KEGG   ENZYME: 1.1.1.388Help
Entry
EC 1.1.1.388                Enzyme                                 

Name
glucose-6-phosphate dehydrogenase (NAD+);
Glc6PDH;
azf (gene name);
archaeal zwischenferment
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
D-glucose-6-phosphate:NAD+ 1-oxidoreductase
Reaction(IUBMB)
D-glucose 6-phosphate + NAD+ = 6-phospho-D-glucono-1,5-lactone + NADH + H+ [RN:R10520]
Reaction(KEGG)
Substrate
D-glucose 6-phosphate [CPD:C00092];
NAD+ [CPD:C00003]
Product
6-phospho-D-glucono-1,5-lactone [CPD:C01236];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme catalyses a step of the pentose phosphate pathway. The enzyme from the archaeon Haloferax volcanii is specific for NAD+. cf. EC 1.1.1.363, glucose-6-phosphate dehydrogenase [NAD(P)+] and EC 1.1.1.49, glucose-6-phosphate dehydrogenase (NADP+).
History
EC 1.1.1.388 created 2015
Pathway
ec00030  Pentose phosphate pathway
Orthology
K19243  NAD+ dependent glucose-6-phosphate dehydrogenase
Genes
VSH: BSZ05_17150
PBA: PSEBR_cmegm64
RUA: D1823_00645
BAE: BATR1942_12880
BRX: BH708_05895
ORN: DV701_11445
HAL: VNG_0128C
HSL: OE_1209F
HDL: HALDL1_04035
HHB: Hhub_1317
HALH: HTSR_1773
HHSR: HSR6_1839
HMA: rrnAC2305
HHI: HAH_2759
NPH: NP_0308A(azf)
NMO: Nmlp_1075
HMU: Hmuk_0576
HWA: HQ_1135A(azf)
HWC: Hqrw_1170(azf)
HVO: HVO_0511(azf)
HME: HFX_0485
HLA: Hlac_0117
HTU: Htur_0435
NMG: Nmag_2247(azf)
NAT: NJ7G_4277
 » show all
Taxonomy
Reference
1  [PMID:25836736]
  Authors
Pickl A, Schonheit P
  Title
The oxidative pentose phosphate pathway in the haloarchaeon Haloferax volcanii involves a novel type of glucose-6-phosphate dehydrogenase--The archaeal Zwischenferment.
  Journal
FEBS Lett 589:1105-11 (2015)
DOI:10.1016/j.febslet.2015.03.026
  Sequence
[hvo:HVO_0511]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.388
IUBMB Enzyme Nomenclature: 1.1.1.388
ExPASy - ENZYME nomenclature database: 1.1.1.388
BRENDA, the Enzyme Database: 1.1.1.388
LinkDB All DBs

DBGET integrated database retrieval system