KEGG   DRUG: PindololHelp
Entry
D00513                      Drug                                   

Name
Pindolol (JP17/USP/INN);
Blocklin-L (TN);
Carvisken (TN);
Visken (TN)
Product
  Generic
Formula
C14H20N2O2
Exact mass
248.1525
Mol weight
248.3208
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01806  Class II antiarrhythmic agent
 DG01466  Adrenergic receptor antagonist
  DG01464  beta-Adrenergic receptor antagonist
   DG01461  beta1-Adrenergic receptor antagonist
   DG01462  beta2-Adrenergic receptor antagonist
   DG01463  beta3-Adrenergic receptor antagonist
Enzyme substrate
 DG01644  CYP2D6 substrate
Transporter substrate
 DG02854  SLC22A2 (OCT2) substrate
Remark
Same as: C07445
Therapeutic category: 2123 2149
ATC code: C07AA03
Product: D00513<JP/US>
Efficacy
Antiarrhythmic, Antihypertensive, Vasodilator, beta-Adrenergic receptor antagonist
  Disease
Hypertension [DS:H01633]
Comment
Propranolol derivative
Target
ADRB [HSA:153 154 155] [KO:K04141 K04142 K04143]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Transporter: SLC22A2 [HSA:6582]
Interaction
Drug interaction
Structure map
map07037  Antiarrhythmic drugs
map07214  beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AA Beta blocking agents, non-selective
     C07AA03 Pindolol
      D00513  Pindolol (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Beta-adrenergic Blocking Agents
   Pindolol
    D00513  Pindolol (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2123  Beta blockers
     D00513  Pindolol (JP17/USP/INN)
   214  Antihypertensives
    2149  Others
     D00513  Pindolol (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRB
     D00513  Pindolol (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00513  Pindolol
Drug classes of therapeutic agents [br08360.html]
 Cardiovascular agents
  D00513
BRITE hierarchy
Other DBs
CAS: 13523-86-9
PubChem: 7847579
ChEBI: 8214
ChEMBL: CHEMBL500
DrugBank: DB00960
LigandBox: D00513
NIKKAJI: J3.439H
LinkDB All DBs
KCF data Show

ATOM        18
            1   C8y C    18.9000  -17.2200
            2   C8y C    18.9000  -18.6200
            3   C8y C    20.1600  -16.5200
            4   C8x C    17.5700  -16.8000
            5   N4x N    17.5700  -19.1100
            6   C8x C    20.1600  -19.3200
            7   C8x C    21.3500  -17.2200
            8   O2a O    20.1600  -15.1200
            9   C8x C    16.8000  -17.9200
            10  C8x C    21.3500  -18.6200
            11  C1b C    21.3500  -14.4200
            12  C1c C    22.5400  -15.1200
            13  C1b C    23.8000  -14.4200
            14  O1a O    22.5400  -16.5200
            15  N1b N    24.9900  -15.1200
            16  C1c C    26.1800  -14.4200
            17  C1a C    27.4400  -15.1200
            18  C1a C    26.1800  -13.0200
BOND        19
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     6  10 2
            10    8  11 1
            11   11  12 1
            12   12  13 1
            13   12  14 1
            14   13  15 1
            15   15  16 1
            16   16  17 1
            17   16  18 1
            18    5   9 1
            19    7  10 1

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