KEGG   NETWORK: N00922
Entry
N00922                      Network                                

Name
FSHR-GNAS-PKA signaling pathway
Definition
(CGA+FSHB) -> FSHR -> GNAS -> ADCY -> cAMP -> PKA
  Expanded
(1081+2488) -> 2492 -> 2778 -> (107,108,109,196883,111,112,113,114,115) -> C00575 -> (5566+5567+5568)
Class
nt06323 KISS1-GnRH-LH/FSH-E2 signaling
Type
Reference
Pathway
hsa04024 cAMP signaling pathway   
Gene
1081  CGA; glycoprotein hormones, alpha polypeptide
2488  FSHB; follicle stimulating hormone subunit beta
2492  FSHR; follicle stimulating hormone receptor
2778  GNAS; GNAS complex locus
107  ADCY1; adenylate cyclase 1
108  ADCY2; adenylate cyclase 2
109  ADCY3; adenylate cyclase 3
196883  ADCY4; adenylate cyclase 4
111  ADCY5; adenylate cyclase 5
112  ADCY6; adenylate cyclase 6
113  ADCY7; adenylate cyclase 7
114  ADCY8; adenylate cyclase 8
115  ADCY9; adenylate cyclase 9
5566  PRKACA; protein kinase cAMP-activated catalytic subunit alpha
5567  PRKACB; protein kinase cAMP-activated catalytic subunit beta
5568  PRKACG; protein kinase cAMP-activated catalytic subunit gamma
Metabolite
C00575  3',5'-Cyclic AMP
Reference
  Authors
Amory JK, Bremner W
  Title
Endocrine regulation of testicular function in men: implications for contraceptive development.
  Journal
Mol Cell Endocrinol 182:175-9 (2001)
DOI:10.1016/s0303-7207(01)00562-7
Reference
  Authors
Walker WH, Cheng J
  Title
FSH and testosterone signaling in Sertoli cells.
  Journal
Reproduction 130:15-28 (2005)
DOI:10.1530/rep.1.00358
Reference
  Authors
Loss ES, Jacobus AP, Wassermann GF
  Title
Rapid signaling responses in Sertoli cell membranes induced by follicle stimulating hormone and testosterone: calcium inflow and electrophysiological changes.
  Journal
Life Sci 89:577-83 (2011)
DOI:10.1016/j.lfs.2011.05.017
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