KEGG   ORTHOLOGY: K02216
Entry
K02216                      KO                                     
Symbol
CHEK1
Name
serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
Pathway
map04110  Cell cycle
map04111  Cell cycle - yeast
map04113  Meiosis - yeast
map04115  p53 signaling pathway
map04218  Cellular senescence
map05166  Human T-cell leukemia virus 1 infection
map05170  Human immunodeficiency virus 1 infection
map05203  Viral carcinogenesis
Disease
H01897  Oocyte/zygote/embryo maturation arrest
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K02216  CHEK1; serine/threonine-protein kinase CHEK1
   04111 Cell cycle - yeast
    K02216  CHEK1; serine/threonine-protein kinase CHEK1
   04113 Meiosis - yeast
    K02216  CHEK1; serine/threonine-protein kinase CHEK1
   04115 p53 signaling pathway
    K02216  CHEK1; serine/threonine-protein kinase CHEK1
   04218 Cellular senescence
    K02216  CHEK1; serine/threonine-protein kinase CHEK1
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K02216  CHEK1; serine/threonine-protein kinase CHEK1
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K02216  CHEK1; serine/threonine-protein kinase CHEK1
   05170 Human immunodeficiency virus 1 infection
    K02216  CHEK1; serine/threonine-protein kinase CHEK1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K02216  CHEK1; serine/threonine-protein kinase CHEK1
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K02216  CHEK1; serine/threonine-protein kinase CHEK1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K02216  CHEK1; serine/threonine-protein kinase CHEK1
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CAMK group
  CAMKL family
   K02216  CHEK1; serine/threonine-protein kinase CHEK1
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  Check point factors
   Other check point factors
    K02216  CHEK1; serine/threonine-protein kinase CHEK1
Other DBs
COG: COG0515
Genes
HSA: 1111(CHEK1)
PTR: 739836(CHEK1)
PPS: 100982317(CHEK1)
GGO: 101131993(CHEK1)
PON: 100436550(CHEK1)
NLE: 100596673(CHEK1)
HMH: 116477131(CHEK1)
MCC: 713358(CHEK1)
MCF: 101926004(CHEK1)
MTHB: 126934853
MNI: 105476258(CHEK1)
CSAB: 103248769(CHEK1)
CATY: 105582604(CHEK1)
PANU: 101019580(CHEK1)
TGE: 112606274(CHEK1)
MLEU: 105554711(CHEK1)
RRO: 104653937(CHEK1)
RBB: 108542336(CHEK1)
TFN: 117080890(CHEK1)
PTEH: 111540298(CHEK1)
CANG: 105506457(CHEK1)
CJC: 100405400(CHEK1)
SBQ: 101044792(CHEK1)
CIMI: 108300793(CHEK1)
CSYR: 103273961(CHEK1)
MMUR: 105881584(CHEK1)
LCAT: 123641207(CHEK1)
PCOQ: 105821450(CHEK1)
OGA: 100942218(CHEK1)
MMU: 12649(Chek1)
MCAL: 110301495(Chek1)
MPAH: 110327308(Chek1)
RNO: 140583(Chek1)
MCOC: 116071915(Chek1)
ANU: 117699162(Chek1)
MUN: 110549439(Chek1)
CGE: 100751099(Chek1)
MAUA: 101843181(Chek1)
PROB: 127231512(Chek1)
PLEU: 114684003(Chek1)
MORG: 121451627(Chek1)
MFOT: 126490587
AAMP: 119809693(Chek1)
NGI: 103735579(Chek1)
HGL: 101701035(Chek1)
CPOC: 100719613(Chek1)
CCAN: 109700303(Chek1)
DORD: 105980875(Chek1)
DSP: 122104226(Chek1) 122123350
PLOP: 125349506(Chek1)
NCAR: 124958320
MMMA: 107153495(Chek1)
OCU: 100345729
OPI: 101533794(CHEK1)
TUP: 102480757(CHEK1)
GVR: 103583154 103608913(CHEK1)
CFA: 609767(CHEK1)
CLUD: 112671112(CHEK1)
VVP: 112920276(CHEK1)
VLG: 121500173(CHEK1)
NPO: 129497889(CHEK1)
AML: 100467858(CHEK1)
UMR: 103660629(CHEK1)
UAH: 113259903(CHEK1)
UAR: 123792711(CHEK1)
ELK: 111153780
LLV: 125110264
MPUF: 101685590(CHEK1)
MNP: 132026435(CHEK1)
MLK: 131838215(CHEK1)
NVS: 122912413(CHEK1)
ORO: 101362614(CHEK1)
EJU: 114226008(CHEK1)
ZCA: 113915303(CHEK1)
MLX: 118013370(CHEK1)
NSU: 110586234(CHEK1)
LWW: 102731543(CHEK1)
FCA: 101083365(CHEK1)
PYU: 121035597(CHEK1)
PCOO: 112865240(CHEK1)
PBG: 122483117(CHEK1)
LRUF: 124505184
PTG: 102948766(CHEK1)
PPAD: 109257420(CHEK1)
PUC: 125939340
AJU: 106976641
HHV: 120243919(CHEK1)
BTA: 513678(CHEK1)
BOM: 102266500
BIU: 109554657(CHEK1)
BBUB: 102398478(CHEK1)
BBIS: 104980692(CHEK1)
CHX: 102184881(CHEK1)
OAS: 101111403(CHEK1)
BTAX: 128068939(CHEK1)
ODA: 120874428(CHEK1)
CCAD: 122430784(CHEK1)
MBEZ: 129548956(CHEK1)
SSC: 100511709(CHEK1)
CFR: 102505566(CHEK1)
CBAI: 105074175(CHEK1)
CDK: 105094454(CHEK1)
VPC: 102526561(CHEK1)
BACU: 103015970(CHEK1)
LVE: 103073805(CHEK1)
OOR: 101270160(CHEK1)
DLE: 111167465(CHEK1)
PCAD: 102989266(CHEK1)
PSIU: 116757609(CHEK1)
NASI: 112396826(CHEK1)
ECB: 100064353(CHEK1)
EPZ: 103557005(CHEK1)
EAI: 106835962(CHEK1)
MYB: 102255905(CHEK1)
MYD: 102751668(CHEK1)
MMYO: 118678155(CHEK1)
MLF: 102437641(CHEK1)
MNA: 107530590(CHEK1)
PKL: 118725741(CHEK1)
EFUS: 103286938(CHEK1)
HAI: 109391372(CHEK1)
DRO: 112301845(CHEK1)
SHON: 118981405(CHEK1)
AJM: 119041045(CHEK1)
PDIC: 114509510(CHEK1)
PHAS: 123832554(CHEK1)
MMF: 118639911(CHEK1)
RFQ: 117017223(CHEK1)
PPAM: 129086390(CHEK1)
PALE: 102882405(CHEK1)
PGIG: 120610459(CHEK1)
PVP: 105296813(CHEK1)
RAY: 107498938(CHEK1)
MJV: 108401047(CHEK1)
TOD: 119240818(CHEK1)
SARA: 101540894(CHEK1) 105943527
LAV: 100658513(CHEK1)
TMU: 101345463
ETF: 101640005(CHEK1)
DNM: 101441252(CHEK1)
MDO: 100016170(CHEK1)
GAS: 123238925(CHEK1)
SHR: 100933648(CHEK1)
AFZ: 127554847
PCW: 110218134(CHEK1)
OAA: 100090345(CHEK1)
GGA: 374260(CHEK1)
PCOC: 116233040(CHEK1)
MGP: 100547861(CHEK1)
CJO: 107324224(CHEK1)
TPAI: 128087515(CHEK1)
LMUT: 125703744(CHEK1)
NMEL: 110387692(CHEK1)
APLA: 101790669(CHEK1)
ACYG: 106040556(CHEK1)
CATA: 118252468(CHEK1)
AFUL: 116497895(CHEK1)
TGU: 100219597(CHEK1)
LSR: 110468180(CHEK1)
SCAN: 103822842(CHEK1)
PMOA: 120508383(CHEK1)
OTC: 121340821(CHEK1)
PRUF: 121360614(CHEK1)
GFR: 102039036(CHEK1)
FAB: 101815748(CHEK1)
OMA: 130262435(CHEK1)
PHI: 102103508(CHEK1)
PMAJ: 107214301(CHEK1)
CCAE: 111939252(CHEK1)
CCW: 104692217(CHEK1)
CBRC: 103618545(CHEK1)
ETL: 114064599(CHEK1)
ZAB: 102064035(CHEK1)
ACHL: 103807438(CHEK1)
SVG: 106860748(CHEK1)
MMEA: 130583027(CHEK1)
HRT: 120762582(CHEK1)
FPG: 101911598(CHEK1)
FCH: 102048652(CHEK1)
CLV: 102094428(CHEK1)
EGZ: 104129228(CHEK1)
NNI: 104016679(CHEK1)
ACUN: 113488427(CHEK1)
TALA: 116961442(CHEK1)
ACHC: 115344766(CHEK1)
HLE: 104840506(CHEK1)
AGEN: 126038521
GCL: 127025784
MUI: 104539884
NNT: 104400295(CHEK1)
SHAB: 115616326(CHEK1)
DPUB: 104308049(CHEK1)
PGUU: 104464013(CHEK1)
CPEA: 104398046(CHEK1)
RTD: 128918724
CUCA: 104066084(CHEK1)
AROW: 112968927(CHEK1)
ASN: 102385348(CHEK1)
AMJ: 102574519(CHEK1)
CPOO: 109317977(CHEK1)
GGN: 109291782(CHEK1)
PSS: 102451245(CHEK1)
CMY: 102945662(CHEK1)
CCAY: 125625503(CHEK1)
DCC: 119846783(CHEK1)
CPIC: 101933610(CHEK1)
TST: 117868633(CHEK1)
CABI: 116818797(CHEK1)
MRV: 120375393(CHEK1)
ACS: 100564808(chek1)
ASAO: 132782654(CHEK1)
PVT: 110070287(CHEK1)
PBI: 103064116(CHEK1)
CTIG: 120313956(CHEK1)
TSR: 106545333(CHEK1)
PGUT: 117668192(CHEK1)
APRI: 131203972(CHEK1)
PTEX: 113451811(CHEK1)
NSS: 113427162(CHEK1)
VKO: 123027171(CHEK1) 123033920
PMUA: 114585208(CHEK1)
PRAF: 128402660(CHEK1)
ZVI: 118097373(CHEK1)
HCG: 128333804(CHEK1)
GJA: 107117803(CHEK1)
STOW: 125442177(CHEK1)
EMC: 129342148(CHEK1)
XLA: 108696394(chek1.L) 398191(chek1.S)
XTR: 100038224(chek1)
NPR: 108783681(CHEK1) 108792688
RTEM: 120915700(CHEK1)
BBUF: 121000276(CHEK1)
BGAR: 122926812(CHEK1)
MUO: 115474693(CHEK1)
GSH: 117361002(CHEK1)
DRE: 393162(chek1)
CCAR: 109069289 109099921(chek1)
PTET: 122326226(chek1)
LROH: 127152033(chek1)
OMC: 131529448(chek1)
PPRM: 120494746(chek1)
RKG: 130096492(chek1)
MAMB: 125253492(chek1)
CIDE: 127504163
MASI: 127429224
TROS: 130570377(chek1)
TDW: 130408027(chek1)
MANU: 129423375(chek1)
IPU: 108278491
IFU: 128622434(chek1)
PHYP: 113541633(chek1)
SMEO: 124398465(chek1)
TFD: 113634915(chek1)
TVC: 132859790(chek1)
AMEX: 103021956(chek1)
CMAO: 118820153(chek1)
EEE: 113573544(chek1)
CHAR: 105895358(chek1)
TRU: 101069769(chek1)
TFS: 130537480(chek1)
LCO: 104929933(chek1)
NCC: 104964655(chek1)
TBEN: 117490151(chek1)
CGOB: 115018952(chek1)
PGEO: 117458706(chek1)
GACU: 117535558(chek1)
ELY: 117262759(chek1)
EFO: 125898268(chek1)
PLEP: 121952155(chek1)
SLUC: 116064872(chek1)
ECRA: 117955169(chek1)
ESP: 116700025(chek1)
PFLV: 114566919(chek1)
GAT: 120822688(chek1)
PPUG: 119215834(chek1)
AFB: 129113508(chek1)
CLUM: 117743221(chek1)
MSAM: 119895100(chek1)
SCHU: 122888650(chek1)
CUD: 121518410(chek1)
ALAT: 119031422(chek1)
MZE: 101487018(chek1)
ONL: 100707719(chek1)
OAU: 116313090(chek1)
OLA: 101170780(chek1)
OML: 112140828(chek1)
XMA: 102238315(chek1)
XCO: 114152470(chek1)
XHE: 116729004(chek1)
PRET: 103475471(chek1)
PFOR: 103142157(chek1)
PLAI: 106956156(chek1)
PMEI: 106921319(chek1)
GAF: 122844415(chek1)
CVG: 107098496(chek1)
CTUL: 119775819(chek1)
GMU: 124875974(chek1) 124876660
NFU: 107386371(chek1)
KMR: 108236904(chek1)
ALIM: 106514075(chek1)
NWH: 119420041(chek1)
AOCE: 111580652(chek1)
MCEP: 125021744(chek1)
CSEM: 103395155(chek1)
POV: 109628292(chek1)
SSEN: 122779755(chek1)
HHIP: 117774183(chek1)
HSP: 118122685(chek1)
LCF: 108893136
SDU: 111234478(chek1)
SLAL: 111666155(chek1)
XGL: 120802605(chek1)
HCQ: 109517900(chek1)
SSCV: 125982679
SBIA: 133491952(chek1)
PEE: 133415819(chek1)
PTAO: 133467490(chek1)
BPEC: 110158508(chek1)
MALB: 109959175(chek1)
BSPL: 114869608(chek1)
SJO: 128371820(chek1)
SASA: 106563964(chek1)
STRU: 115204711(chek1)
OTW: 112236999(chek1)
OMY: 110510298(chek1)
OGO: 124007528(chek1)
ONE: 115123283(chek1)
OKI: 109881514(chek1)
OKE: 118371844(chek1)
SALP: 112078987(chek1)
SNH: 120041456(chek1)
ELS: 105009476(chek1)
SFM: 108924764(chek1)
PKI: 111837953(chek1)
AANG: 118235259(chek1)
LOC: 102696807(chek1)
PSPA: 121309546
LCM: 102357495(CHEK1)
CMK: 103180289(chek1)
RTP: 109921452(chek1)
CPLA: 122540735(chek1)
HOC: 132829610(chek1)
LERI: 129712431(chek1)
PMRN: 116948227(CHEK1)
BFO: 118416821
BBEL: 109482805
CIN: 100185343
SPU: 115921093 592974(Chk1)
APLC: 110985006
AJC: 117108337
SKO: 100367549
DME: Dmel_CG17161(grp)
DER: 6547505
DSE: 6614402
DSI: Dsimw501_GD24070(Dsim_GD24070)
DAN: 6496833
DSR: 110181142
DPO: 6903127
DPE: 6589812
DMN: 108162008
DWI: 6646680
DGR: 6570236
DAZ: 108610244
DNV: 108658305
DHE: 111596373
DVI: 6627442
CCAT: 101455828
BOD: 106616758
BDR: 105228772
TDA: 119688010
SCAC: 106082767
LCQ: 111687874
LSQ: 119608965
GFS: 119633091
ECOE: 129950354
HIS: 119653580
AGA: 1277834
ACOZ: 120955070
AARA: 120900481
AMER: 121596513
ASTE: 118513733
AFUN: 125762106
AMOU: 128301431
AALI: 118456244
AAG: 23687802
AALB: 109421007
CPII: 120415468
CNS: 116338068
BCOO: 119085814
AME: 413964
ACER: 108000363
ALAB: 122712873
ADR: 102678330
AFLR: 100863285
BIM: 100745568
BBIF: 117209786
BVK: 117230505
BVAN: 117166158
BTER: 100651141
BAFF: 126924222
BPYO: 122575545
BPAS: 132912131
FVI: 122534255
CCAL: 108628718
OBB: 114873109
MGEN: 117228452
NMEA: 116433461
CGIG: 122394842
SOC: 105194877
MPHA: 105835436
AEC: 105150077
ACEP: 105621342
PBAR: 105428835
VEM: 105570083
HST: 105190670
DQU: 106743820
CFO: 105249949
FEX: 115239077
LHU: 105679793
PGC: 109856525
OBO: 105277573
PCF: 106791186
PFUC: 122514834
VPS: 122636714
VCRB: 124429815
NVI: 116415964
CSOL: 105360491
TPRE: 106657061
LHT: 122499005
LBD: 127282937
MDL: 103575699
CGLO: 123267688
FAS: 105273308
DAM: 107040402
AGIF: 122856819
CINS: 118071958
VCAN: 122417213
CCIN: 107266515
DSM: 124404098
NPT: 124213203
NFB: 124175198
NLO: 107221706
NVG: 124299282
DPA: 109543242
SOY: 115884493
AGRG: 126746178
ATD: 109597186
CSET: 123314222
AGB: 108914024
LDC: 111513532
NVL: 108569681
APLN: 108739864
PPYR: 116177430
OTU: 111417279
BMOR: 101739025
BMAN: 114252094
MSEX: 115452119
MJU: 123869852
VCD: 124531661
PMAC: 106712696
PXU: 106126999
PRAP: 111003679
LSIN: 126968702
HZE: 124629550
TNL: 113506314
OFU: 114359936
PGW: 126368303
CCRN: 123291117
ACOO: 126834288
DVT: 126904583
BTAB: 109034678
DCI: 103513997
CLEC: 106667684
HHAL: 106678732
NLU: 111063362
HVI: 124356593
FOC: 113212481
TPAL: 117654046
ZNE: 110828242
SGRE: 126278957
IEL: 124157720
FCD: 110845196
DMK: 116930871
DPZ: 124348976
PJA: 122263796
PCHN: 125047115
HAME: 121867162
PCLA: 123763230
PTRU: 123503473
ESN: 127003056
HAZT: 108670354
LSM: 121114857
TCF: 131884332
PPOI: 119094268
RSAN: 119393472
RMP: 119171681
VDE: 111253280
VJA: 111259065
DPTE: 113792438
CSCU: 111620828
PTEP: 107445423
UDV: 129234567
SDM: 118189886
PMEO: 129587624
CEL: CELE_Y39H10A.7(chk-1)
TSP: Tsp_05158
PVUL: 126830015
PCAN: 112568434
BGT: 106066125
GAE: 121386691
HRF: 124116557
HRJ: 124290942
CRG: 105344353
OED: 125678437
MYI: 110465676
PMAX: 117340920
MCAF: 127701224
MMER: 123554179
OBI: 106874761
OSN: 115221768
LAK: 106166281
SHX: MS3_00004470(CHEK1)
EPA: 110232258
ATEN: 116303765
AMIL: 114969891
PDAM: 113678678
SPIS: 111328711
DGT: 114531963
XEN: 124446583
HMG: 100206960
HSY: 130635878
AQU: 100640078
QSU: 112019642
SCE: YBR274W(CHK1)
SEUB: DI49_1298
ERC: Ecym_6307
KMX: KLMA_50053(CHK1)
NCS: NCAS_0B07380(NCAS0B07380)
NDI: NDAI_0B04700(NDAI0B04700)
TPF: TPHA_0O01400(TPHA0O01400)
TDL: TDEL_0D02040(TDEL0D02040)
KAF: KAFR_0C04280(KAFR0C04280)
KNG: KNAG_0C01820(KNAG0C01820)
PIC: PICST_33177(CHK1)
SLB: AWJ20_2911(CHK1)
NCR: NCU08346(un-1)
NTE: NEUTE1DRAFT114358(NEUTE1DRAFT_114358)
MGR: MGG_03729
PGRI: PgNI_00261
SSCK: SPSK_04135
MAW: MAC_07613
MAJ: MAA_00521
CMT: CCM_05529
PTKZ: JDV02_009433(chk1)
BFU: BCIN_05g06110(Bcchk1)
MBE: MBM_03411
ANI: AN5494.2
ALUC: AKAW2_51828S(CHK1)
ACHE: ACHE_10546A(CHK1)
APUU: APUU_40831A(CHK1)
ABE: ARB_07449
TVE: TRV_03991
PTE: PTT_09831
SPO: SPCC1259.13(chk1)
SOM: SOMG_03044(chk1)
CNE: CNG04000
CNB: CNBG0730
TASA: A1Q1_03668
CCAC: CcaHIS019_0404340(chk1)
ABP: AGABI1DRAFT122426(AGABI1DRAFT_122426) AGABI1DRAFT132921(AGABI1DRAFT_132921)
ABV: AGABI2DRAFT120023(AGABI2DRAFT_120023) AGABI2DRAFT122240(AGABI2DRAFT_122240)
MGL: MGL_0494
MRT: MRET_2319
 » show all
Reference
  Authors
Yang XH, Shiotani B, Classon M, Zou L
  Title
Chk1 and Claspin potentiate PCNA ubiquitination.
  Journal
Genes Dev 22:1147-52 (2008)
DOI:10.1101/gad.1632808
  Sequence
[hsa:1111]
Reference
  Authors
Huang M, Miao ZH, Zhu H, Cai YJ, Lu W, Ding J
  Title
Chk1 and Chk2 are differentially involved in homologous recombination repair and cell cycle arrest in response to DNA double-strand breaks induced by camptothecins.
  Journal
Mol Cancer Ther 7:1440-9 (2008)
DOI:10.1158/1535-7163.MCT-07-2116
  Sequence
[hsa:1111]
Reference
PMID:9278511
  Authors
Sanchez Y, Wong C, Thoma RS, Richman R, Wu Z, Piwnica-Worms H, Elledge SJ
  Title
Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25.
  Journal
Science 277:1497-501 (1997)
DOI:10.1126/science.277.5331.1497
  Sequence
[hsa:1111]
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