Homo sapiens (human): 2157 Help Entry 2157              CDS       T01001                                  Gene name F8, AHF, DXS1253E, F8B, F8C, FVIII, HEMA Definition (RefSeq) coagulation factor VIII   KO K03899   coagulation factor VIII Organism hsa  Homo sapiens (human) Pathway hsa04610   Complement and coagulation cascades Disease H00219   Hemophilia Drug target Desmopressin (DG00497):  D00291 D02235<JP/US> Brite KEGG Orthology (KO) [BR:hsa00001]  09150 Organismal Systems   09151 Immune system    04610 Complement and coagulation cascades     2157 (F8) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  F5_F8_type_C Cu-oxidase_3 Cu-oxidase_2 Cu-oxidase CytadhesinP1 PBP1_TM Motif Other DBs NCBI-GeneID:  2157 NCBI-ProteinID:  NP_000123 OMIM:  300841 HGNC:  3546 Ensembl:  ENSG00000185010 Vega:  OTTHUMG00000022688 Pharos:  P00451(Tbio) UniProt:  P00451 LinkDB All DBs Structure PDB:  3HNY 3HNB 1D7P 1IQD 3HOB 4KI5 4XZU 6MF2 2R7E 4BDV 3CDZ 5K8D 3J2S 3J2Q 1FAC 1CFG Thumbnails Position Xq28 AA seq 2351 aa AA seqDB search MQIELSTCFFLCLLRFCFSATRRYYLGAVELSWDYMQSDLGELPVDARFPPRVPKSFPFN TSVVYKKTLFVEFTDHLFNIAKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAV GVSYWKASEGAEYDDQTSQREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSH VDLVKDLNSGLIGALLVCREGSLAKEKTQTLHKFILLFAVFDEGKSWHSETKNSLMQDRD AASARAWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNH RQASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQLRMKNNE EAEDYDDDLTDSEMDVVRFDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPLVLA PDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETFKTREAIQHESGILGPLLYGEVGDTL LIIFKNQASRPYNIYPHGITDVRPLYSRRLPKGVKHLKDFPILPGEIFKYKWTVTVEDGP TKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQRGNQIMSDKRNVILFSVFDE NRSWYLTENIQRFLPNPAGVQLEDPEFQASNIMHSINGYVFDSLQLSVCLHEVAYWYILS IGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWILGCHNSDFRNRG MTALLKVSSCDKNTGDYYEDSYEDISAYLLSKNNAIEPRSFSQNSRHPSTRQKQFNATTI PENDIEKTDPWFAHRTPMPKIQNVSSSDLLMLLRQSPTPHGLSLSDLQEAKYETFSDDPS PGAIDSNNSLSEMTHFRPQLHHSGDMVFTPESGLQLRLNEKLGTTAATELKKLDFKVSST SNNLISTIPSDNLAAGTDNTSSLGPPSMPVHYDSQLDTTLFGKKSSPLTESGGPLSLSEE NNDSKLLESGLMNSQESSWGKNVSSTESGRLFKGKRAHGPALLTKDNALFKVSISLLKTN KTSNNSATNRKTHIDGPSLLIENSPSVWQNILESDTEFKKVTPLIHDRMLMDKNATALRL NHMSNKTTSSKNMEMVQQKKEGPIPPDAQNPDMSFFKMLFLPESARWIQRTHGKNSLNSG QGPSPKQLVSLGPEKSVEGQNFLSEKNKVVVGKGEFTKDVGLKEMVFPSSRNLFLTNLDN LHENNTHNQEKKIQEEIEKKETLIQENVVLPQIHTVTGTKNFMKNLFLLSTRQNVEGSYD GAYAPVLQDFRSLNDSTNRTKKHTAHFSKKGEEENLEGLGNQTKQIVEKYACTTRISPNT SQQNFVTQRSKRALKQFRLPLEETELEKRIIVDDTSTQWSKNMKHLTPSTLTQIDYNEKE KGAITQSPLSDCLTRSHSIPQANRSPLPIAKVSSFPSIRPIYLTRVLFQDNSSHLPAASY RKKDSGVQESSHFLQGAKKNNLSLAILTLEMTGDQREVGSLGTSATNSVTYKKVENTVLP KPDLPKTSGKVELLPKVHIYQKDLFPTETSNGSPGHLDLVEGSLLQGTEGAIKWNEANRP GKVPFLRVATESSAKTPSKLLDPLAWDNHYGTQIPKEEWKSQEKSPEKTAFKKKDTILSL NACESNHAIAAINEGQNKPEIEVTWAKQGRTERLCSQNPPVLKRHQREITRTTLQSDQEE IDYDDTISVEMKKEDFDIYDEDENQSPRSFQKKTRHYFIAAVERLWDYGMSSSPHVLRNR AQSGSVPQFKKVVFQEFTDGSFTQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASR PYSFYSSLISYEEDQRQGAEPRKNFVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDV DLEKDVHSGLIGPLLVCHTNTLNPAHGRQVTVQEFALFFTIFDETKSWYFTENMERNCRA PCNIQMEDPTFKENYRFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGH VFTVRKKEEYKMALYNLYPGVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLVYSNKC QTPLGMASGHIRDFQITASGQYGQWAPKLARLHYSGSINAWSTKEPFSWIKVDLLAPMII HGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNVDSSGIKHNIFN PPIIARYIRLHPTHYSIRSTLRMELMGCDLNSCSMPLGMESKAISDAQITASSYFTNMFA TWSPSKARLHLQGRSNAWRPQVNNPKEWLQVDFQKTMKVTGVTTQGVKSLLTSMYVKEFL ISSSQDGHQWTLFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRM EVLGCEAQDLY NT seq 7056 nt NT seq  +upstreamnt  +downstreamnt atgcaaatagagctctccacctgcttctttctgtgccttttgcgattctgctttagtgcc accagaagatactacctgggtgcagtggaactgtcatgggactatatgcaaagtgatctc ggtgagctgcctgtggacgcaagatttcctcctagagtgccaaaatcttttccattcaac acctcagtcgtgtacaaaaagactctgtttgtagaattcacggatcaccttttcaacatc gctaagccaaggccaccctggatgggtctgctaggtcctaccatccaggctgaggtttat gatacagtggtcattacacttaagaacatggcttcccatcctgtcagtcttcatgctgtt ggtgtatcctactggaaagcttctgagggagctgaatatgatgatcagaccagtcaaagg gagaaagaagatgataaagtcttccctggtggaagccatacatatgtctggcaggtcctg aaagagaatggtccaatggcctctgacccactgtgccttacctactcatatctttctcat gtggacctggtaaaagacttgaattcaggcctcattggagccctactagtatgtagagaa gggagtctggccaaggaaaagacacagaccttgcacaaatttatactactttttgctgta tttgatgaagggaaaagttggcactcagaaacaaagaactccttgatgcaggatagggat gctgcatctgctcgggcctggcctaaaatgcacacagtcaatggttatgtaaacaggtct ctgccaggtctgattggatgccacaggaaatcagtctattggcatgtgattggaatgggc accactcctgaagtgcactcaatattcctcgaaggtcacacatttcttgtgaggaaccat cgccaggcgtccttggaaatctcgccaataactttccttactgctcaaacactcttgatg gaccttggacagtttctactgttttgtcatatctcttcccaccaacatgatggcatggaa gcttatgtcaaagtagacagctgtccagaggaaccccaactacgaatgaaaaataatgaa gaagcggaagactatgatgatgatcttactgattctgaaatggatgtggtcaggtttgat gatgacaactctccttcctttatccaaattcgctcagttgccaagaagcatcctaaaact tgggtacattacattgctgctgaagaggaggactgggactatgctcccttagtcctcgcc cccgatgacagaagttataaaagtcaatatttgaacaatggccctcagcggattggtagg aagtacaaaaaagtccgatttatggcatacacagatgaaacctttaagactcgtgaagct attcagcatgaatcaggaatcttgggacctttactttatggggaagttggagacacactg ttgattatatttaagaatcaagcaagcagaccatataacatctaccctcacggaatcact gatgtccgtcctttgtattcaaggagattaccaaaaggtgtaaaacatttgaaggatttt ccaattctgccaggagaaatattcaaatataaatggacagtgactgtagaagatgggcca actaaatcagatcctcggtgcctgacccgctattactctagtttcgttaatatggagaga gatctagcttcaggactcattggccctctcctcatctgctacaaagaatctgtagatcaa agaggaaaccagataatgtcagacaagaggaatgtcatcctgttttctgtatttgatgag aaccgaagctggtacctcacagagaatatacaacgctttctccccaatccagctggagtg cagcttgaggatccagagttccaagcctccaacatcatgcacagcatcaatggctatgtt tttgatagtttgcagttgtcagtttgtttgcatgaggtggcatactggtacattctaagc attggagcacagactgacttcctttctgtcttcttctctggatataccttcaaacacaaa atggtctatgaagacacactcaccctattcccattctcaggagaaactgtcttcatgtcg atggaaaacccaggtctatggattctggggtgccacaactcagactttcggaacagaggc atgaccgccttactgaaggtttctagttgtgacaagaacactggtgattattacgaggac agttatgaagatatttcagcatacttgctgagtaaaaacaatgccattgaaccaagaagc ttctcccagaattcaagacaccctagcactaggcaaaagcaatttaatgccaccacaatt ccagaaaatgacatagagaagactgacccttggtttgcacacagaacacctatgcctaaa atacaaaatgtctcctctagtgatttgttgatgctcttgcgacagagtcctactccacat gggctatccttatctgatctccaagaagccaaatatgagactttttctgatgatccatca cctggagcaatagacagtaataacagcctgtctgaaatgacacacttcaggccacagctc catcacagtggggacatggtatttacccctgagtcaggcctccaattaagattaaatgag aaactggggacaactgcagcaacagagttgaagaaacttgatttcaaagtttctagtaca tcaaataatctgatttcaacaattccatcagacaatttggcagcaggtactgataataca agttccttaggacccccaagtatgccagttcattatgatagtcaattagataccactcta tttggcaaaaagtcatctccccttactgagtctggtggacctctgagcttgagtgaagaa aataatgattcaaagttgttagaatcaggtttaatgaatagccaagaaagttcatgggga aaaaatgtatcgtcaacagagagtggtaggttatttaaagggaaaagagctcatggacct gctttgttgactaaagataatgccttattcaaagttagcatctctttgttaaagacaaac aaaacttccaataattcagcaactaatagaaagactcacattgatggcccatcattatta attgagaatagtccatcagtctggcaaaatatattagaaagtgacactgagtttaaaaaa gtgacacctttgattcatgacagaatgcttatggacaaaaatgctacagctttgaggcta aatcatatgtcaaataaaactacttcatcaaaaaacatggaaatggtccaacagaaaaaa gagggccccattccaccagatgcacaaaatccagatatgtcgttctttaagatgctattc ttgccagaatcagcaaggtggatacaaaggactcatggaaagaactctctgaactctggg caaggccccagtccaaagcaattagtatccttaggaccagaaaaatctgtggaaggtcag aatttcttgtctgagaaaaacaaagtggtagtaggaaagggtgaatttacaaaggacgta ggactcaaagagatggtttttccaagcagcagaaacctatttcttactaacttggataat ttacatgaaaataatacacacaatcaagaaaaaaaaattcaggaagaaatagaaaagaag gaaacattaatccaagagaatgtagttttgcctcagatacatacagtgactggcactaag aatttcatgaagaaccttttcttactgagcactaggcaaaatgtagaaggttcatatgac ggggcatatgctccagtacttcaagattttaggtcattaaatgattcaacaaatagaaca aagaaacacacagctcatttctcaaaaaaaggggaggaagaaaacttggaaggcttggga aatcaaaccaagcaaattgtagagaaatatgcatgcaccacaaggatatctcctaataca agccagcagaattttgtcacgcaacgtagtaagagagctttgaaacaattcagactccca ctagaagaaacagaacttgaaaaaaggataattgtggatgacacctcaacccagtggtcc aaaaacatgaaacatttgaccccgagcaccctcacacagatagactacaatgagaaggag aaaggggccattactcagtctcccttatcagattgccttacgaggagtcatagcatccct caagcaaatagatctccattacccattgcaaaggtatcatcatttccatctattagacct atatatctgaccagggtcctattccaagacaactcttctcatcttccagcagcatcttat agaaagaaagattctggggtccaagaaagcagtcatttcttacaaggagccaaaaaaaat aacctttctttagccattctaaccttggagatgactggtgatcaaagagaggttggctcc ctggggacaagtgccacaaattcagtcacatacaagaaagttgagaacactgttctcccg aaaccagacttgcccaaaacatctggcaaagttgaattgcttccaaaagttcacatttat cagaaggacctattccctacggaaactagcaatgggtctcctggccatctggatctcgtg gaagggagccttcttcagggaacagagggagcgattaagtggaatgaagcaaacagacct ggaaaagttccctttctgagagtagcaacagaaagctctgcaaagactccctccaagcta ttggatcctcttgcttgggataaccactatggtactcagataccaaaagaagagtggaaa tcccaagagaagtcaccagaaaaaacagcttttaagaaaaaggataccattttgtccctg aacgcttgtgaaagcaatcatgcaatagcagcaataaatgagggacaaaataagcccgaa atagaagtcacctgggcaaagcaaggtaggactgaaaggctgtgctctcaaaacccacca gtcttgaaacgccatcaacgggaaataactcgtactactcttcagtcagatcaagaggaa attgactatgatgataccatatcagttgaaatgaagaaggaagattttgacatttatgat gaggatgaaaatcagagcccccgcagctttcaaaagaaaacacgacactattttattgct gcagtggagaggctctgggattatgggatgagtagctccccacatgttctaagaaacagg gctcagagtggcagtgtccctcagttcaagaaagttgttttccaggaatttactgatggc tcctttactcagcccttataccgtggagaactaaatgaacatttgggactcctggggcca tatataagagcagaagttgaagataatatcatggtaactttcagaaatcaggcctctcgt ccctattccttctattctagccttatttcttatgaggaagatcagaggcaaggagcagaa cctagaaaaaactttgtcaagcctaatgaaaccaaaacttacttttggaaagtgcaacat catatggcacccactaaagatgagtttgactgcaaagcctgggcttatttctctgatgtt gacctggaaaaagatgtgcactcaggcctgattggaccccttctggtctgccacactaac acactgaaccctgctcatgggagacaagtgacagtacaggaatttgctctgtttttcacc atctttgatgagaccaaaagctggtacttcactgaaaatatggaaagaaactgcagggct ccctgcaatatccagatggaagatcccacttttaaagagaattatcgcttccatgcaatc aatggctacataatggatacactacctggcttagtaatggctcaggatcaaaggattcga tggtatctgctcagcatgggcagcaatgaaaacatccattctattcatttcagtggacat gtgttcactgtacgaaaaaaagaggagtataaaatggcactgtacaatctctatccaggt gtttttgagacagtggaaatgttaccatccaaagctggaatttggcgggtggaatgcctt attggcgagcatctacatgctgggatgagcacactttttctggtgtacagcaataagtgt cagactcccctgggaatggcttctggacacattagagattttcagattacagcttcagga caatatggacagtgggccccaaagctggccagacttcattattccggatcaatcaatgcc tggagcaccaaggagcccttttcttggatcaaggtggatctgttggcaccaatgattatt cacggcatcaagacccagggtgcccgtcagaagttctccagcctctacatctctcagttt atcatcatgtatagtcttgatgggaagaagtggcagacttatcgaggaaattccactgga accttaatggtcttctttggcaatgtggattcatctgggataaaacacaatatttttaac cctccaattattgctcgatacatccgtttgcacccaactcattatagcattcgcagcact cttcgcatggagttgatgggctgtgatttaaatagttgcagcatgccattgggaatggag agtaaagcaatatcagatgcacagattactgcttcatcctactttaccaatatgtttgcc acctggtctccttcaaaagctcgacttcacctccaagggaggagtaatgcctggagacct caggtgaataatccaaaagagtggctgcaagtggacttccagaagacaatgaaagtcaca ggagtaactactcagggagtaaaatctctgcttaccagcatgtatgtgaaggagttcctc atctccagcagtcaagatggccatcagtggactctcttttttcagaatggcaaagtaaag gtttttcagggaaatcaagactccttcacacctgtggtgaactctctagacccaccgtta ctgactcgctaccttcgaattcacccccagagttgggtgcaccagattgccctgaggatg gaggttctgggctgcgaggcacaggacctctactga

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