General Injectables and Vaccines), VERAPAMIL HYDROCHLORIDE (Gland Pharma Limited), VERAPAMIL HYDROCHLORIDE (Glenmark Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (HF Acquisition Co LLC), VERAPAMIL HYDROCHLORIDE (HF Acquisition Co. LLC), VERAPAMIL HYDROCHLORIDE (Heritage Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Hospira), VERAPAMIL HYDROCHLORIDE (Hospira), VERAPAMIL HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), VERAPAMIL HYDROCHLORIDE (Major Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Medical Purchasing Solutions), VERAPAMIL HYDROCHLORIDE (Medical Purchasing Solutions), VERAPAMIL HYDROCHLORIDE (Medical Purchasing Solutions), VERAPAMIL HYDROCHLORIDE (Micro Labs Limited), VERAPAMIL HYDROCHLORIDE (Mylan Institutional), VERAPAMIL HYDROCHLORIDE (Mylan Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Mylan Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Mylan Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Nivagen Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Northwind Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (NuCare Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (NuCare Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (NuCare Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (NuCare Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (NuCare Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (NuCare Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Preferred Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Preferred Pharmaceuticals), VERAPAMIL HYDROCHLORIDE (Proficient Rx LP), VERAPAMIL HYDROCHLORIDE (Proficient Rx LP), VERAPAMIL HYDROCHLORIDE (Proficient Rx LP), VERAPAMIL HYDROCHLORIDE (REMEDYREPACK), VERAPAMIL HYDROCHLORIDE (REMEDYREPACK), VERAPAMIL HYDROCHLORIDE (REMEDYREPACK), VERAPAMIL HYDROCHLORIDE (REMEDYREPACK), VERAPAMIL HYDROCHLORIDE (RedPharm Drug), VERAPAMIL HYDROCHLORIDE (RedPharm Drug), VERAPAMIL HYDROCHLORIDE (Sun Pharmaceutical Industries), VERAPAMIL HYDROCHLORIDE (Unit Dose Services), VERAPAMIL HYDROCHLORIDE (Zydus Pharmaceuticals (USA))
組成式   
C27H38N2O4. HCl
質量    
490.2598
分子量   
491.0626
構造式   
Simcomp   
クラス   
循環器系用薬
 DG01653  抗不整脈薬
  DG01807  フェニルアルキルアミン誘導体
その他
 DG01575  カルシウムチャネル遮断薬
  DG01496  カルシウムチャネルL型遮断薬
代謝酵素基質薬
 DG02913  CYP3A4基質薬
トランスポーター基質薬
 DG01665  ABCB1(P糖蛋白質)基質薬
トランスポーター阻害薬
 DG01622  ABCB1(P糖蛋白質)阻害薬
コード   
薬効分類: 2129 2171
ATCコード: C08DA01
化学構造グループ: DG00329
商品 (DG00329): D00619<JP/US>
商品 (mixture): D10282<US>
効能    
抗不整脈薬, 血管拡張薬, カルシウムチャネル遮断薬
  疾患
心房細動 [DS:H00731]
狭心症 [DS:H01632]
心筋梗塞 [DS:H01730]
コメント  
フェニルアルキルアミン誘導体
ターゲット 
CACNA1-L [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  パスウェイ
hsa04010  MAPK シグナル伝達経路
hsa04020  カルシウムシグナル伝達経路
hsa04260  心筋の収縮
hsa04270  血管平滑筋の収縮
代謝    
Enzyme: CYP3A4 [HSA:1576]
Transporter: ABCB1 [HSA:5243]
相互作用  
Transporter inhibition: ABCB1 [HSA:5243]

構造マップ 
map07036  カルシウムチャネル遮断薬
map07037  抗不整脈薬
map07048  抗片頭痛薬
階層分類  
医療用医薬品の薬効分類 [BR:jp08301]
 2  個々の器官系用医薬品
  21  循環器官用薬
   212  不整脈用剤
    2129  その他の不整脈用剤
     D00619  ベラパミル塩酸塩 (JP17)
   217  血管拡張剤
    2171  冠血管拡張剤
     D00619  ベラパミル塩酸塩 (JP17)
医療用医薬品のATC分類 [BR:jp08303]
 C 循環器系
  C08 カルシウムチャネル遮断薬
   C08D 選択的カルシウムチャネル遮断薬、直接に心臓への効果がある
    C08DA フェニルアルキルアミン誘導体
     C08DA01 ベラパミル
      D00619  ベラパミル塩酸塩 (JP17) <JP/US>
医療用医薬品のUSP分類 [BR:jp08302]
 心血管治療薬
  抗不整脈薬
   Vaughn WilliamsクラスIV
    ベラパミル
     D00619  ベラパミル塩酸塩 (JP17)
  カルシウムチャネル遮断薬, 非ジヒドロピリジン
   ベラパミル
    D00619  ベラパミル塩酸塩 (JP17)
ターゲットに基づく医薬品分類 [BR:jp08310]
 イオンチャネル
  電位依存性イオンチャネル
   カルシウムチャネル
    CACNA1-L
     D00619  ベラパミル塩酸塩 (JP17) <JP/US>
日本薬局方収載医薬品 [BR:jp08311]
 化学薬品等
  D00619  ベラパミル塩酸塩
  D00619  ベラパミル塩酸塩錠
  D00619  ベラパミル塩酸塩注射液
薬物代謝酵素とトランスポーター [jp08309.html]
 薬物代謝酵素
  D00619
 薬物トランスポーター
  D00619
リンク   
CAS: 152-11-4
PubChem: 7847685
ChEBI: 53188
ChEMBL: CHEMBL1280
DrugBank: DB00661
LigandBox: D00619
日化辞: J345.194A
LinkDB    

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