KEGG   Homo sapiens (human): 10714
Entry
10714             CDS       T01001                                 

Gene name
POLD3, P66, P68, PPP1R128
Definition
(RefSeq) DNA polymerase delta 3, accessory subunit
  KO
K03504  DNA polymerase delta subunit 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa03410  Base excision repair
hsa03420  Nucleotide excision repair
hsa03430  Mismatch repair
hsa03440  Homologous recombination
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    10714 (POLD3)
   03410 Base excision repair
    10714 (POLD3)
   03420 Nucleotide excision repair
    10714 (POLD3)
   03430 Mismatch repair
    10714 (POLD3)
   03440 Homologous recombination
    10714 (POLD3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    10714 (POLD3)
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    10714 (POLD3)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    10714 (POLD3)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     10714 (POLD3)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   DNA polymerase delta complex
    10714 (POLD3)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Long Patch-BER factors
     DNA polymerase delta complex
      10714 (POLD3)
   MMR (mismatch excision repair)
    DNA polymerase delta complex
     10714 (POLD3)
SSDB
Motif
Pfam: CDC27
Other DBs
NCBI-GeneID: 10714
NCBI-ProteinID: NP_006582
OMIM: 611415
HGNC: 20932
Ensembl: ENSG00000077514
Vega: OTTHUMG00000165621
Pharos: Q15054(Tbio)
UniProt: Q15054 A0A024R5M8
LinkDB
Structure
PDB: 
3E0J

Position
11q13.4
AA seq 466 aa
MADQLYLENIDEFVTDQNKIVTYKWLSYTLGVHVNQAKQMLYDYVERKRKENSGAQLHVT
YLVSGSLIQNGHSCHKVAVVREDKLEAVKSKLAVTASIHVYSIQKAMLKDSGPLFNTDYD
ILKSNLQNCSKFSAIQCAAAVPRAPAESSSSSKKFEQSHLHMSSETQANNELTTNGHGPP
ASKQVSQQPKGIMGMFASKAAAKTQETNKETKTEAKEVTNASAAGNKAPGKGNMMSNFFG
KAAMNKFKVNLDSEQAVKEEKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKR
GKRVALSDDETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLE
PVPKTEPEPPSVKSSSGENKRKRKRVLKSKTYLDGEGCIVTEKVYESESCTDSEEELNMK
TSSVHRPPAMTVKKEPREERKGPKKGTAALGKANRQVSITGFFQRK
NT seq 1401 nt   +upstreamnt  +downstreamnt
atggcggaccagctttatctggaaaatatagacgagttcgtcacggaccaaaacaagatc
gtgacatacaaatggctgagctatacactaggggttcatgttaaccaggccaaacagatg
ctgtatgattatgttgaaaggaaacgaaaagaaaattcaggagcccaactgcatgttacc
tacttggtgtctggcagtctcattcagaatggacattcctgccacaaggttgcagtagtg
agagaagataaattggaagcagtgaagtccaagctagctgtgactgccagcatccatgtg
tacagcatccagaaagccatgctaaaggacagtgggcctctgttcaatactgactatgac
atccttaaaagcaacttgcagaactgcagcaaatttagtgctatacaatgtgcagctgcc
gtccctagagctcctgctgaatcctcttcgtcttccaaaaagtttgagcagtcacatctt
cacatgtcaagtgagacacaagccaacaatgagctgaccaccaatggtcatggcccacct
gcatccaagcaggtttcccagcagcccaaaggaattatgggaatgtttgcctccaaagct
gctgctaaaacccaagaaaccaacaaggaaacgaaaacagaggctaaagaagtaacaaat
gcatctgcagcaggcaacaaggcaccagggaaagggaatatgatgagcaacttttttgga
aaagctgctatgaataaatttaaagtcaatttggactcagaacaagcagtgaaagaagaa
aaaatagtggagcagcctacagtgtctgtcacggaaccaaagctggcaactcctgcaggc
ctgaaaaaatccagcaaaaaagcagagcctgttaaggtgctgcagaaggaaaaaaaaagg
gggaagcgagtagcattatctgatgatgagacaaaggaaactgaaaacatgaggaaaaag
aggagaagaatcaaacttcctgaatctgatagcagtgaagatgaagtctttccagactct
cctggggcttatgaagctgagtcaccatccccacctcctcctccgtctccacctcttgaa
ccagtgccaaagactgagcctgaacctccttctgtcaagagctcaagtggagaaaacaaa
agaaaacgaaaacgcgtactaaaatctaaaacttacctggatggggaaggctgcatagtg
actgaaaaagtctacgagagtgaatcctgcacagatagtgaagaggagcttaacatgaag
acatcctcagtacacagaccccctgccatgactgtgaaaaaagaacccagagaggaacga
aagggccccaagaaagggactgctgctctgggcaaagccaacagacaggtgtccattact
ggcttcttccagaggaaataa

KEGG   Homo sapiens (human): 5424
Entry
5424              CDS       T01001                                 

Gene name
POLD1, CDC2, CRCS10, MDPL, POLD
Definition
(RefSeq) DNA polymerase delta 1, catalytic subunit
  KO
K02327  DNA polymerase delta subunit 1 [EC:2.7.7.7]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa03410  Base excision repair
hsa03420  Nucleotide excision repair
hsa03430  Mismatch repair
hsa03440  Homologous recombination
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    5424 (POLD1)
   03410 Base excision repair
    5424 (POLD1)
   03420 Nucleotide excision repair
    5424 (POLD1)
   03430 Mismatch repair
    5424 (POLD1)
   03440 Homologous recombination
    5424 (POLD1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    5424 (POLD1)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    5424 (POLD1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     5424 (POLD1)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   DNA polymerase delta complex
    5424 (POLD1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Long Patch-BER factors
     DNA polymerase delta complex
      5424 (POLD1)
   MMR (mismatch excision repair)
    DNA polymerase delta complex
     5424 (POLD1)
SSDB
Motif
Pfam: DNA_pol_B DNA_pol_B_exo1 zf-C4pol DNA_pol_B_2
Other DBs
NCBI-GeneID: 5424
NCBI-ProteinID: NP_001243778
OMIM: 174761
HGNC: 9175
Ensembl: ENSG00000062822
Vega: OTTHUMG00000183037
Pharos: P28340(Tclin)
UniProt: P28340 A0A024R4F4
LinkDB
Position
19q13.33
AA seq 1107 aa
MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS
VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSRG
SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR
ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS
FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP
EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC
APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF
LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH
FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG
VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIAT
LDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQIL
ENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSV
TGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAAD
WVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLV
ANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH
VELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ
QLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLS
HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFY
MRKKVRKDLEDQEQLLRRFGPPGPEAW
NT seq 3324 nt   +upstreamnt  +downstreamnt
atggatggcaagcggcggccaggcccagggcccggggtgcccccaaagcgggcccgtggg
ggcctctgggatgatgatgatgcacctcggccatcccaattcgaggaggacctggcactg
atggaggagatggaggcagaacacaggctgcaggagcaggaggaggaggagctgcagtca
gtcctggagggggttgcagacgggcaggtcccaccatcagccatagatcctcgctggctt
cggcccacaccaccagcgctggacccccagacagagcccctcatcttccaacagttggag
attgaccattatgtgggcccagcgcagcctgtgcctggggggcccccaccatcccgcggc
tccgtgcctgtgctccgcgccttcggggtcaccgatgaggggttctctgtctgctgccac
atccacggcttcgctccctacttctacaccccagcgccccctggtttcgggcccgagcac
atgggtgacctgcaacgggagctgaacttggccatcagccgggacagtcgcggggggagg
gagctgactgggccggccgtgctggctgtggaactgtgctcccgagagagcatgtttggg
taccacgggcacggcccctccccgttcctgcgcatcaccgtggcgctgccgcgcctcgtg
gccccggcccgccgtctcctggaacagggcatccgtgtggcaggcctgggcacgcccagc
ttcgcgccctacgaggccaacgtcgactttgagatccggttcatggtggacacggacatc
gtcggctgcaactggctggagctcccagctgggaaatacgccctgaggctgaaggagaag
gctacgcagtgccagctggaggcggacgtgctgtggtctgacgtggtcagtcacccaccg
gaagggccatggcagcgcattgcgcccttgcgcgtgctcagcttcgatatcgagtgcgcc
ggccgcaaaggcatcttccctgagcctgagcgggaccctgtcatccagatctgctcgctg
ggcctgcgctggggggagccggagcccttcctacgcctggcgctcaccctgcggccctgt
gcccccatcctgggtgccaaggtgcagagctacgagaaggaggaggacctgctgcaggcc
tggtccaccttcatccgtatcatggaccccgacgtgatcaccggttacaacatccagaac
ttcgaccttccgtacctcatctctcgggcccagaccctcaaggtacaaacattccctttc
ctgggccgtgtggccggcctttgctccaacatccgggactcttcattccagtccaagcag
acgggccggcgggacaccaaggttgtcagcatggtgggccgcgtgcagatggacatgctg
caggtgctgctgcgggagtacaagctccgctcctacacgctcaatgccgtgagcttccac
ttcctgggcgagcagaaggaggacgtgcagcacagcatcatcaccgacctgcagaatggg
aacgaccagacccgccgccgcctggctgtgtactgcctgaaggatgcctacctgccactg
cggctgctggagcggctcatggtgctggtgaacgccgtggagatggcgagggtcactggc
gtgcccctcagctacctgctcagtcgtggccagcaggtcaaggtcgtatcccagctgttg
cggcaggccatgcacgaggggctgctgatgcccgtggtgaagtcagagggcggcgaggac
tacacgggagccactgtcatcgagcccctcaaagggtactacgacgtccccatcgccacc
ctggacttctcctcgctgtacccgtccatcatgatggcccacaacctgtgttacaccacg
ctccttcggcccgggactgcacagaaactgggcctgactgaggatcagttcatcaggacc
cccaccggggacgagtttgtgaagacctcagtgcggaaggggctgctgccccagatcctg
gagaacctgctcagtgcccggaagagggccaaggccgagctggccaaggagacagacccc
ctccggcgccaggtcctggatggacggcagctggcgctgaaggtgagcgccaactccgta
tacggcttcactggcgcccaggtgggcaagttgccgtgcctggagatctcacagagcgtc
acggggttcggacgtcagatgatcgagaaaaccaagcagctggtggagtctaagtacaca
gtggagaatggctacagcaccagtgccaaggtggtgtatggtgacactgactccgtcatg
tgccgattcggcgtgtcctcggtggctgaggcgatggccctggggcgggaggccgcggac
tgggtgtcaggtcacttcccgtcgcccatccggctggagtttgagaaggtctacttccca
tacctgcttatcagcaagaagcgctacgcgggcctgctcttctcctcccggcccgacgcc
cacgaccgcatggactgcaagggcctggaggccgtgcgcagggacaactgccccctcgtg
gccaacctggtcactgcctcactgcgccgcctgctcatcgaccgagaccctgagggcgcg
gtggctcacgcacaggacgtcatctcggacctgctgtgcaaccgcatcgatatctcccag
ctggtcatcaccaaggagctgacccgcgcggcctccgactatgccggcaagcaggcccac
gtggagctggccgagaggatgaggaagcgggaccccgggagtgcgcccagcctgggcgac
cgcgtcccctacgtgatcatcagtgccgccaagggtgtggccgcctacatgaagtcggag
gacccgctgttcgtgctggagcacagcctgcccattgacacgcagtactacctggagcag
cagctggccaagcccctcctgcgcatcttcgagcccatcctgggcgagggccgtgccgag
gctgtgctactgcggggggaccacacgcgctgcaagacggtgctcacgggcaaggtgggc
ggcctcctggccttcgccaaacgccgcaactgctgcattggctgccgcacagtgctcagc
caccagggagccgtgtgtgagttctgccagccccgggagtctgagctgtatcagaaggag
gtatcccatctgaatgccctggaggagcgcttctcgcgcctctggacgcagtgccagcgc
tgccagggcagcctgcacgaggacgtcatctgcaccagccgggactgccccatcttctac
atgcgcaagaaggtgcggaaggacctggaagaccaggagcagctcctgcggcgcttcgga
ccccctggacctgaggcctggtga

KEGG   Homo sapiens (human): 5425
Entry
5425              CDS       T01001                                 

Gene name
POLD2
Definition
(RefSeq) DNA polymerase delta 2, accessory subunit
  KO
K02328  DNA polymerase delta subunit 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa03410  Base excision repair
hsa03420  Nucleotide excision repair
hsa03430  Mismatch repair
hsa03440  Homologous recombination
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    5425 (POLD2)
   03410 Base excision repair
    5425 (POLD2)
   03420 Nucleotide excision repair
    5425 (POLD2)
   03430 Mismatch repair
    5425 (POLD2)
   03440 Homologous recombination
    5425 (POLD2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    5425 (POLD2)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    5425 (POLD2)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   DNA polymerase delta complex
    5425 (POLD2)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Long Patch-BER factors
     DNA polymerase delta complex
      5425 (POLD2)
   MMR (mismatch excision repair)
    DNA polymerase delta complex
     5425 (POLD2)
SSDB
Motif
Pfam: DNA_pol_E_B DNA_pol_D_N
Other DBs
NCBI-GeneID: 5425
NCBI-ProteinID: NP_001120690
OMIM: 600815
HGNC: 9176
Ensembl: ENSG00000106628
Vega: OTTHUMG00000022909
Pharos: P49005(Tbio)
UniProt: P49005
LinkDB
Structure
PDB: 
3E0J

Position
7p13
AA seq 469 aa
MFSEQAAQRAHTLLSPPSANNATFARVPVATYTNSSQPFRLGERSFSRQYAHIYATRLIQ
MRPFLENRAQQHWGSGVGVKKLCELQPEEKCCVVGTLFKAMPLQPSILREVSEEHNLLPQ
PPRSKYIHPDDELVLEDELQRIKLKGTIDVSKLVTGTVLAVFGSVRDDGKFLVEDYCFAD
LAPQKPAPPLDTDRFVLLVSGLGLGGGGGESLLGTQLLVDVVTGQLGDEGEQCSAAHVSR
VILAGNLLSHSTQSRDSINKAKYLTKKTQAASVEAVKMLDEILLQLSASVPVDVMPGEFD
PTNYTLPQQPLHPCMFPLATAYSTLQLVTNPYQATIDGVRFLGTSGQNVSDIFRYSSMED
HLEILEWTLRVRHISPTAPDTLGCYPFYKTDPFIFPECPHVYFCGNTPSFGSKIIRGPED
QTVLLVTVPDFSATQTACLVNLRSLACQPISFSGFGAEDDDLGGLGLGP
NT seq 1410 nt   +upstreamnt  +downstreamnt
atgttttctgagcaggctgcccagagggcccacactctactgtccccaccatcagccaac
aatgccacctttgcccgggtgccagtggcaacctacaccaactcctcacaacccttccgg
ctaggagagcgcagctttagccggcagtatgcccacatttatgccacccgcctcatccaa
atgagacccttcctggagaaccgggcccagcagcactggggcagtggagtgggagtgaag
aagctgtgtgaactgcagcctgaggagaagtgctgtgtggtgggcactctgttcaaggcc
atgccgctgcagccctccatcctgcgggaggtcagcgaggagcacaacctgctcccccag
cctcctcggagtaaatacatacacccagatgacgagctggtcttggaagatgaactgcag
cgtatcaaactaaaaggcaccattgacgtgtcaaagctggttacggggactgtcctggct
gtgtttggctccgtgagagacgacgggaagtttctggtggaggactattgctttgctgac
cttgctccccagaagcccgcacccccacttgacacagataggtttgtgctactggtgtcc
ggcctgggcctgggtggcggtggaggcgagagcctgctgggcacccagctgctggtggat
gtggtgacggggcagcttggggacgaaggggagcagtgcagcgccgcccacgtctcccgg
gttatcctcgctggcaacctcctcagccacagcacccagagcagggattctatcaataag
gccaaatacctcaccaagaaaacccaggcagccagcgtggaggctgttaagatgctggat
gagatcctcctgcagctgagcgcctcagtgcccgtggacgtgatgccaggcgagtttgat
cccaccaattacacgctcccccagcagcccctccacccctgcatgttcccgctggccact
gcctactccacgctccagctggtcaccaacccctaccaggccaccattgatggagtcaga
tttttggggacatcaggacagaacgtgagtgacattttccgatacagcagcatggaggat
cacttggagatcctggagtggaccctgcgggtccgtcacatcagccccacagcccctgac
actctaggttgttaccccttctacaaaactgacccgttcatcttcccagagtgcccgcat
gtctacttttgtggcaacacccccagctttggctccaaaatcatccgaggtcctgaggac
cagacagtgctgttggtgactgtccctgacttcagtgccacgcagaccgcctgccttgtg
aacctgcgcagcctggcctgccagcccatcagcttctcgggcttcggggcagaggacgat
gacctgggaggcctggggctgggcccctga

KEGG   Homo sapiens (human): 57804
Entry
57804             CDS       T01001                                 

Gene name
POLD4, POLDS, p12
Definition
(RefSeq) DNA polymerase delta 4, accessory subunit
  KO
K03505  DNA polymerase delta subunit 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa03410  Base excision repair
hsa03420  Nucleotide excision repair
hsa03430  Mismatch repair
hsa03440  Homologous recombination
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    57804 (POLD4)
   03410 Base excision repair
    57804 (POLD4)
   03420 Nucleotide excision repair
    57804 (POLD4)
   03430 Mismatch repair
    57804 (POLD4)
   03440 Homologous recombination
    57804 (POLD4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    57804 (POLD4)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    57804 (POLD4)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   DNA polymerase delta complex
    57804 (POLD4)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Long Patch-BER factors
     DNA polymerase delta complex
      57804 (POLD4)
   MMR (mismatch excision repair)
    DNA polymerase delta complex
     57804 (POLD4)
SSDB
Motif
Pfam: DNA_pol_delta_4
Other DBs
NCBI-GeneID: 57804
NCBI-ProteinID: NP_066996
OMIM: 611525
HGNC: 14106
Ensembl: ENSG00000175482
Vega: OTTHUMG00000167135
Pharos: Q9HCU8(Tdark)
UniProt: Q9HCU8 A0A024R5D7 Q6NSD7
LinkDB
Position
11q13.2
AA seq 107 aa
MGRKRLITDSYPVVKRREGPAGHSKGELAPELGEEPQPRDEEEAELELLRQFDLAWQYGP
CTGITRLQRWCRAKQMGLEPPPEVWQVLKTHPGDPRFQCSLWHLYPL
NT seq 324 nt   +upstreamnt  +downstreamnt
atgggccggaagcggctcatcactgattcctacccggttgtgaagaggagggaggggccc
gctgggcacagcaagggggagctggcacccgagctaggggaggagccccagccccgcgac
gaggaggaagcggagctggagctgctgaggcagtttgacctggcctggcagtacgggccc
tgcaccgggatcacacggctgcagcgctggtgtcgggccaagcagatgggcttggagcct
cccccagaggtgtggcaggtgctgaagacccaccccggagacccccgcttccagtgcagt
ctctggcatctctatcccctatga

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