KEGG   NETWORK: N01472
Entry
N01472                      Network                                
Name
Okazaki fragment maturation
Definition
POLD+PCNA -> DNA2 == RNaseH2 == FEN1 -> LIG1
  Expanded
5424+5425+10714+57804+5111 -> 1763 == 10535+79621+84153 == 2237 -> 3978
Class
nt06509 DNA replication
Type
Reference
Pathway
hsa03030  DNA replication
Gene
5424  POLD1; DNA polymerase delta 1, catalytic subunit
5425  POLD2; DNA polymerase delta 2, accessory subunit
10714  POLD3; DNA polymerase delta 3, accessory subunit
57804  POLD4; DNA polymerase delta 4, accessory subunit
5111  PCNA; proliferating cell nuclear antigen
1763  DNA2; DNA replication helicase/nuclease 2
10535  RNASEH2A; ribonuclease H2 subunit A
79621  RNASEH2B; ribonuclease H2 subunit B
84153  RNASEH2C; ribonuclease H2 subunit C
2237  FEN1; flap structure-specific endonuclease 1
3978  LIG1; DNA ligase 1
Reference
PMID:28301743
  Authors
Burgers PMJ, Kunkel TA
  Title
Eukaryotic DNA Replication Fork.
  Journal
Annu Rev Biochem 86:417-438 (2017)
DOI:10.1146/annurev-biochem-061516-044709
Reference
PMID:21278448
  Authors
Zheng L, Shen B
  Title
Okazaki fragment maturation: nucleases take centre stage.
  Journal
J Mol Cell Biol 3:23-30 (2011)
DOI:10.1093/jmcb/mjq048
Reference
PMID:28159842
  Authors
Liu B, Hu J, Wang J, Kong D
  Title
Direct Visualization of RNA-DNA Primer Removal from Okazaki Fragments Provides Support for Flap Cleavage and Exonucleolytic Pathways in Eukaryotic Cells.
  Journal
J Biol Chem 292:4777-4788 (2017)
DOI:10.1074/jbc.M116.758599
LinkDB

DBGET integrated database retrieval system