KEGG   DRUG: Nifedipine
Entry
D00437                      Drug                                   
Name
Nifedipine (JP18/USP/INN);
Adalat (TN);
Afeditab CR (TN);
Procardia (TN)
Product
PROCARDIA (Pfizer Laboratories Div Pfizer)
  Generic
NIFEDIPINE (A-S Medication Solutions), NIFEDIPINE (A-S Medication Solutions), NIFEDIPINE (A-S Medication Solutions), NIFEDIPINE (A-S Medication Solutions), NIFEDIPINE (A-S Medication Solutions), NIFEDIPINE (A-S Medication Solutions), NIFEDIPINE (A-S Medication Solutions), NIFEDIPINE (A-S Medication Solutions), NIFEDIPINE (A-S Medication Solutions), NIFEDIPINE (A-S Medication Solutions), NIFEDIPINE (Alembic Pharmaceuticals Limited), NIFEDIPINE (Alembic Pharmaceuticals), NIFEDIPINE (American Health Packaging), NIFEDIPINE (American Health Packaging), NIFEDIPINE (Aphena Pharma Solutions - Tennessee), NIFEDIPINE (Aphena Pharma Solutions - Tennessee), NIFEDIPINE (Aphena Pharma Solutions - Tennessee), NIFEDIPINE (Aphena Pharma Solutions - Tennessee), NIFEDIPINE (Aphena Pharma Solutions - Tennessee), NIFEDIPINE (Aphena Pharma Solutions - Tennessee), NIFEDIPINE (Ascend Laboratories), NIFEDIPINE (Aurobindo Pharma Limited), NIFEDIPINE (AvPAK), NIFEDIPINE (Bryant Ranch Prepack), NIFEDIPINE (Bryant Ranch Prepack), NIFEDIPINE (Bryant Ranch Prepack), NIFEDIPINE (Bryant Ranch Prepack), NIFEDIPINE (Bryant Ranch Prepack), NIFEDIPINE (Bryant Ranch Prepack), NIFEDIPINE (Bryant Ranch Prepack), NIFEDIPINE (Bryant Ranch Prepack), NIFEDIPINE (Bryant Ranch Prepack), NIFEDIPINE (Cadila Healthcare Limited), NIFEDIPINE (Cardinal Health 107), NIFEDIPINE (Cardinal Health 107), NIFEDIPINE (Chartwell RX), NIFEDIPINE (Chartwell RX), NIFEDIPINE (Denton Pharma), NIFEDIPINE (Elite Pharmaceutical Solution), NIFEDIPINE (Golden State Medical Supply), NIFEDIPINE (Golden State Medical Supply), NIFEDIPINE (Greenstone LLC), NIFEDIPINE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), NIFEDIPINE (Ingenus Pharmaceuticals), NIFEDIPINE (Ingenus Pharmaceuticals), NIFEDIPINE (Lannett Company), NIFEDIPINE (Leading Pharma), NIFEDIPINE (Leading Pharma), NIFEDIPINE (Legacy Pharmaceutical Packaging), NIFEDIPINE (Legacy Pharmaceutical Packaging), NIFEDIPINE (Major Pharmaceuticals), NIFEDIPINE (Major Pharmaceuticals), NIFEDIPINE (Major Pharmaceuticals), NIFEDIPINE (Northwind Pharmaceuticals), NIFEDIPINE (Northwind Pharmaceuticals), NIFEDIPINE (Northwind Pharmaceuticals), NIFEDIPINE (Northwind Pharmaceuticals), NIFEDIPINE (Northwind Pharmaceuticals), NIFEDIPINE (Northwind Pharmaceuticals), NIFEDIPINE (Northwind Pharmaceuticals), NIFEDIPINE (NuCare Pharmaceuticals), NIFEDIPINE (NuCare Pharmaceuticals), NIFEDIPINE (NuCare Pharmaceuticals), NIFEDIPINE (Oceanside Pharmaceuticals), NIFEDIPINE (Oceanside Pharmaceuticals), NIFEDIPINE (Oceanside Pharmaceuticals), NIFEDIPINE (Oceanside Pharmaceuticals), NIFEDIPINE (PD-Rx Pharmaceuticals), NIFEDIPINE (PD-Rx Pharmaceuticals), NIFEDIPINE (Preferred Pharmaceuticals), NIFEDIPINE (Preferred Pharmaceuticals), NIFEDIPINE (Proficient Rx LP), NIFEDIPINE (Proficient Rx LP), NIFEDIPINE (Proficient Rx LP), NIFEDIPINE (REMEDYREPACK), NIFEDIPINE (REMEDYREPACK), NIFEDIPINE (RedPharm Drug), NIFEDIPINE (ST. MARY'S MEDICAL PARK PHARMACY), NIFEDIPINE (ST. MARY'S MEDICAL PARK PHARMACY), NIFEDIPINE (TWI Pharmaceuticals), NIFEDIPINE (TWi Pharmaceuticals), NIFEDIPINE (Zydus Lifesciences Limited), NIFEDIPINE (Zydus Pharmaceuticals (USA)), NIFEDIPINE (Zydus Pharmaceuticals (USA))
Formula
C17H18N2O6
Exact mass
346.1165
Mol weight
346.33
Structure
Simcomp
Class
Cardiovascular agent
 DG01575  Calcium channel blocker
  DG01496  Calcium channel L type blocker
 DG03231  Antihypertensive
  DG01928  Dihydropyridine calcium channel blocker
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Same as: C07266
Therapeutic category: 2171
ATC code: C08CA05
Product: D00437<JP/US>
Efficacy
Antihypertensive, Vasodilator, Calcium channel blocker
  Disease
Hypertension [DS:H01633]
Vasospastic angina [DS:H01632]
Chronic stable angina [DS:H01632]
Comment
Dihydropyridine derivative
Target
CACNA1-L [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
hsa04020  Calcium signaling pathway
hsa04260  Cardiac muscle contraction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Structure map
map07036  Calcium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
    C08CA Dihydropyridine derivatives
     C08CA05 Nifedipine
      D00437  Nifedipine (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Calcium Channel Blocking Agents, Dihydropyridines
   Nifedipine
    D00437  Nifedipine (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   217  Vasodilators
    2171  Coronary dilators
     D00437  Nifedipine (JP18/USP/INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01575  Calcium channel blocker
   DG01496  Calcium channel L type blocker
    D00437  Nifedipine
  DG03231  Antihypertensive
   DG01928  Dihydropyridine calcium channel blocker
    D00437  Nifedipine
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D00437  Nifedipine
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01928  Dihydropyridine calcium channel blocker
   D00437  Nifedipine
  DG03231  Antihypertensive
   D00437  Nifedipine
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Calcium channels
    CACNA1-L
     D00437  Nifedipine (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00437  Nifedipine
  D00437  Nifedipine extended-release capsules
  D00437  Nifedipine fine granules
  D00437  Nifedipine enteric fine granules
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00437
Other DBs
CAS: 21829-25-4
PubChem: 7847503
ChEBI: 7565
PDB-CCD: C5U[PDBj]
LigandBox: D00437
NIKKAJI: J3.467C
LinkDB
KCF data

ATOM        25
            1   C1y C    25.0718  -15.8137
            2   C8y C    25.0602  -18.1895
            3   C2y C    23.9336  -15.1657
            4   C2y C    26.2101  -15.1657
            5   C8y C    23.9161  -18.8492
            6   C8x C    26.1927  -18.8492
            7   C2y C    23.9336  -13.8522
            8   C7a C    22.8010  -15.8137
            9   C2y C    26.2101  -13.8522
            10  C7a C    27.3427  -15.8137
            11  C8x C    23.9161  -20.1509
            12  N2b N    22.7953  -18.1895 #+
            13  C8x C    26.1927  -20.1509
            14  N1x N    25.0718  -13.1984
            15  C1a C    22.8010  -13.1984
            16  O7a O    21.6687  -15.1657
            17  O6a O    22.8070  -17.0279
            18  C1a C    27.3427  -13.1984
            19  O7a O    28.4693  -15.1657
            20  O6a O    27.3427  -17.1271
            21  C8x C    25.0602  -20.8163
            22  O3a O    24.2896  -17.2029
            23  O3a O    20.9448  -19.4212 #-
            24  C1a C    20.5362  -15.8137
            25  C1a C    29.6018  -15.8137
BOND        26
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     4  10 1
            10    5  11 2
            11    5  12 1
            12    6  13 1
            13    7  14 1
            14    7  15 1
            15    8  16 1
            16    8  17 2
            17    9  18 1
            18   10  19 1
            19   10  20 2
            20   11  21 1
            21   12  22 2
            22   12  23 1
            23   16  24 1
            24   19  25 1
            25    9  14 1
            26   13  21 2

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