KEGG   ENZYME: 1.2.1.23
Entry
EC 1.2.1.23                 Enzyme                                 
Name
2-oxoaldehyde dehydrogenase (NAD+);
alpha-ketoaldehyde dehydrogenase;
methylglyoxal dehydrogenase;
NAD+-linked alpha-ketoaldehyde dehydrogenase;
2-ketoaldehyde dehydrogenase;
NAD+-dependent alpha-ketoaldehyde dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
2-oxoaldehyde:NAD+ 2-oxidoreductase
Reaction(IUBMB)
a 2-oxoaldehyde + NAD+ + H2O = a 2-oxo carboxylate + NADH + H+ [RN:R01337]
Reaction(KEGG)
R01337 > R00203;
(other) R01735
Substrate
2-oxoaldehyde [CPD:C00538];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
2-oxo carboxylate [CPD:C00161];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Not identical with EC 1.2.1.49 2-oxoaldehyde dehydrogenase (NADP+).
History
EC 1.2.1.23 created 1972, modified 1986
Pathway
ec00620  Pyruvate metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:4383524]
  Authors
Monder C.
  Title
Alpha-keto aldehyde dehydrogenase, an enzyme that catalyzes the enzymic oxidation of methylglyoxal to pyruvate.
  Journal
J Biol Chem 242:4603-9 (1967)
Reference
2  [PMID:7107626]
  Authors
Ray M, Ray S.
  Title
On the interaction of nucleotides and glycolytic intermediates with NAD-linked alpha-ketoaldehyde dehydrogenase.
  Journal
J Biol Chem 257:10571-4 (1982)
Reference
3  [PMID:7107625]
  Authors
Ray S, Ray M.
  Title
Purification and characterization of NAD and NADP-linked alpha-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate.
  Journal
J Biol Chem 257:10566-70 (1982)
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.23
IUBMB Enzyme Nomenclature: 1.2.1.23
ExPASy - ENZYME nomenclature database: 1.2.1.23
BRENDA, the Enzyme Database: 1.2.1.23
CAS: 37250-91-2
LinkDB

KEGG   REACTION: R00203
Entry
R00203                      Reaction                               
Name
pyruvaldehyde:NAD+ oxidoreductase;
2-oxopropanal:NAD+ oxidoreductase
Definition
Methylglyoxal + NAD+ + H2O <=> Pyruvate + NADH + H+
Equation
C00546 + C00003 + C00001 <=> C00022 + C00004 + C00080
Reaction class
RC00001  C00003_C00004
RC00104  C00022_C00546
Enzyme
1.2.1.22        1.2.1.23
Pathway
rn00620  Pyruvate metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.22
     R00203  Methylglyoxal + NAD+ + H2O <=> Pyruvate + NADH + H+
    1.2.1.23
     R00203  Methylglyoxal + NAD+ + H2O <=> Pyruvate + NADH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.2.1.23
   R01337  2-Oxoaldehyde <=> 2-Oxo acid
    R00203  Methylglyoxal <=> Pyruvate
Orthology
K07248  lactaldehyde dehydrogenase / glycolaldehyde dehydrogenase [EC:1.2.1.22 1.2.1.21]
Other DBs
RHEA: 52007
LinkDB

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