KEGG   ENZYME: 1.1.1.388
Entry
EC 1.1.1.388                Enzyme                                 
Name
glucose-6-phosphate dehydrogenase (NAD+);
Glc6PDH;
azf (gene name);
archaeal zwischenferment
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
D-glucose-6-phosphate:NAD+ 1-oxidoreductase
Reaction(IUBMB)
D-glucose 6-phosphate + NAD+ = 6-phospho-D-glucono-1,5-lactone + NADH + H+ [RN:R10520]
Reaction(KEGG)
R10520 > R10907
Substrate
D-glucose 6-phosphate [CPD:C00092];
NAD+ [CPD:C00003]
Product
6-phospho-D-glucono-1,5-lactone [CPD:C01236];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme catalyses a step of the pentose phosphate pathway. The enzyme from the archaeon Haloferax volcanii is specific for NAD+. cf. EC 1.1.1.363, glucose-6-phosphate dehydrogenase [NAD(P)+] and EC 1.1.1.49, glucose-6-phosphate dehydrogenase (NADP+).
History
EC 1.1.1.388 created 2015
Pathway
ec00030  Pentose phosphate pathway
Orthology
K19243  NAD+ dependent glucose-6-phosphate dehydrogenase
Genes
VNI: VIBNI_B0433
VSH: BSZ05_17150
MMEO: OOT43_15260
EMP: EZMO1_3099
LABP: FJ695_05645
RUA: D1823_00645
PHQ: D1820_15470
TRO: trd_1948
MTAR: DF168_00247(udh_1)
PLON: Pla110_18890(fcl_3)
TPLA: ElP_06550
HBS: IPV69_22805
BLI: BL00020(ytbQ)
BLD: BLi03170(ytbQ)
BLH: BaLi_c32420(ytbQ)
BSON: S101395_01332
BPU: BPUM_2667
BPUM: BW16_14380
BPUS: UP12_13645
BXI: BK049_13705
BALT: CFN77_14320
BSAF: BSL056_15045
BACW: QR42_13450
OIH: OB2094
JEP: BW721_01640
JDA: BW727_101137(udh)
JAR: G7057_00785
AGRO: JSQ78_04010
BFA: Bfae_19740
BRX: BH708_05895
BRV: CFK39_02265
BGG: CFK41_06745
BRZ: CFK38_09045
BSAU: DWV08_07345
BRR: C1N80_08935
BRHA: NLU66_09695
BRAC: RBL05_08595
ARS: ADJ73_06060
JLI: EXU32_08155
JME: EEW87_000815
JCR: O9K63_03330
JAI: V1351_06540
JTR: V3C34_09250
ORN: DV701_11445
SERW: FY030_05825
GEZ: FE251_10790
RSUA: LQF12_03265
MICG: GJV80_12200
TFL: RPIT_03130
TEZ: BKM78_12175
TLA: TLA_TLA_02453(udh_2)
BRT: J4N02_06995
PSOI: PCC79_06960
VER: HUT12_13150
LMAJ: GKN94_01060 GKN94_07470 GKN94_12220 GKN94_13395 GKN94_13605
KBS: EPA93_05700
HAL: VNG_0128C
HSL: OE_1209F
HANR: LJ422_00595
HDL: HALDL1_04035
HHB: Hhub_1317
HAGS: JT689_01935
HABO: JRZ79_00460
HNO: LT974_01500
HLU: LT972_12330
HANX: ABSL23_06525(azf)
HALH: HTSR_1773
HHSR: HSR6_1839
HSU: HLASF_0479
HSF: HLASA_0476
HAHS: HSRCO_0778(wcaG)
SALR: FQU85_02990
HALR: EFA46_005210 EFA46_010660 EFA46_010735
HJE: HacjB3_14685
HDO: MUK72_03965
HALX: M0R89_08310
HAXZ: M0R88_08495
HAYC: NGM10_00575 NGM10_07300
HAXY: NGM07_14215
SALI: L593_05140 L593_11535
SAIM: K0C01_00340
HARA: AArcS_2737(wcaG11)
HMA: rrnAC2305
HHI: HAH_2759
HHN: HISP_14025
HAB: SG26_03090 SG26_06305
HTA: BVU17_13435
HALJ: G9465_22030 G9465_23975
HSIN: KDQ40_15555
NPH: NP_0308A(azf)
NMO: Nmlp_1075
NHO: HWV23_07375
NSAL: HWV07_10755
HMU: Hmuk_0576
HALZ: E5139_06035
HALL: LC1Hm_3107
HAZP: GBQ70_06030
HALI: BV210_06955
HSN: DV733_11575
HDS: HSR122_1890(wcaG3)
HRR: HZS55_00310 HZS55_21660
HPEL: HZS54_00365 HZS54_10485 HZS54_25135
HLT: I7X12_13175 I7X12_14960
HARC: HARCEL1_00695
SSAI: N0B31_17210
HAAD: MW046_08820
HWA: HQ_1135A(azf)
HWC: Hqrw_1170(azf)
HVO: HVO_0511(azf) HVO_B0096
HALE: G3A49_02635 G3A49_06695
HLN: SVXHx_0470(azf) SVXHx_3376(azf)
HME: HFX_0485
HGI: ABY42_02395 ABY42_15930 ABY42_18635
HLS: KU306_07145
HBO: Hbor_27280
HAQ: DU484_01385 DU484_06630
HAJ: DU500_01935 DU500_06900
HAER: DU502_17440
HRA: EI982_13605
HLM: DV707_13470
HALM: FCF25_06995 FCF25_09350
HLA: Hlac_0117 Hlac_2457
HALP: DOS48_00600
HALB: EKH57_11815
HEZZ: EO776_00480
HALQ: Hrr1229_006340
HSS: J7656_00745
HSAI: HPS36_06255
HAZZ: KI388_14110
SRUB: C2R22_02330 C2R22_03520 C2R22_19640 C2R22_24195
HAE: halTADL_0298
HALN: B4589_010180 B4589_012900
HALG: HUG10_05530 HUG10_15360 HUG10_15910 HUG10_17945 HUG10_20285
HALU: HUG12_18245
HMP: K6T50_13120
HRE: K6T36_13035
HRM: K6T25_03630
HACB: Hbl1158_04965
HDF: AArcSl_0115 AArcSl_0416
HAAA: AArcCO_0262(wcaG)
HAH: Halar_2838 Halar_3481
HTU: Htur_0435 Htur_0833 Htur_4212 Htur_4433
HSAL: JMJ58_07010 JMJ58_23600
HAKZ: J0X25_08735
NMG: Nmag_2247(azf)
HXA: Halxa_0384 Halxa_1805
NAT: NJ7G_4277
NPE: Natpe_3416
NVR: FEJ81_16400 FEJ81_22085
NPL: FGF80_15460
NAY: HYG81_12865 HYG81_23160
HALY: HYG82_13630 HYG82_18190
HJT: DVR14_07215
HLO: J0X27_16360
NGE: Natgr_1320
HRU: Halru_2600
SAWL: NGM29_04355
HALV: NGM15_13960
NOU: Natoc_0279
HLR: HALLA_02775 HALLA_04445 HALLA_04630 HALLA_06030
HLC: CHINAEXTREME02945
NAJ: B1756_06410
NAG: AArcMg_0155
NAN: AArc1_0157
NARA: QQ977_06765(azf)
NBG: DV706_08395
NAS: GCU68_03710
HDA: BB347_12925
NCON: LC1Nh_0694
 » show all
Reference
1  [PMID:25836736]
  Authors
Pickl A, Schonheit P
  Title
The oxidative pentose phosphate pathway in the haloarchaeon Haloferax volcanii involves a novel type of glucose-6-phosphate dehydrogenase - The archaeal Zwischenferment.
  Journal
FEBS Lett 589:1105-11 (2015)
DOI:10.1016/j.febslet.2015.03.026
  Sequence
[hvo:HVO_0511]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.388
IUBMB Enzyme Nomenclature: 1.1.1.388
ExPASy - ENZYME nomenclature database: 1.1.1.388
BRENDA, the Enzyme Database: 1.1.1.388
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