Entry
Name
Ajmaline (JP18); Ajimalin (TN)
Formula
C20H26N2O2
Exact mass
326.1994
Mol weight
326.43
Structure
Mol file KCF file DB search
Simcomp
Neighbor
Source
Rauvolfia serpentina [TAX:
4060 ]
Class
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01649 Class Ia antiarrhythmic agent
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
Remark
Efficacy
Antiarrhythmic, Sodium channel blocker
Comment
Indole alkaloid
Target
Pathway
hsa04261 Adrenergic signaling in cardiomyocytes
Metabolism
Enzyme: CYP2D6 [HSA:
1565 ]
Interaction
DDI search
Structure map
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303 ]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01B ANTIARRHYTHMICS, CLASS I AND III
C01BA Antiarrhythmics, class Ia
C01BA05 Ajmaline
D00199 Ajmaline (JP18)
Drug groups [BR:br08330 ]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01649 Class Ia antiarrhythmic agent
D00199 Ajmaline
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
D00199 Ajmaline
Target-based classification of drugs [BR:br08310 ]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D00199 Ajmaline (JP18)
SCN2A
D00199 Ajmaline (JP18)
SCN3A
D00199 Ajmaline (JP18)
SCN4A
D00199 Ajmaline (JP18)
SCN5A
D00199 Ajmaline (JP18)
SCN8A
D00199 Ajmaline (JP18)
SCN9A
D00199 Ajmaline (JP18)
SCN10A
D00199 Ajmaline (JP18)
SCN11A
D00199 Ajmaline (JP18)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311 ]
Chemicals
D00199 Ajmaline
D00199 Ajmaline tablets
Drug metabolizing enzymes and transporters [br08309.html ]
Drug metabolizing enzymes
D00199
BRITE hierarchy
Other DBs
LinkDB
All DBs
KCF data
Show ATOM 24
1 C8x C 20.0200 -16.5900
2 C8x C 20.0200 -17.9900
3 C8x C 21.2324 -18.6900
4 C8y C 22.4449 -17.9900
5 C8y C 22.4449 -16.5900
6 C8x C 21.2324 -15.8900
7 N1y N 23.7764 -18.4226
8 C1y C 24.5993 -17.2900
9 C1z C 23.7764 -16.1574
10 C1y C 25.9916 -17.1437
11 N1y N 26.5610 -15.8647
12 C1y C 25.7381 -14.7321
13 C1x C 24.3458 -14.8784
14 C1x C 27.2706 -17.7131
15 C1y C 27.8400 -16.4341
16 C1y C 29.1794 -16.2051
17 C1y C 27.9005 -15.6357
18 C1b C 30.5794 -16.2051
19 C1y C 26.5329 -12.8581
20 O1a O 29.1532 -14.9290
21 C1y C 23.8464 -12.8674
22 C1a C 23.7764 -19.8226
23 O1a O 22.8030 -11.8971
24 C1a C 31.2973 -17.4482
BOND 29
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 5 9 1
11 8 10 1
12 10 11 1
13 11 12 1
14 12 13 1
15 9 13 1
16 10 14 1
17 14 15 1
18 15 16 1
19 16 17 1
20 11 17 1
21 16 18 1 #Up
22 12 19 1 #Up
23 15 19 1 #Up
24 17 20 1 #Down
25 9 21 1 #Up
26 21 19 1
27 7 22 1
28 21 23 1 #Down
29 18 24 1