| Entry |
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| Name |
Hydrocortisone sodium succinate (JP18/USP);
A-hydrocort (TN);
Solu-cortef (TN) |
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| Product |
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| Generic |
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| Formula |
C25H33O8. Na
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| Exact mass |
484.2073
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| Mol weight |
484.51
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Dermatological agent
DG03243 Atopic dermatitis agent
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
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| Remark |
| Therapeutic category: | 2452 |
| Product (DG00012): | D00088<JP/US> D00165<US> D00977<JP> D00978<JP/US> D01619<JP/US> D01886<JP/US> D02288<US> |
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| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
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| Disease |
Asthma [DS: H00079] Atopic dermatitis [DS: H01358] Contact dermatitis [DS: H01357] Perennial or seasonal allergic rhinitis [DS: H01360] Bullous dermatitis herpetiformis [DS: H01362] Mycosis fungoides [DS: H01463] Pemphigus [DS: H01648] Severe erythema multiforme [DS: H01695] Stevens-Johnson syndrome [DS: H01694] Ulcerative colitis [DS: H01466] Acquired (autoimmune) hemolytic anemia [DS: H01585] Diamond-Blackfan anemia [DS: H00237] Pure red cell aplasia [DS: H01586] Multiple sclerosis [DS: H01490] Nephrotic syndrome [DS: H01657] Pulmonary tuberculosis [DS: H00342] Ankylosing spondylitis [DS: H01674] Psoriatic arthritis [DS: H01507] Rheumatoid arthritis [DS: H00630] Juvenile rheumatoid arthritis [DS: H01672] Dermatomyositis [DS: H01604] Temporal arteritis [DS: H01698] Polymyositis [DS: H01604] Systemic lupus erythematosus [DS: H00080] |
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
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| Interaction |
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| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A01 STOMATOLOGICAL PREPARATIONS
A01A STOMATOLOGICAL PREPARATIONS
A01AC Corticosteroids for local oral treatment
A01AC03 Hydrocortisone
D00978 Hydrocortisone sodium succinate (JP18/USP) <JP/US>
A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
A07E INTESTINAL ANTIINFLAMMATORY AGENTS
A07EA Corticosteroids acting locally
A07EA02 Hydrocortisone
D00978 Hydrocortisone sodium succinate (JP18/USP) <JP/US>
C CARDIOVASCULAR SYSTEM
C05 VASOPROTECTIVES
C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
C05AA Corticosteroids
C05AA01 Hydrocortisone
D00978 Hydrocortisone sodium succinate (JP18/USP) <JP/US>
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AA Corticosteroids, weak (group I)
D07AA02 Hydrocortisone
D00978 Hydrocortisone sodium succinate (JP18/USP) <JP/US>
D07X CORTICOSTEROIDS, OTHER COMBINATIONS
D07XA Corticosteroids, weak, other combinations
D07XA01 Hydrocortisone
D00978 Hydrocortisone sodium succinate (JP18/USP) <JP/US>
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB09 Hydrocortisone
D00978 Hydrocortisone sodium succinate (JP18/USP) <JP/US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BA Corticosteroids, plain
S01BA02 Hydrocortisone
D00978 Hydrocortisone sodium succinate (JP18/USP) <JP/US>
S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
S01CB Corticosteroids/antiinfectives/mydriatics in combination
S01CB03 Hydrocortisone
D00978 Hydrocortisone sodium succinate (JP18/USP) <JP/US>
S02 OTOLOGICALS
S02B CORTICOSTEROIDS
S02BA Corticosteroids
S02BA01 Hydrocortisone
D00978 Hydrocortisone sodium succinate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
Hydrocortisone
D00978 Hydrocortisone sodium succinate (JP18/USP)
Inflammatory Bowel Disease Agents
Glucocorticoids
Hydrocortisone
D00978 Hydrocortisone sodium succinate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
24 Hormones
245 Adrenal hormone preparations
2452 Cortisones
D00978 Hydrocortisone sodium succinate (JP18/USP)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00012 Hydrocortisone
D00978 Hydrocortisone sodium succinate
Dermatological agent
DG03243 Atopic dermatitis agent
D00978 Hydrocortisone sodium succinate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00012 Hydrocortisone
D00978 Hydrocortisone sodium succinate
Drug classes [BR:br08332]
Anti-inflammatory
DG01955 Corticosteroid
D00978 Hydrocortisone sodium succinate
Dermatological agent
DG03243 Atopic dermatitis agent
D00978 Hydrocortisone sodium succinate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D00978 Hydrocortisone sodium succinate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00978 Hydrocortisone sodium succinate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00978
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00012 Hydrocortisone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00012 Hydrocortisone
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 34
1 C1z C 20.9235 -16.1233
2 C1y C 20.9409 -17.4723
3 C1z C 22.0855 -15.4342
4 C1x C 19.7729 -15.4518
5 C1a C 20.9231 -14.8152
6 C1y C 19.7846 -18.1554
7 C1x C 23.2184 -17.5247
8 C1x C 23.2710 -16.0999
9 C5a C 22.1496 -13.8520
10 O1a O 23.4403 -15.0020
11 C1y C 18.5875 -16.1349
12 C1y C 18.5935 -17.4840
13 C1x C 19.7846 -19.5044
14 C1b C 23.3877 -13.1980
15 O5a O 20.9351 -13.1512
16 O1a O 17.3613 -15.4401
17 C1z C 17.4431 -18.1613
18 C1x C 18.6109 -20.1935
19 O7a O 24.5848 -13.9512
20 C2y C 17.4548 -19.5161
21 C1x C 16.2577 -17.4956
22 C1a C 17.4310 -16.8708
23 C7a C 25.7994 -13.2505
24 C2x C 16.2693 -20.2109
25 C1x C 15.0839 -18.1730
26 C1b C 27.0082 -13.9512
27 O6a O 25.7877 -11.8373
28 C5x C 15.0605 -19.6037
29 C1b C 28.2170 -13.2505
30 O5x O 13.8751 -20.2402
31 C6a C 29.4141 -13.9512
32 O6a O 29.4081 -15.3351
33 O6a O 30.5761 -13.1980 #-
34 Z Na 33.3791 -13.5130 #+
BOND 36
1 1 2 1
2 1 3 1
3 1 4 1
4 1 5 1 #Up
5 2 6 1
6 2 7 1
7 3 8 1
8 3 9 1 #Up
9 3 10 1 #Down
10 4 11 1
11 6 12 1
12 6 13 1
13 9 14 1
14 9 15 2
15 11 16 1 #Up
16 12 17 1
17 13 18 1
18 14 19 1
19 17 20 1
20 17 21 1
21 17 22 1 #Up
22 19 23 1
23 20 24 2
24 21 25 1
25 23 26 1
26 23 27 2
27 24 28 1
28 26 29 1
29 28 30 2
30 29 31 1
31 31 32 2
32 31 33 1
33 7 8 1
34 11 12 1
35 18 20 1
36 25 28 1
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