| Entry |
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| Name |
Hydrocortisone acetate (JP18/USP);
Cortifoam (TN);
U-cort (TN) |
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| Product |
|
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| Formula |
C23H32O6
|
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| Exact mass |
404.2199
|
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| Mol weight |
404.50
|
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
|
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| Remark |
| Product (DG00012): | D00088<JP/US> D00165<US> D00977<JP> D00978<JP/US> D01619<JP/US> D01886<JP> D02288<US> |
| Product (mixture): | D02139<US> D04425<JP> D04806<JP> D04879<JP> D11657<US> D11855<US> D12134<US> |
|
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| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
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| Disease |
Ulcerative proctitis [DS: H01466] |
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
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| Interaction |
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| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A01 STOMATOLOGICAL PREPARATIONS
A01A STOMATOLOGICAL PREPARATIONS
A01AC Corticosteroids for local oral treatment
A01AC03 Hydrocortisone
D00165 Hydrocortisone acetate (JP18/USP) <US>
A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
A07E INTESTINAL ANTIINFLAMMATORY AGENTS
A07EA Corticosteroids acting locally
A07EA02 Hydrocortisone
D00165 Hydrocortisone acetate (JP18/USP) <US>
C CARDIOVASCULAR SYSTEM
C05 VASOPROTECTIVES
C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
C05AA Corticosteroids
C05AA01 Hydrocortisone
D00165 Hydrocortisone acetate (JP18/USP) <US>
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AA Corticosteroids, weak (group I)
D07AA02 Hydrocortisone
D00165 Hydrocortisone acetate (JP18/USP) <US>
D07X CORTICOSTEROIDS, OTHER COMBINATIONS
D07XA Corticosteroids, weak, other combinations
D07XA01 Hydrocortisone
D00165 Hydrocortisone acetate (JP18/USP) <US>
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB09 Hydrocortisone
D00165 Hydrocortisone acetate (JP18/USP) <US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BA Corticosteroids, plain
S01BA02 Hydrocortisone
D00165 Hydrocortisone acetate (JP18/USP) <US>
S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
S01CB Corticosteroids/antiinfectives/mydriatics in combination
S01CB03 Hydrocortisone
D00165 Hydrocortisone acetate (JP18/USP) <US>
S02 OTOLOGICALS
S02B CORTICOSTEROIDS
S02BA Corticosteroids
S02BA01 Hydrocortisone
D00165 Hydrocortisone acetate (JP18/USP) <US>
USP drug classification [BR:br08302]
Dermatological Agents
Dermatitis and Pruitus Agents
Glucocorticoids, Low Potency
Hydrocortisone
D00165 Hydrocortisone acetate (JP18/USP)
Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
Hydrocortisone
D00165 Hydrocortisone acetate (JP18/USP)
Inflammatory Bowel Disease Agents
Glucocorticoids
Hydrocortisone
D00165 Hydrocortisone acetate (JP18/USP)
Classification of Japanese OTC drugs [BR:br08313]
Agents for urogenital organs and anus
30 Hemorrhoid drugs for external use
D00165 Hydrocortisone acetate (JP18/USP)
Agents for integumentary system
57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
D00165 Hydrocortisone acetate (JP18/USP)
Risk category of Japanese OTC drugs [BR:br08312]
Designated second-class OTC drugs
Inorganic and organic chemicals
Hydrocortisone acetate
D00165 Hydrocortisone acetate (JP18/USP)
Second-class OTC drugs
Inorganic and organic chemicals
Hydrocortisone acetate
D00165 Hydrocortisone acetate (JP18/USP)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00012 Hydrocortisone
D00165 Hydrocortisone acetate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00012 Hydrocortisone
D00165 Hydrocortisone acetate
Drug classes [BR:br08332]
Anti-inflammatory
DG01955 Corticosteroid
D00165 Hydrocortisone acetate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D00165 Hydrocortisone acetate (JP18/USP) <US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00165 Hydrocortisone acetate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00165
Rx-to-OTC switch list in the USA [br08315.html]
D00165
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00012 Hydrocortisone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00012 Hydrocortisone
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 29
1 C1z C 29.2845 -16.8454
2 C1y C 29.2784 -18.2246
3 C1z C 30.4784 -16.1589
4 C1x C 28.0785 -16.1650
5 C1a C 29.2723 -15.4970
6 C1y C 28.0848 -18.9235
7 C1x C 31.6349 -18.1731
8 C1x C 31.6410 -16.8330
9 C5a C 30.4845 -14.8105
10 O1a O 31.7443 -15.7389
11 C1y C 26.9219 -16.7898
12 C1y C 26.9406 -18.0576
13 C1x C 28.0909 -20.2966
14 C1b C 31.7895 -14.0498
15 O5a O 29.3216 -14.1364
16 O1a O 25.7160 -16.1960
17 C1z C 25.7160 -18.9298
18 C1x C 26.9035 -20.9706
19 O7a O 33.1255 -14.8786
20 C2y C 25.7160 -20.2903
21 C1x C 24.5346 -18.2555
22 C1a C 25.7407 -17.5380
23 C7a C 34.3501 -14.3158
24 C2x C 24.5346 -20.9769
25 C1x C 23.3719 -18.9298
26 C1a C 35.5006 -14.7920
27 O6a O 34.3748 -12.9056
28 C5x C 23.3719 -20.2903
29 O5x O 22.2029 -20.9583
BOND 32
1 1 2 1
2 1 3 1
3 1 4 1
4 1 5 1 #Up
5 2 6 1
6 2 7 1
7 3 8 1
8 3 9 1 #Up
9 3 10 1 #Down
10 4 11 1
11 6 12 1
12 6 13 1
13 9 14 1
14 9 15 2
15 11 16 1 #Up
16 12 17 1
17 13 18 1
18 14 19 1
19 17 20 1
20 17 21 1
21 17 22 1 #Up
22 19 23 1
23 20 24 2
24 21 25 1
25 23 26 1
26 23 27 2
27 24 28 1
28 28 29 2
29 7 8 1
30 11 12 1
31 18 20 1
32 25 28 1
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