KEGG   ENZYME: 2.1.1.378
Entry
EC 2.1.1.378                Enzyme                                 
Name
[methyl-Co(III) glycine betaine-specific corrinoid protein]---tetrahydrofolate methyltransferase;
mtgA (gene name);
DSY3157 (locus name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
[methyl-Co(III) glycine betaine-specific corrinoid protein]:tetrahydrofolate N-methyltransferase
Reaction(IUBMB)
a [methyl-Co(III) glycine betaine-specific corrinoid protein] + tetrahydrofolate = a [Co(I) glycine betaine-specific corrinoid protein] + 5-methyltetrahydrofolate [RN:R02289]
Reaction(KEGG)
R02289
Substrate
[methyl-Co(III) glycine betaine-specific corrinoid protein];
tetrahydrofolate [CPD:C00101]
Product
[Co(I) glycine betaine-specific corrinoid protein];
5-methyltetrahydrofolate [CPD:C00440]
Comment
This enzyme, characterized from the anaerobic bacterium Desulfitobacterium hafniense Y51, catalyses a similar reaction to that of EC 2.1.1.258, 5-methyltetrahydrofolate---corrinoid/iron-sulfur protein Co-methyltransferase, but in the opposite direction, transferring a methyl group from a methylated corrinoid protein to tetrahydrofolate. The corrinoid protein is specifically methylated by EC 2.1.1.376, glycine betaine---corrinoid protein Co-methyltransferase.
History
EC 2.1.1.378 created 2021
Pathway
ec00670  One carbon pool by folate
ec01100  Metabolic pathways
Orthology
K25221  [methyl-Co(III) glycine betaine-specific corrinoid protein]---tetrahydrofolate methyltransferase
Genes
CACECACET_c34490(mtrH)
GFEGferi_19930
DSYDSY3157
DHDDhaf_4327
DDHDesde_3696
DORDesor_0411
DMIDesmer_0447
FWADCMF_08820
TJRTherJR_2947
AWOAwo_c07520(mttA2)
STEDSPTER_06960(mtgA_2)
 » show all
Reference
1  [PMID:25313086]
  Authors
Ticak T, Kountz DJ, Girosky KE, Krzycki JA, Ferguson DJ Jr.
  Title
A nonpyrrolysine member of the widely distributed trimethylamine methyltransferase family is a glycine betaine methyltransferase.
  Journal
Proc Natl Acad Sci U S A 111:E4668-76 (2014)
DOI:10.1073/pnas.1409642111
  Sequence
[dsy:DSY3157]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.378
IUBMB Enzyme Nomenclature: 2.1.1.378
ExPASy - ENZYME nomenclature database: 2.1.1.378
BRENDA, the Enzyme Database: 2.1.1.378
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