Entry
Name
phospholipid-hydroperoxide glutathione peroxidase;
peroxidation-inhibiting protein;
PHGPX;
peroxidation-inhibiting protein:peroxidase,glutathione (phospholipid hydroperoxide-reducing);
phospholipid hydroperoxide glutathione peroxidase;
hydroperoxide glutathione peroxidase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
BRITE hierarchy
Sysname
glutathione:lipid-hydroperoxide oxidoreductase
Reaction(IUBMB)
2 glutathione + a hydroperoxy-fatty-acyl-[lipid] = glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O [RN:
R03167 ]
Reaction(KEGG)
Substrate
glutathione [CPD:
C00051 ];
hydroperoxy-fatty-acyl-[lipid]
Product
glutathione disulfide [CPD:
C00127 ];
hydroxy-fatty-acyl-[lipid];
H2O [CPD:
C00001 ]
Comment
A protein containing a selenocysteine residue. The products of action of EC
1.13.11.12 lipoxygenase on phospholipids can act as acceptors; H2O2 can also act, but much more slowly (cf. EC
1.11.1.9 glutathione peroxidase).
History
EC 1.11.1.12 created 1989, modified 2015
Pathway
ec00590 Arachidonic acid metabolism
Orthology
K05361 phospholipid-hydroperoxide glutathione peroxidase
Genes
MYB : 102247160 102257806(GPX4)
MLF : 102424448(GPX4) 106697200
PDIC : 114503559(GPX4) 114515394
SARA : 101549194 101556647(GPX4)
XLA : 100036920(gpx4.L) 734888(gpx4.S)
DRE : 352928(gpx4a) 352929(gpx4b)
CCAR : 109071199 109095832(gpx4b)
CGIB : 127938347 127943422 127951669
PTET : 122328086(gpx4a) 122335633(gpx4b)
LROH : 127154036(gpx4a) 127178548(gpx4b)
GRF : 141339116(gpx4a) 141343981(gpx4b)
OMC : 131522086 131530650(gpx4a)
PPRM : 120471296(gpx4b) 120486531(gpx4a)
RKG : 130075349(gpx4b) 130089248(gpx4a)
MAMB : 125251077(gpx4b) 125252116(gpx4a)
CIDE : 127519981 127522684
CERY : 137003417(gpx4b) 137027722(gpx4a)
MASI : 127438863 127443054
TROS : 130548448(gpx4a) 130555007(gpx4b)
TDW : 130418275(gpx4b) 130430621(gpx4a)
MANU : 129443230 129453119 141362386
IFU : 128613432(gpx4a) 128624279(gpx4b)
SMEO : 124390796(gpx4a) 124403356(gpx4b)
TVC : 132845451(gpx4b) 132852631(gpx4a) 132852639 132852660
TRN : 134302451(gpx4b) 134331354(gpx4a)
AMEX : 103026361(gpx4b) 103047294(gpx4a)
CMAO : 118797289(gpx4b) 118818681(gpx4a)
CHAR : 105889685(gpx4a) 122131805
SPIL : 134068608 134102740
TFS : 130529177(gpx4a) 130539092
TNG : GSTEN00024700G001 GSTEN00028551G001
TBEN : 117488934 117496016(gpx4a)
CGOB : 115006643 115023020
PGEO : 117445429(gpx4a) 117462837
GACU : 117532617 117555205(gpx4a)
EMAC : 134865874 134869266(gpx4a)
ELY : 117254152(gpx4a) 117272200
EFO : 125895672(gpx4a) 125902182
PLEP : 121939387(gpx4a) 121951193
SLUC : 116037299 116063394(gpx4a)
ECRA : 117950202(gpx4a) 117953870
ESP : 116696111(gpx4) 116699145
PFLV : 114561982(gpx4) 114565634
PPUG : 119209805 119216983 119216984
CLUM : 117730040(gpx4a) 117746743
PSWI : 130193447(gpx4a) 130198386
CANA : 137779359 137795521(gpx4a)
CVE : 137866484(gpx4a) 137892401
MSAM : 119884432 119900945(gpx4a) 119902192
SCHU : 122878234(gpx4a) 122886314
CUD : 121512726(gpx4a) 121520718
SPUL : 138607030(gpx4a) 138611338
LMIX : 132972047(gpx4a) 132979002
ALAT : 119011833 119029309(gpx4a)
ASTR : 137599206(gpx4a) 137611999
MZE : 101475014 101481366(gpx4)
OAU : 116319194 116327902(gpx4a)
OLA : 101160642 101160762 111946273
OML : 112147668 112150257(gpx4a)
CSAI : 133451920 133458162(gpx4a)
XMA : 102218769 102219707(gpx4)
XCO : 114147031 114150819(gpx4)
XHE : 116722172 116725535(gpx4)
PRET : 103463715(gpx4) 103479268
PFOR : 103151222 103151223 103155162(gpx4)
PLAI : 106949670(gpx4) 106961711
PMEI : 106917758(gpx4) 106918624 106926317
GAF : 122838806(gpx4a) 122840802
PPRL : 129361645 129371536(gpx4a)
CVG : 107091856 107095297(gpx4)
CTUL : 119773700 119790048(gpx4a)
GMU : 124869953 124873595(gpx4a)
NFU : 107384121 107393348(gpx4)
KMR : 108230562(gpx4a) 108239424
NWH : 119407986(gpx4a) 119414633
AOCE : 111563473(gpx4a) 111571007
EJA : 138198621(gpx4a) 138202810
BFRE : 138618847(gpx4a) 138625275
MCEP : 125009873(gpx4a) 125011311
CSEM : 103376758(gpx4) 103395914
SSEN : 122780472(gpx4a) 122781861(gpx4b)
SSOE : 131465842 131466215(gpx4a)
HHIP : 117760019(gpx4a) 117778055
HSP : 118118007 124854676(gpx4a)
PPLT : 128448346(gpx4a) 128455032
SMAU : 118311442 118318584(gpx4a)
SLAL : 111653742(gpx4) 111658891
XGL : 120790974(gpx4a) 120799459
SSCV : 125972914(gpx4a) 125985250
SBIA : 133503717(gpx4a) 133511306
PEE : 133406844(gpx4a) 133411661
PTAO : 133480984(gpx4a) 133489082
BPEC : 110157283 110174007(gpx4)
ENY : 140353768(gpx4a) 140356385
MALB : 109966994(gpx4) 109969232
BSPL : 114845018 114853090(gpx4a)
SJO : 128361533(gpx4a) 128368581
SSCO : 133984601(gpx4a) 133990330
SASA : 100194734(gpx4b) 106573579
STRU : 115157354 115158193
OTW : 112250826 112252227(gpx4a) 112260797
OKE : 118373929(gpx4a) 118389079
SALP : 111952959 111957159 111975698
CCLU : 121535669 121576785(gpx4a)
OEP : 134010936(gpx4a) 134036191
PKI : 111836622(gpx4) 111860199
AANG : 118224614(gpx4a) 118230010(gpx4b)
AROT : 135251323(gpx4b) 135253006(gpx4a)
CCOG : 133126770 133129392
ARUT : 117428936 117966230
BBEL : 109478343 109484469
LPIC : 129270906 129270920
RZE : 108377947 108381437 108381438
CQU : CpipJ_CPIJ006047 CpipJ_CPIJ010637
AGIF : 122849604 122855894
VCAN : 122417172 122417219 122417221 122417335 122417342 122417361
SOY : 115874706 115877136 115880649 115880650
AGRG : 126741086 126742075 126742196 126750027
ATD : 109596245 109596246 109596247
CSET : 123306794 123307673 123308152 123309141 123322658
AGB : 108907641 108907642 108907643
LDC : 111504102 111512566 111512567
APLN : 108732800 108737053 108737061 108737077 112906260
PPYR : 116180501 116180502
OTU : 111413348 111413361 111413391
DPL : KGM_202360 KGM_212277
SLIU : 111357572 111357612
CFEL : 113364132 113364133
BTAB : 109035151 109036432
SGRE : 126272591 126352401 126352417
DPX : DAPPUDRAFT_220769 DAPPUDRAFT_233749 DAPPUDRAFT_310801
PCLA : 123746973 138349823
RSAN : 119374760 119404627
VJA : 111259647 111267629 111267630
CSCU : 111620010 111620011 111620045
PCAN : 112554193 112573590
SMM : Smp_058690 Smp_058700 Smp_124360
PDAM : 113682059 113683366
EHX : EMIHUDRAFT_61670 EMIHUDRAFT_67177
ยป show all
Taxonomy
Reference
Authors
Ursini F, Maiorino M, Gregolin C.
Title
The selenoenzyme phospholipid hydroperoxide glutathione peroxidase.
Journal
Reference
Authors
Schnurr K, Belkner J, Ursini F, Schewe T, Kuhn H
Title
The selenoenzyme phospholipid hydroperoxide glutathione peroxidase controls the activity of the 15-lipoxygenase with complex substrates and preserves the specificity of the oxygenation products.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 1.11.1.12
LinkDB
All DBs