Entry |
|
Name |
1-deoxy-11beta-hydroxypentalenate dehydrogenase;
1-deoxy-11beta-hydroxypentalenic acid dehydrogenase;
ptlF (gene name);
penF (gene name)
|
Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
|
Sysname |
1-deoxy-11beta-hydroxypentalenate:NAD+ oxidoreductase
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Reaction(IUBMB) |
1-deoxy-11beta-hydroxypentalenate + NAD+ = 1-deoxy-11-oxopentalenate + NADH + H+ [RN: R10156]
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Reaction(KEGG) |
|
Substrate |
1-deoxy-11beta-hydroxypentalenate [CPD: C20403];
NAD+ [CPD: C00003]
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Product |
|
Comment |
Isolated from the bacterium Streptomyces avermitilis and present in many other Streptomyces species. Part of the pathway for pentalenolactone biosynthesis.
|
History |
EC 1.1.1.340 created 2012
|
Pathway |
ec00999 | Biosynthesis of various secondary metabolites - part 1 |
ec01110 | Biosynthesis of secondary metabolites |
|
Orthology |
K17747 | 1-deoxy-11beta-hydroxypentalenate dehydrogenase |
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Genes |
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Reference |
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Authors |
You Z, Omura S, Ikeda H, Cane DE |
Title |
Pentalenolactone biosynthesis: Molecular cloning and assignment of biochemical function to PtlF, a short-chain dehydrogenase from Streptomyces avermitilis, and identification of a new biosynthetic intermediate. |
Journal |
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Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 1.1.1.340 |
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LinkDB |
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