KEGG   DRUG: Hydrocortisone acetateHelp
Entry
D00165                      Drug                                   

Name
Hydrocortisone acetate (JP17/USP);
Carmol-HC (TN);
Cortifoam (TN)
Product
  Generic
Formula
C23H32O6
Exact mass
404.2199
Mol weight
404.4966
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG01633  CYP3A substrate
Remark
Same as: C02821
ATC code: A01AC03 A07EA02 C05AA01 D07AA02 D07XA01 H02AB09 S01BA02 S01CB03 S02BA01
Chemical structure group: DG00012
Product (DG00012): D00088<JP/US> D00165<US> D00977<JP> D00978<JP/US> D01619<JP/US> D01886<JP/US> D02288<US>
Product (mixture): D02139<US> D04425<JP> D04806<JP> D04879<JP> D11657<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Ulcerative proctitis [DS:H01466]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC03 Hydrocortisone
      D00165  Hydrocortisone acetate (JP17/USP) <US>
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA02 Hydrocortisone
      D00165  Hydrocortisone acetate (JP17/USP) <US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA01 Hydrocortisone
      D00165  Hydrocortisone acetate (JP17/USP) <US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA02 Hydrocortisone
      D00165  Hydrocortisone acetate (JP17/USP) <US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA01 Hydrocortisone
      D00165  Hydrocortisone acetate (JP17/USP) <US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB09 Hydrocortisone
      D00165  Hydrocortisone acetate (JP17/USP) <US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA02 Hydrocortisone
      D00165  Hydrocortisone acetate (JP17/USP) <US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB03 Hydrocortisone
      D00165  Hydrocortisone acetate (JP17/USP) <US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA01 Hydrocortisone
      D00165  Hydrocortisone acetate (JP17/USP) <US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Hydrocortisone
   D00165  Hydrocortisone acetate (JP17/USP)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Hydrocortisone
    D00165  Hydrocortisone acetate (JP17/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for  urogenital organs and anus
  30 Hemorrhoid drugs for external use
   D00165  Hydrocortisone acetate (JP17/USP)
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00165  Hydrocortisone acetate (JP17/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Hydrocortisone acetate
    D00165  Hydrocortisone acetate (JP17/USP)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Hydrocortisone acetate
    D00165  Hydrocortisone acetate (JP17/USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00165  Hydrocortisone acetate (JP17/USP) <US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00165  Hydrocortisone acetate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00165
Topical steroids potency [br08317.html]
 Classification in Japan
  D00165
Rx-to-OTC switch list in the USA [br08315.html]
 D00165
BRITE hierarchy
Other DBs
CAS: 50-03-3
PubChem: 7847233
ChEBI: 17609
ChEMBL: CHEMBL1091 CHEMBL306147 CHEMBL69509
LigandBox: D00165
NIKKAJI: J4.096G
LinkDB All DBs
KCF data Show

ATOM        29
            1   C1z C    29.2845  -16.8454
            2   C1y C    29.2784  -18.2246
            3   C1z C    30.4784  -16.1589
            4   C1x C    28.0785  -16.1650
            5   C1a C    29.2723  -15.4970
            6   C1y C    28.0848  -18.9235
            7   C1x C    31.6349  -18.1731
            8   C1x C    31.6410  -16.8330
            9   C5a C    30.4845  -14.8105
            10  O1a O    31.7443  -15.7389
            11  C1y C    26.9219  -16.7898
            12  C1y C    26.9406  -18.0576
            13  C1x C    28.0909  -20.2966
            14  C1b C    31.7895  -14.0498
            15  O5a O    29.3216  -14.1364
            16  O1a O    25.7160  -16.1960
            17  C1z C    25.7160  -18.9298
            18  C1x C    26.9035  -20.9706
            19  O7a O    33.1255  -14.8786
            20  C2y C    25.7160  -20.2903
            21  C1x C    24.5346  -18.2555
            22  C1a C    25.7407  -17.5380
            23  C7a C    34.3501  -14.3158
            24  C2x C    24.5346  -20.9769
            25  C1x C    23.3719  -18.9298
            26  C1a C    35.5006  -14.7920
            27  O6a O    34.3748  -12.9056
            28  C5x C    23.3719  -20.2903
            29  O5x O    22.2029  -20.9583
BOND        32
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     3  10 1 #Down
            10    4  11 1
            11    6  12 1
            12    6  13 1
            13    9  14 1
            14    9  15 2
            15   11  16 1 #Up
            16   12  17 1
            17   13  18 1
            18   14  19 1
            19   17  20 1
            20   17  21 1
            21   17  22 1 #Up
            22   19  23 1
            23   20  24 2
            24   21  25 1
            25   23  26 1
            26   23  27 2
            27   24  28 1
            28   28  29 2
            29    7   8 1
            30   11  12 1
            31   18  20 1
            32   25  28 1

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