KEGG   ENZYME: 2.3.1.86
Entry
EC 2.3.1.86                 Enzyme                                 
Name
fatty-acyl-CoA synthase system;
yeast fatty acid synthase;
FAS1 (gene name);
FAS2 (gene name);
fatty-acyl-CoA synthase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing)
Reaction(IUBMB)
acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H+ = long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP+ [RN:R05190]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
malonyl-CoA [CPD:C00083];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
long-chain-acyl-CoA;
CoA [CPD:C00010];
CO2 [CPD:C00011];
NADP+ [CPD:C00006]
Comment
The enzyme from yeasts (Ascomycota and Basidiomycota) is a multi-functional protein complex composed of two subunits. One subunit catalyses the reactions EC 1.1.1.100, 3-oxoacyl-[acyl-carrier-protein] reductase and EC 2.3.1.41, beta-ketoacyl-[acyl-carrier-protein] synthase I, while the other subunit catalyses the reactions of EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, EC 2.3.1.39, [acyl-carrier-protein] S-malonyltransferase, EC 4.2.1.59, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, EC 1.3.1.10, enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and EC 1.1.1.279, (R)-3-hydroxyacid-ester dehydrogenase. The enzyme system differs from the animal system (EC 2.3.1.85, fatty-acid synthase system) in that the enoyl reductase domain requires FMN as a cofactor, and the ultimate product is an acyl-CoA (usually palmitoyl-CoA) instead of a free fatty acid.
History
EC 2.3.1.86 created 1984, modified 2003, modified 2013, modified 2019
Pathway
ec00061  Fatty acid biosynthesis
ec01100  Metabolic pathways
Orthology
K00667  fatty acid synthase subunit alpha, fungi type
K00668  fatty acid synthase subunit beta, fungi type
Genes
PXB103941732
QSU111990661 111990671 112029203 112029266
SCEYKL182W(FAS1) YPL231W(FAS2)
SEUBDI49_3200 DI49_5237
SPAOSPAR_K00390 SPAR_P00450
AGOAGOS_AER085C AGOS_AFL138W
ERCEcym_2158 Ecym_3239
KLAKLLA0_B02717g KLLA0_C15983g
KMXKLMA_40526(FAS1) KLMA_70219(FAS2)
LTHKLTH0D15070g KLTH0G09526g KLTH0H03190g
VPOKpol_1002p24 Kpol_1055p60
ZROZYRO0B13068g ZYRO0E07766g
CGRCAGL0D00528g CAGL0E06138g
NCSNCAS_0G01260(NCAS0G01260) NCAS_0J01680(NCAS0J01680)
NDINDAI_0F01390(NDAI0F01390) NDAI_0J02670(NDAI0J02670)
TPFTPHA_0B02040(TPHA0B02040) TPHA_0H01860(TPHA0H01860)
TBLTBLA_0C02010(TBLA0C02010) TBLA_0I03120(TBLA0I03120)
TDLTDEL_0A06700(TDEL0A06700) TDEL_0C04130(TDEL0C04130) TDEL_0E00900(TDEL0E00900)
TGBHG536_0A08260 HG536_0B03070 HG536_0E02010
KAFKAFR_0A05730(KAFR0A05730) KAFR_0F01200(KAFR0F01200)
KNGKNAG_0B06300(KNAG0B06300) KNAG_0D00890(KNAG0D00890)
ZMKHG535_0A06580 HG535_0B06760 HG535_0D02420
PPAPAS_chr1-1_0008 PAS_chr1-4_0295
DHADEHA2B08140g DEHA2B10032g
PICPICST_80966(FAS2) PICST_85125(FAS1)
PGUPGUG_02105 PGUG_02173
SPAASPAPADRAFT_138494 SPAPADRAFT_140888(FAS2)
LELLELG_02891 LELG_02892 LELG_03854
CALCAALFM_C304830CA(FAS2) CAALFM_C500190CA(FAS1)
CTPCTRG_02501 CTRG_05241
COTCORT_0C01740 CORT_0E04830
CDUCD36_50220(FAS1) CD36_84800
CTENCANTEDRAFT_107026 CANTEDRAFT_110568
YLIYALI0B15059g YALI0B19382g
CLUCLUG_03422 CLUG_04160
CLUSA9F13_01g07634 A9F13_04g03652
CAURCJI97_001309 CJI97_001964
SLBAWJ20_164(FAS2) AWJ20_861(FAS1)
PKZC5L36_0A10650 C5L36_0C07500
BNNFOA43_003644(FAS1) FOA43_003890(FAS2)
BBRXBRETT_000610(FAS2) BRETT_004505(FAS1_1) BRETT_004531(FAS1_2)
OPAHPODL_04019 HPODL_04992
SLUDSCDLUD_001146 SCDLUD_002874 SCDLUD_004286
NCRNCU07307(cel-2) NCU07308(cel-1)
NTENEUTE1DRAFT61252(NEUTE1DRAFT_61252) NEUTE1DRAFT61255(NEUTE1DRAFT_61255)
SMPSMAC_00840 SMAC_00841
PANPODANSg3685 PODANSg3686 PODANSg8559 PODANSg8560
TTTTHITE_2122453 THITE_2122457
MTMMYCTH_2310228 MYCTH_2310232
CTHRCTHT_0037740 CTHT_0037750
MGRMGG_04118 MGG_12154
PPEIPpBr36_04603 PpBr36_04604
TMNUCRPA7_6807 UCRPA7_6808
SSCKSPSK_04790 SPSK_04795
FGRFGSG_00036 FGSG_05321 FGSG_05322 FGSG_11656
FPUFPSE_07168 FPSE_07169 FPSE_07818 FPSE_07819
FVRFVEG_04241 FVEG_04242
FOXFOXG_06391 FOXG_06392 FOXG_14342 FOXG_15138
NHENECHADRAFT_64009 NECHADRAFT_72277
TRETRIREDRAFT_48788 TRIREDRAFT_78591
TRRM419DRAFT_35261 M419DRAFT_98783
MAWMAC_02878 MAC_02884 MAC_06764 MAC_06765 MAC_07602
MAJMAA_01138 MAA_01139 MAA_01642 MAA_10451
CMTCCM_02997 CCM_02998
PLJVFPFJ_00702 VFPFJ_00704
VALVDBG_01018 VDBG_01020
VDAVDAG_00631 VDAG_00632
CFJCFIO01_03118 CFIO01_03119
CLUPCLUP02_17680 CLUP02_17683
CHIGCH63R_09523 CH63R_09765 CH63R_09768 CH63R_13996 CH63R_13998
SAPOSAPIO_CDS7370 SAPIO_CDS7371
ELAUCREL1_2864 UCREL1_2866 UCREL1_3665 UCREL1_3666
PFYPFICI_02555 PFICI_02560 PFICI_04683 PFICI_04684 PFICI_09703 PFICI_09706
SSLSS1G_13073 SS1G_13074
BFUBCIN_01g00440(Bcfas2) BCIN_01g00450
MBEMBM_00558 MBM_00559
PSCOLY89DRAFT_624908 LY89DRAFT_624910 LY89DRAFT_650084 LY89DRAFT_784300
GLZGLAREA_01152 GLAREA_01153 GLAREA_08470 GLAREA_08471
ANIAN3380.2 AN3381.2 AN7814.2 AN7815.2 AN7873.2 AN7880.2 AN9407.2 AN9408.2
AFMAFUA_3G04210 AFUA_3G04220
ACTACLA_060580 ACLA_060590 ACLA_093750 ACLA_093760
NFINFIA_006480 NFIA_006490
AORAO090010000107 AO090010000108 AO090010000156 AO090010000171 AO090011000040 AO090011000046 AO090026000012 AO090026000013 AO090124000083 AO090124000084
ANGANI_1_1114084(An09g01740) ANI_1_1156084(An09g02010) ANI_1_1466104(An12g01980) ANI_1_1468104(An12g01990) ANI_1_202174(An10g00630) ANI_1_204174(An10g00650) ANI_1_2056014(An01g00050) ANI_1_2488074(An08g10860) ANI_1_2494074(An08g10930) ANI_1_6014(An01g00060)
AFVAFLA_006307 AFLA_006308 AFLA_007399 AFLA_007408 AFLA_009127 AFLA_009128 AFLA_013645 AFLA_013646 AFLA_013700 AFLA_013717
ALUCAKAW2_20202A(FAS1) AKAW2_20203S(FAS2_1) AKAW2_40150S AKAW2_40162S AKAW2_52045S AKAW2_71015A AKAW2_71016A AKAW2_81151A AKAW2_81152S
ACHEACHE_40272A(FAS1) ACHE_40273S(FAS2)
APUUAPUU_20048A APUU_20049S APUU_31411A APUU_31412S APUU_50288A(FAS2) APUU_50289S(FAS1)
PCSPc14g00740 Pc14g00750 Pc21g10840 Pc21g10870
PDPPDIP_67930 PDIP_67940 PDIP_87680 PDIP_87700
TMFPMAA_005570 PMAA_005580 PMAA_068580 PMAA_068590 PMAA_091380 PMAA_091400 PMAA_101830 PMAA_101840
TRGTRUGW13939_07283 TRUGW13939_07284 TRUGW13939_10098 TRUGW13939_10099
CIMCIMG_08477 CIMG_08479 CIMG_08564 CIMG_08565
CPWCPC735_061450 CPC735_061460 CPC735_062220 CPC735_062230
UREUREG_02553 UREG_02554 UREG_04458 UREG_04459
PBLPAAG_01524 PAAG_01525
PBNPADG_00254 PADG_00255
ABEARB_02752 ARB_02757 ARB_06046 ARB_06048
TVETRV_06188 TRV_06193 TRV_06922 TRV_06923
AJEHCAG_07636 HCAG_07637
BGHBDBG_09189 BDBG_09190
PNOSNOG_01107 SNOG_01108 SNOG_02166 SNOG_02167 SNOG_09089 SNOG_09091
PTEPTT_02058 PTT_02059 PTT_10814 PTT_10815 PTT_18039
BZECOCCADRAFT_102373 COCCADRAFT_113337 COCCADRAFT_31318 COCCADRAFT_7010
BSCCOCSADRAFT_235908 COCSADRAFT_97659
BORCOCMIDRAFT_1000 COCMIDRAFT_82264
AALTCC77DRAFT_928877 CC77DRAFT_929241
ZTRMYCGRDRAFT_108403(FAS1) MYCGRDRAFT_69244
PFJMYCFIDRAFT_212667 MYCFIDRAFT_53243
FFUCLAFUR5_10725 CLAFUR5_10726 CLAFUR5_14275 CLAFUR5_14276
BCOMBAUCODRAFT_144102 BAUCODRAFT_151421 BAUCODRAFT_62139 BAUCODRAFT_77435
NPAUCRNP2_2698 UCRNP2_2699 UCRNP2_3239 UCRNP2_4858 UCRNP2_7996 UCRNP2_7999
TMLGSTUM_00002095001
SPOSPAC4A8.11c(fas2) SPAC926.09c(fas1)
CNECNE04360 CNE04370
CNBCNBE4360 CNBE4370
CNGCNAG_02099 CNAG_02100
CGICGB_E5650C CGB_E5660W
TMSTREMEDRAFT_40511 TREMEDRAFT_45355
TASAA1Q1_06630 A1Q1_06631
TVSTRAVEDRAFT_149581 TRAVEDRAFT_41081
DSQDICSQDRAFT_80488
PCOPHACADRAFT_206686
SHSSTEHIDRAFT_165793
HIRHETIRDRAFT_433870
PSQPUNSTDRAFT_137436 PUNSTDRAFT_143350
ADLAURDEDRAFT_112733
FMEFOMMEDRAFT_17335
GTRGLOTRDRAFT_112049
LBCLACBIDRAFT_296983(FAS-2)
CCICC1G_07064
ABPAGABI1DRAFT61049(AGABI1DRAFT_61049)
ABVAGABI2DRAFT217954(AGABI2DRAFT_217954)
PCUBJR316_0005820
MRRMoror_12902
MOREE1B28_011100
SCMSCHCO_01176814(SCHCODRAFT_01176814) SCHCO_0235165(SCHCODRAFT_0235165) SCHCO_02627311(SCHCODRAFT_02627311)
CPUTCONPUDRAFT_71103
SLASERLADRAFT_449191
WSEWALSEDRAFT_31561
WICJ056_004245
UMAUMAG_06460 UMAG_10339
PFPPFL1_00007(fas2) PFL1_04986
PGRPGTG_06184 PGTG_06788 PGTG_21688
MLRMELLADRAFT_115404 MELLADRAFT_45383 MELLADRAFT_79679
ACANACA1_069690
PIFPITG_10922 PITG_10926 PITG_18025
PSOJPHYSODRAFT_324166 PHYSODRAFT_341458 PHYSODRAFT_478148 PHYSODRAFT_556584
SPARSPRG_21373
MAUBMAUB_47630
TBWNCTC13354_01644(fabF)
LKMEFP84_19320
 » show all
Reference
1  [PMID:4590449]
  Authors
Schweizer E, Kniep B, Castorph H, Holzner U.
  Title
Pantetheine-free mutants of the yeast fatty-acid-synthetase complex.
  Journal
Eur J Biochem 39:353-62 (1973)
DOI:10.1111/j.1432-1033.1973.tb03133.x
Reference
2  [PMID:6137188]
  Authors
Wakil SJ, Stoops JK, Joshi VC.
  Title
Fatty acid synthesis and its regulation.
  Journal
Annu Rev Biochem 52:537-79 (1983)
DOI:10.1146/annurev.bi.52.070183.002541
Reference
3  [PMID:16950653]
  Authors
Tehlivets O, Scheuringer K, Kohlwein SD
  Title
Fatty acid synthesis and elongation in yeast.
  Journal
Biochim Biophys Acta 1771:255-70 (2007)
DOI:10.1016/j.bbalip.2006.07.004
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.86
IUBMB Enzyme Nomenclature: 2.3.1.86
ExPASy - ENZYME nomenclature database: 2.3.1.86
BRENDA, the Enzyme Database: 2.3.1.86
CAS: 94219-29-1
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