KEGG   DRUG: Spironolactone
Entry
D00443                      Drug                                   
Name
Spironolactone (JP18/USP/INN);
Aldactone (TN)
Product
ALDACTONE (Pfizer Laboratories Div Pfizer), CAROSPIR (ATLANTIC BIOLOGICALS CORP.), CAROSPIR (CMP Pharma)
  Generic
SPIRONOLACTONE (A-S Medication Solutions), SPIRONOLACTONE (A-S Medication Solutions), SPIRONOLACTONE (A-S Medication Solutions), SPIRONOLACTONE (A-S Medication Solutions), SPIRONOLACTONE (A-S Medication Solutions), SPIRONOLACTONE (A-S Medication Solutions), SPIRONOLACTONE (A-S Medication Solutions), SPIRONOLACTONE (A-S Medication Solutions), SPIRONOLACTONE (A-S Medication Solutions), SPIRONOLACTONE (A-S Medication Solutions), SPIRONOLACTONE (A-S Medication Solutions), SPIRONOLACTONE (A-S Medication Solutions), SPIRONOLACTONE (A-S Medication Solutions), SPIRONOLACTONE (A-S Medication Solutions), SPIRONOLACTONE (A-S Medication Solutions), SPIRONOLACTONE (A-S Medication Solutions), SPIRONOLACTONE (ATLANTIC BIOLOGICALS CORP.), SPIRONOLACTONE (ATLANTIC BIOLOGICALS CORP.), SPIRONOLACTONE (Accord Healthcare), SPIRONOLACTONE (American Health Packaging), SPIRONOLACTONE (Amneal Pharmaceuticals LLC), SPIRONOLACTONE (Amneal Pharmaceuticals NY LLC), SPIRONOLACTONE (Amneal Pharmaceuticals of New York LLC), SPIRONOLACTONE (Aphena Pharma Solutions - Tennessee), SPIRONOLACTONE (Aphena Pharma Solutions - Tennessee), SPIRONOLACTONE (Aphena Pharma Solutions - Tennessee), SPIRONOLACTONE (Aphena Pharma Solutions - Tennessee), SPIRONOLACTONE (Asclemed USA), SPIRONOLACTONE (Asclemed USA), SPIRONOLACTONE (Aurobindo Pharma Limited), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Cardinal Health 107), SPIRONOLACTONE (Cardinal Health 107), SPIRONOLACTONE (Cardinal Health 107), SPIRONOLACTONE (Direct_Rx), SPIRONOLACTONE (Direct_Rx), SPIRONOLACTONE (Direct_Rx), SPIRONOLACTONE (Direct_Rx), SPIRONOLACTONE (Jubilant Cadista Pharmacuticals), SPIRONOLACTONE (Jubilant Cadista Pharmacuticals), SPIRONOLACTONE (Major Pharmaceuticals), SPIRONOLACTONE (McKesson Corporation dba SKY Packaging), SPIRONOLACTONE (Mylan Institutional), SPIRONOLACTONE (Mylan Pharmaceuticals), SPIRONOLACTONE (NCS HealthCare of KY), SPIRONOLACTONE (NCS HealthCare of KY), SPIRONOLACTONE (NCS HealthCare of KY), SPIRONOLACTONE (NorthStar Rx LLC), SPIRONOLACTONE (NorthStar Rx LLC), SPIRONOLACTONE (NorthStar RxLLC), SPIRONOLACTONE (Northwind Pharmaceuticals), SPIRONOLACTONE (Northwind Pharmaceuticals), SPIRONOLACTONE (Northwind Pharmaceuticals), SPIRONOLACTONE (Northwind Pharmaceuticals), SPIRONOLACTONE (NuCare Pharmaceuticals), SPIRONOLACTONE (NuCare Pharmaceuticals), SPIRONOLACTONE (NuCare Pharmaceuticals), SPIRONOLACTONE (NuCare Pharmaceuticals), SPIRONOLACTONE (NuCare Pharmaceuticals), SPIRONOLACTONE (NuCare Pharmaceuticals), SPIRONOLACTONE (NuCare Pharmaceuticals), SPIRONOLACTONE (NuCare Pharmaceuticals), SPIRONOLACTONE (NuCare Pharmaceuticals), SPIRONOLACTONE (Oxford Pharmaceuticals), SPIRONOLACTONE (PD-Rx Pharmaceuticals), SPIRONOLACTONE (PD-Rx Pharmaceuticals), SPIRONOLACTONE (PD-Rx Pharmaceuticals), SPIRONOLACTONE (PD-Rx Pharmaceuticals), SPIRONOLACTONE (PD-Rx Pharmaceuticals), SPIRONOLACTONE (PD-Rx Pharmaceuticals), SPIRONOLACTONE (Padagis US LLC), SPIRONOLACTONE (PharmPak), SPIRONOLACTONE (Preferred Pharmaceuticals Inc..), SPIRONOLACTONE (Preferred Pharmaceuticals), SPIRONOLACTONE (Preferred Pharmaceuticals), SPIRONOLACTONE (Preferred Pharmaceuticals), SPIRONOLACTONE (Preferred Pharmaceuticals), SPIRONOLACTONE (Preferred Pharmaceuticals), SPIRONOLACTONE (Proficient Rx LP), SPIRONOLACTONE (Proficient Rx LP), SPIRONOLACTONE (Proficient Rx LP), SPIRONOLACTONE (Proficient Rx LP), SPIRONOLACTONE (Proficient Rx LP), SPIRONOLACTONE (Proficient Rx LP), SPIRONOLACTONE (QPharma), SPIRONOLACTONE (QPharma), SPIRONOLACTONE (Quality Care Products), SPIRONOLACTONE (Quality Care Products), SPIRONOLACTONE (REMEDYREPACK), SPIRONOLACTONE (REMEDYREPACK), SPIRONOLACTONE (REMEDYREPACK), SPIRONOLACTONE (REMEDYREPACK), SPIRONOLACTONE (REMEDYREPACK), SPIRONOLACTONE (REMEDYREPACK), SPIRONOLACTONE (REMEDYREPACK), SPIRONOLACTONE (REMEDYREPACK), SPIRONOLACTONE (REMEDYREPACK), SPIRONOLACTONE (REMEDYREPACK), SPIRONOLACTONE (REMEDYREPACK), SPIRONOLACTONE (REMEDYREPACK), SPIRONOLACTONE (REMEDYREPACK), SPIRONOLACTONE (RPK Pharmaceuticals), SPIRONOLACTONE (RPK Pharmaceuticals), SPIRONOLACTONE (RPK Pharmaceuticals), SPIRONOLACTONE (RPK Pharmaceuticals), SPIRONOLACTONE (RPK Pharmaceuticals), SPIRONOLACTONE (RPK Pharmaceuticals), SPIRONOLACTONE (RPK Pharmaceuticals), SPIRONOLACTONE (RedPharm Drug), SPIRONOLACTONE (Sun Pharmaceutical Industries), SPIRONOLACTONE (Zydus Lifesciences Limited), SPIRONOLACTONE (Zydus Pharmaceuticals (USA))
Formula
C24H32O4S
Exact mass
416.2021
Mol weight
416.57
Structure
Simcomp
Class
Cardiovascular agent
 DG03231  Antihypertensive
  DG01676  Aldosterone antagonist
 DG01885  Potassium-sparing diuretic
Remark
Same as: C07310
Therapeutic category: 2133
ATC code: C03DA01
Product: D00443<JP/US>
Product (mixture): D10270<US>
Efficacy
Antihypertensive, Diuretic, Aldosterone antagonist
  Disease
Primary hyperaldosteronism [DS:H01603]
Nephrotic syndrome [DS:H01657]
Essential hypertension [DS:H01633]
Target
NR3C2 (MR) [HSA:4306] [KO:K08555]
  Pathway
hsa04960  Aldosterone-regulated sodium reabsorption
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03D ALDOSTERONE ANTAGONISTS AND OTHER POTASSIUM-SPARING AGENTS
    C03DA Aldosterone antagonists
     C03DA01 Spironolactone
      D00443  Spironolactone (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Mineralocorticoid Receptor Antagonist
   Spironolactone
    D00443  Spironolactone (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   213  Diuretics
    2133  Antialdosterones
     D00443  Spironolactone (JP18/USP/INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG03231  Antihypertensive
   DG01676  Aldosterone antagonist
    D00443  Spironolactone
  DG01885  Potassium-sparing diuretic
   D00443  Spironolactone
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01676  Aldosterone antagonist
   D00443  Spironolactone
  DG03231  Antihypertensive
   D00443  Spironolactone
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C2 (MR)
     D00443  Spironolactone (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00443  Spironolactone
  D00443  Spironolactone tablets
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00443
Other DBs
CAS: 52-01-7
PubChem: 7847509
ChEBI: 9241
PDB-CCD: SNL[PDBj]
LigandBox: D00443
NIKKAJI: J4.474A
LinkDB
KCF data

ATOM        29
            1   C1z C    28.2976  -16.1582
            2   C1z C    27.0958  -16.8292
            3   C1x C    29.4642  -16.8582
            4   O7x O    29.4059  -15.3591
            5   C1x C    27.1950  -15.3533
            6   C1y C    27.0784  -18.2059
            7   C1x C    25.9176  -16.1408
            8   C1a C    26.4017  -15.2890
            9   C1x C    29.4468  -18.2292
            10  C7x C    28.9917  -14.0524
            11  C1x C    27.6209  -14.0466
            12  C1y C    25.8942  -18.8825
            13  C1x C    24.7217  -16.8175
            14  O6a O    29.8026  -12.9499
            15  C1y C    24.7100  -18.1883
            16  C1y C    25.8942  -20.2533
            17  C1z C    23.5199  -18.8709
            18  C1x C    24.6983  -20.9417
            19  S2a S    27.0784  -20.9476
            20  C2y C    23.5142  -20.2417
            21  C1x C    22.3300  -18.1825
            22  C1a C    23.5082  -17.4942
            23  C5a C    28.2683  -20.2593
            24  C2x C    22.3300  -20.9359
            25  C1x C    21.1398  -18.8709
            26  C1a C    29.4525  -20.9476
            27  O5a O    28.2743  -18.8825
            28  C5x C    21.1398  -20.2417
            29  O5x O    19.9499  -20.9359
BOND        33
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Up
            4     1   5 1 #Down
            5     2   6 1
            6     2   7 1
            7     2   8 1 #Up
            8     3   9 1
            9     4  10 1
            10    5  11 1
            11    6  12 1
            12    7  13 1
            13   10  14 2
            14   12  15 1
            15   12  16 1
            16   15  17 1
            17   16  18 1
            18   16  19 1 #Down
            19   17  20 1
            20   17  21 1
            21   17  22 1 #Up
            22   19  23 1
            23   20  24 2
            24   21  25 1
            25   23  26 1
            26   23  27 2
            27   24  28 1
            28   28  29 2
            29    6   9 1
            30   10  11 1
            31   13  15 1
            32   18  20 1
            33   25  28 1

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