KEGG   DRUG: NifedipineHelp
Entry
D00437                      Drug                                   

Name
Nifedipine (JP17/USP/INN);
Adalat (TN);
Afeditab CR (TN);
Procardia (TN)
Product
  Generic
NIFEDIPINE (A-S Medication Solutions), NIFEDIPINE (A-S Medication Solutions), NIFEDIPINE (Actavis Pharma), NIFEDIPINE (Actavis Pharma), AFEDITAB (Actavis Pharma), NIFEDIPINE (Aidarex Pharmaceuticals LLC), NIFEDICALXL (Aidarex Pharmaceuticals LLC), NIFEDIPINE (Alvogen), NIFEDIPINE (American Health Packaging), NIFEDIPINE (American Health Packaging), NIFEDIPINE (American Health Packaging), NIFEDIPINE (Aphena Pharma Solutions - Tennessee), AFEDITAB (Aphena Pharma Solutions - Tennessee), NIFEDIPINE (Aphena Pharma Solutions - Tennessee), NIFEDIPINE (Aphena Pharma Solutions - Tennessee), NIFEDIPINE (Aphena Pharma Solutions - Tennessee), NIFEDIPINE (Aphena Pharma Solutions - Tennessee), NIFEDIPINE (Aphena Pharma Solutions - Tennessee), NIFEDIPINE (AvPAK), NIFEDIPINE (AvPAK), NIFEDIPINE (Bryant Ranch Prepack), NIFEDICAL (Bryant Ranch Prepack), NIFEDIPINE (Bryant Ranch Prepack), NIFEDIPINE (Bryant Ranch Prepack), NIFEDIPINE (Cadila Healthcare Limited), NIFEDIPINE (Cadila Healthcare Limited), NIFEDICAL (Cardinal Health), NIFEDIPINE (Cardinal Health), NIFEDIPINE (Cardinal Health), NIFEDIPINE (Cardinal Health), AFEDITAB (Carilion Materials Management), NIFEDIPINE (Carilion Materials Management), NIFEDIPINE (DIRECT RX), NIFEDIPINE (DIRECT RX), NIFEDIPINE (Dispensing Solutions), NIFEDIPINE (Golden State Medical Supply), NIFEDIPINE (Greenstone LLC), NIFEDIPINE (Greenstone LLC), NIFEDIPINE (Heritage Pharmaceuticals), NIFEDIPINE (Ingenus Pharmaceuticals), NIFEDIPINE (Intergel Pharmaceuticals), NIFEDIPINE (International Laboratories), NIFEDIPINE (Kremers Urban Pharmaceuticals), NIFEDIPINE (Lake Erie Medical DBA Quality Care Products LLC), NIFEDIPINE (Lake Erie Medical DBA Quality Care Products LLC), NIFEDIPINE (Lake Erie Medical DBA Quality Care Products LLC), NIFEDIPINE (Lake Erie Medical DBA Quality Care Products LLC), NIFEDIPINE (Lake Erie Medical DBA Quality Care Products LLC), NIFEDIPINE (Lake Erie Medical DBA Quality Care Products LLC), NIFEDIPINE (Leading Pharma), NIFEDIPINE (Leading Pharma), NIFEDIPINE (Legacy Pharmaceutical Packaging), NIFEDIPINE (Lupin Pharmaceuticals), NIFEDIPINE (Major Pharmaceuticals), NIFEDIPINE (Mylan Institutional), NIFEDIPINE (Mylan Pharmaceuticals), NIFEDIPINE (Mylan Pharmaceuticals), NIFEDIPINE (NCS HealthCare of KY), NIFEDIPINE (NuCare Pharmaceuticals), NIFEDIPINE (NuCare Pharmaceuticals), NIFEDIPINE (NuCare Pharmaceuticals), NIFEDIPINE (NuCare Pharmaceuticals), NIFEDIPINE (NuCare Pharmaceuticals), NIFEDIPINE (NuCare Pharmaceuticals), NIFEDIPINE (NuCare Pharmaceuticals), NIFEDIPINE (NuCare Pharmaceuticals), NIFEDIPINE (NuCare Pharmaceuticals), NIFEDIPINE (NuCare Pharmaceuticals), NIFEDIPINE (NuCare Pharmaceuticals), NIFEDIPINE (NuCare Pharmaceuticals), NIFEDIPINE (NuCare Pharmaceuticals), NIFEDIPINE (NuCare Pharmaceuticals), NIFEDIPINE (NuCare Pharmaceuticals), NIFEDIPINE (NuCare Pharmaceuticals), NIFEDIPINE (Oceanside Pharmaceuticals), NIFEDIPINE (Oceanside Pharmaceuticals), NIFEDIPINE (Oceanside Pharmaceuticals), NIFEDIPINE (Oceanside Pharmaceuticals), NIFEDIPINE (PD-Rx Pharmaceuticals), NIFEDIPINE (PD-Rx Pharmaceuticals), NIFEDIPINE (Par Pharmaceutical), NIFEDIPINE (Par Pharmaceutical), NIFEDIPINE (Par Pharmaceutical), NIFEDIPINE (Preferred Pharmaceuticals), NIFEDIPINE (Preferred Pharmaceuticals), NIFEDIPINE (Preferred Pharmaceuticals), NIFEDIPINE (Preferred Pharmaceuticals), NIFEDIPINE (Preferred Pharmaceuticals), NIFEDIPINE (Proficient Rx LP), NIFEDIPINE (REMEDYREPACK), NIFEDIPINE (REMEDYREPACK), NIFEDIPINE (REMEDYREPACK), NIFEDIPINE (REMEDYREPACK), NIFEDIPINE (Rebel Distributors Corp), NIFEDIPINE (Rebel Distributors Corp), NIFEDIPINE (Rebel Distributors Corp), NIFEDIPINE (Rebel Distributors Corp), NIFEDIPINE (RedPharm Drug), NIFEDIAC CC (State of Florida DOH Central Pharmacy), NIFEDIPINE (State of Florida DOH Central Pharmacy), NIFEDIPINE (State of Florida DOH Central Pharmacy), NIFEDICAL (State of Florida DOH Central Pharmacy), NIFEDIPINE (State of Florida DOH Central Pharmacy), NIFEDIAC CC (State of Florida DOH Central Pharmacy), NIFEDIPINE (TWi Pharmaceuticals), NIFEDIPINE (TWi Pharmaceuticals), NIFEDIPINE (TYA Pharmaceuticals), NIFEDIPINE (Teva Pharmaceuticals USA), NIFEDIPINE (Unit Dose Services), NIFEDIPINE (Unit Dose Services), NIFEDIPINE (Zydus Pharmaceuticals (USA)), NIFEDIPINE (Zydus Pharmaceuticals (USA)), NIFEDIPINE (bryant ranch prepack)
Formula
C17H18N2O6
Exact mass
346.1165
Mol weight
346.3346
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01928  Dihydropyridine calcium channel blocker
Other
 DG01575  Calcium channel blocker
  DG01496  Calcium channel L type blocker
Enzyme substrate
 DG01633  CYP3A substrate
Remark
Same as: C07266
Therapeutic category: 2171
ATC code: C08CA05
Product: D00437<JP/US>
Efficacy
Antihypertensive, Vasodilator, Calcium channel blocker
  Disease
Hypertension [DS:H01633]
Vasospastic angina [DS:H01632]
Chronic stable angina [DS:H01632]
Comment
Dihydropyridine derivative
Target
CACNA1-L [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
hsa04020  Calcium signaling pathway
hsa04260  Cardiac muscle contraction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07036  Calcium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
    C08CA Dihydropyridine derivatives
     C08CA05 Nifedipine
      D00437  Nifedipine (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Calcium Channel Blocking Agents
   Nifedipine
    D00437  Nifedipine (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   217  Vasodilators
    2171  Coronary dilators
     D00437  Nifedipine (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Calcium channels
    CACNA1-L
     D00437  Nifedipine (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00437  Nifedipine
  D00437  Nifedipine extended-release capsules
  D00437  Nifedipine fine granules
  D00437  Nifedipine enteric fine granules
Drug classes of therapeutic agents [br08360.html]
 Cardiovascular agents
  D00437
BRITE hierarchy
Other DBs
CAS: 21829-25-4
PubChem: 7847503
ChEBI: 7565
ChEMBL: CHEMBL193
DrugBank: DB01115
LigandBox: D00437
NIKKAJI: J3.467C
LinkDB All DBs
KCF data Show

ATOM        25
            1   C1y C    25.0718  -15.8137
            2   C8y C    25.0602  -18.1895
            3   C2y C    23.9336  -15.1657
            4   C2y C    26.2101  -15.1657
            5   C8y C    23.9161  -18.8492
            6   C8x C    26.1927  -18.8492
            7   C2y C    23.9336  -13.8522
            8   C7a C    22.8010  -15.8137
            9   C2y C    26.2101  -13.8522
            10  C7a C    27.3427  -15.8137
            11  C8x C    23.9161  -20.1509
            12  N2b N    22.7953  -18.1895 #+
            13  C8x C    26.1927  -20.1509
            14  N1x N    25.0718  -13.1984
            15  C1a C    22.8010  -13.1984
            16  O7a O    21.6687  -15.1657
            17  O6a O    22.8070  -17.0279
            18  C1a C    27.3427  -13.1984
            19  O7a O    28.4693  -15.1657
            20  O6a O    27.3427  -17.1271
            21  C8x C    25.0602  -20.8163
            22  O3a O    24.2896  -17.2029
            23  O3a O    20.9448  -19.4212 #-
            24  C1a C    20.5362  -15.8137
            25  C1a C    29.6018  -15.8137
BOND        26
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     4  10 1
            10    5  11 2
            11    5  12 1
            12    6  13 1
            13    7  14 1
            14    7  15 1
            15    8  16 1
            16    8  17 2
            17    9  18 1
            18   10  19 1
            19   10  20 2
            20   11  21 1
            21   12  22 2
            22   12  23 1
            23   16  24 1
            24   19  25 1
            25    9  14 1
            26   13  21 2

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