Homo sapiens (human): 2235 Help Entry 2235              CDS       T01001                                  Gene name FECH, EPP, EPP1, FCE Definition (RefSeq) ferrochelatase   KO K01772   protoporphyrin/coproporphyrin ferrochelatase [EC:4.99.1.1 4.99.1.9] Organism hsa  Homo sapiens (human) Pathway hsa00860   Porphyrin and chlorophyll metabolism hsa01100   Metabolic pathways hsa01240   Biosynthesis of cofactors Module hsa_M00868   Heme biosynthesis, animals and fungi, glycine => heme Network nt06011  Heme biosynthesis   Element N00601   Heme biosynthesis N00602   FECH deficiency in heme biosynthesis Disease H00201   Erythropoietic porphyria H01763   Porphyria Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09108 Metabolism of cofactors and vitamins    00860 Porphyrin and chlorophyll metabolism     2235 (FECH) Enzymes [BR:hsa01000]  4. Lyases   4.99  Other lyases    4.99.1  Sole sub-subclass for lyases that do not belong in the other subclasses     4.99.1.1  protoporphyrin ferrochelatase      2235 (FECH)     4.99.1.9  coproporphyrin ferrochelatase      2235 (FECH) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Ferrochelatase Motif Other DBs NCBI-GeneID:  2235 NCBI-ProteinID:  NP_000131 OMIM:  612386 HGNC:  3647 Ensembl:  ENSG00000066926 Vega:  OTTHUMG00000132740 Pharos:  P22830(Tbio) UniProt:  P22830 Q7KZA3 LinkDB All DBs Structure PDB:  3HCN 3AQI 2HRC 4F4D 3HCO 3HCP 2QD4 1HRK 3W1W 4KLR 3HCR 2QD1 2QD2 2QD3 2PO5 2PO7 2QD5 2PNJ 4KLC 4MK4 2HRE 4KMM 4KLA Thumbnails Position 18q21.31 AA seq 423 aa AA seqDB search MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQV QPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQ EQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERD GLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADH ILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLV WQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKEC GVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTS QQL NT seq 1272 nt NT seq  +upstreamnt  +downstreamnt atgcgttcactcggcgcaaacatggctgcggccctgcgcgccgcgggcgtcctgctccgc gatccgctggcatccagcagctggagggtctgtcagccatggaggtggaagtcaggtgca gctgcagcggccgtcaccacagaaacagcccagcatgcccagggtgcaaaacctcaagtt caaccgcagaagaggaagccgaaaactggaatattaatgctaaacatgggaggccctgaa actcttggagatgttcacgacttccttctgagactcttcttggaccgagacctcatgaca cttcctattcagaataagctggcaccattcatcgccaaacgccgaacccccaagattcaa gagcagtaccgcaggattggaggcggatcccccatcaagatatggacttccaagcaggga gagggcatggtgaagctgctggatgaattgtcccccaacacagcccctcacaaatactat attggatttcggtacgtccatcctttaacagaagaagcaattgaagagatggagagagat ggcctagaaagggctattgctttcacacagtatccacagtacagctgctccaccacaggc agcagcttaaatgccatttacagatactataatcaagtgggacggaagcccacgatgaag tggagcactattgacaggtggcccacacatcacctcctcatccagtgctttgcagatcat attctaaaggaactggaccattttccacttgagaagagaagcgaggtggtcattctgttt tctgctcactcactgcccatgtctgtggtcaacagaggcgacccatatcctcaggaggta agcgccactgtccaaaaagtcatggaaaggctggagtactgcaacccctaccgactggtg tggcaatccaaggttggtccaatgccctggttgggtcctcaaacagacgaatctatcaaa gggctttgtgagagggggaggaagaatatcctcttggttccgatagcatttaccagtgac catattgaaacgctgtatgagctggacatcgagtactctcaagttttagccaaggagtgt ggagttgaaaacatcagaagagctgagtctcttaatggaaatccattgttctctaaggcc ctggccgacttggtgcattcacacatccagtcaaacgagctgtgttccaagcagctgacc ctgagctgtccgctctgtgtcaatcctgtctgcagggagactaaatccttcttcaccagc cagcagctgtga

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