KEGG   ENZYME: 2.3.1.86
Entry
EC 2.3.1.86                 Enzyme                                 
Name
fatty-acyl-CoA synthase system;
yeast fatty acid synthase;
FAS1 (gene name);
FAS2 (gene name);
fatty-acyl-CoA synthase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing)
Reaction(IUBMB)
acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H+ = long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP+ [RN:R05190]
Reaction(KEGG)
R05190;
(other) R01624 R01626 R04355 R04428 R04430 R04533 R04534 R04535 R04536 R04537 R04543 R04544 R04566 R04568 R04725 R04726 R04952 R04953 R04954 R04956 R04957 R04959 R04960 R04962 R04963 R04964 R04965 R04967 R04968 R04970 R10700
Substrate
acetyl-CoA [CPD:C00024];
malonyl-CoA [CPD:C00083];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
long-chain-acyl-CoA;
CoA [CPD:C00010];
CO2 [CPD:C00011];
NADP+ [CPD:C00006]
Comment
The enzyme from yeasts (Ascomycota and Basidiomycota) is a multi-functional protein complex composed of two subunits. One subunit catalyses the reactions EC 1.1.1.100, 3-oxoacyl-[acyl-carrier-protein] reductase and EC 2.3.1.41, beta-ketoacyl-[acyl-carrier-protein] synthase I, while the other subunit catalyses the reactions of EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, EC 2.3.1.39, [acyl-carrier-protein] S-malonyltransferase, EC 4.2.1.59, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, EC 1.3.1.10, enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and EC 1.1.1.279, (R)-3-hydroxyacid-ester dehydrogenase. The enzyme system differs from the animal system (EC 2.3.1.85, fatty-acid synthase system) in that the enoyl reductase domain requires FMN as a cofactor, and the ultimate product is an acyl-CoA (usually palmitoyl-CoA) instead of a free fatty acid.
History
EC 2.3.1.86 created 1984, modified 2003, modified 2013, modified 2019
Pathway
ec00061  Fatty acid biosynthesis
ec01100  Metabolic pathways
Orthology
K00667  fatty acid synthase subunit alpha, fungi type
K00668  fatty acid synthase subunit beta, fungi type
Genes
PXB: 103941732
SCE: YKL182W(FAS1) YPL231W(FAS2)
SEUB: DI49_3200 DI49_5237
SPAO: SPAR_K00390 SPAR_P00450
AGO: AGOS_AER085C AGOS_AFL138W
ERC: Ecym_2158 Ecym_3239
KLA: KLLA0_B02717g KLLA0_C15983g
KMX: KLMA_40526(FAS1) KLMA_70219(FAS2)
LTH: KLTH0D15070g KLTH0G09526g KLTH0H03190g
VPO: Kpol_1002p24 Kpol_1055p60
ZRO: ZYRO0B13068g ZYRO0E07766g
CGR: CAGL0D00528g CAGL0E06138g
NCS: NCAS_0G01260(NCAS0G01260) NCAS_0J01680(NCAS0J01680)
NDI: NDAI_0F01390(NDAI0F01390) NDAI_0J02670(NDAI0J02670)
TPF: TPHA_0B02040(TPHA0B02040) TPHA_0H01860(TPHA0H01860)
TBL: TBLA_0C02010(TBLA0C02010) TBLA_0I03120(TBLA0I03120)
TGB: HG536_0A08260 HG536_0B03070 HG536_0E02010
TDL: TDEL_0A06700(TDEL0A06700) TDEL_0C04130(TDEL0C04130) TDEL_0E00900(TDEL0E00900)
KAF: KAFR_0A05730(KAFR0A05730) KAFR_0F01200(KAFR0F01200)
KNG: KNAG_0B06300(KNAG0B06300) KNAG_0D00890(KNAG0D00890)
ZMK: HG535_0A06580 HG535_0B06760 HG535_0D02420
PPA: PAS_chr1-1_0008 PAS_chr1-4_0295
DHA: DEHA2B08140g DEHA2B10032g
PIC: PICST_80966(FAS2) PICST_85125(FAS1)
PGU: PGUG_02105 PGUG_02173
SPAA: SPAPADRAFT_138494 SPAPADRAFT_140888(FAS2)
LEL: LELG_02891 LELG_02892 LELG_03854
CAL: CAALFM_C304830CA(FAS2) CAALFM_C500190CA(FAS1)
CTP: CTRG_02501 CTRG_05241
COT: CORT_0C01740 CORT_0E04830
CDU: CD36_50220(FAS1) CD36_84800
CTEN: CANTEDRAFT_107026 CANTEDRAFT_110568
YLI: YALI0B15059g YALI0B19382g
CLU: CLUG_03422 CLUG_04160
CLUS: A9F13_01g07634 A9F13_04g03652
CAUR: CJI96_0001346 CJI96_0004975
SLB: AWJ20_164(FAS2) AWJ20_861(FAS1)
PKZ: C5L36_0A10650 C5L36_0C07500
BNN: FOA43_003644(FAS1) FOA43_003890(FAS2)
BBRX: BRETT_000610(FAS2) BRETT_004505(FAS1_1) BRETT_004531(FAS1_2)
OPA: HPODL_04019 HPODL_04992
SLUD: SCDLUD_001146 SCDLUD_002874 SCDLUD_004286
NCR: NCU07307(cel-2) NCU07308(cel-1)
NTE: NEUTE1DRAFT61252(NEUTE1DRAFT_61252) NEUTE1DRAFT61255(NEUTE1DRAFT_61255)
SMP: SMAC_00840 SMAC_00841
PAN: PODANSg3685 PODANSg3686 PODANSg8559 PODANSg8560
TTT: THITE_2122453 THITE_2122457
MTM: MYCTH_2310228 MYCTH_2310232
CTHR: CTHT_0037740 CTHT_0037750
MGR: MGG_04118 MGG_12154
PPEI: PpBr36_04603 PpBr36_04604
TMN: UCRPA7_6807 UCRPA7_6808
SSCK: SPSK_04790 SPSK_04795
FGR: FGSG_00036 FGSG_05321 FGSG_05322 FGSG_11656
FPU: FPSE_07168 FPSE_07169 FPSE_07818 FPSE_07819
FVR: FVEG_04241 FVEG_04242
FOX: FOXG_06391 FOXG_06392 FOXG_14342 FOXG_15138
NHE: NECHADRAFT_64009 NECHADRAFT_72277
FFC: NCS54_01273000 NCS54_01273100 NCS54_01495800
TRE: TRIREDRAFT_48788 TRIREDRAFT_78591
TRR: M419DRAFT_35261 M419DRAFT_98783
MAW: MAC_02878 MAC_02884 MAC_06764 MAC_06765 MAC_07602
MAJ: MAA_01138 MAA_01139 MAA_01642 MAA_10451
CMT: CCM_02997 CCM_02998
PLJ: VFPFJ_00702 VFPFJ_00704
PTKZ: JDV02_007946(FAS1_1) JDV02_007947(FAS1_2)
VAL: VDBG_01018 VDBG_01020
VDA: VDAG_00631 VDAG_00632
CFJ: CFIO01_03118 CFIO01_03119
CLUP: CLUP02_17680 CLUP02_17683
CHIG: CH63R_09523 CH63R_09765 CH63R_09768 CH63R_13996 CH63R_13998
SAPO: SAPIO_CDS7370 SAPIO_CDS7371
ELA: UCREL1_2864 UCREL1_2866 UCREL1_3665 UCREL1_3666
PFY: PFICI_02555 PFICI_02560 PFICI_04683 PFICI_04684 PFICI_09703 PFICI_09706
SSL: SS1G_13073 SS1G_13074
BFU: BCIN_01g00440(Bcfas2) BCIN_01g00450
MBE: MBM_00558 MBM_00559
PSCO: LY89DRAFT_624908 LY89DRAFT_624910 LY89DRAFT_650084 LY89DRAFT_784300
GLZ: GLAREA_01152 GLAREA_01153 GLAREA_08470 GLAREA_08471
ANI: AN3380.2 AN3381.2 AN7814.2 AN7815.2 AN7873.2 AN7880.2 AN9407.2 AN9408.2
AFM: AFUA_3G04210 AFUA_3G04220
ACT: ACLA_060580 ACLA_060590 ACLA_093750 ACLA_093760
NFI: NFIA_006480 NFIA_006490
AOR: AO090010000107 AO090010000108 AO090010000156 AO090010000171 AO090011000040 AO090011000046 AO090026000012 AO090026000013 AO090124000083 AO090124000084
ANG: ANI_1_1114084(An09g01740) ANI_1_1156084(An09g02010) ANI_1_1466104(An12g01980) ANI_1_1468104(An12g01990) ANI_1_202174(An10g00630) ANI_1_204174(An10g00650) ANI_1_2056014(An01g00050) ANI_1_2488074(An08g10860) ANI_1_2494074(An08g10930) ANI_1_6014(An01g00060)
AFV: AFLA_006307 AFLA_006308 AFLA_007399 AFLA_007408 AFLA_009127 AFLA_009128 AFLA_013645 AFLA_013646 AFLA_013700 AFLA_013717
ALUC: AKAW2_20202A(FAS1) AKAW2_20203S(FAS2_1) AKAW2_40150S AKAW2_40162S AKAW2_52045S AKAW2_71015A AKAW2_71016A AKAW2_81151A AKAW2_81152S
ACHE: ACHE_40272A(FAS1) ACHE_40273S(FAS2)
APUU: APUU_20048A APUU_20049S APUU_31411A APUU_31412S APUU_50288A(FAS2) APUU_50289S(FAS1)
PCS: Pc14g00740 Pc14g00750 Pc21g10840 Pc21g10870
PDP: PDIP_67930 PDIP_67940 PDIP_87680 PDIP_87700
TMF: EYB26_005504 EYB26_005505 EYB26_006384 EYB26_006385 EYB26_007408 EYB26_007410 EYB26_009147 EYB26_009148
TRG: TRUGW13939_07283 TRUGW13939_07284 TRUGW13939_10098 TRUGW13939_10099
CIM: CIMG_08477 CIMG_08479 CIMG_08564 CIMG_08565
CPW: CPC735_061450 CPC735_061460 CPC735_062220 CPC735_062230
URE: UREG_02553 UREG_02554 UREG_04458 UREG_04459
PBL: PAAG_01524 PAAG_01525
PBN: PADG_00254 PADG_00255
ABE: ARB_02752 ARB_02757 ARB_06046 ARB_06048
TVE: TRV_06188 TRV_06193 TRV_06922 TRV_06923
AJE: HCAG_07636 HCAG_07637
BGH: BDBG_09189 BDBG_09190
PNO: SNOG_01107 SNOG_01108 SNOG_02166 SNOG_02167 SNOG_09089 SNOG_09091
PTE: PTT_02058 PTT_02059 PTT_10814 PTT_10815 PTT_18039
BZE: COCCADRAFT_102373 COCCADRAFT_113337 COCCADRAFT_31318 COCCADRAFT_7010
BSC: COCSADRAFT_235908 COCSADRAFT_97659
BOR: COCMIDRAFT_1000 COCMIDRAFT_82264
AALT: CC77DRAFT_928877 CC77DRAFT_929241
ZTR: MYCGRDRAFT_108403(FAS1) MYCGRDRAFT_69244
PFJ: MYCFIDRAFT_212667 MYCFIDRAFT_53243
FFU: CLAFUR5_10725 CLAFUR5_10726 CLAFUR5_14275 CLAFUR5_14276
BCOM: BAUCODRAFT_144102 BAUCODRAFT_151421 BAUCODRAFT_62139 BAUCODRAFT_77435
NPA: UCRNP2_2698 UCRNP2_2699 UCRNP2_3239 UCRNP2_4858 UCRNP2_7996 UCRNP2_7999
TML: GSTUM_00002095001
SPO: SPAC4A8.11c(fas2) SPAC926.09c(fas1)
SOM: SOMG_03675(fas2) SOMG_04610(fas1)
CNE: CNE04360 CNE04370
CNB: CNBE4360 CNBE4370
CNG: CNAG_02099 CNAG_02100
CGI: CGB_E5650C CGB_E5660W
TMS: TREMEDRAFT_40511 TREMEDRAFT_45355
TASA: A1Q1_06630 A1Q1_06631
TVS: TRAVEDRAFT_149581 TRAVEDRAFT_41081
DSQ: DICSQDRAFT_80488
PCO: PHACADRAFT_206686
SHS: STEHIDRAFT_165793
HIR: HETIRDRAFT_433870
PSQ: PUNSTDRAFT_137436 PUNSTDRAFT_143350
ADL: AURDEDRAFT_112733
FME: FOMMEDRAFT_17335
GTR: GLOTRDRAFT_112049
RSX: RhiXN_03112
LBC: LACBIDRAFT_296983(FAS-2)
CCI: CC1G_07064
ABP: AGABI1DRAFT61049(AGABI1DRAFT_61049)
ABV: AGABI2DRAFT217954(AGABI2DRAFT_217954)
PCUB: JR316_0005820
MRR: Moror_12902
MORE: E1B28_011100
SCM: SCHCO_01176814(SCHCODRAFT_01176814) SCHCO_0235165(SCHCODRAFT_0235165) SCHCO_02627311(SCHCODRAFT_02627311)
CPUT: CONPUDRAFT_71103
SLA: SERLADRAFT_449191
WSE: WALSEDRAFT_31561
WIC: J056_004245
UMA: UMAG_06460 UMAG_10339
PFP: PFL1_00007(fas2) PFL1_04986
SGRA: EX895_002632 EX895_005623
PGR: PGTG_06184 PGTG_06788 PGTG_21688
PTRC: PtA15_18A140 PtA15_5A843 PtA15_8A197
MLR: MELLADRAFT_115404 MELLADRAFT_45383 MELLADRAFT_79679
ACAN: ACA1_069690
PIF: PITG_10922 PITG_10926 PITG_18025
PSOJ: PHYSODRAFT_324166 PHYSODRAFT_341458 PHYSODRAFT_478148 PHYSODRAFT_556584
SPAR: SPRG_21373
MAUB: MAUB_47630
TBW: NCTC13354_01644(fabF)
LKM: EFP84_19320
 » show all
Reference
1  [PMID:4590449]
  Authors
Schweizer E, Kniep B, Castorph H, Holzner U.
  Title
Pantetheine-free mutants of the yeast fatty-acid-synthetase complex.
  Journal
Eur J Biochem 39:353-62 (1973)
DOI:10.1111/j.1432-1033.1973.tb03133.x
Reference
2  [PMID:6137188]
  Authors
Wakil SJ, Stoops JK, Joshi VC.
  Title
Fatty acid synthesis and its regulation.
  Journal
Annu Rev Biochem 52:537-79 (1983)
DOI:10.1146/annurev.bi.52.070183.002541
Reference
3  [PMID:16950653]
  Authors
Tehlivets O, Scheuringer K, Kohlwein SD
  Title
Fatty acid synthesis and elongation in yeast.
  Journal
Biochim Biophys Acta 1771:255-70 (2007)
DOI:10.1016/j.bbalip.2006.07.004
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.86
IUBMB Enzyme Nomenclature: 2.3.1.86
ExPASy - ENZYME nomenclature database: 2.3.1.86
BRENDA, the Enzyme Database: 2.3.1.86
CAS: 94219-29-1
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