KEGG   NETWORK: N00575Help
Entry
N00575                      Network                                

Name
HSV ICP27 to IFN signaling pathway
Definition
hsvICP27 -| (STAT1+STAT2+IRF9) => (ZAP1,EIF2AK,OAS)
  Expanded
K19443 -| (6772+6773+10379) => (148266,27102,5610,9451,440275,4938,4939,4940)
Class
nt06122 IFN signaling (viruses)
nt06168 Herpes simplex virus 1 (HSV-1)
Type
Pathogen
Pathway
hsa05168  Herpes simplex virus 1 infection
Disease
H00365  Herpes simplex virus infection
Gene
6772  STAT1; signal transducer and activator of transcription 1
6773  STAT2; signal transducer and activator of transcription 2
10379  IRF9; interferon regulatory factor 9
148266  ZNF569; zinc finger protein 569
27102  EIF2AK1; eukaryotic translation initiation factor 2 alpha kinase 1
5610  EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2
9451  EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3
440275  EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4
4938  OAS1; 2'-5'-oligoadenylate synthetase 1
4939  OAS2; 2'-5'-oligoadenylate synthetase 2
4940  OAS3; 2'-5'-oligoadenylate synthetase 3
Perturbant
K19443  UL54; mRNA export factor
Reference
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
  Authors
Johnson KE, Song B, Knipe DM
  Title
Role for herpes simplex virus 1 ICP27 in the inhibition of type I interferon signaling.
  Journal
Virology 374:487-94 (2008)
DOI:10.1016/j.virol.2008.01.001
Reference
  Authors
Nan Y, Wu C, Zhang YJ
  Title
Interplay between Janus Kinase/Signal Transducer and Activator of Transcription Signaling Activated by Type I Interferons and Viral Antagonism.
  Journal
Front Immunol 8:1758 (2017)
DOI:10.3389/fimmu.2017.01758
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