KEGG   DRUG: Prochlorperazine
Entry
D00493                      Drug                                   
Name
Prochlorperazine (JAN/USP/INN);
Compro (TN)
Product
  Generic
Formula
C20H24ClN3S
Exact mass
373.1379
Mol weight
373.9427
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
 DG03200  Antipsychotic agent
  DG01905  Phenothiazine antipsychotics
Remark
Same as: C07403
ATC code: N05AB04
Chemical structure group: DG00876
Product (DG00876): D00493<US> D00479<JP/US> D02022<JP> D02609<US>
Efficacy
Antipsychotic, Anti-emetic, Dopamine D2 receptor antagonist
Comment
Phenothiazine derivative
Target
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
Interaction
Structure map
map07029  Antipsychotics - phenothiazines
map07048  Antimigraines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AB Phenothiazines with piperazine structure
     N05AB04 Prochlorperazine
      D00493  Prochlorperazine (JAN/USP/INN) <US>
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Prochlorperazine
    D00493  Prochlorperazine (JAN/USP/INN)
 Antipsychotics
  1st Generation/Typical
   Prochlorperazine
    D00493  Prochlorperazine (JAN/USP/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    DG00876  Prochlorperazine
     D00493  Prochlorperazine
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG00876  Prochlorperazine
     D00493  Prochlorperazine
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D00493  Prochlorperazine (JAN/USP/INN) <US>
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    DG00876  Prochlorperazine
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG00876  Prochlorperazine
Other DBs
CAS: 58-38-8
PubChem: 7847559
ChEBI: 8435
PDB-CCD: P77[PDBj]
LigandBox: D00493
NIKKAJI: J1.386B
LinkDB
KCF data

ATOM        25
            1   C8x C     9.8700  -14.4200
            2   C8x C     9.8700  -15.8200
            3   C8x C    11.0824  -16.5200
            4   C8y C    12.2949  -15.8200
            5   C8y C    12.2949  -14.4200
            6   C8x C    11.0824  -13.7200
            7   S2x S    13.5073  -16.5200
            8   C8y C    14.7197  -15.8200
            9   C8y C    14.7197  -14.4200
            10  N4y N    13.5073  -13.7200
            11  C8x C    15.9322  -16.5200
            12  C8x C    17.1446  -15.8200
            13  C8y C    17.1446  -14.4200
            14  C8x C    15.9322  -13.7200
            15  C1b C    13.5073  -12.3200
            16  X   Cl   18.3611  -13.7177
            17  C1b C    14.7218  -11.6188
            18  C1b C    15.9183  -12.3098
            19  N1y N    17.1051  -11.6246
            20  C1x C    18.2966  -12.3128
            21  C1x C    19.5091  -11.6129
            22  N1y N    19.5093  -10.2129
            23  C1x C    18.3178   -9.5248
            24  C1x C    17.1053  -10.2246
            25  C1a C    20.7341   -9.5058
BOND        28
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    8  11 2
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16    9  14 2
            17   10  15 1
            18   13  16 1
            19   15  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   19  24 1
            28   22  25 1

» Japanese version   » Back

KEGG   DRUG: Prochlorperazine maleate
Entry
D00479                      Drug                                   
Name
Prochlorperazine maleate (JP18/USP);
Compazine (TN)
Product
  Generic
Formula
C20H24ClN3S. (C4H4O4)2
Exact mass
605.1599
Mol weight
606.087
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
 DG03200  Antipsychotic agent
  DG01905  Phenothiazine antipsychotics
Remark
Therapeutic category: 1172
ATC code: N05AB04
Chemical structure group: DG00876
Product (DG00876): D00493<US> D00479<JP/US> D02022<JP> D02609<US>
Efficacy
Antipsychotic, Anti-emetic, Dopamine D2 receptor antagonist
  Disease
Schizophrenia [DS:H01649]
Comment
Phenothiazine derivative
Target
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
Interaction
Structure map
map07029  Antipsychotics - phenothiazines
map07048  Antimigraines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AB Phenothiazines with piperazine structure
     N05AB04 Prochlorperazine
      D00479  Prochlorperazine maleate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Prochlorperazine
    D00479  Prochlorperazine maleate (JP18/USP)
 Antipsychotics
  1st Generation/Typical
   Prochlorperazine
    D00479  Prochlorperazine maleate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1172  Phenothiazines
     D00479  Prochlorperazine maleate (JP18/USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    DG00876  Prochlorperazine
     D00479  Prochlorperazine maleate
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG00876  Prochlorperazine
     D00479  Prochlorperazine maleate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D00479  Prochlorperazine maleate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00479  Prochlorperazine maleate
  D00479  Prochlorperazine maleate tablets
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    DG00876  Prochlorperazine
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG00876  Prochlorperazine
Other DBs
CAS: 84-02-6
PubChem: 7847545
ChEBI: 8436
LigandBox: D00479
NIKKAJI: J215.253C
LinkDB
KCF data

ATOM        41
            1   C2b C    39.0699  -17.9328
            2   C2b C    37.4396  -17.9386
            3   C6a C    39.7454  -19.1089
            4   C6a C    36.7699  -19.1205
            5   O6a O    39.0756  -20.2792
            6   O6a O    41.1078  -19.0915
            7   O6a O    35.4074  -19.1205
            8   O6a O    37.4510  -20.2909
            9   C8x C    22.1200  -19.3900
            10  C8x C    22.1200  -20.7900
            11  C8x C    23.3100  -21.4900
            12  C8y C    24.5700  -20.7900
            13  C8y C    24.5700  -19.3900
            14  C8x C    23.3100  -18.6900
            15  S2x S    25.7600  -21.4900
            16  C8y C    26.9500  -20.7900
            17  C8y C    26.9500  -19.3900
            18  N4y N    25.7600  -18.6900
            19  C8x C    28.2100  -21.4900
            20  C8x C    29.4000  -20.7900
            21  C8y C    29.4000  -19.3900
            22  C8x C    28.2100  -18.6900
            23  C1b C    25.7600  -17.2900
            24  X   Cl   30.5900  -18.6900
            25  C1b C    26.9500  -16.5900
            26  C1b C    28.1400  -17.2900
            27  N1y N    29.3300  -16.5900
            28  C1x C    30.5200  -17.2900
            29  C1x C    31.7800  -16.5900
            30  N1y N    31.7800  -15.1900
            31  C1x C    30.5900  -14.4900
            32  C1x C    29.3300  -15.1900
            33  C1a C    32.9700  -14.4900
            34  C2b C    39.0699  -17.9328
            35  C2b C    37.4396  -17.9386
            36  C6a C    36.7699  -19.1205
            37  O6a O    35.4074  -19.1205
            38  O6a O    37.4510  -20.2909
            39  C6a C    39.7454  -19.1089
            40  O6a O    39.0756  -20.2792
            41  O6a O    41.1078  -19.0915
BOND        42
            1     9  10 2
            2    10  11 1
            3    11  12 2
            4    12  13 1
            5    13  14 2
            6     9  14 1
            7    12  15 1
            8    15  16 1
            9    16  17 1
            10   17  18 1
            11   13  18 1
            12   16  19 2
            13   19  20 1
            14   20  21 2
            15   21  22 1
            16   17  22 2
            17   18  23 1
            18   21  24 1
            19   23  25 1
            20   25  26 1
            21   26  27 1
            22   27  28 1
            23   28  29 1
            24   29  30 1
            25   30  31 1
            26   31  32 1
            27   27  32 1
            28   30  33 1
            29    1   2 2
            30    1   3 1
            31    2   4 1
            32    3   5 1
            33    3   6 2
            34    4   7 1
            35    4   8 2
            36   34  35 2
            37   34  39 1
            38   35  36 1
            39   39  40 1
            40   39  41 2
            41   36  37 1
            42   36  38 2
BRACKET     1    34.1600  -21.1400   34.1600  -16.9400
            1    41.6500  -16.9400   41.6500  -21.1400
            1  2
 ORIGINAL  1    1   2   4   7   8   3   5   6
 REPEAT    1   34  35  36  37  38  39  40  41

» Japanese version   » Back

KEGG   DRUG: Prochlorperazine mesilate
Entry
D02022                      Drug                                   
Name
Prochlorperazine mesilate (JAN);
Prochlorperazine dimethanesulfonate;
Novamin (TN)
Formula
C20H24ClN3S. (CH4SO3)2
Exact mass
565.1142
Mol weight
566.154
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
 DG03200  Antipsychotic agent
  DG01905  Phenothiazine antipsychotics
Remark
Same as: C13524
Therapeutic category: 1172
ATC code: N05AB04
Chemical structure group: DG00876
Product (DG00876): D00493<US> D00479<JP/US> D02022<JP> D02609<US>
Efficacy
Antipsychotic, Dopamine D2 receptor antagonist
Comment
Phenothiazine derivative
Target
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
Interaction
Structure map
map07029  Antipsychotics - phenothiazines
map07048  Antimigraines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AB Phenothiazines with piperazine structure
     N05AB04 Prochlorperazine
      D02022  Prochlorperazine mesilate (JAN) <JP>
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Prochlorperazine
    D02022  Prochlorperazine mesilate (JAN)
 Antipsychotics
  1st Generation/Typical
   Prochlorperazine
    D02022  Prochlorperazine mesilate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1172  Phenothiazines
     D02022  Prochlorperazine mesilate (JAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    DG00876  Prochlorperazine
     D02022  Prochlorperazine mesilate
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG00876  Prochlorperazine
     D02022  Prochlorperazine mesilate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D02022  Prochlorperazine mesilate (JAN) <JP>
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    DG00876  Prochlorperazine
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG00876  Prochlorperazine
Other DBs
CAS: 51888-09-6
PubChem: 7849084
ChEBI: 34932
LigandBox: D02022
NIKKAJI: J299.340F
LinkDB
KCF data

ATOM        35
            1   S4a S    37.7980  -17.9935
            2   C1a C    36.4023  -17.9935
            3   O1d O    39.1937  -17.9935
            4   O1d O    37.7908  -16.5978
            5   O1d O    37.7908  -19.3893
            6   C8x C    23.0300  -18.0600
            7   C8x C    23.0300  -19.4600
            8   C8x C    24.2200  -20.1600
            9   C8y C    25.4800  -19.4600
            10  C8y C    25.4800  -18.0600
            11  C8x C    24.2200  -17.3600
            12  S2x S    26.6700  -20.1600
            13  C8y C    27.8600  -19.4600
            14  C8y C    27.8600  -18.0600
            15  N4y N    26.6700  -17.3600
            16  C8x C    29.1200  -20.1600
            17  C8x C    30.3100  -19.4600
            18  C8y C    30.3100  -18.0600
            19  C8x C    29.1200  -17.3600
            20  C1b C    26.6700  -15.9600
            21  X   Cl   31.5000  -17.3600
            22  C1b C    27.8600  -15.2600
            23  C1b C    29.0500  -15.9600
            24  N1y N    30.2400  -15.2600
            25  C1x C    31.4300  -15.9600
            26  C1x C    32.6900  -15.2600
            27  N1y N    32.6900  -13.8600
            28  C1x C    31.5000  -13.1600
            29  C1x C    30.2400  -13.8600
            30  C1a C    33.8800  -13.1600
            31  S4a S    37.7980  -17.9935
            32  C1a C    36.4023  -17.9935
            33  O1d O    39.1937  -17.9935
            34  O1d O    37.7908  -16.5978
            35  O1d O    37.7908  -19.3893
BOND        36
            1     6   7 2
            2     7   8 1
            3     8   9 2
            4     9  10 1
            5    10  11 2
            6     6  11 1
            7     9  12 1
            8    12  13 1
            9    13  14 1
            10   14  15 1
            11   10  15 1
            12   13  16 2
            13   16  17 1
            14   17  18 2
            15   18  19 1
            16   14  19 2
            17   15  20 1
            18   18  21 1
            19   20  22 1
            20   22  23 1
            21   23  24 1
            22   24  25 1
            23   25  26 1
            24   26  27 1
            25   27  28 1
            26   28  29 1
            27   24  29 1
            28   27  30 1
            29    1   2 1
            30    1   3 1
            31    1   4 2
            32    1   5 2
            33   31  32 1
            34   31  33 1
            35   31  34 2
            36   31  35 2
BRACKET     1    34.3700  -20.3700   34.3700  -15.5400
            1    40.7400  -15.5400   40.7400  -20.3700
            1  2
 ORIGINAL  1    1   2   3   4   5
 REPEAT    1   31  32  33  34  35

» Japanese version   » Back

KEGG   DRUG: Prochlorperazine edisylate
Entry
D02609                      Drug                                   
Name
Prochlorperazine edisylate (USP);
Compazine syrup (TN)
Product
  Generic
Formula
C20H24ClN3S. C2H6O6S2
Exact mass
563.0985
Mol weight
564.1381
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
 DG03200  Antipsychotic agent
  DG01905  Phenothiazine antipsychotics
Remark
ATC code: N05AB04
Chemical structure group: DG00876
Product (DG00876): D00493<US> D00479<JP/US> D02022<JP> D02609<US>
Efficacy
Anti-emetic, Antipsychotic, Dopamine D2 receptor antagonist
Comment
Phenothiazine derivative
Target
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
Interaction
Structure map
map07029  Antipsychotics - phenothiazines
map07048  Antimigraines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AB Phenothiazines with piperazine structure
     N05AB04 Prochlorperazine
      D02609  Prochlorperazine edisylate (USP) <US>
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Prochlorperazine
    D02609  Prochlorperazine edisylate (USP)
 Antipsychotics
  1st Generation/Typical
   Prochlorperazine
    D02609  Prochlorperazine edisylate (USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    DG00876  Prochlorperazine
     D02609  Prochlorperazine edisylate
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG00876  Prochlorperazine
     D02609  Prochlorperazine edisylate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D02609  Prochlorperazine edisylate (USP) <US>
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    DG00876  Prochlorperazine
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG00876  Prochlorperazine
Other DBs
CAS: 1257-78-9
PubChem: 17396779
LigandBox: D02609
NIKKAJI: J349.704F
LinkDB
KCF data

ATOM        35
            1   C8x C    24.0100  -14.8400
            2   C8x C    24.0100  -16.2400
            3   C8x C    25.2000  -16.9400
            4   C8y C    26.4600  -16.2400
            5   C8y C    26.4600  -14.8400
            6   C8x C    25.2000  -14.1400
            7   S2x S    27.6500  -16.9400
            8   C8y C    28.8400  -16.2400
            9   C8y C    28.8400  -14.8400
            10  N4y N    27.6500  -14.1400
            11  C8x C    30.1000  -16.9400
            12  C8x C    31.2900  -16.2400
            13  C8y C    31.2900  -14.8400
            14  C8x C    30.1000  -14.1400
            15  C1b C    27.6500  -12.7400
            16  X   Cl   32.4800  -14.1400
            17  C1b C    28.8400  -12.0400
            18  C1b C    30.0300  -12.7400
            19  N1y N    31.2200  -12.0400
            20  C1x C    32.4100  -12.7400
            21  C1x C    33.6700  -12.0400
            22  N1y N    33.6700  -10.6400
            23  C1x C    32.4800   -9.9400
            24  C1x C    31.2200  -10.6400
            25  C1a C    34.8600   -9.9400
            26  S4a S    37.9624  -13.5100
            27  C1b C    39.1749  -14.2100
            28  C1b C    40.3873  -13.5100
            29  S4a S    41.5997  -14.2100
            30  O1d O    36.7500  -12.8100
            31  O1d O    38.6566  -12.3073
            32  O1d O    37.2570  -14.7321
            33  O1d O    42.8122  -14.9100
            34  O1d O    42.2947  -13.0061
            35  O1d O    40.8950  -15.4310
BOND        37
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    8  11 2
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16    9  14 2
            17   10  15 1
            18   13  16 1
            19   15  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   19  24 1
            28   22  25 1
            29   26  27 1
            30   27  28 1
            31   28  29 1
            32   26  30 1
            33   26  31 2
            34   26  32 2
            35   29  33 1
            36   29  34 2
            37   29  35 2

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