PATHWAY: ko04120 Help
Entry Name Ubiquitin mediated proteolysis
Description Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class Genetic Information Processing; Folding, sorting and degradationBRITE hierarchy
Pathway map ko04120 Ubiquitin mediated proteolysis
Other DBs Orthology K02207 UBE2R, UBC3, CDC34; ubiquitin-conjugating enzyme E2 R [EC:2.3.2.23 ]
K02927 RP-L40e, RPL40, UBA52; ubiquitin-large subunit ribosomal protein L40e
K02977 RP-S27Ae, RPS27A, UBA80; ubiquitin-small subunit ribosomal protein S27Ae
K03094 SKP1, CBF3D; S-phase kinase-associated protein 1
K03348 APC1, ANAPC1; anaphase-promoting complex subunit 1
K03349 APC2, ANAPC2; anaphase-promoting complex subunit 2
K03350 APC3, CDC27; anaphase-promoting complex subunit 3
K03351 APC4, ANAPC4; anaphase-promoting complex subunit 4
K03352 APC5, ANAPC5; anaphase-promoting complex subunit 5
K03353 APC6, CDC16; anaphase-promoting complex subunit 6
K03354 APC7, ANAPC7; anaphase-promoting complex subunit 7
K03355 APC8, CDC23; anaphase-promoting complex subunit 8
K03356 APC9; anaphase-promoting complex subunit 9
K03357 APC10, ANAPC10, DOC1; anaphase-promoting complex subunit 10
K03358 APC11, ANAPC11; anaphase-promoting complex subunit 11
K03359 APC12, CDC26; anaphase-promoting complex subunit 12
K03360 GRR1; F-box and leucine-rich repeat protein GRR1
K03361 CDC4; F-box and WD-40 domain protein CDC4
K03362 FBXW1_11, BTRC, beta-TRCP; F-box and WD-40 domain protein 1/11
K03363 CDC20; cell division cycle 20, cofactor of APC complex
K03364 CDH1, FZR1; cell division cycle 20-like protein 1, cofactor of APC complex
K03871 VHL; von Hippel-Lindau disease tumor supressor
K03875 SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K03876 MEL26; BTB domain ubiquitin protein ligase cofactor
K04416 MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25 ]
K04552 UBE2L3, UBCH7; ubiquitin-conjugating enzyme E2 L3 [EC:2.3.2.23 ]
K04553 UBE2L6, UBCH8; ubiquitin/ISG15-conjugating enzyme E2 L6 [EC:2.3.2.23 ]
K04554 UBE2J2, NCUBE2, UBC6; ubiquitin-conjugating enzyme E2 J2 [EC:2.3.2.23 ]
K04649 UBE2K, HIP2, UBC1; ubiquitin-conjugating enzyme (huntingtin interacting protein 2) [EC:2.3.2.23 ]
K04694 SOCS1, JAB; suppressor of cytokine signaling 1
K04696 SOCS3, CIS3; suppressor of cytokine signaling 3
K04706 PIAS1; E3 SUMO-protein ligase PIAS1 [EC:2.3.2.-]
K05630 WWP2, AIP2; NEDD4-like E3 ubiquitin-protein ligase WWP2 [EC:2.3.2.26 ]
K05633 WWP1, AIP5; NEDD4-like E3 ubiquitin-protein ligase WWP1 [EC:2.3.2.26 ]
K06689 UBE2D, UBC4, UBC5; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23 ]
K07868 RHOBTB1_2; Rho-related BTB domain-containing protein 1/2
K09561 STUB1, CHIP; STIP1 homology and U-box containing protein 1 [EC:2.3.2.27 ]
K10054 PML, TRIM19; E3 SUMO-protein ligase PML [EC:2.3.2.-]
K10099 FBXO2, NFB42; F-box protein 2
K10140 DDB2; DNA damage-binding protein 2
K10144 RCHY1, PIRH2; RING finger and CHY zinc finger domain-containing protein 1 [EC:2.3.2.27 ]
K10259 MET30; F-box and WD-40 domain protein MET30
K10260 FBXW7, SEL10; F-box and WD-40 domain protein 7
K10264 FBXW8; F-box and WD-40 domain protein 8
K10447 KLHL9_13; kelch-like protein 9/13
K10456 KLHL19, KEAP1, INRF2; kelch-like protein 19
K10570 ERCC8, CKN1, CSA; DNA excision repair protein ERCC-8
K10573 UBE2A, UBC2, RAD6A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23 ]
K10577 UBE2I, UBC9; ubiquitin-conjugating enzyme E2 I
K10578 UBE2J1, NCUBE1, UBC6; ubiquitin-conjugating enzyme E2 J1 [EC:2.3.2.23 ]
K10580 UBE2N, BLU, UBC13; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23 ]
K10586 BIRC6, BRUCE; baculoviral IAP repeat-containing protein 6 (apollon) [EC:2.3.2.23 ]
K10592 HUWE1, MULE, ARF-BP1, TOM1; E3 ubiquitin-protein ligase HUWE1 [EC:2.3.2.26 ]
K10598 PPIL2, CYC4, CHP60; peptidyl-prolyl cis-trans isomerase-like 2 [EC:5.2.1.8 ]
K10600 UBOX5, UIP5; U-box domain-containing protein 5
K10601 SYVN1, HRD1; E3 ubiquitin-protein ligase synoviolin [EC:2.3.2.27 ]
K10603 AIRE; autoimmune regulator
K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27 ]
K10607 TRIM32, HT2A; tripartite motif-containing protein 32 [EC:2.3.2.27 ]
K10608 TRIM37, MUL; tripartite motif-containing protein 37 [EC:2.3.2.27 ]
K10610 DDB1; DNA damage-binding protein 1
K10611 RBX2, ROC2, RNF7; RING-box protein 2
K10684 UBLE1A, SAE1; ubiquitin-like 1-activating enzyme E1 A [EC:6.2.1.45 ]
K10685 UBLE1B, SAE2, UBA2; ubiquitin-like 1-activating enzyme E1 B [EC:6.2.1.45 ]
K10699 UBE1L2, UBA6; ubiquitin-activating enzyme E1-like protein 2 [EC:6.2.1.45 ]
K12416 SWM1, APC13; anaphase-promoting complex subunit SWM1
K12456 APC13, ANAPC13; anaphase-promoting complex subunit 13
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K16061 BIRC7_8; baculoviral IAP repeat-containing protein 7/8
K16063 PIAS2; E3 SUMO-protein ligase PIAS2 [EC:2.3.2.-]
K16064 PIAS3; E3 SUMO-protein ligase PIAS3 [EC:2.3.2.-]
K25228 APC15, ANAPC15; anaphase-promoting complex subunit 15
K25229 APC16, ANAPC16; anaphase-promoting complex subunit 16
Reference Authors Kamura T.
Title [Cullin-based E3 family]
Journal Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference Authors Matsuda N.
Title [Overview: hereditary disorders caused by dysfunction of ubiquitylation]
Journal Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference Authors Tokunaga F.
Title [E2 ubiquitin-conjugating enzymes: structures and functions]
Journal Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference Authors Nalepa G, Rolfe M, Harper JW.
Title Drug discovery in the ubiquitin-proteasome system.
Journal Reference Authors Hsu YJ, Goodman SR.
Title Spectrin and ubiquitination: a review.
Journal Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference Authors Hatakeyama S, Nakayama KI.
Title Ubiquitylation as a quality control system for intracellular proteins.
Journal Reference Authors Lee J, Zhou P.
Title DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
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