KEGG   ENZYME: 1.1.1.388
Entry
EC 1.1.1.388                Enzyme                                 

Name
glucose-6-phosphate dehydrogenase (NAD+);
Glc6PDH;
azf (gene name);
archaeal zwischenferment
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
D-glucose-6-phosphate:NAD+ 1-oxidoreductase
Reaction(IUBMB)
D-glucose 6-phosphate + NAD+ = 6-phospho-D-glucono-1,5-lactone + NADH + H+ [RN:R10520]
Reaction(KEGG)
R10520 > R10907
Substrate
D-glucose 6-phosphate [CPD:C00092];
NAD+ [CPD:C00003]
Product
6-phospho-D-glucono-1,5-lactone [CPD:C01236];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme catalyses a step of the pentose phosphate pathway. The enzyme from the archaeon Haloferax volcanii is specific for NAD+. cf. EC 1.1.1.363, glucose-6-phosphate dehydrogenase [NAD(P)+] and EC 1.1.1.49, glucose-6-phosphate dehydrogenase (NADP+).
History
EC 1.1.1.388 created 2015
Pathway
ec00030  Pentose phosphate pathway
Orthology
K19243  NAD+ dependent glucose-6-phosphate dehydrogenase
Genes
GQU: AWC35_10960
SMAC: SMDB11_4230
SMW: SMWW4_v1c01330
SPE: Spro_0125
SRR: SerAS9_0085
SRL: SOD_c00800
SRY: M621_00395
SPLY: Q5A_000425(udh)
SRS: SerAS12_0085
SRA: SerAS13_0084
SMAF: D781_0092
SERF: L085_05040
BLI: BL00020(ytbQ)
BLD: BLi03170(ytbQ)
BLH: BaLi_c32420(ytbQ)
BPU: BPUM_2667
BPUM: BW16_14380
BPUS: UP12_13645
BACW: QR42_13450
OIH: OB2094
JDA: BW727_101137(udh)
TRO: trd_1948
HAL: VNG_0128C
HSL: OE_1209F
HHB: Hhub_1317
HALH: HTSR_1773
HHSR: HSR6_1839
HMA: rrnAC2305
HHI: HAH_2759
NPH: NP_0308A(azf)
NMO: Nmlp_1075
HMU: Hmuk_0576
HALL: LC1Hm_3107
HWA: HQ_1135A(azf)
HWC: Hqrw_1170(azf)
HVO: HVO_0511(azf)
HME: HFX_0485
NMG: Nmag_2247(azf)
NAT: NJ7G_4277
 » show all
Reference
1  [PMID:25836736]
  Authors
Pickl A, Schonheit P
  Title
The oxidative pentose phosphate pathway in the haloarchaeon Haloferax volcanii involves a novel type of glucose-6-phosphate dehydrogenase--The archaeal Zwischenferment.
  Journal
FEBS Lett 589:1105-11 (2015)
DOI:10.1016/j.febslet.2015.03.026
  Sequence
[hvo:HVO_0511]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.388
IUBMB Enzyme Nomenclature: 1.1.1.388
ExPASy - ENZYME nomenclature database: 1.1.1.388
BRENDA, the Enzyme Database: 1.1.1.388
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