KEGG   NETWORK: N01452
Entry
N01452                      Network                                
Name
Homologous recombination
Definition
RPA == BRCA1+BARD1 == BRCA2+PALB2+DSS1 == RAD51 == BCDX2,CX3 -> RAD54 -> PCNA+RFC == POLD,POLE,POLK,POLH
  Expanded
6117+6118+6119+29935 == 672+580 == 675+79728+7979 == 5888 == (5890+5889+5892+7516),(5889+7517) -> 8438+25788 -> 5111+(5981+5982+5983+5984+5985) == (5424+5425+10714+57804),(5426+5427+54107+56655),51426,5429
Class
nt06506 Double-strand break repair
Type
Reference
Pathway
hsa03440  Homologous recombination
Gene
6117  RPA1; replication protein A1
6118  RPA2; replication protein A2
6119  RPA3; replication protein A3
29935  RPA4; replication protein A4
672  BRCA1; BRCA1 DNA repair associated
580  BARD1; BRCA1 associated RING domain 1
675  BRCA2; BRCA2 DNA repair associated
79728  PALB2; partner and localizer of BRCA2
7979  SEM1; SEM1 26S proteasome subunit
5888  RAD51; RAD51 recombinase
5890  RAD51B; RAD51 paralog B
5889  RAD51C; RAD51 paralog C
5892  RAD51D; RAD51 paralog D
7516  XRCC2; X-ray repair cross complementing 2
7517  XRCC3; X-ray repair cross complementing 3
8438  RAD54L; RAD54 like
25788  RAD54B; RAD54 homolog B
5111  PCNA; proliferating cell nuclear antigen
5981  RFC1; replication factor C subunit 1
5982  RFC2; replication factor C subunit 2
5983  RFC3; replication factor C subunit 3
5984  RFC4; replication factor C subunit 4
5985  RFC5; replication factor C subunit 5
5424  POLD1; DNA polymerase delta 1, catalytic subunit
5425  POLD2; DNA polymerase delta 2, accessory subunit
10714  POLD3; DNA polymerase delta 3, accessory subunit
57804  POLD4; DNA polymerase delta 4, accessory subunit
5426  POLE; DNA polymerase epsilon, catalytic subunit
5427  POLE2; DNA polymerase epsilon 2, accessory subunit
54107  POLE3; DNA polymerase epsilon 3, accessory subunit
56655  POLE4; DNA polymerase epsilon 4, accessory subunit
51426  POLK; DNA polymerase kappa
5429  POLH; DNA polymerase eta
Reference
PMID:32971475
  Authors
Rahimian E, Amini A, Alikarami F, Pezeshki SMS, Saki N, Safa M
  Title
DNA repair pathways as guardians of the genome: Therapeutic potential and possible prognostic role in hematologic neoplasms.
  Journal
DNA Repair (Amst) 96:102951 (2020)
DOI:10.1016/j.dnarep.2020.102951
Reference
PMID:31711518
  Authors
Mota MBS, Carvalho MA, Monteiro ANA, Mesquita RD
  Title
DNA damage response and repair in perspective: Aedes aegypti, Drosophila melanogaster and Homo sapiens.
  Journal
Parasit Vectors 12:533 (2019)
DOI:10.1186/s13071-019-3792-1
Reference
PMID:31748913
  Authors
Sun Y, McCorvie TJ, Yates LA, Zhang X
  Title
Structural basis of homologous recombination.
  Journal
Cell Mol Life Sci 77:3-18 (2020)
DOI:10.1007/s00018-019-03365-1
Reference
PMID:30551670
  Authors
Sullivan MR, Bernstein KA
  Title
RAD-ical New Insights into RAD51 Regulation.
  Journal
Genes (Basel) 9:629 (2018)
DOI:10.3390/genes9120629
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