ORTHOLOGY: K05361
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Entry
K05361 KO
Symbol
GPX4
Name
phospholipid-hydroperoxide glutathione peroxidase [EC:
1.11.1.12
]
Pathway
map00480
Glutathione metabolism
map00590
Arachidonic acid metabolism
map01100
Metabolic pathways
map04216
Ferroptosis
Reaction
R03167
glutathione:lipid-hydroperoxide oxidoreductase
R07034
glutathione: 5-HPETE oxidoreductase
R07035
glutathione: 15-HPETE oxidoreductase
R13043
glutathione:12(S)-HPETE oxidoreductase
Disease
H01825
Spondylometaphyseal dysplasia, Sedaghatian type
Brite
KEGG Orthology (KO) [BR:
ko00001
]
09100 Metabolism
09103 Lipid metabolism
00590 Arachidonic acid metabolism
K05361 GPX4; phospholipid-hydroperoxide glutathione peroxidase
09106 Metabolism of other amino acids
00480 Glutathione metabolism
K05361 GPX4; phospholipid-hydroperoxide glutathione peroxidase
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
K05361 GPX4; phospholipid-hydroperoxide glutathione peroxidase
Enzymes [BR:
ko01000
]
1. Oxidoreductases
1.11 Acting on a peroxide as acceptor
1.11.1 Peroxidases
1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase
K05361 GPX4; phospholipid-hydroperoxide glutathione peroxidase
BRITE hierarchy
Other DBs
GO:
0047066
Genes
HSA:
2879
(GPX4)
PTR:
741876
(GPX4)
PPS:
100990361
(GPX4)
GGO:
129528812
(GPX4)
PON:
100458624
(GPX4)
PPYG:
129021026
(GPX4)
NLE:
100601223
(GPX4)
HMH:
116484117
(GPX4)
SSYN:
129465760
(GPX4)
MCC:
705333
(GPX4)
MCF:
102142580
(GPX4)
MNI:
105486305
(GPX4)
CSAB:
103233593
(GPX4)
CATY:
105591702
(GPX4)
TGE:
112613047
(GPX4)
MLEU:
105551983
(GPX4)
RRO:
104671424
(GPX4)
RBB:
108537892
(GPX4)
TFN:
117075813
(GPX4)
PTEH:
111526799
(GPX4)
CANG:
105527614
(GPX4)
CJC:
100391793
(GPX4)
SBQ:
101053315
(GPX4)
CIMI:
108293158
(GPX4)
ANAN:
105705965
(GPX4)
CSYR:
103262147
(GPX4)
MMUR:
105860773
(GPX4)
LCAT:
123632821
(GPX4)
PCOQ:
105811258
(GPX4)
OGA:
100963823
(GPX4)
MMU:
625249
(Gpx4)
MCAL:
110303889
(Gpx4)
MPAH:
110326696
(Gpx4)
RNO:
29328
(Gpx4)
MCOC:
116075700
(Gpx4)
ANU:
117696848
(Gpx4)
MUN:
110551358
(Gpx4)
CGE:
100765235
(Gpx4)
MAUA:
101837194
(Gpx4)
PROB:
127216642
(Gpx4)
PLEU:
114684123
(Gpx4)
MORG:
121459510
(Gpx4)
MFOT:
126489253
AAMP:
119820907
(Gpx4)
NGI:
103737339
(Gpx4)
HGL:
101708875
(Gpx4)
CPOC:
100730119
(Gpx4)
CCAN:
109681876
(Gpx4)
DORD:
105990480
(Gpx4)
DSP:
122122854
(Gpx4)
PLOP:
125348520
(Gpx4)
NCAR:
124968734
MMMA:
107157240
(Gpx4)
OPI:
101530962
(GPX4)
TUP:
102483947
(GPX4)
GVR:
103603492
CFA:
119864793
(GPX4)
CLUD:
112666172
(GPX4)
VLG:
121494565
(GPX4)
NPO:
129521530
(GPX4)
AML:
100464258
UMR:
103681777
(GPX4)
UAH:
113242720
(GPX4)
UAR:
123794043
(GPX4)
ELK:
111161740
LLV:
125087255
MPUF:
101678371
(GPX4)
MNP:
132009636
(GPX4)
MLK:
131823181
(GPX4)
NVS:
122909965
(GPX4)
ORO:
101377930
(GPX4)
EJU:
114226343
(GPX4)
ZCA:
113916983
(GPX4)
MLX:
118005304
(GPX4)
NSU:
110594093
(GPX4)
LWW:
102731580
(GPX4)
FCA:
101095956
(GPX4)
PYU:
121021417
(GPX4)
PCOO:
112852674
(GPX4)
PBG:
122488586
(GPX4)
PVIV:
125159712
(GPX4)
LRUF:
124527695
PTG:
102949955
(GPX4)
PPAD:
109257691
(GPX4)
PUC:
125928788
AJU:
106978096
HHV:
120242414
(GPX4)
BTA:
286809
(GPX4)
BOM:
102284111
(GPX4)
BIU:
109561977
(GPX4)
BBUB:
102404388
(GPX4)
BBIS:
104991950
(GPX4)
CHX:
100860867
(GPX4)
OAS:
101113149
(GPX4)
BTAX:
128051158
(GPX4)
ODA:
120863712
(GPX4)
CCAD:
122439865
(GPX4)
MBEZ:
129558181
(GPX4)
SSC:
399537
(GPX4)
CFR:
102515650
(GPX4)
CBAI:
105078123
(GPX4)
CDK:
105104118
(GPX4)
VPC:
102544950
(GPX4)
BACU:
103000913
(GPX4)
BMUS:
118893604
(GPX4)
LVE:
103071491
(GPX4)
OOR:
101270118
(GPX4)
DLE:
111170533
(GPX4)
PCAD:
102992869
(GPX4)
PSIU:
116750457
(GPX4)
NASI:
112396387
(GPX4)
ECB:
102147383
(GPX4)
EAI:
106834230
(GPX4)
MYB:
102247160
102257806
(GPX4)
MYD:
102758267
(GPX4)
MMYO:
118659354
(GPX4)
MLF:
102424448
(GPX4)
106697200
PKL:
118711787
(GPX4)
EFUS:
103294305
(GPX4)
MNA:
107534552
(GPX4)
DRO:
112312403
(GPX4)
SHON:
118984402
(GPX4)
AJM:
119044582
119044584
(GPX4)
119047584
PDIC:
114503559
(GPX4)
114515394
PHAS:
123813806
(GPX4)
MMF:
118616188
(GPX4)
PPAM:
129080073
(GPX4)
HAI:
109390605
RFQ:
117037754
(GPX4)
PALE:
102878189
(GPX4)
PGIG:
120583686
(GPX4)
PVP:
105302263
(GPX4)
RAY:
107500914
(GPX4)
MJV:
108388787
(GPX4)
TOD:
119240497
(GPX4)
SARA:
101549194
101556647
(GPX4)
SETR:
126029646
(GPX4)
LAV:
100675152
(GPX4)
TMU:
101355012
ETF:
101650828
(GPX4)
DNM:
101428069
MDO:
100015749
(GPX4)
GAS:
123232218
(GPX4)
SHR:
100930158
(GPX4)
AFZ:
127545099
PCW:
110223406
(GPX4)
TVP:
118846557
(GPX4)
OAA:
100088643
(GPX4)
GGA:
374056
(GPX4)
PCOC:
116235806
(GPX4)
MGP:
100379155
(GPX4)
CJO:
107325473
(GPX4)
TPAI:
128072038
(GPX4)
LMUT:
125684976
(GPX4)
NMEL:
110389092
(GPX4)
APLA:
101796330
(GPX4)
CATA:
118260068
(GPX4)
AFUL:
116499031
(GPX4)
TGU:
100190423
(GPX4)
LSR:
110479113
(GPX4)
SCAN:
115483836
(GPX4)
PMOA:
120495770
(GPX4)
OTC:
121342529
(GPX4)
PRUF:
121360999
(GPX4)
GFR:
102045367
(GPX4)
FAB:
101817765
(GPX4)
OMA:
130264347
(GPX4)
PHI:
102113402
(GPX4)
PMAJ:
107215549
(GPX4)
CCAE:
111940246
(GPX4)
CCW:
104697013
(GPX4)
CBRC:
103622134
(GPX4)
ETL:
114066400
(GPX4)
ZAB:
102072687
(GPX4)
ZLE:
135458770
(GPX4)
SVG:
106857097
(GPX4)
MMEA:
130580173
(GPX4)
HRT:
120763542
(GPX4)
FPG:
101916317
(GPX4)
FCH:
102055857
(GPX4)
CLV:
102092188
(GPX4)
EGZ:
104127393
(GPX4)
NNI:
104016300
(GPX4)
PCRI:
104031556
(GPX4)
PLET:
104626575
(GPX4)
EHS:
104514689
(GPX4)
TALA:
116961654
(GPX4)
PADL:
103922946
(GPX4)
AFOR:
103899414
(GPX4)
ACHC:
115349084
(GPX4)
HALD:
104314809
(GPX4)
HLE:
104829163
(GPX4)
AGEN:
126041774
GCL:
127025524
CCRI:
104159269
(GPX4)
CSTI:
104557679
(GPX4)
MUI:
104535977
(GPX4)
BREG:
104631930
(GPX4)
SHAB:
115618028
(GPX4)
DPUB:
104300525
(GPX4)
CPEA:
104392460
(GPX4)
CVF:
104287163
(GPX4)
RTD:
128900479
(GPX4)
CUCA:
104065785
(GPX4)
BRHI:
104497570
(GPX4)
AAM:
106493531
(GPX4)
AROW:
112965676
(GPX4)
NPD:
112946817
(GPX4)
TGT:
104577742
(GPX4)
DNE:
112988049
(GPX4)
SCAM:
104139528
(GPX4)
ASN:
102386897
(GPX4)
AMJ:
102570581
(GPX4)
CPOO:
109312300
(GPX4)
GGN:
109294939
(GPX4)
PSS:
102460999
(GPX4)
CMY:
102948400
(GPX4)
CCAY:
125627096
(GPX4)
DCC:
119848363
(GPX4)
CPIC:
101944764
(GPX4)
TST:
117869003
(GPX4)
CABI:
116828925
(GPX4)
MRV:
120391529
(GPX4)
ACS:
100563257
(gpx4)
ASAO:
132781105
(GPX4)
PVT:
110079257
(GPX4)
SUND:
121936901
(GPX4)
PBI:
103065827
(GPX4)
PMUR:
107295211
(GPX4)
CTIG:
120297082
(GPX4)
TSR:
106550757
(GPX4)
PGUT:
117668634
(GPX4)
APRI:
131188331
(GPX4)
PTEX:
113452253
(GPX4)
NSS:
113429770
(GPX4)
VKO:
123036606
(GPX4)
PMUA:
114588449
(GPX4)
PRAF:
128405825
(GPX4)
ZVI:
118087571
(GPX4)
HCG:
128347864
(GPX4)
GJA:
107107351
(GPX4)
STOW:
125433909
(GPX4)
EMC:
129331415
(GPX4)
XLA:
100036920
(gpx4.L)
734888
(gpx4.S)
XTR:
100496541
(gpx4)
NPR:
108789489
(GPX4)
RTEM:
120913798
(GPX4)
BBUF:
120989460
(GPX4)
BGAR:
122920161
(GPX4)
MUO:
115480885
(GPX4)
GSH:
117365837
(GPX4)
DRE:
352928
(gpx4a)
352929
(gpx4b)
SRX:
107723219
107739954
SANH:
107660382
SGH:
107552704
CCAR:
109071199
109095832
CGIB:
127938347
127943422
127951669
PTET:
122328086
(gpx4a)
122335633
(gpx4b)
LROH:
127154036
(gpx4a)
127178548
(gpx4b)
OMC:
131522086
131530650
(gpx4a)
PPRM:
120471296
(gpx4b)
120486531
(gpx4a)
RKG:
130075349
(gpx4b)
130089248
(gpx4a)
MAMB:
125251077
(gpx4b)
125252116
(gpx4a)
CIDE:
127519981
127522684
MASI:
127438863
127443054
TROS:
130548448
(gpx4a)
130555007
(gpx4b)
TDW:
130418275
(gpx4b)
130430621
(gpx4a)
MANU:
129443230
(gpx4b)
IPU:
100528418
(gpx4b)
IFU:
128613432
(gpx4a)
128624279
(gpx4b)
PHYP:
113533158
(gpx4)
SMEO:
124390796
(gpx4a)
124403356
(gpx4b)
TFD:
113645121
(gpx4b)
TVC:
132845451
(gpx4b)
132852631
(gpx4a)
132852639
132852660
TRN:
134302451
(gpx4b)
134331354
(gpx4a)
AMEX:
103026361
(gpx4b)
103047294
(gpx4a)
CMAO:
118797289
(gpx4b)
118818681
(gpx4a)
EEE:
113585970
(gpx4)
CHAR:
105889685
(gpx4a)
122131805
TRU:
101066389
101070699
TFS:
130529177
(gpx4a)
130539092
TNG:
GSTEN00024700G001
GSTEN00028551G001
LCO:
104929635
104930512
NCC:
104958153
(gpx4)
TBEN:
117488934
117496016
(gpx4a)
CGOB:
115006643
115023020
PGEO:
117445429
(gpx4a)
117462837
GACU:
117532617
117555205
(gpx4a)
EMAC:
134865874
134869266
(gpx4a)
ELY:
117254152
(gpx4a)
117272200
EFO:
125895672
(gpx4a)
125902182
PLEP:
121939387
(gpx4a)
121951193
SLUC:
116037299
116063394
(gpx4a)
ECRA:
117950202
(gpx4a)
117953870
ESP:
116696111
(gpx4)
116699145
PFLV:
114561982
(gpx4)
114565634
GAT:
120815942
PPUG:
119209805
119216983
AFB:
129094762
129112261
CLUM:
117730040
(gpx4a)
117746743
PSWI:
130193447
(gpx4a)
130198386
MSAM:
119884432
119900945
(gpx4a)
119902192
SCHU:
122878234
(gpx4a)
122886314
CUD:
121512726
(gpx4a)
121520718
ALAT:
119011833
119029309
(gpx4a)
MZE:
101475014
101481366
(gpx4)
ONL:
100696691
100711165
OAU:
116319194
116327902
(gpx4a)
OLA:
101160642
101160762
111946273
OML:
112147668
112150257
(gpx4a)
CSAI:
133451920
133458162
(gpx4a)
XMA:
102218769
102219707
(gpx4)
XCO:
114147031
114150819
(gpx4)
XHE:
116722172
116725535
(gpx4)
PRET:
103463715
(gpx4)
103479268
PFOR:
103151222
103151223
103155162
(gpx4)
PLAI:
106949670
(gpx4)
106961711
PMEI:
106917758
(gpx4)
106918624
106926317
GAF:
122838806
(gpx4a)
122840802
PPRL:
129361645
129371536
(gpx4a)
CVG:
107091856
107095297
(gpx4)
CTUL:
119773700
119790048
(gpx4a)
GMU:
124869953
124873595
(gpx4a)
NFU:
107384121
107393348
(gpx4)
KMR:
108230562
(gpx4a)
108239424
ALIM:
106526245
(gpx4)
NWH:
119407986
(gpx4a)
119414633
AOCE:
111563473
111571007
MCEP:
125009873
(gpx4a)
125011311
CSEM:
103376758
(gpx4)
103395914
POV:
109625825
109647764
SSEN:
122780472
(gpx4a)
122781861
(gpx4b)
HHIP:
117760019
(gpx4a)
117778055
HSP:
118118007
124854676
(gpx4a)
PPLT:
128448346
(gpx4a)
128455032
SMAU:
118311442
118318584
(gpx4a)
LCF:
108879022
108883623
SDU:
111229087
111231965
SLAL:
111653742
(gpx4)
111658891
XGL:
120790974
(gpx4a)
120799459
HCQ:
109507458
109532270
SSCV:
125972914
125985250
SBIA:
133503717
(gpx4a)
133511306
PEE:
133406844
(gpx4a)
133411661
PTAO:
133480984
(gpx4a)
133489082
BPEC:
110157283
110174007
(gpx4)
MALB:
109966994
(gpx4)
109969232
BSPL:
114845018
114853090
(gpx4a)
SJO:
128361533
(gpx4a)
128368581
SASA:
100194734
(gpx4b)
106573579
STRU:
115157354
115158193
OTW:
112250826
112252227
(gpx4a)
112260797
OMY:
110506115
(gpx4a)
OGO:
123999099
(gpx4a)
ONE:
115114709
OKI:
109889213
OKE:
118373929
(gpx4a)
118389079
SALP:
111952959
111957159
111975698
SNH:
120056116
CCLU:
121535669
121576785
(gpx4a)
ELS:
105011502
105022279
SFM:
108919780
108921631
PKI:
111836622
(gpx4)
111860199
AANG:
118224614
(gpx4a)
118230010
(gpx4b)
LOC:
102683270
(gpx4)
PSPA:
121301423
ARUT:
117428936
117966230
PSEX:
120537631
LCM:
102346539
102365140
CMK:
103189927
RTP:
109931453
(gpx4b)
CPLA:
122565353
HOC:
132829173
LERI:
129711308
PMRN:
116951847
LRJ:
133349064
(GPX4)
BFO:
118421311
BBEL:
109478343
109484469
CIN:
100175675
(gpx_e)
SCLV:
120327570
LPIC:
129270906
129270920
APLC:
110989974
AJC:
117112402
SKO:
102807044
RZE:
108377947
108381437
108381438
AGA:
1274093
ACOZ:
120952681
ASTE:
118517422
AFUN:
125765397
AMOU:
128306964
AALI:
118462734
AALB:
109401758
CQU:
CpipJ_CPIJ006047
CpipJ_CPIJ010637
AME:
726269
ACER:
107994450
ALAB:
122714729
ADR:
102674260
AFLR:
100869880
BIM:
100743362
BBIF:
117207632
BVK:
117231056
BVAN:
117156330
BTER:
100648859
BAFF:
126921778
BPYO:
122567717
BPAS:
132912831
FVI:
122531333
CCAL:
108626755
OBB:
114877693
OLG:
117602899
MGEN:
117219236
NMEA:
116432653
CGIG:
122399219
SOC:
105193617
MPHA:
105837252
ACEP:
105625818
PBAR:
105425460
VEM:
105566065
HST:
105183432
DQU:
106745051
CFO:
105248391
FEX:
115245404
LHU:
105668639
PGC:
109853223
PCF:
106790095
PFUC:
122519916
VPS:
122631076
VCRB:
124422329
VVE:
124957163
NVI:
100114603
100123141
CSOL:
105366802
TPRE:
106652294
LHT:
122504735
LBD:
127284921
MDL:
106693859
CGLO:
123265503
FAS:
105269323
DAM:
107040528
AGIF:
122849604
122855894
CINS:
118068406
VCAN:
122417172
122417219
122417221
122417335
122417342
122417361
CCIN:
107269072
DSM:
124414050
NPT:
124223814
NFB:
124186366
NLO:
107223532
NVG:
124309201
AROA:
105685353
TCA:
658307
(GLEAN_10355)
DPA:
109546481
SOY:
115874706
115877136
115880649
115880650
AGRG:
126741086
126742075
126742196
126750027
ATD:
109596245
109596246
109596247
CSET:
123306794
123307673
123308152
123309141
123322658
AGB:
108907641
108907642
108907643
LDC:
111504102
111512566
111512567
DVV:
114329379
NVL:
108566482
APLN:
108732800
108737053
108737061
108737077
112906260
PPYR:
116180501
116180502
OTU:
111413348
111413361
DPL:
KGM_202360
KGM_212277
VCD:
124543819
PPOT:
106100013
PXU:
106121901
ZCE:
119833957
CCRC:
123696978
HAW:
110372557
110372599
HZE:
124634171
TNL:
113505368
SLIU:
111357572
111357612
OFU:
114360488
CFEL:
113364132
113364133
AGS:
114123314
ACOO:
126846384
DVT:
126896888
BTAB:
109035151
109036432
ZNE:
110827342
CSEC:
111863272
SGRE:
126272591
126352401
126352417
IEL:
124157339
FCD:
110842172
110852997
DPX:
DAPPUDRAFT_220769
DAPPUDRAFT_233749
DAPPUDRAFT_310801
DMK:
116916349
116916352
DPZ:
124340674
124340676
PVM:
113800343
PJA:
122265622
PCHN:
125030356
PMOO:
119576094
HAME:
121860142
PCLA:
123746973
CQD:
128698770
PTRU:
123511450
ESN:
127008367
MNZ:
135220005
HAZT:
108680142
EAF:
111699065
111712316
LSM:
121114086
121114097
121131904
TCF:
131877241
PPOI:
119099814
DSV:
119432506
119433848
RSAN:
119374760
119404627
RMP:
119176173
119181298
VDE:
111254008
VJA:
111259647
111267629
111267630
TUT:
107368679
DPTE:
113797481
DFR:
124494483
CSCU:
111620010
111620011
111620045
PTEP:
107457231
ABRU:
129963237
UDV:
129228176
SDM:
118191819
LPOL:
106470024
PMEO:
129588880
TSP:
Tsp_02268
Tsp_02272
LGI:
LOTGIDRAFT_208098
PVUL:
126818474
PCAN:
112554193
112573590
BGT:
106061375
GAE:
121376352
HRF:
124116706
HRJ:
124255688
124255701
CRG:
105330305
CANU:
128165689
CVN:
111120183
111120666
OED:
125668418
MYI:
110445160
PMAX:
117325643
MCAF:
127714052
MMER:
123524341
RPHI:
132750097
DPOL:
127855281
OBI:
106869007
106874999
OSN:
115223566
115223910
LJP:
135469897
LAK:
106176459
106176464
SMM:
Smp_058690
Smp_058700
Smp_124360
EGL:
EGR_06748
LLON:
135487124
NVE:
116621178
EPA:
110238768
110242483
ATEN:
116303299
ADF:
107353881
AMIL:
114973227
PDAM:
113682059
113683366
SPIS:
111325528
DGT:
114528108
XEN:
124445385
124447112
HMG:
100212361
100215761
HSY:
130630656
PSOJ:
PHYSODRAFT_317624
SPAR:
SPRG_01802
EHX:
EMIHUDRAFT_61670
EMIHUDRAFT_67177
» show all
Taxonomy
UniProt
Reference
PMID:
8323565
Authors
Sunde RA, Dyer JA, Moran TV, Evenson JK, Sugimoto M
Title
Phospholipid hydroperoxide glutathione peroxidase: full-length pig blastocyst cDNA sequence and regulation by selenium status.
Journal
Biochem Biophys Res Commun 193:905-11 (1993)
DOI:
10.1006/bbrc.1993.1711
Sequence
[ssc:
399537
]
LinkDB
All DBs
DBGET
integrated database retrieval system