| Entry |
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| Name |
N-acetylaspartylglutamylglutamate synthase;
N-acetylaspartylglutamylglutamate synthetase;
NAAG(2) synthase;
NAAG synthetase II;
NAAGS-II;
RIMKLA (gene name) (ambiguous)
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| Class |
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
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| Sysname |
N-acetyl-L-aspartate:L-glutamate ligase (ADP, N-acetyl-L-aspartyl-L-glutamyl-L-glutamate-forming)
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| Reaction(IUBMB) |
2 ATP + N-acetyl-L-aspartate + 2 L-glutamate = 2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate [RN: R10679]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
ADP [CPD: C00008];
phosphate [CPD: C00009];
N-acetyl-L-aspartyl-L-glutamyl-L-glutamate [CPD: C20776]
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| Comment |
The enzyme, found in mammals, also has the activity of EC 6.3.2.41, N-acetylaspartylglutamate synthase.
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| History |
EC 6.3.2.42 created 2014
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| Pathway |
| ec00250 | Alanine, aspartate and glutamate metabolism |
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| Orthology |
| K18311 | N-acetylaspartylglutamate/N-acetylaspartylglutamylglutamate synthase |
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| Genes |
| DMER: | 138803277 138823603(Rimkla) |
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| Reference |
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| Authors |
Lodder-Gadaczek J, Becker I, Gieselmann V, Wang-Eckhardt L, Eckhardt M |
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| Title |
N-acetylaspartylglutamate synthetase II synthesizes N-acetylaspartylglutamylglutamate. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 6.3.2.42 |
| ExPASy - ENZYME nomenclature database: | 6.3.2.42 |
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| LinkDB |
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