KEGG   ENZYME: 1.1.1.340
Entry
EC 1.1.1.340                Enzyme                                 
Name
1-deoxy-11beta-hydroxypentalenate dehydrogenase;
1-deoxy-11beta-hydroxypentalenic acid dehydrogenase;
ptlF (gene name);
penF (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
1-deoxy-11beta-hydroxypentalenate:NAD+ oxidoreductase
Reaction(IUBMB)
1-deoxy-11beta-hydroxypentalenate + NAD+ = 1-deoxy-11-oxopentalenate + NADH + H+ [RN:R10156]
Reaction(KEGG)
R10156
Substrate
1-deoxy-11beta-hydroxypentalenate [CPD:C20403];
NAD+ [CPD:C00003]
Product
1-deoxy-11-oxopentalenate [CPD:C20400];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Isolated from the bacterium Streptomyces avermitilis and present in many other Streptomyces species. Part of the pathway for pentalenolactone biosynthesis.
History
EC 1.1.1.340 created 2012
Pathway
ec00998  Biosynthesis of various antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17747  1-deoxy-11beta-hydroxypentalenate dehydrogenase
Genes
SMA: SAVERM_2993(ptlF)
SBH: SBI_09675
SCI: B446_29675
SCW: TU94_27385
SLE: sle_13200(sle_13200)
SSIA: A7J05_09260
SGJ: IAG43_27135
SHK: J2N69_35825
Reference
1  [PMID:17178094]
  Authors
You Z, Omura S, Ikeda H, Cane DE
  Title
Pentalenolactone biosynthesis: Molecular cloning and assignment of biochemical function to PtlF, a short-chain dehydrogenase from Streptomyces avermitilis, and identification of a new biosynthetic intermediate.
  Journal
Arch Biochem Biophys 459:233-40 (2007)
DOI:10.1016/j.abb.2006.11.016
  Sequence
[sma:SAVERM_2993]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.340
IUBMB Enzyme Nomenclature: 1.1.1.340
ExPASy - ENZYME nomenclature database: 1.1.1.340
BRENDA, the Enzyme Database: 1.1.1.340
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