COMPOUND: C22533
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Entry
C22533 Compound
Name
Complement component 3b;
C3b
Sequence
(A chain)
SNLDEDIIAE ENIVSRSEFP ESWLWNVEDL KEPPKNGIST KLMNIFLKDS ITTWEILAVS
MSDKKGICVA DPFEVTVMQD FFIDLRLPYS VVRNEQVEIR AVLYNYRQNQ ELKVRVELLH
NPAFCSLATT KRRHQQTVTI PPKSSLSVPY VIVPLKTGLQ EVEVKAAVYH HFISDGVRKS
LKVVPEGIRM NKTVAVRTLD PERLGREGVQ KEDIPPADLS DQVPDTESET RILLQGTPVA
QMTEDAVDAE RLKHLIVTPS GCGEQNMIGM TPTVIAVHYL DETEQWEKFG LEKRQGALEL
IKKGYTQQLA FRQPSSAFAA FVKRAPSTWL TAYVVKVFSL AVNLIAIDSQ VLCGAVKWLI
LEKQKPDGVF QEDAPVIHQE MIGGLRNNNE KDMALTAFVL ISLQEAKDIC EEQVNSLPGS
ITKAGDFLEA NYMNLQRSYT VAIAGYALAQ MGRLKGPLLN KFLTTAKDKN RWEDPGKQLY
NVEATSYALL ALLQLKDFDF VPPVVRWLNE QRYYGGGYGS TQATFMVFQA LAQYQKDAPD
HQELNLDVSL QLPSRSSKIT HRIHWESASL LRSEETKENE GFTVTAEGKG QGTLSVVTMY
HAKAKDQLTC NKFDLKVTIK PAPETEKRPQ DAKNTMILEI CTRYRGDQDA TMSILDISMM
TGFAPDTDDL KQLANGVDRY ISKYELDKAF SDRNTLIIYL DKVSHSEDDC LAFKVHQYFN
VELIQPGAVK VYAYYNLEES CTRFYHPEKE DGKLNKLCRD ELCRCAEENC FIQKSDDKVT
LEERLDKACE PGVDYVYKTR LVKVQLSNDF DEYIMAIEQT IKSGSDEVQV GQQRTFISPI
KCREALKLEE KKHYLMWGLS SDFWGEKPNL SYIIGKDTWV EHWPEEDECQ DEENQKQCQD
LGAFTESMVV FGCPN
(Disulfide bridge: 125-765)
(B chain)
SPMYSIITPN ILRLESEETM VLEAHDAQGD VPVTVTVHDF PGKKLVLSSE KTVLTPATNH
MGNVTFTIPA NREFKSEKGR NKFVTVQATF GTQVVEKVVL VSLQSGYLFI QTDKTIYTPG
STVLYRIFTV NHKLLPVGRT VMVNIENPEG IPVKQDSLSS QNQLGVLPLS WDIPELVNMG
QWKIRAYYEN SPQQVFSTEF EVKEYVLPSF EVIVEPTEKF YYIYNEKGLE VTITARFLYG
KKVEGTAFVI FGIQDGEQRI SLPESLKRIP IEDGSGEVVL SRKVLLDGVQ NPRAEDLVGK
SLYVSATVIL HSGSDMVQAE RSGIPIVTSP YQIHFTKTPK YFKPGMPFDL MVFVTNPDGS
PAYRVPVAVQ GEDTVQSLTQ GDGVAKLSIN THPSQKPLSI TVRTKKQELS EAEQATRTMQ
ALPYSTVGNS NNYLHLSVLR TELRPGETLN VNFLLRMDRA HEAKIRYYTY LIMNKGRLLK
AGRQVREPGQ DLVVLPLSIT TDFIPSFRLV AYYTLIGASG QREVVADSVW VDVKDSCVGS
LVVKSGQSED RQPVPGQQMT LKIEGDHGAR VVLVAVDKGV FVLNKKNKLT QSKIWDVVEK
ADIGCTPGSG KDYAGVFSDA GLTFTSSSGQ QTAQRAELQC PQPAA
(Disulfide bridge: A68-B537)
Organism
Homo sapiens [HSA:
718
]
Type
Peptide
Pathway
map04610
Complement and coagulation cascades
Network
nt06168
Herpes simplex virus 1 (HSV-1)
nt06513
Complement cascade
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» Japanese version
COMPOUND: C22540
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Entry
C22540 Compound
Name
Complement factor Bb;
Bb
Sequence
KIVLDPSGSM NIYLVLDGSD SIGASNFTGA KKCLVNLIEK VASYGVKPRY GLVTYATYPK
IWVKVSEADS SNADWVTKQL NEINYEDHKL KSGTNTKKAL QAVYSMMSWP DDVPPEGWNR
TRHVIILMTD GLHNMGGDPI TVIDEIRDLL YIGKDRKNPR EDYLDVYVFG VGPLVNQVNI
NALASKKDNE QHVFKVKDME NLEDVFYQMI DESQSLSLCG MVWEHRKGTD YHKQPWQAKI
SVIRPSKGHE SCMGAVVSEY FVLTAAHCFT VDDKEHSIKV SVGGEKRDLE IEVVLFHPNY
NINGKKEAGI PEFYDYDVAL IKLKNKLKYG QTIRPICLPC TEGTTRALRL PPTTTCQQQK
EELLPAQDIK ALFVSEEEKK LTRKEVYIKN GDKKGSCERD AQYAPGYDKV KDISEVVTPR
FLCTGGVSPY ADPNTCRGDS GGPLIVHKRS RFIQVGVISW GVVDVCKNQK RQKQVPAHAR
DFHINLFQVL PWLKEKLQDE DLGFL
Organism
Homo sapiens [HSA:
629
]
Type
Peptide
Pathway
map04610
Complement and coagulation cascades
Network
nt06513
Complement cascade
LinkDB
All DBs
» Japanese version
Homo sapiens (human): 5199
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Entry
5199 CDS
T01001
Symbol
CFP, BFD, PFC, PFD, PROPERDIN
Name
(RefSeq) complement factor properdin
KO
K15412
complement factor properdin
Organism
hsa
Homo sapiens (human)
Pathway
hsa05168
Herpes simplex virus 1 infection
Network
nt06513
Complement cascade
Element
N01494
Alternative pathway of complement cascade, C3/5 convertase formation
Disease
H00104
Alternative complement pathway component defects
Drug target
Tarperprumig:
D12823
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09160 Human Diseases
09172 Infectious disease: viral
05168 Herpes simplex virus 1 infection
5199 (CFP)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
TSP_1
TSR
TSP1_spondin
Motif
Other DBs
NCBI-GeneID:
5199
NCBI-ProteinID:
NP_001138724
OMIM:
300383
HGNC:
8864
Ensembl:
ENSG00000126759
UniProt:
P27918
A0A0S2Z4I5
Structure
PDB
LinkDB
All DBs
Position
X:complement(47623282..47630305)
Genome browser
AA seq
469 aa
AA seq
DB search
MITEGAQAPRLLLPPLLLLLTLPATGSDPVLCFTQYEESSGKCKGLLGGGVSVEDCCLNT
AFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTL
EWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQE
SEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPG
LAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDA
TRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRC
AGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPKYPPTVSM
VEGQGEKNVTFWGRPLPRCEELQGQKLVVEEKRPCLHVPACKDPEEEEL
NT seq
1410 nt
NT seq
+upstream
nt +downstream
nt
atgatcacagagggagcgcaggcccctcgattgttgctgccgccgctgctcctgctgctc
accctgccagccacaggctcagaccccgtgctctgcttcacccagtatgaagaatcctcc
ggcaagtgcaagggcctcctggggggtggtgtcagcgtggaagactgctgtctcaacact
gcctttgcctaccagaaacgtagtggtgggctctgtcagccttgcaggtccccacgatgg
tccctgtggtccacatgggccccctgttcggtgacgtgctctgagggctcccagctgcgg
taccggcgctgtgtgggctggaatgggcagtgctctggaaaggtggcacctgggaccctg
gagtggcagctccaggcctgtgaggaccagcagtgctgtcctgagatgggcggctggtct
ggctgggggccctgggagccttgctctgtcacctgctccaaagggacccggacccgcagg
cgagcctgtaatcaccctgctcccaagtgtgggggccactgcccaggacaggcacaggaa
tcagaggcctgtgacacccagcaggtctgccccacacacggggcctgggccacctggggc
ccctggaccccctgctcagcctcctgccacggtggaccccacgaacctaaggagacacga
agccgcaagtgttctgcacctgagccctcccagaaacctcctgggaagccctgcccgggg
ctagcctacgagcagcggaggtgcaccggcctgccaccctgcccagtggctgggggctgg
gggccttggggccctgtgagcccctgccctgtgacctgtggcctgggccagaccatggaa
caacggacgtgcaatcaccctgtgccccagcatgggggccccttctgtgctggcgatgcc
acccggacccacatctgcaacacagctgtgccctgccctgtggatggggagtgggactcg
tggggggagtggagcccctgtatccgacggaacatgaagtccatcagctgtcaagaaatc
ccgggccagcagtcacgcgggaggacctgcaggggccgcaagtttgacggacatcgatgt
gccgggcaacagcaggatatccggcactgctacagcatccagcactgccccttgaaagga
tcatggtcagagtggagtacctgggggctgtgcatgcccccctgtggacctaatcctacc
cgtgcccgccagcgcctctgcacacccttgctccccaagtacccgcccaccgtttccatg
gtcgaaggtcagggcgagaagaacgtgaccttctgggggagaccgctgccacggtgtgag
gagctacaagggcagaagctggtggtggaggagaaacgaccatgtctacacgtgcctgct
tgcaaagaccctgaggaagaggaactctaa
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