KEGG   DRUG: Chlorothiazide
Entry
D00519                      Drug                                   
Name
Chlorothiazide (JAN/USP/INN);
Diuril (TN)
Product
DIURIL (Salix Pharmaceuticals)
Formula
C7H6ClN3O4S2
Exact mass
294.9488
Mol weight
295.73
Structure
Simcomp
Class
Cardiovascular agent
 DG03231  Antihypertensive
  DG01749  Thiazide diuretic
 DG01690  Sulfonamide diuretic
  DG01749  Thiazide diuretic
Remark
Same as: C07461
ATC code: C03AA04
Chemical structure group: DG00268
Product (DG00268): D00519<US> D03471<US>
Efficacy
Antihypertensive, Diuretic, Na+-Cl- symport inhibitor
  Disease
Hypertension [DS:H01633]
Comment
Thiazides
Target
SLC12A3 (TSC) [HSA:6559] [KO:K14426]
Interaction
Structure map
map07017  Sulfonamide derivatives - diuretics
map07055  Sulfonamide derivatives - overview
map07233  Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03A LOW-CEILING DIURETICS, THIAZIDES
    C03AA Thiazides, plain
     C03AA04 Chlorothiazide
      D00519  Chlorothiazide (JAN/USP/INN) <US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Diuretics, Thiazide
   Chlorothiazide
    D00519  Chlorothiazide (JAN/USP/INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG03231  Antihypertensive
   DG01749  Thiazide diuretic
    DG00268  Chlorothiazide
     D00519  Chlorothiazide
  DG01690  Sulfonamide diuretic
   DG01749  Thiazide diuretic
    DG00268  Chlorothiazide
     D00519  Chlorothiazide
Drug classes [BR:br08332]
 Cardiovascular agent
  DG03231  Antihypertensive
   D00519  Chlorothiazide
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A3 (TSC)
     D00519  Chlorothiazide (JAN/USP/INN) <US>
Drug groups [BR:br08330]
 Cardiovascular agent
  DG03231  Antihypertensive
   DG01749  Thiazide diuretic
    DG00268  Chlorothiazide
  DG01690  Sulfonamide diuretic
   DG01749  Thiazide diuretic
    DG00268  Chlorothiazide
Other DBs
CAS: 58-94-6
PubChem: 7847585
ChEBI: 3640
LigandBox: D00519
NIKKAJI: J2.807J
LinkDB
KCF data

ATOM        17
            1   C8y C    19.8889  -15.0612
            2   C8y C    19.8946  -16.4185
            3   C8x C    21.0648  -14.3768
            4   S2x S    18.7070  -14.3943
            5   C8x C    21.0705  -17.0914
            6   N5x N    18.7304  -17.1088
            7   C8y C    22.2407  -15.0495
            8   N4x N    17.5371  -15.0846
            9   O3c O    17.3849  -13.5811
            10  O3c O    19.9298  -13.5577
            11  C8y C    22.2465  -16.4068
            12  C8x C    17.5488  -16.4419
            13  S4a S    23.4166  -14.3651
            14  X   Cl   23.4283  -17.0797
            15  N1a N    24.6568  -13.5168
            16  O3c O    24.5457  -15.3714
            17  O3c O    22.3284  -13.3295
BOND        18
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 1
            8     4   9 2
            9     4  10 2
            10    5  11 2
            11    6  12 2
            12    7  13 1
            13   11  14 1
            14   13  15 1
            15   13  16 2
            16   13  17 2
            17    7  11 1
            18    8  12 1

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KEGG   DRUG: Chlorothiazide sodium
Entry
D03471                      Drug                                   
Name
Chlorothiazide sodium (USP);
Diuril (TN)
Product
  Generic
CHLOROTHIAZIDE (Fresenius Kabi USA), CHLOROTHIAZIDE (Fresenius Kabi USA), CHLOROTHIAZIDE (Fresenius Kabi USA), CHLOROTHIAZIDE SODIUM (American Regent), CHLOROTHIAZIDE SODIUM (Gland Pharma Limited), CHLOROTHIAZIDE SODIUM (Sagent Pharmaceuticals), CHLOROTHIAZIDE SODIUM (Sagent Pharmaceuticals), CHLOROTHIAZIDE SODIUM (Sun Pharmaceutical Industries)
Formula
C7H5ClN3O4S2. Na
Exact mass
316.9308
Mol weight
317.71
Structure
Simcomp
Class
Cardiovascular agent
 DG03231  Antihypertensive
  DG01749  Thiazide diuretic
 DG01690  Sulfonamide diuretic
  DG01749  Thiazide diuretic
Remark
ATC code: C03AA04
Chemical structure group: DG00268
Product (DG00268): D00519<US> D03471<US>
Efficacy
Antihypertensive, Diuretic
  Disease
Nephrotic syndrome [DS:H01657]
Target
SLC12A3 (TSC) [HSA:6559] [KO:K14426]
Interaction
Structure map
map07017  Sulfonamide derivatives - diuretics
map07055  Sulfonamide derivatives - overview
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03A LOW-CEILING DIURETICS, THIAZIDES
    C03AA Thiazides, plain
     C03AA04 Chlorothiazide
      D03471  Chlorothiazide sodium (USP) <US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Diuretics, Thiazide
   Chlorothiazide
    D03471  Chlorothiazide sodium (USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG03231  Antihypertensive
   DG01749  Thiazide diuretic
    DG00268  Chlorothiazide
     D03471  Chlorothiazide sodium
  DG01690  Sulfonamide diuretic
   DG01749  Thiazide diuretic
    DG00268  Chlorothiazide
     D03471  Chlorothiazide sodium
Drug classes [BR:br08332]
 Cardiovascular agent
  DG03231  Antihypertensive
   D03471  Chlorothiazide sodium
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A3 (TSC)
     D03471  Chlorothiazide sodium (USP) <US>
Drug groups [BR:br08330]
 Cardiovascular agent
  DG03231  Antihypertensive
   DG01749  Thiazide diuretic
    DG00268  Chlorothiazide
  DG01690  Sulfonamide diuretic
   DG01749  Thiazide diuretic
    DG00268  Chlorothiazide
Other DBs
CAS: 7085-44-1
PubChem: 17397608
LigandBox: D03471
NIKKAJI: J8.891I
LinkDB
KCF data

ATOM        18
            1   C8y C    19.8888  -15.0612
            2   C8y C    19.8945  -16.4185
            3   C8x C    21.0647  -14.3768
            4   S2x S    18.7069  -14.3943
            5   C8x C    21.0704  -17.0913
            6   N5x N    18.7303  -17.1087
            7   C8y C    22.2406  -15.0495
            8   N4x N    17.5370  -15.0846 #-
            9   O3c O    17.3848  -13.5811
            10  O3c O    19.9297  -13.5577
            11  C8y C    22.2464  -16.4068
            12  C8x C    17.5487  -16.4418
            13  S4a S    23.4165  -14.3651
            14  X   Cl   23.4282  -17.0796
            15  N1a N    24.6567  -13.5168
            16  O3c O    24.5456  -15.3714
            17  O3c O    22.3283  -13.3295
            18  Z   Na   14.0700  -15.1900 #+
BOND        18
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 1
            8     4   9 2
            9     4  10 2
            10    5  11 2
            11    6  12 2
            12    7  13 1
            13   11  14 1
            14   13  15 1
            15   13  16 2
            16   13  17 2
            17    7  11 1
            18    8  12 1

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