KEGG   DRUG: Disopyramide
Entry
D00303                      Drug                                   

Name
Disopyramide (JP18/USAN/INN);
Rythmodan P (TN)
Formula
C21H29N3O
Exact mass
339.2311
Mol weight
339.4745
Structure
Simcomp
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01649  Class Ia antiarrhythmic agent
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Same as: C06965
Therapeutic category: 2129
ATC code: C01BA03
Chemical structure group: DG00194
Product (DG00194): D00303<JP> D00637<JP/US>
Efficacy
Antiarrhythmic, Sodium channel blocker
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Structure map
map07037  Antiarrhythmic drugs
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BA Antiarrhythmics, class Ia
     C01BA03 Disopyramide
      D00303  Disopyramide (JP18/USAN/INN) <JP>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Antiarrhythmics
   Vaughn Williams-Class I
    Disopyramide
     D00303  Disopyramide (JP18/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D00303  Disopyramide (JP18/USAN/INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01649  Class Ia antiarrhythmic agent
     DG00194  Disopyramide
      D00303  Disopyramide
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00194  Disopyramide
     D00303  Disopyramide
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00303  Disopyramide (JP18/USAN/INN) <JP>
    SCN2A
     D00303  Disopyramide (JP18/USAN/INN) <JP>
    SCN3A
     D00303  Disopyramide (JP18/USAN/INN) <JP>
    SCN4A
     D00303  Disopyramide (JP18/USAN/INN) <JP>
    SCN5A
     D00303  Disopyramide (JP18/USAN/INN) <JP>
    SCN8A
     D00303  Disopyramide (JP18/USAN/INN) <JP>
    SCN9A
     D00303  Disopyramide (JP18/USAN/INN) <JP>
    SCN10A
     D00303  Disopyramide (JP18/USAN/INN) <JP>
    SCN11A
     D00303  Disopyramide (JP18/USAN/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00303  Disopyramide
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00303
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01649  Class Ia antiarrhythmic agent
     DG00194  Disopyramide
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00194  Disopyramide
Other DBs
CAS: 3737-09-5
PubChem: 7847369
ChEBI: 4657
ChEMBL: CHEMBL517
DrugBank: DB00280
LigandBox: D00303
NIKKAJI: J3.408H
LinkDB
KCF data

ATOM        25
            1   C8x C    22.8200  -18.9000
            2   C8x C    22.8200  -20.3000
            3   C8x C    24.0324  -21.0000
            4   N5x N    25.2449  -20.3000
            5   C8y C    25.2449  -18.9000
            6   C8x C    24.0324  -18.2000
            7   C8x C    27.6697  -20.3000
            8   C8y C    27.6697  -18.9000
            9   C1d C    26.4573  -18.2000
            10  C8x C    28.8822  -21.0000
            11  C8x C    30.0946  -20.3000
            12  C8x C    30.0946  -18.9000
            13  C8x C    28.8822  -18.2000
            14  C1b C    26.4573  -16.8000
            15  C1b C    27.6718  -16.0988
            16  C5a C    24.4049  -17.0800
            17  N1a N    24.4049  -15.6800
            18  O5a O    23.2168  -17.7786
            19  N1c N    27.6718  -14.5602
            20  C1c C    28.8679  -13.8695
            21  C1c C    26.4430  -13.8506
            22  C1a C    25.2393  -14.5455
            23  C1a C    26.4432  -12.4601
            24  C1a C    30.0553  -14.5551
            25  C1a C    28.8680  -12.4603
BOND        26
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    9  14 1
            16   14  15 1
            17    9  16 1
            18   16  17 1
            19   16  18 2
            20   15  19 1
            21   19  20 1
            22   19  21 1
            23   21  22 1
            24   21  23 1
            25   20  24 1
            26   20  25 1

» Japanese version   » Back

KEGG   DRUG: Disopyramide phosphate
Entry
D00637                      Drug                                   

Name
Disopyramide phosphate (JAN/USP);
Norpace (TN)
Product
  Generic
Formula
C21H29N3O. H3PO4
Exact mass
437.208
Mol weight
437.4696
Structure
Simcomp
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01649  Class Ia antiarrhythmic agent
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Same as: C07740
Therapeutic category: 2129
ATC code: C01BA03
Chemical structure group: DG00194
Product (DG00194): D00303<JP> D00637<JP/US>
Efficacy
Antiarrhythmic, Sodium channel blocker
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Structure map
map07037  Antiarrhythmic drugs
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BA Antiarrhythmics, class Ia
     C01BA03 Disopyramide
      D00637  Disopyramide phosphate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Antiarrhythmics
   Vaughn Williams-Class I
    Disopyramide
     D00637  Disopyramide phosphate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D00637  Disopyramide phosphate (JAN/USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01649  Class Ia antiarrhythmic agent
     DG00194  Disopyramide
      D00637  Disopyramide phosphate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00194  Disopyramide
     D00637  Disopyramide phosphate
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00637  Disopyramide phosphate (JAN/USP) <JP/US>
    SCN2A
     D00637  Disopyramide phosphate (JAN/USP) <JP/US>
    SCN3A
     D00637  Disopyramide phosphate (JAN/USP) <JP/US>
    SCN4A
     D00637  Disopyramide phosphate (JAN/USP) <JP/US>
    SCN5A
     D00637  Disopyramide phosphate (JAN/USP) <JP/US>
    SCN8A
     D00637  Disopyramide phosphate (JAN/USP) <JP/US>
    SCN9A
     D00637  Disopyramide phosphate (JAN/USP) <JP/US>
    SCN10A
     D00637  Disopyramide phosphate (JAN/USP) <JP/US>
    SCN11A
     D00637  Disopyramide phosphate (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00637
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01649  Class Ia antiarrhythmic agent
     DG00194  Disopyramide
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00194  Disopyramide
Other DBs
CAS: 22059-60-5
PubChem: 7847703
ChEBI: 4658
ChEMBL: CHEMBL1201020
DrugBank: DB00280
LigandBox: D00637
NIKKAJI: J289.957D
LinkDB
KCF data

ATOM        30
            1   P1b P    35.9712  -15.3016
            2   O1c O    37.3683  -15.3074
            3   O1c O    35.9655  -16.6987
            4   O1c O    34.5741  -15.3016
            5   O1c O    35.9655  -13.8986
            6   C8x C    25.2790  -16.8457
            7   C8x C    25.2790  -18.2076
            8   C8x C    26.4584  -18.8885
            9   N5x N    27.6379  -18.2076
            10  C8y C    27.6379  -16.8457
            11  C8x C    26.4584  -16.1647
            12  C8x C    29.9967  -18.2076
            13  C8y C    29.9967  -16.8457
            14  C1d C    28.8173  -16.1647
            15  C8x C    31.1762  -18.8885
            16  C8x C    32.3556  -18.2076
            17  C8x C    32.3556  -16.8457
            18  C8x C    31.1762  -16.1647
            19  C1b C    28.8173  -14.8028
            20  C1b C    29.9988  -14.1207
            21  C5a C    26.8208  -15.0752
            22  N1a N    26.8208  -13.7133
            23  O5a O    25.6650  -15.7548
            24  N1c N    29.9988  -12.6240
            25  C1c C    31.1623  -11.9521
            26  C1c C    28.8034  -11.9337
            27  C1a C    27.6325  -12.6097
            28  C1a C    28.8036  -10.5810
            29  C1a C    32.3174  -12.6190
            30  C1a C    31.1624  -10.5812
BOND        30
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 2
            5     6   7 2
            6     7   8 1
            7     8   9 2
            8     9  10 1
            9    10  11 2
            10    6  11 1
            11   12  13 1
            12   13  14 1
            13   10  14 1
            14   12  15 2
            15   15  16 1
            16   16  17 2
            17   17  18 1
            18   13  18 2
            19   14  19 1
            20   19  20 1
            21   14  21 1
            22   21  22 1
            23   21  23 2
            24   20  24 1
            25   24  25 1
            26   24  26 1
            27   26  27 1
            28   26  28 1
            29   25  29 1
            30   25  30 1

» Japanese version   » Back

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