Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy

D-glucose-6-phosphate:NAD+ 1-oxidoreductase

D-glucose 6-phosphate + NAD+ = 6-phospho-D-glucono-1,5-lactone + NADH + H+ [RN:R10520]

R10520 > R10907
Reaction

D-glucose 6-phosphate [CPD:C00092];
NAD+ [CPD:C00003]

The enzyme catalyses a step of the pentose phosphate pathway. The enzyme from the archaeon Haloferax volcanii is specific for NAD+. cf. EC 1.1.1.363, glucose-6-phosphate dehydrogenase [NAD(P)+] and EC 1.1.1.49, glucose-6-phosphate dehydrogenase (NADP+).

EC 1.1.1.388 created 2015

1  [PMID:25836736]

Pickl A, Schonheit P

The oxidative pentose phosphate pathway in the haloarchaeon Haloferax volcanii involves a novel type of glucose-6-phosphate dehydrogenase - The archaeal Zwischenferment.

FEBS Lett 589:1105-11 (2015)
DOI:10.1016/j.febslet.2015.03.026

[hvo:HVO_0511]