KEGG   ORTHOLOGY: K17747
Entry
K17747                      KO                                     
Symbol
ptlF
Name
1-deoxy-11beta-hydroxypentalenate dehydrogenase [EC:1.1.1.340]
Pathway
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00819  Pentalenolactone biosynthesis, farnesyl-PP => pentalenolactone
Reaction
R10156  1-deoxy-11beta-hydroxypentalenate:NAD+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various antibiotics
    K17747  ptlF; 1-deoxy-11beta-hydroxypentalenate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.340  1-deoxy-11beta-hydroxypentalenate dehydrogenase
     K17747  ptlF; 1-deoxy-11beta-hydroxypentalenate dehydrogenase
Genes
SPBS: L7H23_13565
SMA: SAVERM_2993(ptlF)
SBH: SBI_09675
SCI: B446_29675
SCW: TU94_27385
SLE: sle_13200(sle_13200)
SSIA: A7J05_09260
SGJ: IAG43_27135
SHK: J2N69_35825
Reference
PMID:17178094
  Authors
You Z, Omura S, Ikeda H, Cane DE
  Title
Pentalenolactone biosynthesis: Molecular cloning and assignment of biochemical function to PtlF, a short-chain dehydrogenase from Streptomyces avermitilis, and identification of a new biosynthetic intermediate.
  Journal
Arch Biochem Biophys 459:233-40 (2007)
DOI:10.1016/j.abb.2006.11.016
  Sequence
[sma:SAVERM_2993]
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