Entry Name Meiosis - yeast
Description During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, then segregates from, its homologous pair, while the sister chromatids segregate from each other at meoisis II. In yeast, the switch to enter growth phase or meiosis phase is controlled by nutritional signals. At the onset of meiosis, nutritional signaling pathways converge on transcriptional regulation of Ime1. Ime1 is a transcriptional activator to promote expression of early meiosis-specific genes required for pre-meiotic DNA replication and meiotic recombination. Two of the early meiosis-specific genes, a transcriptional activator, Ndt80, and a CDK2 homolog, Ime2, are required for the transcription of middle meiosis-specific genes, which includes B-type cyclin genes and genes involved in spore wall formation. Polo-like kinase Cdc5, whose expression is activated by Ndt80, is required for the critical step in meiotic progression. Cdc5 regulates sister-kinetochore co-orientation by promoting the localization of Mam1 and Lrs4, components of the co-orientation complex, to kinetochores. Cdc5 also phosphorylates the meiotic cohesin subunit Rec8, which is essential for its cleavage and removal by separase. Moreover, Cdc5 promotes the release of protein phosphatase Cdc14 from the nuclezus, which is required for anaphase I spindle disassembly and exit from meiosis I. The centromeric protein Sgo1 is a key regulator of meiotic chromosome segregation. Sgo1 with PP2A may protect pericentromeric but not arm cohesion of sister chromatids during meiosis I. Sgo1 then disappears at meiosis II to allow sister chromatids to separate.
Class Cellular Processes; Cell growth and deathBRITE hierarchy
Pathway map Ortholog table Other DBs Orthology K06646 G1/S-specific cyclin CLN3
K06649 regulatory protein SWI4
K06648 regulatory protein SWI6
K06650 G1/S-specific cyclin CLN2
K09235 zinc finger protein RME1
K08139 MFS transporter, SP family, sugar:H+ symporter
K12762 G protein-coupled receptor GPR1
K04630 guanine nucleotide-binding protein G(i) subunit alpha
K09468 zinc finger protein MSN2/4
K12763 enhanced filamentous growth protein 1
K12764 meiosis-inducing protein 1
K03085 substrate and inhibitor of the cyclin-dependent protein kinase CDC28
K06651 S-phase entry cyclin 5/6
K02213 cell division control protein 6
K12414 DNA replication licensing factor, required for pre-replication complex assembly
K02603 origin recognition complex subunit 1
K02604 origin recognition complex subunit 2
K02605 origin recognition complex subunit 3
K02606 origin recognition complex subunit 4
K02607 origin recognition complex subunit 5
K02608 origin recognition complex subunit 6
K06628 cell division control protein 45
K02309 regulatory subunit for Cdc7p protein kinase
K09243 transcriptional regulatory protein UME6
K10878 meiotic recombination protein SPO11
K10872 meiotic recombination protein DMC1
K12768 synaptonemal complex protein ZIP1
K12769 meiosis-specific transcription factor NDT80
K12770 GLC7-interacting protein 1
K12772 sporulation-specific protein 4
K12773 sporulation-regulated protein 3
K02220 G2/mitotic-specific cyclin 1
K06659 G2/mitotic-specific cyclin 3/4
K12576 sporulation-specific protein 12
K12575 kinetochore protein SLK19
K12774 monopolin complex subunit MAM1
K12775 monopolin complex subunit LRS4
K06269 serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16 ]
K12776 meiosis-specific serine/threonine-protein kinase MEK1 [EC:2.7.11.1 ]
K12778 meiosis-specific protein
K12779 suppressor of MAR1-1 protein
K02544 G2-specific checkpoint protein
K06663 DNA damage checkpoint protein
K06662 cell cycle checkpoint protein
K02543 cell cycle checkpoint protein MEC1
K06661 DNA repair protein RAD9
K02831 ser/thr/tyr protein kinase RAD53 [EC:2.7.11.-]
K06636 structural maintenance of chromosome 1
K06669 structural maintenance of chromosome 3 (chondroitin sulfate proteoglycan 6)
K12780 meiotic recombination protein REC8, fungi type
K06671 cohesin complex subunit SA-1/2
K02537 mitotic spindle assembly checkpoint protein MAD2
K06679 mitotic spindle assembly checkpoint protein MAD1
K03348 anaphase-promoting complex subunit 1
K03349 anaphase-promoting complex subunit 2
K03350 anaphase-promoting complex subunit 3
K03351 anaphase-promoting complex subunit 4
K03352 anaphase-promoting complex subunit 5
K03353 anaphase-promoting complex subunit 6
K03354 anaphase-promoting complex subunit 7
K03355 anaphase-promoting complex subunit 8
K03356 anaphase-promoting complex subunit 9
K03357 anaphase-promoting complex subunit 10
K03358 anaphase-promoting complex subunit 11
K03359 anaphase-promoting complex subunit 12
K12416 anaphase-promoting complex subunit SWM1
K03363 cell division cycle 20, cofactor of APC complex
K11584 serine/threonine-protein phosphatase 2A regulatory subunit B'
K04382 serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16 ]
K03456 serine/threonine-protein phosphatase 2A regulatory subunit A
K12781 anaphase-promoting complex subunit MND2
K12782 meiosis-specific APC/C activator protein AMA1
K12783 sporulation-specific protein 1
Compound Reference Authors Honigberg SM, Purnapatre K
Title Signal pathway integration in the switch from the mitotic cell cycle to meiosis in yeast.
Journal Reference Authors Kassir Y, Adir N, Boger-Nadjar E, Raviv NG, Rubin-Bejerano I, Sagee S, Shenhar G
Title Transcriptional regulation of meiosis in budding yeast.
Journal Reference Authors Honigberg SM
Title Ime2p and Cdc28p: co-pilots driving meiotic development.
Journal Reference Authors Hochwagen A, Amon A
Title Checking your breaks: surveillance mechanisms of meiotic recombination.
Journal Reference Authors Hollingsworth NM
Title Deconstructing meiosis one kinase at a time: polo pushes past pachytene.
Journal Reference Authors Sourirajan A, Lichten M
Title Polo-like kinase Cdc5 drives exit from pachytene during budding yeast meiosis.
Journal Reference Authors Roeder GS, Bailis JM
Title The pachytene checkpoint.
Journal Reference Authors Barr FA, Sillje HH, Nigg EA
Title Polo-like kinases and the orchestration of cell division.
Journal Reference Authors Lee BH, Amon A
Title Polo kinase--meiotic cell cycle coordinator.
Journal Reference Authors Buonomo SB, Rabitsch KP, Fuchs J, Gruber S, Sullivan M, Uhlmann F, Petronczki M, Toth A, Nasmyth K
Title Division of the nucleolus and its release of CDC14 during anaphase of meiosis I depends on separase, SPO12, and SLK19.
Journal Reference Authors Oelschlaegel T, Schwickart M, Matos J, Bogdanova A, Camasses A, Havlis J, Shevchenko A, Zachariae W
Title The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1.
Journal Reference Authors Dai W, Wang X
Title The Yin and Yang of centromeric cohesion of sister chromatids: mitotic kinases meet protein phosphatase 2A.
Journal Reference Authors Clift D, Bizzari F, Marston AL
Title Shugoshin prevents cohesin cleavage by PP2A(Cdc55)-dependent inhibition of separase.
Journal Reference Authors Pesin JA, Orr-Weaver TL
Title Regulation of APC/C activators in mitosis and meiosis.
Journal Reference Authors Diamond AE, Park JS, Inoue I, Tachikawa H, Neiman AM
Title The anaphase promoting complex targeting subunit Ama1 links meiotic exit to cytokinesis during sporulation in Saccharomyces cerevisiae.
Journal Related ko04120 Ubiquitin mediated proteolysis
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