| Entry |
|
|---|
| Name |
Triamterene (JP18/USP/INN);
Dyrenium (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C12H11N7
|
|---|
| Exact mass |
253.1076
|
|---|
| Mol weight |
253.26
|
|---|
| Structure |
|
|---|
| Class |
Cardiovascular agent
DG03231 Antihypertensive
DG01885 Potassium-sparing diuretic
|
|---|
| Remark |
| Therapeutic category: | 2133 |
| Product (mixture): | D10269<US> |
|
|---|
| Efficacy |
Diuretic, Aldosterone antagonist, Epithelial sodium channel blocker |
|---|
| Disease |
Nephrotic syndrome [DS: H01657] |
|---|
| Comment |
potassium-sparing diuretic
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04960 | Aldosterone-regulated sodium reabsorption |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C03 DIURETICS
C03D ALDOSTERONE ANTAGONISTS AND OTHER POTASSIUM-SPARING AGENTS
C03DB Other potassium-sparing agents
C03DB02 Triamterene
D00386 Triamterene (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Diuretics, Potassium-sparing
Triamterene
D00386 Triamterene (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
213 Diuretics
2133 Antialdosterones
D00386 Triamterene (JP18/USP/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG03231 Antihypertensive
D00386 Triamterene
DG01885 Potassium-sparing diuretic
D00386 Triamterene
Drug classes [BR:br08332]
Cardiovascular agent
DG03231 Antihypertensive
D00386 Triamterene
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
Epithelial sodium channel (SCNN)
SCNN1
D00386 Triamterene (JP18/USP/INN) <JP/US>
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C2 (MR)
D00386 Triamterene (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00386 Triamterene
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 19
1 C8y C 23.7354 -19.6412
2 C8y C 23.7354 -18.2292
3 N5x N 24.9550 -20.3298
4 N5x N 22.5099 -20.3357
5 N5x N 24.9374 -17.5347
6 C8y C 22.5216 -17.5407
7 C8y C 26.1512 -19.6412
8 C8y C 21.2962 -19.6412
9 C8y C 26.1512 -18.2292
10 N5x N 21.2962 -18.2409
11 N1a N 22.5216 -16.1459
12 N1a N 27.3649 -20.3298
13 N1a N 20.0826 -20.3531
14 C8y C 27.3532 -17.5114
15 C8x C 27.3765 -16.1402
16 C8x C 28.5961 -18.2116
17 C8x C 28.5904 -15.4399
18 C8x C 29.8040 -17.5114
19 C8x C 29.8274 -16.1226
BOND 21
1 1 2 1
2 1 3 1
3 1 4 2
4 2 5 1
5 2 6 2
6 3 7 2
7 4 8 1
8 5 9 2
9 6 10 1
10 6 11 1
11 7 12 1
12 8 13 1
13 9 14 1
14 14 15 2
15 14 16 1
16 15 17 1
17 16 18 2
18 17 19 2
19 7 9 1
20 8 10 2
21 18 19 1
|
|---|
